Article
Biochemistry & Molecular Biology
Bianca Wagner, Clara L. Haerig, Bertram Walter, Jens Sommer, Gebhard Sammer, Martin Berghoff
Summary: Cognitive impairments are common in multiple sclerosis (MS) patients, even those without significant cognitive deficits. This study found reduced activation in the hippocampus, pallidum, and anterior cingulate cortex (ACC) in MS patients during an attention network task. These functional brain changes might serve as a biological indicator of susceptibility to cognitive impairment in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neuroimaging
Christopher J. Cagna, Ahmet O. Ceceli, Joshua Sandry, Jamil P. Bhanji, Elizabeth Tricomi, Ekaterina Dobryakova
Summary: This study investigated feedback-based learning ability in multiple sclerosis (MS) patients, as well as associated cortico-striatal function and connectivity. The results showed that MS patients displayed preserved feedback-based learning ability despite reporting greater cognitive fatigue. Furthermore, the functional connectivity between the ventral striatum and task-relevant regions was stronger in MS patients compared to neurotypical individuals during feedback receipt.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Martin Sjogard, Vincent Wens, Jeroen Van Schependom, Lars Costers, Marie D'hooghe, Miguel D'haeseleer, Mark Woolrich, Serge Goldman, Guy Nagels, Xavier De Tiege
Summary: This study found that multiple sclerosis has a significant impact on resting-state functional brain connectivity and is related to disability, disease duration, and specific cognitive functioning changes. Healthy subjects and patients showed significant differences in cognitive fatigue and verbal fluency scores, with distinct correlation patterns between rsFC and these cognitive functions.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Maria A. Rocca, Paola Valsasina, Bruno Colombo, Vittorio Martinelli, Massimo Filippi
Summary: Fatigue in multiple sclerosis patients improved regardless of treatment. Changes in resting state functional connectivity were located in sensorimotor, inferior frontal, and subcortical regions for fampridine- and amantadine-treated patients, while in associative sensory cortices for placebo-treated patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Christian Wilson R. Turalde, Adrian Espiritu, Veeda Michelle M. Anlacan
Summary: The study reviewed the efficacy and safety of memantine in multiple sclerosis patients but found no significant improvements in cognitive function, spasticity, fatigue, and disability compared to placebo. Memantine was associated with mild adverse events like dizziness, fatigue, and anxiety. Future research should consider different MS subtypes, co-administration of disease-modifying therapies, longer duration of administration, and more sensitive outcome measures.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Marcello Moccia, Luca Fontana, Raffaele Palladino, Fabrizia Falco, Ferdinando Finiello, Mauro Fedele, Roberta Lanzillo, Liberata Reppuccia, Maria Triassi, Vincenzo Brescia Morra, Ivo Iavicoli
Summary: This study compares the differences in occupational history and early working impairments between people with multiple sclerosis (MS) and healthy workers. The results show that workers with MS are more working disabled, less exposed to workplace risks, and more limited in fitness to work compared with controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Daniela Pinter, Silvia Erika Kober, Viktoria Fruhwirth, Lisa Berger, Anna Damulina, Michael Khalil, Christa Neuper, Guilherme Wood, Christian Enzinger
Summary: This study found that cognitive improvement after neurofeedback training in patients with MS was associated with increased brain microstructure and functional connectivity. Successful neurofeedback training may help improve cognitive function.
JOURNAL OF NEUROLOGY
(2021)
Article
Sport Sciences
Nicolas Royer, Callum G. Brownstein, Djahid Kennouche, Loic Espeit, Anthony Teston, Claire Boutet, Leonard Feasson, Jean-philippe Camdessanche, Guillaume Y. Millet
Summary: This study aimed to investigate the correlates of MS-related fatigue in patients with relapsing-remitting multiple sclerosis (MS), with a particular focus on fatigability. The results revealed that the high fatigue group exhibited greater performance fatigability and higher perceived exertion than the low fatigue group during a dynamic task.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Clinical Neurology
Dila Basci, Zeliha Tulek
Summary: This study aimed to assess cognitive function and its determinants in patients with multiple sclerosis (PwMS) using Addenbrooke Cognitive Assessment Battery (ACE-R). The results showed that compared to healthy controls, PwMS had lower ACE-R scores in all domains, with memory and fluency being the lowest and visuospatial being the highest. Age, education, depression, and fatigue were associated with cognitive test scores, with education, depression, and fatigue remaining significant in the multivariable analysis.
NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Sorayya Askari, Domenica Fanelli, Keri Harvey
Summary: This review examines interventions for managing cognitive fatigue in multiple sclerosis patients, identifying educational programs and self-management interventions as effective in reducing the negative effects of cognitive fatigue. Further research is needed to determine the most appropriate and effective approaches for cognitive fatigue management.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Neurosciences
Yaelan Jung, Tess Allegra Forest, Dirk B. Walther, Amy S. Finn
Summary: A defining feature of children's cognition is the slow development of their attention, but little is known about how developing attentional abilities modulate neural representations in children. It is possible that attention might be less likely to shape neural representations in children compared to adults, and this hypothesis was tested through brain activity measurements using fMRI.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Lukas Lorentz, Andre Schueppen, Boris Suchan, Ferdinand Binkofski
Summary: This study aims to examine the effects of stereoscopic vs. monoscopic presentation on neural processing during a visual attention task. The results showed that stereoscopic presentation led to increased activation in the V3A area and elevated activation in the dorsal attention network. Additionally, stereoscopic presentation reduced attentional engagement costs.
Article
Clinical Neurology
Alessandro Dinoto, Sara Baldini, Maria Elisa Morelli, Fulvio Pasquin, Alessio Bratina, Antonio Bosco, Arianna Sartori, Paolo Manganotti
Summary: Fatigue in multiple sclerosis patients is closely related to autonomic nervous system symptoms, with orthostatic intolerance potentially playing a predominant role, while cognitive impairment seems to be unrelated to autonomic nervous system symptoms.
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Anna Maria Sobczak, Bartosz Bohaterewicz, Anna Ceglarek, Aleksandra Zyrkowska, Magdalena Fafrowicz, Agnieszka Slowik, Marcin Wnuk, Monika Marona, Klaudia Nowak, Kamila Zur-Wyrozumska, Tadeusz Marek
Summary: This study investigates the functional architecture of resting-state networks associated with fatigue in patients with multiple sclerosis (MS). It identifies differences in functional connectivity and brain activity between patients with high and low levels of fatigue.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Rehabilitation
James S. Krause, Clara L. Dismuke-Greer, Phillip Rumrill, Karla Reed, Melinda Jarnecke, Deborah Backus
Summary: This study aimed to investigate the relationship between prediagnosis employment, education, demographic statuses, disease factors, and job retention among people with multiple sclerosis (MS). The results showed that prediagnostic educational attainment, employment category, age, and race were significantly related to job retention. Additionally, disease severity and fatigue were found to have an impact on job retention.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)