Article
Biochemistry & Molecular Biology
Damien D. Pearse, Andrew B. Hefley, Alejo A. Morales, Mousumi Ghosh
Summary: This study investigated the expression of transglutaminase-2 (TG2) in brain tissue of multiple sclerosis (MS) patients and its correlation with binding partners and effectors involved in inflammation, scar formation, and repair antagonism. The results showed that TG2 was upregulated in active lesions and colocalized with astrocytes and extracellular matrix components.
Review
Biochemistry & Molecular Biology
Sylwia Pietrasik, Angela Dziedzic, Elzbieta Miller, Michal Starosta, Joanna Saluk-Bijak
Summary: Multiple sclerosis is a neurodegenerative disease with a variable course, often characterized by alternating periods of exacerbation and stabilization. Distinguishing between subtypes early can lead to faster implementation of appropriate treatment. Research suggests circulating microRNAs may be valuable for MS diagnosis and predicting disease subtype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Luis A. Rodriguez de Antonio, Ines Cuberta-Gonzalez, Inmaculada Garcia-Castanon, Celia Oreja-Guevara
Summary: This study compared the clinical and radiological effectiveness of ocrelizumab in PPMS and RRMS patients, and found that ocrelizumab was effective in reducing relapses and MRI activity. The most common adverse events were infusion-related reactions, infections, and hematological side effects.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Smaranda Maier, Laura Barcutean, Sebastian Andone, Doina Manu, Emanuela Sarmasan, Zoltan Bajko, Rodica Balasa
Summary: Despite extensive research and recent developments in disease-modifying therapies, the transition from relapsing-remitting MS to progressive MS remains a critical factor for long-term prognosis. The main mechanism in progressive MS is neurodegeneration, leading to irreversible disability. Currently, diagnosing progressive MS is retrospective and can be delayed for several years. With the need for early identification and selection of high-risk patients, this review discusses progress in finding reliable biomarkers between molecular fields, MRI parameters, and OCT measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Daniel Merlo, Jim Stankovich, Claire Bai, Tomas Kalincik, Chao Zhu, Melissa Gresle, Jeannette Lechner-Scott, Trevor Kilpatrick, Michael Barnett, Bruce Taylor, David Darby, Helmut Butzkueven, Anneke Van der Walt
Summary: This study utilized a computerized cognitive battery and latent class mixed models to identify discrete longitudinal reaction time trajectories in patients with relapsing-remitting multiple sclerosis. The findings indicate that a group of participants showed slowing reaction times and were more likely to experience 6-month confirmed disability progression.
Article
Immunology
Eva Feodora Romahn, Tun Wiltgen, Matthias Bussas, Lilian Aly, Rebecca Wicklein, Christina Noll, Achim Berthele, Vera Dehmelt, Christian Mardin, Claus Zimmer, Thomas Korn, Bernhard Hemmer, Jan S. Kirschke, Mark Muehlau, Benjamin Knier
Summary: Optical coherence tomography angiography can assess retinal vessel structures in patients with multiple sclerosis. The thinning and loss of retinal vessels are associated with brain atrophy and disability in multiple sclerosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rehabilitation
Lindsey M. Knowles, Kala M. Phillips, Tracy E. Herring, Kevin N. Alschuler, Mark P. Jensen, Aaron P. Turner, Dawn M. Ehde
Summary: Pain intensity and interference are similar across patients with progressive MS and RRMS. Common factors associated with higher average pain intensity include more severe disability, lower education level, unemployment, and smoking.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilaria Boscolo Galazzo, Lorenza Brusini, Muge Akinci, Federica Cruciani, Marco Pitteri, Stefano Ziccardi, Albulena Bajrami, Marco Castellaro, Ahmed M. A. Salih, Francesca B. Pizzini, Jorge Jovicich, Massimiliano Calabrese, Gloria Menegaz
Summary: This study investigated the morphometric and microstructural differences in gray matter between PPMS and RRMS using MRI, revealing significant alterations between the two phenotypes, particularly in the hippocampus. The support vector machine classifier based on selected features showed a 70% accuracy and 69% precision in discriminating between the two MS groups. These findings highlight the potential of dMRI in distinguishing between PPMS and RRMS and emphasize the central role of the hippocampus in MS pathology.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Immunology
Emanuele D'Amico, Aurora Zanghi, Nunziatina Laura Parrinello, Alessandra Romano, Giuseppe Alberto Palumbo, Clara Grazia Chisari, Simona Toscano, Francesco Di Raimondo, Mario Zappia, Francesco Patti
Summary: This study characterized the immune cell phenotypes of patients recently diagnosed with relapsing-remitting multiple sclerosis who had not received disease-modifying therapies. The results revealed differences in myeloid, B, and T cells between these patients and healthy controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rehabilitation
Lindsey M. Knowles, Elizabeth C. Esselman, Aaron P. Turner, Kala M. Phillips, Tracy E. Herring, Kevin N. Alschuler, Dawn M. Ehde
Summary: This study investigated depressive symptom severity and suicidal ideation in individuals with progressive multiple sclerosis and relapsing-remitting multiple sclerosis, finding no significant differences between the two groups. Common risk factors for greater depressive symptom severity included younger age, greater disability, and speech and swallowing problems. Screening for and treating depressive disorders in all MS patients is crucial.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Pablo Rodriguez de Vera Gomez, Mariola Mendez Muros, Alberto Torres Cuadro, Francisco Javier Toyos Saenz de Miera, Rocio Lopez Ruiz, Raquel Guerrero Vazquez, Juan Jesus Garcia Gonzalez, Antonio Manuel Garrido Hermosilla, Tomas Martin Hernandez
Summary: This study describes the clinical and biochemical characteristics of GD-ALZ and the clinical course of GO-ALZ cases in patients treated with Alemtuzumab for RRMS. GD-ALZ was observed in 32.6% of the cases, mainly affecting women with an average age of 41.9 years. Having first-degree relatives with hypothyroidism was identified as a risk factor. GO-ALZ was diagnosed in 13.6% of the cases, with 3 cases requiring anti-IL-6 treatment.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ornella Argento, Barbara Spano, Laura Serra, Chiara Concetta Incerti, Marco Bozzali, Carlo Caltagirone, Ada Francia, Mariangela Fratino, Ugo Nocentini, Chiara Piacentini, Maria Esmeralda Quartuccio, Valerio Pisani
Summary: Difficulties in emotion processing and social cognition in multiple sclerosis (MS) patients may affect their adaptation to the social environment. Our study found that MS patients, especially those with secondary progressive MS (SPMS), showed poorer performance in emotion recognition compared to healthy controls. MRI analysis indicated significant associations between RMEt scores and gray matter volumes in various brain regions in SPMS patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Eva M. Strijbis, Eline Coerver, Jop Mostert, Zoe L. E. van Kempen, Joep Killestein, Jacynthe Comtois, Pavle Repovic, James D. Bowen, Gary Cutter, Marcus Koch
Summary: This study investigates the association between age and inflammatory disease activity in relapsing-remitting multiple sclerosis (RRMS) using patient-level data from randomized controlled trials (RCTs) of natalizumab treatment. The results show that older age is associated with lower prevalence and degree of focal inflammatory disease activity in treated and untreated RRMS patients. These findings provide important insights for the design of RCTs and the decision-making process of immunomodulatory treatment in RRMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Zhizheng Zhuo, Yongmei Li, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Jinli Ding, Decai Tian, Xinli Wang, Jinhui Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Xuemei Han, Sven Haller, Frederik Barkhof, Fudong Shi, Yaou Liu
Summary: Three MRI subtypes of RRMS were identified with distinct clinical and imaging features and different prognoses. The subtypes showed variations in cognitive impairment and conversion rate to SPMS.
JOURNAL OF NEUROLOGY
(2021)
Letter
Clinical Neurology
Harald Kropshofer, Dieter A. Haering, Ludwig Kappos, David Leppert, Jens Kuhle
Summary: The results of this study contradict with earlier large phase 3 studies, suggesting that high baseline serum neurofilament light chain levels are associated with increased risk of disability progression in MS. The authors hypothesize that this discrepancy may be due to the anti-inflammatory effects of natalizumab, which suppresses inflammatory activity and renders sNfL unrelated to disability progression.
Article
Clinical Neurology
Pietro E. Doneddu, Marta Ruiz, Elisa Bianchi, Giuseppe Liberatore, Fiore Manganelli, Dario Cocito, Giuseppe Cosentino, Luana Benedetti, Girola A. Marfia, Massimiliano Filosto, Chiara Briani, Claudia Giannotta, Eduardo Nobile-Orazio
Summary: A diagnostic score was developed to distinguish anti-MAG neuropathy from CIDP and was applied to patients with atypical anti-MAG neuropathy. The score allowed an accurate discrimination between the two groups and may help in selecting proper treatment for patients with anti-MAG antibodies.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Katina Aleksovska, Claudio L. A. Bassetti, Thomas Berger, Vanessa Carvalho, Joao Costa, Guenther Deuschl, Kristian S. Frederiksen, Joke Jaarsma, Teia Kobulashvili, Maurizio Leone, Lucia Pavlakova, Michele Romoli, Luca Vignatelli
Summary: This paper aims to establish a set of criteria for prioritizing topics for future European Academy of Neurology (EAN) guidelines. Through literature review, a Delphi consensus procedure, and voting, a set of approved criteria were determined, and the first 30 topics were selected. The process involved both a bottom-up approach with community involvement and a top-down approach with board member selection.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Emanuele D'Amico, Aurora Zanghi, Virginia Manuti, Caterina Allegretta, Antonella Amoruso, Gaetano Serviddio, Carlo Avolio
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Filippo Martinelli-Boneschi, Antonio Colombo, Nereo Bresolin, Maria Sessa, Pietro Bassi, Giampiero Grampa, Eugenio Magni, Maurizio Versino, Carlo Ferrarese, Davide Zarcone, Alberto Albanese, Giuseppe Micieli, Carla Zanferrari, Antonio Cagnana, Claudio Ferrante, Angelo Zilioli, Davide Locatelli, Maria Vittoria Calloni, Maria Luisa Delodovici, Mattia Pozzato, Valerio Patisso, Francesco Bortolan, Camillo Foresti, Barbara Frigeni, Stefania Canella, Rubjona Xhani, Massimo Crabbio, Alessandro Clemenzi, Marco Mauri, Simone Beretta, Isidoro La Spina, Simona Bernasconi, Tiziana De Santis, Anna Cavallini, Michela Ranieri, Elisabetta D'Adda, Maria Elisa Fruguglietti, Lorenzo Peverelli, Edoardo Agosti, Olivia Leoni, Andrea Rigamonti, Andrea Salmaggi
Summary: This study investigated the incidence, clinical characteristics, and outcomes of GBS in COVID-19 patients. The results showed an increased incidence of GBS in COVID-19 patients, suggesting a higher risk of GBS in individuals with COVID-19. Additionally, the study found a reduction in GBS events during the pandemic, which may be attributed to a decrease in the spread of more common respiratory infections.
NEUROLOGICAL SCIENCES
(2023)
Correction
Clinical Neurology
Filippo Martinelli-Boneschi, Antonio Colombo, Nereo Bresolin, Maria Sessa, Pietro Bassi, Giampiero Grampa, Eugenio Magni, Maurizio Versino, Carlo Ferrarese, Davide Zarcone, Alberto Albanese, Giuseppe Micieli, Carla Zanferrari, Antonio Cagnana, Claudio Ferrante, Angelo Zilioli, Davide Locatelli, Maria Vittoria Calloni, Maria Luisa Delodovici, Mattia Pozzato, Valerio Patisso, Francesco Bortolan, Camillo Foresti, Barbara Frigeni, Stefania Canella, Rubjona Xhani, Massimo Crabbio, Alessandro Clemenzi, Marco Mauri, Simone Beretta, Isidoro La Spina, Simona Bernasconi, Tiziana De Santis, Anna Cavallini, Michela Ranieri, Elisabetta D'Adda, Maria Elisa Fruguglietti, Lorenzo Peverelli, Edoardo Agosti, Olivia Leoni, Andrea Rigamonti, Andrea Salmaggi
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Giulia Cardamone, Elvezia Maria Paraboschi, Giulia Solda, Giuseppe Liberatore, Valeria Rimoldi, Javier Cibella, Federica Airi, Veronica Tisato, Claudia Cantoni, Francesca Gallia, Donato Gemmati, Laura Piccio, Stefano Duga, Eduardo Nobile-Orazio, Rosanna Asselta
Summary: This study investigated the circRNA expression profile in peripheral blood mononuclear cells (PBMCs) of multiple sclerosis (MS) patients and found a correlation with genetic and epigenetic background. Additionally, it discovered that MS-associated circRNA variants may impact disease pathogenesis by altering circRNA profiles.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Francesco Patti, Clara Grazia Chisari, Simona Toscano, Pietro Annovazzi, Paola Banfi, Roberto Bergamaschi, Raffaella Clerici, Marta Zaffira Conti, Antonio Cortese, Roberta Fantozzi, Diana Ferraro, Mariano Fischetti, Maura Frigo, Maurizia Gatto, Paolo Immovilli, Stefania Leoni, Simona Malucchi, Giorgia Maniscalco, Girolama Alessandra Marfia, Damiano Paolicelli, Paola Perini, Carlo Serrati, Rocco Totaro, Gabriella Turano, Paola Valentino, Mauro Zaffaroni, Cristina Zuliani, Diego Centonze
Summary: This study aimed to evaluate the association between cognitive profile, attitude, and preferences of patients concerning treatment choice in multiple sclerosis. The results showed that more than 50% of patients chose a collaborative role in making treatment decisions, and these patients had higher cognitive abilities.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Health Care Sciences & Services
Laura Ferre, Ferdinando Clarelli, Beatrice Pignolet, Elisabetta Mascia, Marco Frasca, Silvia Santoro, Melissa Sorosina, Florence Bucciarelli, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Roland Liblau, Massimo Filippi, Giorgio Valentini, Federica Esposito
Summary: In this study, machine learning methods were used to predict the response of multiple sclerosis patients to fingolimod based on clinical and genetic features. Two patient cohorts from Italy and France were analyzed, and separate predictive models with genetic features only and combined clinical-genetic features were obtained. The results showed that machine learning methods can provide accurate prediction of fingolimod response.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Correction
Clinical Neurology
Chiara Zanetta, Maria A. Rocca, Alessandro Meani, Vittorio Martinelli, Laura Ferre, Lucia Moiola, Massimo Filippi
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Pietro Emiliano Doneddu, Houseyin Akyil, Fiore Manganelli, Chiara Briani, Dario Cocito, Luana Benedetti, Anna Mazzeo, Raffaella Fazio, Massimiliano Filosto, Giuseppe Cosentino, Vincenzo Di Stefano, Giovanni Antonini, Girolama Alessandra Marfia, Maurizio Inghilleri, Gabriele Siciliano, Angelo Maurizio Clerici, Marinella Carpo, Angelo Schenone, Marco Luigetti, Giuseppe Lauria, Sabrina Mata, Tiziana Rosso, Giacomo Maria Minicuci, Marta Lucchetta, Guido Cavaletti, Giuseppe Liberatore, Emanuele Spina, Marta Campagnolo, Erdita Peci, Francesco Germano, Luca Gentile, Camilla Strano, Stefano Cotti Piccinelli, Elisa Vegezzi, Luca Leonardi, Giorgia Mataluni, Marco Ceccanti, Erika Schirinzi, Marina Romozzi, Eduardo Nobile-Orazio
Summary: This study assessed the ability of the 2021 European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) clinical criteria for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) to classify the whole spectrum of clinical heterogeneity of the disease and define the clinical characteristics of unclassifiable clinical forms. The results showed that a proportion of patients with CIDP did not strictly fulfill the 2021 EAN/PNS clinical criteria, and these unclassifiable clinical phenotypes may pose diagnostic challenges and deserve more attention in clinical practice and research.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Cristiano Scandurra, Laura Rosa, Antonio Carotenuto, Marcello Moccia, Sebastiano Arena, Antonio Ianniello, Agostino Nozzolillo, Mariavittoria Turrini, Lidia Mislin Streito, Gianmarco Abbadessa, Elisabetta Ferraro, Manuela Mattioli, Alessandro Chiodi, Nelson Mauro Maldonato, Simona Bonavita, Marinella Clerico, Cinzia Cordioli, Lucia Moiola, Francesco Patti, Luigi Lavorgna, Massimo Filippi, Giovanna Borriello, Emanuele D'Amico, Carlo Pozzilli, Vincenzo Brescia Morra, Maria Petracca, Roberta Lanzillo
Summary: Despite being a common issue, sexual dysfunction in people with multiple sclerosis (pwMS) is underinvestigated. This study aimed to assess the potential determinants of sexual dysfunction in pwMS by considering its relationship with disease severity, illness perception, and depressive symptoms. The results showed that disease severity indirectly affects sexual dysfunction through illness perception and depressive symptoms. Illness perception plays a more crucial role in sexual dysfunction for pwMS with mild disability. Modulating the effect of illness perception might be a valid approach to mitigate sexual dysfunction symptoms in pwMS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Roberto Gnavi, Ilenia Eboli, Paolo Emilio Alboini, Sandra D'Alfonso, Roberta Picariello, Giuseppe Costa, Maurizio Leone
Summary: The aim of this study was to evaluate the effect of the COVID-19 pandemic on the health outcomes of people with multiple sclerosis (PWMS). The study found that PWMS had a higher risk of hospitalization and admission to the ICU during the pandemic, but the increase in mortality was not statistically significant.
Article
Public, Environmental & Occupational Health
Valerio Manfrini, Roberto Badagliacca, Elisabetta Messaggio, Roberto Poscia, Roberto Torre, Paolo Manunta, Carmine Dario Vizza
Summary: This study found that patients with idiopathic pulmonary arterial hypertension had higher plasma concentrations of endogenous ouabain (EO) than control subjects. The concentrations were negatively correlated with pulmonary arterial pressure and vascular resistance, suggesting a potential role of EO in the adaptation of right ventricular afterload.
ANNALI DELL ISTITUTO SUPERIORE DI SANITA
(2023)
Article
Clinical Neurology
Bruno Brochet, Alessandra Solari, Jeannette Lechner-Scott, Fredrik Piehl, Dawn Langdon, Raymond Hupperts, Krzysztof Selmaj, Francesco Patti, Luis Brieva, Eva Maria Maida, Nektaria Alexandri, Andrzej Smyk, Axel Nolting, Birgit Keller, Xavier Montalban, Eva Kubala Havrdova
Summary: Cladribine tablet treatment significantly improved the health-related quality of life in people with highly active relapsing multiple sclerosis, with good safety and tolerability.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Clara Grazia Chisari, Joe Guadagno, Peyman Adjamian, Carlos Vila Silvan, Teresa Greco, Makarand Bagul, Francesco Patti
Summary: A significant proportion of patients with multiple sclerosis-associated spasticity experienced a meaningful reduction in spasticity severity after 12 weeks of treatment with nabiximols.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)