Review
Biochemistry & Molecular Biology
Trevor Poitras, Douglas W. Zochodne
Summary: Common mechanisms of peripheral axon regeneration are recruited following diverse forms of damage to peripheral nerve axons. Supporting peripheral axon regrowth could be achieved through direct axon support or manipulation of the inflammatory milieu. Understanding the molecular barriers to regrowth and exploiting the downstream signaling pathways that impact neuron growth are promising approaches for promoting adult peripheral axon regeneration. This review emphasizes intrinsic aspects of adult peripheral axon regeneration and highlights several molecular barriers to regrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Raul P. Oliveira, Ivo F. Machado, Carlos M. Palmeira, Anabela P. Rolo
Summary: Liver regeneration is a complex phenomenon that can be compromised by extensive liver damage, with ischemia/reperfusion injury (IRI) being a common source of damage. Sestrin 2 (SESN2) plays an important role in liver regeneration and IRI by protecting cells from mitochondrial dysfunction and oxidative stress, highlighting its potential therapeutic significance.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Yingying Zeng, Guiping Zhu, Mengchan Zhu, Juan Song, Hui Cai, Yuanlin Song, Jian Wang, Meiling Jin
Summary: The study demonstrated that EDA treatment has a protective effect on alleviating PM-induced lung inflammation by maintaining mitochondrial balance and regulating the ROS-NF-kappa B p65 signaling pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Review
Biochemistry & Molecular Biology
Dong Keon Yon, Yong Jun Kim, Dong Choon Park, Su Young Jung, Sung Soo Kim, Joon Hyung Yeo, Jeongmin Lee, Jae Min Lee, Seung Geun Yeo
Summary: A literature review on the role of autophagy in peripheral nerve injury and regeneration was conducted. The review identified several factors, such as LC3II/I, PI3K, mTOR, Beclin-1, ATG3, ATG5, ATG7, ATG9, and ATG12, that are involved in the process of nerve degeneration and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ping Pang, Wei Si, Han Wu, Jiaming Ju, Kuiwu Liu, Chunlei Wang, Yingqiong Jia, Hongtao Diao, Linghua Zeng, Weitao Jiang, Yang Yang, Yuting Xiong, Xue Kong, Zhengwei Zhang, Feng Zhang, Jinglun Song, Ning Wang, Baofeng Yang, Yu Bian
Summary: YTHDF2 affects myocardial ischemia-reperfusion injury by regulating RNA stability. Silencing YTHDF2 protects cardiac function and reduces infarct size, while overexpressing YTHDF2 exacerbates pathological processes. RNA analysis reveals that YTHDF2 recognizes m6A modification sites to promote the degradation of SLC7A11. Inhibition of SLC7A11 impairs heart function, increases infarct size, and the release of LDH. These findings provide novel potential therapeutic targets for treating ischemic cardiac diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Yanxia Fei, Jiali Shao, Ge Huang, Lijuan Wang, Shuangfa Zou, Huiping Sun, Chumei Zheng, Jinfeng Yang
Summary: This study investigated the protective effect of edaravone (ED) on hepatic ischemia-reperfusion injury (HIRI) in rats and explored its mechanism involving exosomal miRNA. The results showed that ED could attenuate the liver damage caused by HIRI, as evidenced by lower levels of ALT, AST, oxidative stress, and inflammatory markers. Additionally, ED prevented the downregulation of miRNA PC-3p-190-42101 and its expression was correlated with the level of inflammatory factors. These findings suggest that ED protects the liver from IRI by regulating the inflammatory factors through the modulation of miRNA expression in plasma exosomes.
CURRENT MOLECULAR PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Article
Neurosciences
P. Komirishetty, K. Zubkow, A. Areti, H. Ong, D. W. Zochodne
Summary: The study found that local delivery of Rb1 siRNA can promote nerve regeneration at the outset, enhancing reinnervation of epidermal axons. Combining intrinsic Rb1 knockdown with exogenous insulin can significantly improve growth patterns of adult sensory neurons in vitro and enhance regeneration outcomes in vivo. Overall, the findings highlight the responsiveness of regrowing peripheral neurons to both intrinsic and exogenous approaches that improve their recovery, as well as a novel local approach to manipulate gene expression and outcome in regrowing axons.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Cell Biology
Jingxin Zhang, Binjing Zhang, Jinglan Zhang, Weimin Lin, Shiwen Zhang
Summary: Magnesium as a suitable material for promoting peripheral nerve regeneration has both challenges and potentials, but there is currently limited research on this topic, requiring further exploration to address the shortcomings and challenges identified.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Kuan-Hung Chen, Han-Tan Chai, Chih-Hung Chen, Chi-Ruei Huang, John Y. Chiang, Pei-Hsun Sung, Yi-Ching Chu, Hon-Kan Yip
Summary: The study demonstrated that combined CsA and Mel were superior to either CsA or Mel alone in protecting the brain against ischemia-reperfusion injury. The combination treatment showed significant reductions in neuronal damage and various biomarkers expressions in both cell and animal experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Xiaolan Li, Xiang Zhang, Ming Hao, Dongxu Wang, Ziping Jiang, Liqun Sun, Yongjian Gao, Ye Jin, Peng Lei, Yue Zhuo
Summary: This review summarizes the importance of collagen in peripheral nerve regeneration, focusing on its characteristics, role, and optimization methods. Collagen, as a biomaterial, plays a crucial role in peripheral nerve repair and can be further optimized by adjusting its structure and physical properties, as well as combining it with bioactive components.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yangnan Hu, Zhuoyue Chen, Hongyang Wang, Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu, Yuanjin Zhao, Renjie Chai
Summary: Inspired by the structures of peripheral nerves, researchers have developed a conductive topological scaffold for nerve repair using modified butterfly wings. The scaffold showed increased neurite length and guided cellular orientation, and successfully repaired nerve defects in rats.
Article
Chemistry, Multidisciplinary
Shuting Wang, Haotian Lu, Xinchang Kang, Zhenqing Wang, Shengtao Yang, Xuehui Zhang, Xuetao Shi
Summary: The study presents an adhesive, conductive, and immunomodulatory nerve hydrogel bandage that can promote peripheral nerve regeneration and facilitate anatomical and functional recovery of neural tissue.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Teng Wan, Yi-Lin Wang, Feng-Shi Zhang, Xiao-Meng Zhang, Yi-Chong Zhang, Hao-Ran Jiang, Meng Zhang, Pei-Xun Zhang
Summary: This review discusses the importance of porous structures in peripheral nerve guidance conduits (NGCs) and their impact on physical properties and cellular behavior during peripheral nerve regeneration. It provides an overview of the features and classification of porous structures in NGCs, as well as common methods for constructing them. The review also emphasizes the significance of ideal porous structures in the regeneration of peripheral nerve tissue engineering materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
