期刊
MUSCLE & NERVE
卷 41, 期 3, 页码 335-341出版社
WILEY-BLACKWELL
DOI: 10.1002/mus.21485
关键词
aging; IGF-1; nerve injury; nerve regeneration; neuromuscular junction
资金
- Orthopedic Research and Education Foundation
- National Institutes of Health [P01-AG11370]
Age is an important predictor of neuromuscular recovery after peripheral nerve injury. Insulin-like growth factor 1 (IGF-1) is a potent neurotrophic factor that is known to decline with increasing age. The purpose of this study was to determine if locally delivered IGF-1 would improve nerve regeneration and neuromuscular recovery in aged animals. Young and aged rats underwent nerve transection and repair with either saline or IGF-1 continuously delivered to the site of the nerve repair. After 3 months, nerve regeneration and neuromuscular junction morphology were assessed. In both young and aged animals, IGF-1 significantly improved axon number, diameter, and density. IGF-1 also significantly increased myelination and Schwann cell activity and preserved the morphology of the postsynaptic neuromuscular junction (NMJ). These results show that aged regenerating nerve is sensitive to IGF-1 treatment. Muscle Nerve 41: 335-341, 2010
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