期刊
MULTIPLE SCLEROSIS JOURNAL
卷 18, 期 1, 页码 108-112出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458511421185
关键词
demyelination; immunology; relapsing-remitting; Tysabri
资金
- MSRA
Auto-antibody mediated astrocyte injury is implicated as a primary event in neuromyelitis optica (NMO) by biomarker, post-mortem and experimental studies that differentiate the condition from multiple sclerosis. We describe the clinical, radiological and neuropathological features of a severe cerebral attack in a natalizumab-treated patient with relapsing myelitis and serum aquaporin-4 antibodies. Our findings support autopsy evidence that abrupt astrocyte destruction precedes demyelination in NMO, and emphasize the importance of serological testing in patients with limited disease. Adherence to current NMO diagnostic criteria may delay treatment, or lead to inappropriate therapy with beta-interferon or natalizumab.
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