Article
Neurosciences
Maria Isabel Carrasco-Campos, Cristina Perez-Ramirez, Elena Macias-Cortes, Elena Puerta-Garcia, Antonio Sanchez-Pozo, Carmen Arnal-Garcia, Francisco Javier Barrero-Hernandez, Miguel Angel Calleja-Hernandez, Alberto Jimenez-Morales, Marisa Canadas-Garre
Summary: This study found that gene polymorphisms in TNFRSF10A-rs20576 and CTSS-rs1136774 have an impact on the response to IFN-beta after 24 months of treatment, while the variations in CBLB (rs12487066), OAS1 (rs10774671) or GRIA3 (rs12557782) genes do not affect individual response to IFN-beta.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Patricia Ramos-Ramirez, Carina Malmhall, Omar Tliba, Madeleine Radinger, Apostolos Bossios
Summary: Adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios(-) Tregs, and the effect was amplified by T2 inflammation in Helios(+) Tregs. This suggests a potential role of adiponectin in regulating Treg function in human inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Marcello Moccia, Giuseppina Affinito, Antonio Capacchione, Roberta Lanzillo, Antonio Carotenuto, Emma Montella, Maria Triassi, Vincenzo Brescia Morra, Raffaele Palladino
Summary: This study demonstrates the feasibility of merging clinical registry and routinely-collected healthcare data for future multiple sclerosis research, and confirms the important role of interferon beta formulations in managing MS with positive clinical outcomes. Differences between interferon beta formulations are primarily driven by adherence and healthcare resource utilization.
Article
Immunology
Despoina T. Florou, Athanasios Mavropoulos, Efthymios Dardiotis, Vana Tsimourtou, Vasileios Siokas, Athina-Maria Aloizou, Christos Liaskos, Christina Tsigalou, Christina Katsiari, Lazaros Sakkas, Georgios Hadjigeorgiou, Dimitrios P. Bogdanos
Summary: The study showed that tetracyclines, particularly minocycline, can suppress IFN-gamma and IL-17-producing cells from MS patients in vitro, suggesting a potential therapeutic effect in vivo.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Luis F. Gonzalez, Eric Acuna, Gabriel Arellano, Paola Morales, Paula Sotomayor, Felipe Oyarzun-Ampuero, Rodrigo Naves
Summary: A new delivery system of IFN-β nanoparticles via intranasal administration was developed to improve clinical symptoms and control neuroinflammation in an experimental model of multiple sclerosis, showing potential effectiveness, non-invasiveness, and cost-effectiveness as a therapy for MS.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Weiwei Xiang, Chong Xie, Yangtai Guan
Summary: This review focuses on the unique roles of immunoregulatory B10 cells in multiple sclerosis (MS), including their identification and development, signals that promote IL-10 production, and the potential and challenges of B10-based therapies for MS.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Immunology
Pablo Aliaga-Gaspar, Isaac Hurtado-Guerrero, Nicolas Lundahl Ciano-Petersen, Patricia Urbaneja, Isabel Brichette-Mieg, Virginia Reyes, Jose Luis Rodriguez-Bada, Roberto Alvarez-Lafuente, Rafael Arroyo, Ester Quintana, Lluis Ramio-Torrenta, Ana Alonso, Laura Leyva, Oscar Fernandez, Begona Oliver-Martos
Summary: IFN-beta treatment induces sIFNAR2 production in RRMS, with higher levels associated with a reduction in therapeutic response. In the short-term, some patients showed increased sIFNAR2 expression after IFN-beta stimulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mona Tarighi, Mehdi Shahbazi, Payam Saadat, Abdolreza Daraei, Ali Alizadeh Khatir, Kimiya Rahimifard, Mousa Mohammadnia-Afrouzi
Summary: This study examined the frequency and gene expression levels of regulatory T cells (Tregs) in secondary progressive multiple sclerosis (SPMS) patients. The results showed that the percentage of Tregs with CD4 and CD25 markers did not differ significantly compared to healthy controls, but the lymphocytes with CD4/CD25/FOXP3/Helios markers were significantly reduced in SPMS patients. The expression of the Helios gene was also decreased in these patients. These findings suggest that a deficiency in Tregs may be involved in the immunological mechanisms of SPMS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dermatology
Zhen Yu, Hao Cheng, Tingting Ding, Yuying Liang, Chenglan Yan, Chong Gao, Hongyan Wen
Summary: The study found that there is an imbalance of lymphocyte subsets in systemic sclerosis (SSc) patients, and low-dose IL-2 therapy can restore the balance and reduce disease activity.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Leila Karimi, Nahid Eskandari, Vahid Shaygannejad
Summary: The study showed that IFN-beta therapy was more effective on Th17 cells in RRMS patients, but did not significantly affect the expression of hsa-miR-326 and hsa-miR-29b-3p.
NEUROIMMUNOMODULATION
(2022)
Article
Immunology
Ide Smets, Teresa Prezzemolo, Maya Imbrechts, Klara Mallants, Tania Mitera, Stephanie Humblet-Baron, Benedicte Dubois, Patrick Matthys, Adrian Liston, An Goris
Summary: The study indicates that both fingolimod and interferon-beta induce BAFF protein and mRNA expression, leading to a shift in the B cell pool towards a regulatory phenotype. Specifically, BAFF protein correlated with an increase in transitional B cells, decrease in switched B cells, and reduction in B cell-surface BAFF-R expression. However, BAFF does not directly influence the expression of immunoregulatory cytokines IL-10 and IL-35.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Janne Verreycken, Paulien Baeten, Bieke Broux
Summary: Multiple sclerosis (MS) is an autoimmune disorder characterized by demyelination and neurodegeneration in the central nervous system. Regulatory T cells (Tregs), which have the ability to suppress immune reactions and regenerate, may have therapeutic potential for MS. However, Tregs in people with MS are functionally impaired. To exert their anti-inflammatory and regenerative effects in the brain, Tregs must first migrate across the blood-brain barrier (BBB).
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Immunology
Alexandre Xavier, Maria Pia Campagna, Vicki E. E. Maltby, Trevor Kilpatrick, Bruce V. V. Taylor, Helmut Butzkueven, Anne-Louise Ponsonby, Rodney J. J. Scott, Vilija G. G. Jokubaitis, Rodney A. A. Lea, Jeannette Lechner-Scott
Summary: This study shows that IFN beta treatment modifies the methylation profile of interferon response genes in MS patients, and a methylation treatment score (MTS) was constructed to accurately distinguish between treated and untreated patients. The study also found that IFN beta treatment recruits the endogenous anti-viral molecular machinery and affects the methylation levels of dendritic cells and regulatory CD4+ T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nanako Nishiyama, Chigusa Nakahashi-Oda, Akira Shibuya
Summary: This study found that IFN-beta has a dual effect on the development of iTreg cells, inhibiting their proliferation but enhancing their anti-apoptotic ability and suppression of conventional T cells.
Article
Biology
Cristina-Florentina Plesa, Diana Maria Chitimus, Carmen Adella Sirbu, Monica Marilena Tantu, Minerva Claudia Ghinescu, Daniela Anghel, Florentina Ionita-Radu
Summary: This case study describes a particular association between the remission phase of multiple sclerosis and the violent onset of interferon-induced thrombotic thrombocytopenic purpura.
Review
Cell Biology
Daniele Cartelli, Guido Cavaletti, Giuseppe Lauria, Cristina Meregalli
Summary: Axonal degeneration is a key feature of many neurological disorders. This article focuses on the similarities in the mechanisms and molecular players driving the early phase of axon degeneration in Parkinson's disease and chemotherapy-induced peripheral neuropathies. It also reviews key molecules that can modulate these targets, potentially improving patients' quality of life by blocking axonal degeneration and promoting neuronal regeneration.
Review
Cell Biology
Paola Alberti, Sara Semperboni, Guido Cavaletti, Arianna Scuteri
Summary: Neurons are permanent cells that rely on finely tuned homeostasis for proper function, with microtubules playing a key role in cellular equilibrium by mobilizing molecular cargos. Alterations in cytoskeletal dynamics can impact neuronal excitability, highlighting the importance of understanding these processes in human diseases and neuronal functioning. Microscopic approaches for visualizing and assessing the cytoskeleton, particularly in mitochondrial trafficking, are essential for further research in this area.
Article
Biochemistry & Molecular Biology
Roberta Listro, Alessio Malacrida, Francesca Alessandra Ambrosio, Giacomo Rossino, Marcello Di Giacomo, Valeria Cavalloro, Martina Garbagnoli, Pasquale Linciano, Daniela Rossi, Guido Cavaletti, Giosue Costa, Stefano Alcaro, Mariarosaria Miloso, Simona Collina
Summary: The research team isolated a secondary metabolite called Hib-ester from Hibiscus Sabdariffa L. calyces, which possesses antiproliferative properties against human MM. Compound 13 and 14 were found to be more potent than Hib-ester, providing a new chemical class for developing possible drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Alessio Malacrida, Marie Deschamps-Wright, Roberta Rigolio, Guido Cavaletti, Mariarosaria Miloso
Summary: In this study, the efficacy of Rigosertib and the expression of p53 in different tumor cell lines were evaluated. The results showed that Rigosertib had different efficacy depending on the cell line, with the highest sensitivity observed in lung cancer cells. This suggests that Rigosertib could be a potential antineoplastic agent against lung cancer in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Annalisa Canta, Valentina A. A. Carozzi, Alessia Chiorazzi, Cristina Meregalli, Norberto Oggioni, Virginia Rodriguez-Menendez, Barbara Sala, Roberto Cosimo Melcangi, Silvia Giatti, Raffaella Lombardi, Roberto Bianchi, Paola Marmiroli, Guido Cavaletti
Summary: The development and progression of diabetic polyneuropathy (DPN) involve multiple mechanisms. Reliable animal models of DPN are still challenging. Most of the current knowledge on DPN pathogenesis is based on results from rodent models, despite their differences from humans.
Article
Environmental Sciences
Eleonora Pozzi, Elisa Ballarini, Virginia Rodriguez-Menendez, Annalisa Canta, Alessia Chiorazzi, Laura Monza, Mario Bossi, Paola Alberti, Alessio Malacrida, Cristina Meregalli, Arianna Scuteri, Guido Cavaletti, Valentina Alda Carozzi
Summary: Chemotherapy-induced peripheral neurotoxicity, a common dose-limiting toxicity of anticancer drugs, was investigated in this study. The study focused on the effects of paclitaxel and cisplatin on satellite glial cells (SGCs) in the dorsal root ganglia (DRG) and their interactions. It was found that paclitaxel strongly activated SGCs, altering their physical contact with sensory neurons. SGCs may play a key role in paclitaxel-induced peripheral neurotoxicity, providing potential druggable targets for its treatment and prevention.
Article
Environmental Sciences
Guido Cavaletti, Alessia D'Acunti, Alessandro Porcu, Gabriella Masiello, Laura Del Campo, Gianfranca Traclo, Francesco De Lorenzo, Davide Paolo Bernasconi
Summary: Chemotherapy-induced neurotoxicity is a well-known complication of effective anticancer treatments, causing cognitive impairment and peripheral neuropathy. The social and economic effects of this condition on patients' lifestyles and relationships are under-investigated and largely unknown.
Article
Medicine, General & Internal
Daniele Moratto, Elda Mimiola, Federico Serana, Martina Garuti, Viviana Giustini, Aldo M. Roccaro, Salvatore Casari, Massimiliano Beccaria, Duilio Brugnoni, Marco Chiarini, Massimo Franchini
Summary: This study investigates the immunological changes in COVID-19 patients treated with convalescent plasma transfusion. The results show that proper immunophenotyping can be potentially useful for monitoring patients receiving convalescent plasma transfusion to predict higher risk of medical complications. The study also reveals that convalescent plasma can improve immunological parameters, but baseline immunological characteristics generally persist in patients who progress to death or long-term care.
Review
Biochemistry & Molecular Biology
Pier Giorgio Natali, Mauro Piantelli, Marco Minacori, Margherita Eufemi, Luisa Imberti
Summary: It is well known that multiple phytonutrients in their natural state are more effective than single nutrients alone. This study demonstrates that tomatoes, with their comprehensive array of prostate-health-preserving micronutrients, are superior to single-nutrient counterparts in reducing age-related prostate diseases. The researchers developed a tomato food supplement enriched with olive polyphenols, which contains significantly higher levels of cis-lycopene compared to industry-produced tomato products. Animal experiments showed that the supplement, with antioxidant activity comparable to N-acetylcysteine, significantly reduced levels of prostate-cancer-promoting cytokines. Clinical studies on patients with benign prostatic hyperplasia also showed improved urinary symptoms and quality of life with supplement intake. Furthermore, the supplement suppressed the development of prostate cancer in a mouse model and interfered with cancer signaling. It suggests that tomato consumption, especially in high-risk individuals, may delay or prevent age-related prostate diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Guido Cavaletti, Katherine Forsey, Paola Alberti
Summary: This review provides evidence-based recommendations on the use of neurotoxic drugs in patients with Charcot-Marie-Tooth disease (CMT). The study found that vincristine and possibly paclitaxel can occasionally induce a more severe course of drug-related peripheral neurotoxicity in CMT patients. Caution is therefore recommended when using these compounds. However, there is no convincing evidence for similar recommendations for other drugs.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Review
Virology
Eugenia Quiros-Roldan, Alessandra Sottini, Simona Giulia Signorini, Federico Serana, Giorgio Tiecco, Luisa Imberti
Summary: Anti-cytokine autoantibodies, especially anti-type I interferons, are increasingly being found in immunodeficient, autoimmune, and immune-dysregulated conditions. These antibodies may lead to a predisposition to infections in otherwise healthy individuals. They have been implicated in the pathogenesis of COVID-19 and found mainly in critically ill patients, but have also been detected in patients with infections unrelated to COVID-19. This review provides an overview of these autoantibodies, their clinical associations, and their potential role as either beneficial or harmful agents, as well as their possible association with gender and immunosenescence.
Article
Biochemistry & Molecular Biology
Anna Hucke, Rita Schroeter, Cecilia Ceresa, Alessia Chiorazzi, Annalisa Canta, Sara Semperboni, Paola Marmiroli, Guido Cavaletti, Burkhard Gess, Giuliano Ciarimboli
Summary: CDDP is an efficient chemotherapeutic agent, but it has significant unwanted side effects. This study suggests that OCT may play a role in causing these side effects by facilitating the uptake of CDDP. Mice lacking the OCT2 gene showed reduced kidney and neurological impairments compared to wild-type mice. OCT could be potential targets for reducing unwanted side effects and improving CDDP anticancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Guido Cavaletti, Chiara Pizzamiglio, Albert Man, Thomas M. Engber, Cristoforo Comi, Darren Wilbraham
Summary: Two studies demonstrate that blood neurofilament light chain (NfL) can be used as a biomarker to monitor and mitigate chemotherapy-induced peripheral neuropathy (CIPN). NfL is strongly associated with cumulative dose of chemotherapy and CIPN20 sensory subscore. Although further studies with more patients are planned in an ongoing clinical trial, these findings provide evidence of the potential use of serum NfL as a biomarker for CIPN in breast cancer patients.
Article
Clinical Neurology
Alessia Chiorazzi, Annalisa Canta, Valentina Alda Carozzi, Cristina Meregalli, Eleonora Pozzi, Elisa Ballarini, Virginia Rodriguez-Menendez, Paola Marmiroli, Guido Cavaletti, Paola Alberti
Summary: The study investigated the use of nerve excitability testing (NET) in two different CIPN rat models (oxaliplatin and paclitaxel), showing distinct patterns of axonal hyperexcitability and damage in the animals. Results suggest that NET could serve as an early surrogate marker in clinical trials for detecting precocious changes leading to axonal damage.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Biochemistry & Molecular Biology
Nicoletta Cordani, Luca Mologni, Rocco Piazza, Pietro Tettamanti, Viola Cogliati, Mario Mauri, Matteo Villa, Federica Malighetti, Camillo Di Bella, Marta Jaconi, Maria Grazia Cerrito, Guido Cavaletti, Marialuisa Lavitrano, Marina Elena Cazzaniga
Summary: CDK4/6 inhibitors have shown significant improvement in the progression-free survival of hormone-receptor-positive and HER2-negative metastatic breast cancer. However, there is a high percentage of patients who are unresponsive or refractory to these inhibitors, and no reliable biomarkers have been identified to predict patients' response to treatment. This study focused on palbociclib, a selective CDK4/6 inhibitor, and found that TWIST1 could be a potential target for reversing resistance to palbociclib. This study provides new insights into the mechanisms of resistance to CDK4/6 inhibitors and identifies potential markers for patient follow-up during treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)