期刊
MUSCLE & NERVE
卷 42, 期 3, 页码 339-347出版社
WILEY
DOI: 10.1002/mus.21678
关键词
high-frequency alternating current; intrafascicular; microelectrode arrays; muscle block; nerve conduction block; neuromuscular block
资金
- National Institutes of Health [R01-NS039667]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1134545] Funding Source: National Science Foundation
High-frequency alternating current (HFAC) applied to a peripheral nerve can reversibly block skeletal muscle contractions. We evaluated the ability of HFAC delivered via intrafascicular electrodes to selectively block activation of targeted muscles without affecting activation of other muscles. Utah slanted electrode arrays (USEAs) were implanted into the sciatic nerves of five cats, and HFAC was delivered to individual USEA electrodes. The effects of HFAC block were monitored by recording evoked electromyograms (EMGs) and three-dimensional endpoint forces. In each animal, activity evoked in targeted muscles by nerve cuff stimulation could be selectively abolished by HFAC delivered via individual USEA electrodes. Two mechanisms of blockade were evoked: selective neuromuscular blocks were achieved with 500-8000-Hz HFAC, and selective nerve conduction block was achieved in one animal using 16-kHz HFAC. These results show that intrafascicular HFAC can be used to block selected muscles independent of activation of other muscles. Muscle Nerve 42: 339-347,2010
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