Article
Immunology
Liang Wang, Lei Du, Qinying Li, Fang Li, Bei Wang, Yuanqi Zhao, Qiang Meng, Wenyu Li, Juyuan Pan, Junhui Xia, Shitao Wu, Jie Yang, Heng Li, Jianhua Ma, Jingzi ZhangBao, Wenjuan Huang, Xuechun Chang, Hongmei Tan, Jian Yu, Lei Zhou, Chuanzhen Lu, Min Wang, Qiang Dong, Jiahong Lu, Chongbo Zhao, Chao Quan
Summary: This study investigates the predictors of relapse, and severe visual or motor disability in patients with NMOSD and develops corresponding predictive models. Early identification of patients at risk of unfavorable outcomes is crucial for informing treatment decisions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Bo Kyeong Yoon, Tun Naw Sut, Ki Yeol Yoo, Seung Hwa Lee, Youngkyu Hwang, Joshua A. Jackman, Nam-Joon Cho
Summary: A streamlined ELISA strategy using lipid nanoparticles as a blocking agent was developed, showing fewer processing steps, quicker protocol time, and superior detection performance compared to conventional BSA blocking. This method has been successfully applied to COVID-19 antibody detection and is broadly applicable for rapid ELISA diagnostics development.
APPLIED MATERIALS TODAY
(2021)
Article
Multidisciplinary Sciences
Youhee Heo, Kwanwoo Shin, Min Cheol Park, Ji Yoon Kang
Summary: This report introduces a method for enhancing the sensitivity of chemifluorescence-based ELISA, using photooxidation-induced fluorescence amplification (PIFA). PIFA utilizes autocatalytic photooxidation to amplify the fluorescent product, improving detection sensitivity. The method requires minimal modifications to the fluorescence reader and is compatible with conventional ELISA assays.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Supaluk Krittanai, Rattanathorn Choonong, Khunkhang Butdapheng, Jakkrit Jabsanthia, Seiichi Sakamoto, Waraporn Putalun
Summary: This study aimed to develop an enzyme-linked immunosorbent assay (ELISA) using a glabridin-specific antibody. The glabridin-bovine serum albumin conjugates were injected into mice to produce hybridomas, and a highly specific antibody against glabridin was produced. The developed ELISA method showed high sensitivity and specificity for quantifying glabridin in plant materials and human serum samples.
PHYTOCHEMICAL ANALYSIS
(2023)
Article
Food Science & Technology
Xiya Zhang, Mingyue Ding, Chensi Zhang, Yexuan Mao, Youyi Wang, Peipei Li, Haiyang Jiang, Zhanhui Wang, Xuezhi Yu
Summary: The researchers developed a rapid icELISA method for monitoring brevetoxin levels in oysters, providing a useful tool for the detection of these toxins in shellfish samples.
Article
Chemistry, Applied
Long Xu, Fanfan Yang, Alberto C. P. Dias, Xiaoying Zhang
Summary: Sunset yellow is a commonly used food colorant, but excessive and illegal use may pose health risks. Researchers have applied quantum dots in the analysis of sunset yellow and developed two new detection methods. These methods are efficient, highly sensitive, and capable of distinguishing sunset yellow from analogues.
Article
Clinical Neurology
Liang Wang, Hongmei Tan, Wenjuan Huang, Xuechun Chang, Jingzi ZhangBao, Lei Zhou, Chuanzhen Lu, Min Wang, Jiahong Lu, Chongbo Zhao, Chao Quan
Summary: This study evaluated the clinical characteristics and prognosis of late onset neuromyelitis optica spectrum disorder (LO-NMOSD) and compared them with early onset NMOSD (EO-NMOSD) and NMOSD with different antibody serostatuses. The study found that patients with LO-NMOSD, especially those with AQP4 antibodies, had a worse prognosis. Age at disease onset and antibody serostatus were predictors of blindness and motor dysfunction.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica and its spectrum is a relapsing demyelinating disorder of the central nervous system, encompassing six syndromes and associated with aquaporin-4 autoantibodies. Effective treatment is able to prevent relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica, previously known as Devic's disease, is a relapsing demyelinating disorder of the central nervous system that encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment is crucial in preventing relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Chemistry, Applied
Shunsuke Fujii, Tomoe Ohta, Riho Ehama, Mizuki Irikida, Shuichi Nomura, Yukihiro Shoyama, Takuhiro Uto
Summary: This study developed a simple and reliable method for the detection and quantification of FMN in food samples, and successfully applied it in cell-based assays.
Review
Immunology
Edgar Carnero Contentti, Jorge Correale
Summary: Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease characterized by acute optic neuritis and transverse myelitis. It is caused by a pathogenic serum IgG antibody targeting the water channel aquaporin 4 (AQP4). Recent studies have shown significant progress in identifying new treatments for NMOSD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Oliver Schmetzer, Elisa Lakin, Ben Roediger, Ankelien Duchow, Susanna Asseyer, Friedemann Paul, Nadja Siebert
Summary: This study examined the role of anti-AQP4-IgG in patients with Neuromyelitis optica spectrum disorder (NMOSD). The results suggest that anti-AQP4-IgG may not play a predominant role in driving NMOSD, but rather may be associated with the disease and could be a relevant factor in only a subgroup of patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Tetsuya Akaishi, Toshiyuki Takahashi, Kazuo Fujihara, Tatsuro Misu, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima
Summary: NMOSD patients positive for AQP4-IgG have a higher association with Sjogren's syndrome, with a higher prevalence of comorbid SjS among female patients and a higher relapse rate.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Shuo Zhao, Huanfen Zhou, Quangang Xu, Hong Dai, Shihui Wei
Summary: The study found that low-dose rituximab is significantly effective and well-tolerated in treating NMO-ON, reducing symptoms and improving vision stability or improvement in most patients during the follow-up period. High relapse-free rate was observed in patients who were followed up for over 12 months.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Liang Wang, Lei Du, Qinying Li, Fang Li, Bei Wang, Yuanqi Zhao, Qiang Meng, Wenyu Li, Juyuan Pan, Junhui Xia, Shitao Wu, Jie Yang, Heng Li, Jianhua Ma, Jingzi ZhangBao, Wenjuan Huang, Xuechun Chang, Hongmei Tan, Jian Yu, Lei Zhou, Chuanzhen Lu, Min Wang, Qiang Dong, Jiahong Lu, Chongbo Zhao, Chao Quan
Summary: This study confirmed the superiority of deep learning in designing a predictive model for relapse in patients with AQP4-ab-positive NMOSD, with the LogisticHazard model showing the best predictive power in validation.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Hwan Tae Park, Jong Kuk Kim, Nicolas Tricaud
Article
Multidisciplinary Sciences
Soo Jin Park, Jong Kuk Kim, Hyun-Hwi Kim, Byeol-A. Yoon, Dong Yoon Ji, Chang-Wan Lee, Ho Jin Kim, Kyoung Heon Kim, Ha Young Shin, Sung Jean Park, Do Yup Lee
SCIENTIFIC REPORTS
(2019)
Article
Clinical Neurology
Sun-Uk Lee, Hyo-Jung Kim, Jeong-Yoon Choi, Jong Kuk Kim, Ji-Soo Kim
Article
Multidisciplinary Sciences
Suk Hyun Lee, Hyunsu Soh, Jin Hwa Chung, Eun Hye Cho, Sang Ju Lee, Ji-Min Ju, Joong Hyuk Sheen, Hyori Kim, Seung Jun Oh, Sang-Jin Lee, Junho Chung, Kyungho Choi, Seog-Young Kim, Jin-Sook Ryu
Article
Clinical Neurology
Yeseul Kim, Jae-Won Hyun, Mark R. Woodhall, Yu-Mi Oh, Ji-Eun Lee, Ji Yun Jung, So Yeon Kim, Min Young Lee, Su-Hyun Kim, Woojun Kim, Sarosh R. Irani, Patrick Waters, Kyungho Choi, Ho Jin Kim
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Review
Immunology
Eun Young Choi, Kyungho Choi, Giri Nam, Woojin Kim, Minho Chung
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Clinical Neurology
Byeol-A Yoon, Dong-Ho Ha, Hwan Tae Park, Susumu Kusunoki, Motoi Kuwahara, Jong Hwa Lee, Jong Seok Bae, Jong Kuk Kim
Summary: The finger drop sign is proposed as a new clinical variant of acute motor axonal neuropathy (AMAN) based on immunological and radiological evidence. This unique syndrome is characterized by sustained weakness of the finger extensors and a distinctive pattern of abnormal signals mainly in muscles innervated by the posterior interosseous nerve on limb MRI. Testing showed positivity for immunoglobulin G antibody against ganglioside complex of GM1 and phosphatidic acid in all patients. Understanding the pathophysiology of this syndrome may provide insights into antiganglioside-antibody-mediated axonal injury in Guillain-Barre syndrome.
Article
Multidisciplinary Sciences
Bo Ra Kim, Dong-Ho Ha, Jong Kuk Kim, Young Hee Kim
Article
Multidisciplinary Sciences
Ji-Min Ju, Giri Nam, Young-Kwan Lee, Minho Jung, Hanna Chang, Woojin Kim, Woo Jeong Shon, Ji Young Lim, Joo Young Kim, Jun Chang, Chang Ki Min, Dong-Sup Lee, Kyungho Choi, Dong-Mi Shin, Eun Young Choi
Summary: The study found that myeloid-derived IDO1 enhances GVHD survival by regulating ROS levels and limiting the differentiation of MDSCs into proinflammatory neutrophils. This provides mechanistic insight into the immune-regulatory roles of the metabolic enzyme IDO1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Dong Hyun Kim, Hee Young Kim, Sunjung Cho, Su-Jin Yoo, Won-Ju Kim, Hye Ran Yeon, Kyungho Choi, Je-Min Choi, Seong Wook Kang, Won-Woo Lee
Summary: The study demonstrates the crucial role of IL-1RII receptor in regulating IL-17 responses, affecting the functionality of CD4(+) T cells by limiting IL-1 beta responsiveness.
Article
Oncology
Seung-Phil Shin, A-Ra Goh, Ji-Min Ju, Hyeon-Gu Kang, Seok-Jun Kim, Jong-Kwang Kim, Eun-Jung Park, Yong-Soo Bae, Kyungho Choi, Yuh-Seog Jung, Sang-Jin Lee
Summary: CD200 acts as an immune checkpoint molecule that inhibits innate immune cell activation, promoting tumor growth and inducing M2-like macrophage polarization. However, the protumor effects of CD200 can be abolished by local injection of Ad5sCD200R1.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Review
Clinical Neurology
Jee-Eun Kim, Byeol-A Yoon, Yoo Hwan Kim, Jong Kuk Kim, Jong Seok Bae
Summary: This study aimed to identify and characterize Miller Fisher syndrome (MFS) following COVID-19 vaccination. The findings suggest that MFS following COVID-19 vaccination has different pathophysiology compared to MFS following COVID-19 infection and Guillain-Barre Syndrome (GBS) following COVID-19 vaccination. Considering the rare incidence and diagnostic challenges of this neurological syndrome, it should be recognized as an adverse event of COVID-19 vaccination.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Biochemistry & Molecular Biology
Sangho Lee, Han-Teo Lee, Young Ah Kim, Il-Hwan Lee, Seong-Jun Kang, Kyeongpyo Sim, Chung-Gyu Park, Kyungho Choi, Hong-Duk Youn
Summary: A peptide derived from CABIN1 binds strongly to the cellular enzyme calcineurin and inhibits its activity, providing a potential therapeutic option for diseases related to the calcineurin-NFAT pathway.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Immunology
Ji Hyun Sim, Jin-Hee Kim, Ae Kyung Park, Jeeyun Lee, Kyoung-Mee Kim, Hyun Mu Shin, Minji Kim, Kyungho Choi, Eun Young Choi, Insoo Kang, Dong-Sup Lee, Hang-Rae Kim
JOURNAL OF IMMUNOLOGY
(2020)
Article
Clinical Neurology
Il Han Yoo, WooJoong Kim, Youngkyu Shim, Sun Ah Choi, Soo Yeon Kim, Hunmin Kim, Byung Chan Lim, Hee Hwang, Jieun Choi, Ki Joong Kim, Yeseul Kim, Jae-Won Hyun, Su-Hyun Kim, Kyungho Choi, Ho Jin Kim, Jong-Hee Chae
JOURNAL OF CLINICAL NEUROLOGY
(2020)