Article
Clinical Neurology
Marion Selton, Guillaume Mathey, Marc Soudant, Philippe Manceau, Rene Anxionnat, Marc Debouverie, Jacques Jonas
Summary: This study aims to evaluate whether epileptic seizures may be a prognostic marker of MS disability. The results suggest that epileptic seizures may be associated with the severity and progression of MS. If epileptic seizures occur early in MS, they may serve as a prognostic marker, while if they develop during the course of the disease, they may worsen the progression of MS.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ruth Leadbetter, Michael MacAskill, Daniell J. Myall, Bruce Taylor, Purwa Joshi, Deborah F. Mason
Summary: A long-term study on multiple sclerosis patients in New Zealand found that their median survival age is 7.2 years lower than the general population and they have twice the mortality risk. The survival gap is greater for those with an early age of onset and progressive-onset disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Katharine Elizabeth Harding, Gillian Ingram, Emma Clare Tallantyre, Fady Joseph, Mark Wardle, Trevor P. Pickersgill, Mark D. Willis, Valentina Tomassini, Owen Rhys Pearson, Neil P. Robertson
Summary: This study provides a detailed contemporary model of disability outcomes in a representative population-based MS cohort. The results support a trend of increasing time to disability milestones compared with historical reference populations, and document disability variation with the use of transitional matrices. This study has important implications for patient counseling, clinical trial design, and assessment of therapeutic interventions.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Melinda Magyari, Hanna Joensen, Tine Iskov Kopp, Luigi Pontieri, Nils Koch-Henriksen
Summary: The course of multiple sclerosis appears to be milder in recent decades. Patients in more recent onset cohorts have shorter diagnostic delays and a higher rate of starting disease-modifying treatment within 1 year. The prognosis is better for later onset cohorts.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Malthe Faurschou Wandall-Holm, Mathias Due Buron, Tine Iskov Kopp, Karsten Thielen, Finn Sellebjerg, Melinda Magyari
Summary: Initiating treatment early reduces the risk of disability pension in patients with RRMS. This finding highlights the importance of early diagnosis and treatment on a patient-centered, socioeconomic disability milestone.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Jeff Rodgers, Tim Friede, Frederick W. Vonberg, Cris S. Constantinescu, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, Helen Ford, Lennora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin McDonnell, Brendan McLean, Owen R. Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Heather C. Wilson, David Ford, Rod M. Middleton, Richard Nicholas
Summary: The negative impact of smoking in multiple sclerosis is well documented, but there is limited evidence on the benefits of smoking cessation for disease progression. This study found that current smokers had higher disability scores compared to those who had never smoked, and there was no improvement in scores with increasing time since quitting. However, when smokers quit, the rate of motor disability deterioration slowed down to match that of non-smokers. This suggests that smoking cessation is beneficial for people with multiple sclerosis.
Review
Clinical Neurology
M. Puthenparampil, P. Perini, R. Bergamaschi, M. Capobianco, M. Filippi, P. Gallo
Summary: Italy is considered a high-risk country for multiple sclerosis (MS), with the incidence and prevalence gradually increasing over the past years. Research suggests that environmental factors may better explain this trend than genetic heterogeneity.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Torbjorn Akerstedt, Tomas Olsson, Lars Alfredsson, Anna Karin Hedstroem
Summary: Insufficient sleep and low sleep quality may increase the risk of developing multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Stefan Bittner, Jiwon Oh, Eva Kubala Havrdova, Mar Tintore, Frauke Zipp
Summary: Blood-based serum neurofilament light chain (sNfL) is being investigated as a biomarker for prognosis and treatment response in multiple sclerosis patients. It reflects ongoing inflammatory-driven neuroaxonal damage and has the potential to guide individualized clinical decision-making.
Article
Clinical Neurology
Friederike Neuss, Felix von Podewils, Zhong Irene Wang, Marie Suesse, Uwe Klaus Zettl, Matthias Grothe
Summary: This study described a cohort of patients with both MS and epileptic seizures, finding that a significant percentage of MS patients with seizures had competing causes at the time of the first seizure. A detailed diagnostic setup including patient history, EEG, and MRI is recommended for evaluation and treatment decisions.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Elisa Longinetti, Simon Englund, Joachim Burman, Katharina Fink, Anna Fogdell-Hahn, Martin Gunnarsson, Jan Hillert, Annette Magdalene Langer-Gould, Jan Lycke, Petra Nilsson, Jonatan Salzer, Anders Svenningsson, Johan Mellergard, Tomas Olsson, Fredrik Piehl, Thomas Frisell
Summary: This study analyzed a Swedish nationwide observational study on RRMS to identify trajectories of processing speed and physical disability after DMT start. The results showed that patients' processing speed remained stable over time, while those with moderate physical disability experienced deterioration in physical function. However, there was a strong association between processing speed and disability.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Immunology
Klaus Berek, Angelika Bauer, Dagmar Rudzki, Michael Auer, Robert Barket, Anne Zinganell, Magdalena Lerch, Livia Hofer, Astrid Grams, Paulina Poskaite, Sebastian Wurth, Thomas Berger, Franziska Di Pauli, Florian Deisenhammer, Harald Hegen, Markus Reindl
Summary: This study investigated the distribution of 65 different cytokines, chemokines, and related molecules in the cerebrospinal fluid (CSF) and serum of newly diagnosed people with multiple sclerosis (pwMS). The results showed that 29 cytokines and chemokines were significantly elevated in the CSF, while 15 were elevated in the serum. Additionally, associations were found between 34 analytes and sex, age, CSF, MRI parameters, and disease progression. These findings contribute to a better understanding of the pathophysiology of multiple sclerosis and its association with disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Niklas Frahm, Melanie Peters, Jorg Baetzing, David Ellenberger, Manas K. Akmatov, Judith Haas, Paulus S. Rommer, Alexander Stahmann, Uwe K. Zettl, Jakob Holstiege
Summary: This study is the largest in terms of both the size of the source population (87% of German children aged <18 years) and the study period (2009-2018) worldwide. The analysis showed an increase in MS prevalence over the past 10 years, with a higher proportion of female patients in the 15-17 age group in 2018.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Claudio Gasperini, Luca Prosperini, Alex Rovira, Mar Tintore, Jaume Sastre-Garriga, Carla Tortorella, Shalom Haggiag, Simonetta Galgani, Ruggero Capra, Carlo Pozzilli, Xavier Montalban, Jordi Rio
Summary: The study aimed to develop and validate a scoring system combining baseline prognostic factors and 1-year variables of treatment response to predict the long-term risk of disability accumulation in patients with RRMS. The RoAD score showed to be a useful tool in predicting the risk of reaching a disability milestone and optimizing treatment strategy for RRMS patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Matthias Grothe, David Ellenberger, Paulus S. Rommer, Alexander Stahmann, Uwe K. Zettl
Summary: This study analyzed the data of 30,713 multiple sclerosis patients and found that patients with epileptic seizures at onset had a faster disease progression. Among them, patients with polysymptomatic onset had a more severe progression.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Review
Clinical Neurology
Sandra Vukusic, Clarisse Carra-Dalliere, Jonathan Ciron, Elisabeth Maillart, Laure Michel, Emmanuelle Leray, Anne-Marie Guennoc, Bertrand Bourre, David Laplaud, Geraldine Androdias, Caroline Bensa, Kevin Bigaut, Damien Biotti, Pierre Branger, Olivier Casez, Mikael Cohen, Elodie Daval, Romain Deschamps, Cecile Donze, Anne-Laure Dubessy, Cecile Dulau, Francoise Durand-Dubief, Maxime Guillaume, Benjamin Hebant, Laurent Kremer, Arnaud Kwiatkowski, Julien Lannoy, Adil Maarouf, Eric Manchon, Guillaume Mathey, Xavier Moisset, Alexis Montcuquet, Julie Pique, Thomas Roux, Romain Marignier, Christine Lebrun-Frenay
Summary: The objective of this study was to develop evidence-based recommendations on pregnancy management for persons with multiple sclerosis (MS). A total of 104 proposed recommendations were reached through a thorough review of literature and expert consensus. These recommendations cover various aspects including pregnancy planning, follow-up, delivery routes, anesthesia, prevention of relapses, breastfeeding, vaccinations, etc. These recommendations are expected to harmonize counseling and treatment practices, and provide better and individualized choices for individuals with MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Manon Rival, Eric Thouvenot, Lucile Du Trieu de Terdonck, Sabine Laurent-Chabalier, Christophe Demattei, Ugur Uygunoglu, Giovanni Castelnovo, Mikael Cohen, Darin T. Okuda, Orhun H. Kantarci, Daniel Pelletier, Christina Azevedo, Philippe Marin, Sylvain Lehmann, Aksel Siva, Thibault Mura, Christine Lebrun-Frenay
Summary: This study evaluates the predictive value of serum neurofilament light chain (sNfL) and CSF NfL (cNfL) in patients with radiologically isolated syndrome (RIS) for evidence of disease activity and clinical conversion. The results indicate that both sNfL and cNfL can independently predict disease activity and clinical conversion.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Darin T. Okuda, Orhun Kantarci, Christine Lebrun-Frenay, Maria Pia Sormani, Christina J. Azevedo, Francesca Bovis, Le H. Hua, Lilyana Amezcua, Ellen M. Mowry, Christophe Hotermans, Jason Mendoza, John S. Walsh, Christian von Hehn, Wendy S. Vargas, Stacy Donlon, Robert T. Naismith, Annette Okai, Gabriel Pardo, Pavle Repovic, Olaf Stuve, Aksel Siva, Daniel Pelletier
Summary: This study evaluated the impact of therapeutic intervention in preventing the first symptom manifestation in individuals with radiologically isolated syndrome (RIS), the pre-clinical phase of multiple sclerosis (MS). The results showed that drug treatment significantly reduced the risk of clinical symptoms.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Antoine Gavoille, Fabien Rollot, Romain Casey, Marc Debouverie, Emmanuelle Le Page, Jonathan Ciron, Jerome De Seze, Aurelie Ruet, Elisabeth Maillart, Pierre Labauge, Helene Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun-Frenay, Thibault Moreau, David Axel Laplaud, Eric Berger, Bruno Stankoff, Pierre Clavelou, Eric Thouvenot, Olivier Heinzlef, Jean Pelletier, Abdullatif Al Khedr, Olivier Casez, Bertrand Bourre, Philippe Cabre, Abir Wahab, Laurent Magy, Jean-Philippe Camdessanche, Aude Maurousset, Solene Moulin, Nasr Haifa Ben, Dalia Dimitri Boulos, Karolina Hankiewicz, Jean-Philippe Neau, Corinne Pottier, Chantal Nifle, Muriel Rabilloud, Fabien Subtil, Sandra Vukusic
Summary: Using a causal inference approach, this study aimed to estimate the long-term effects of pregnancy on disability and relapse risk in multiple sclerosis (MS) patients. The study found no significant long-term effects of pregnancy on disability, but it did affect relapse risk during the perpartum and postpartum years.
Article
Clinical Neurology
Kevin Polet, Solange Hesse, Mikael Cohen, Adeline Morisot, Benoit Kullmann, Lydiane Mondot, Sandrine Louchart de la Chapelle, Alain Pesce, Christine Lebrun-Frenay
Summary: Facial emotion recognition may be impaired in patients with multiple sclerosis, especially in progressive forms. This impairment is related to altered eye-gaze strategies during the observation of emotional faces.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Michael Levraut, Sabine Laurent-Chabalier, Xavier Ayrignac, Kevin Bigaut, Manon Rival, Sanae Squalli, Helene Zephir, Tifanie Alberto, Jean-David Pekar, Jonathan Ciron, Damien Biotti, Benedicte Puissant-Lubrano, Jean-Philippe Camdessanche, Yannick Tholance, Olivier Casez, Bertrand Toussaint, Jeanne Marion, Thibault Moreau, Daniela Lakomy, Audrey Thomasset, Elisabeth Maillart, Delphine Sterlin, Aude Maurousset, Auriane Rocher, David Axel Laplaud, Edith Bigot-Corbel, Pierre-Olivier Bertho, Jean Pelletier, Joseph Boucraut, Pierre Labauge, Thierry Vincent, Jerome De Seze, Isabelle Jahn, Barbara Seitz-Polski, Eric Thouvenot, Christine Lebrun-Frenay
Summary: This study aimed to determine the diagnostic performances of kappa free light chains (KFLC) in diagnosing MS. The results showed that KFLC index and KFLC intrathecal fraction (IF) had similar performances in differentiating MS from other CNS disorders.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Caroline Ruetsch-Chelli, Darin T. T. Okuda, Fanny Rocher, Sophie Tartare-Deckert, Marcel Deckert, Christine Lebrun-Frenay
Summary: This study investigated the effects of four S1P(1)-RM drugs approved for managing multiple sclerosis on melanoma cell lines in vitro and found that these drugs can promote the proliferation of melanoma cells at therapeutic concentrations. Therefore, increased dermatologic surveillance should be considered for patients with multiple sclerosis receiving S1P(1)-RM treatments.
NEUROLOGY AND THERAPY
(2023)
Letter
Clinical Neurology
Christine Lebrun-Frenay, Orhun H. Kantarci, Aksel Siva, Daniel Pelletier, Darin T. Okuda
Article
Clinical Neurology
Susana Otero-Romero, Christine Lebrun-Frenay, Saul Reyes, Maria Pia Amato, Magda Campins, Mauricio Farez, Massimo Filippi, Yael Hacohen, Bernhard Hemmer, Rosa Juuti, Melinda Magyari, Celia Oreja-Guevara, Aksel Siva, Sandra Vukusic, Mar Tintore
Summary: This study developed a European consensus on vaccination strategies for people with multiple sclerosis (pwMS) who are candidates for disease-modifying therapies (DMTs). A multidisciplinary working group used formal consensus methodology to formulate recommendations based on the quality of evidence and risk-benefit balance. A total of 53 recommendations were agreed upon, aiming to homogenize immunization practices in pwMS.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Susana Otero-Romero, Christine Lebrun-Frenay, Saul Reyes, Maria Pia Amato, Magda Campins, Mauricio Farez, Massimo Filippi, Yael Hacohen, Bernhard Hemmer, Rosa Juuti, Melinda Magyari, Celia Oreja-Guevara, Aksel Siva, Sandra Vukusic, Mar Tintore
Summary: This study aims to develop an evidence-based vaccination strategy for pwMS who are candidates for disease-modifying therapies. A multidisciplinary working group conducted a systematic literature search and formulated 53 recommendations based on the quality of evidence. The goal of this study is to homogenize immunization practices in pwMS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Editorial Material
Clinical Neurology
Christine Lebrun-Frenay, Darin T. Okuda
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
J. -C. Lafontaine, J. Boucher, J. Giovannelli, J. Petit, O. Outteryck, S. Balagny, H. Zephir
Summary: The aim of this study is to describe and assess the safety of home infusion of natalizumab. The results indicate that the established home natalizumab procedure is safe using the university hospital home-care department.
REVUE NEUROLOGIQUE
(2023)
Article
Clinical Neurology
Juliette Pelle, Anais R. Briant, Pierre Branger, Nathalie Derache, Charlotte Arnaud, Christine Lebrun-Frenay, Mikael Cohen, Lydiane Mondot, Jerome De Seze, Kevin Bigaut, Nicolas Collongues, Laurent Kremer, Damien Ricard, Flavie Bompaire, Charlotte Ohlmann, Magali Sallansonnet-Froment, Jonathan Ciron, Damien Biotti, Beatrice Pignolet, Jean-Jacques Parienti, Gilles Defer
Summary: A retrospective multicenter cohort study in France found that off-label extended interval dosing (EID) of natalizumab can effectively reduce the risk of progressive multifocal leukoencephalopathy (PML) in relapsing-remitting multiple sclerosis (RRMS) patients, and the risk of relapse is comparable to standard interval dosing (SID).
NEUROLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
P. Gagnerie, S. Sanges, P. Guerreschi, E. Wiel, G. Lebuffe, T. Sanctorum, M. Jourdain, S. Morell-Dubois, H. Zephir
Summary: Healthcare role-play is an interesting technique for training doctors to deliver bad news. Placing doctors in the roles of patients or relatives encourages reflection.
REVUE DE MEDECINE INTERNE
(2023)
Article
Health Care Sciences & Services
Sarah Wilson, Floriane Calocer, Fabien Rollot, Mathieu Fauvernier, Laurent Remontet, Laure Tron, Sandra Vukusic, Emmanuelle Le Page, Marc Debouverie, Jonathan Ciron, Aurelie Ruet, Jerome De Seze, Helene Zephir, Thibault Moreau, Christine Lebrun-Frenay, David-Axel Laplaud, Pierre Clavelou, Pierre Labauge, Eric Berger, Jean Pelletier, Olivier Heinzlef, Eric Thouvenot, Jean Philippe Camdessanche, Emmanuelle Leray, Olivier Dejardin, Gilles Defer
Summary: This study examined the effects of socio-economic status on mortality in patients with multiple sclerosis. The findings showed that patients with lower socio-economic status had higher mortality rates. Therefore, improving overall care for multiple sclerosis patients with lower socio-economic status could help reduce socio-economic inequalities in disease-related mortality.
LANCET REGIONAL HEALTH-EUROPE
(2023)
