期刊
MUSCLE & NERVE
卷 41, 期 2, 页码 257-260出版社
WILEY
DOI: 10.1002/mus.21559
关键词
mdx mouse; mitochondrial respiratory chain; creatine kinase; brain
资金
- CNPq
- FAPESC
- Instituto Cerebro e Mente
- UNESC
In this study we investigated energy metabolism in the mdx mouse brain. To this end, prefrontal cortex, cerebellum, hippocampus, striatum, and cortex were analyzed. There was a decrease in Complex I but not in Complex 11 activity in all structures. There was an increase in Complex III activity in striatum and a decrease in Complex IV activity in prefrontal cortex and striatum. Mitochondrial creatine kinase activity was increased in hippocampus, prefrontal cortex, cortex, and striatum. Our results indicate that there is energy metabolism dysfunction in the mdx mouse brain. Muscle Nerve 41: 257-260, 2010
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