Article
Clinical Neurology
Marco Pisa, Tommaso Croese, Gloria Dalla Costa, Simone Guerrieri, Su-Chun Huang, Annamaria Finardi, Lorena Fabbella, Francesca Sangalli, Bruno Colombo, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Roberto Furlan, Letizia Leocani
Summary: Optical coherence tomography (OCT) is increasingly important in evaluating patients with multiple sclerosis, showing neuro-retinal changes indicative of inflammatory and disease burden. Subclinical optic nerve involvement and thinning of ganglion cell layer in eyes without acute optic neuritis are associated with greater disease burden, reflecting early disease phases.
Review
Clinical Neurology
Christopher Martin Allen, Ellen Mowry, Mar Tintore, Nikos Evangelou
Summary: Clinically isolated syndrome (CIS) is a single attack of inflammatory demyelination of the central nervous system, which can predict the development of multiple sclerosis. MRI scanning remains the most influential prognostic investigation during diagnosis, while multiple testing methods and medical history information also contribute to the diagnosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Amjad I. AlTokhis, Abrar AlAmrani, Abdulmajeed Alotaibi, Anna Podlasek, Cris S. Constantinescu
Summary: Definite imaging predictors for long-term disability in multiple sclerosis (MS) are currently lacking. However, recent findings suggest that white matter lesion (WML) counts and volumes may be able to predict long-term disability in MS. A meta-analysis of studies found that T2 brain lesion counts and volumes were associated with disability progression after 10 years, with a significant association between the presence of four or more lesions at baseline and EDSS 3 and EDSS 6. These findings suggest that lesion counts and volumes could provide additional guidance in treatment decision making.
Article
Clinical Neurology
Kevin N. Alschuler, Daniel Whibley, Anna L. Kratz, Mark P. Jensen, Annette Wundes, Gloria von Geldern, Peiqing Qian, Charles H. Bombardier, Dawn M. Ehde
Summary: The study found that in the first year post-MS/CIS diagnosis, the average QOL was high and stable, with only a few variables predicting baseline QOL and changes over time. This suggests that early assessment of certain factors can help predict current and future QOL outcomes for patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Lukas Haider, Karen Chung, Giselle Birch, Arman Eshaghi, Stephanie Mangesius, Ferran Prados, Carmen Tur, Olga Ciccarelli, Frederik Barkhof, Declan Chard
Summary: The study found that brain regional atrophy within the first 5 years following a clinically isolated syndrome predicts the risk of developing progressive multiple sclerosis or experiencing related death 30 years later, as well as disability 25 years later.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Benoit Combes, Anne Kerbrat, Guillaume Pasquier, Olivier Commowick, Brandon Le Bon, Francesca Galassi, Philippe L'Hostis, Nora El Graoui, Raphael Chouteau, Emmanuel Cordonnier, Gilles Edan, Jean-Christophe Ferre
Summary: This study developed a workflow that can help clinicians detect new lesions in Multiple Sclerosis patients more accurately and efficiently, which could have significant implications on the therapeutic management of MS patients.
FRONTIERS IN MEDICINE
(2021)
Article
Neurosciences
Maria-Eleftheria Evangelopoulos, Georgios Koutsis, Fotini Boufidou, Manolis Markianos
Summary: Cholesterol levels may be associated with disease characteristics in multiple sclerosis, particularly with demyelination and immune response. This study found lower levels of plasma and cerebrospinal fluid cholesterol in patients with multiple sclerosis. Patients with positive oligoclonal bands had even lower cerebrospinal fluid cholesterol levels, which may be related to disease progression and enhanced humoral immune response.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Immunology
Klaus Berek, Gabriel Bsteh, Michael Auer, Franziska Di Pauli, Anne Zinganell, Thomas Berger, Florian Deisenhammer, Harald Hegen
Summary: The study found that the CSF parameters in MS patients varied across disease courses, with less frequent blood-CSF-barrier dysfunction and intrathecal IgA/IgM synthesis when the novel RL were applied.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Michelle Maiworm, Celona Hamid, Marlies Wagner, Ulrike Noeth, Ralf Deichmann, Alexander Seiler, Rene-Maxime Gracien
Summary: This study aimed to assess microstructural damage of cortical grey matter in patients with relapsing-remitting multiple sclerosis (RRMS) using multiparametric quantitative MRI techniques. The results showed that T1, PD, and T2 values significantly increased over 2 years, indicating progressive demyelination and increasing water content. These parameters may serve as promising surrogate markers of diffuse cortical inflammation in RRMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Clinical Neurology
Massimiliano Calabrese, Damiano Marastoni, Francesco Crescenzo, Antonio Scalfari
Summary: This review discusses the challenges in diagnosing patients with the first demyelinating attack or RIS, focusing on the updated diagnostic criteria, considering neuroinflammatory conditions in the differential diagnosis, and identifying factors that predict MS development. Accurate interpretation of demyelinating attacks, MRI results, and the importance of cerebrospinal fluid examination are emphasized for an early and precise MS diagnosis to start timely disease-modifying therapy and improve long-term outcomes.
CURRENT OPINION IN NEUROLOGY
(2021)
Review
Clinical Neurology
Maria Pia Amato, Nicola De Stefano, Matilde Inglese, Emanuele Morena, Giovanni Ristori, Marco Salvetti, Maria Trojano
Summary: Despite significant progress in MS treatment, there are still two major unmet needs: understanding the disease's etiology and designing definitive cures, as well as preventing severe and disabling manifestations. Radiologically isolated syndrome and prodromal MS pose the risk of progressing to overt disease. Implementation of study groups and disease registry are important for conducting informative clinical trials.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Victor Chavarria, Guillermo Espinosa-Ramirez, Julio Sotelo, Jose Flores-Rivera, Omar Anguiano, Ana Campos Hernandez, Edgar Daniel Guzman-Rios, Aleli Salazar, Graciela Ordonez, Benjamin Pineda
Summary: This study investigates the predictors of conversion from Clinically Isolated Syndrome (CIS) to Clinical Definite Multiple Sclerosis (CDMS) in Mexican patients. Motor symptoms, multifocal syndromes, and alterations of somatosensory evoked potentials were associated with conversion to CDMS. The presence of at least one lesion on magnetic resonance imaging was the main factor associated with an increased risk of conversion to CDMS.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Clinical Neurology
Massimo Filippi, Paolo Preziosa, Alessandro Meani, Gloria Dalla Costa, Sarlota Mesaros, Jelena Drulovic, Jovana Ivanovic, Alex Rovira, Mar Tintore, Xavier Montalban, Olga Ciccarelli, Wallace Brownlee, Katherine Miszkiel, Christian Enzinger, Michael Khalil, Frederik Barkhof, Eva M. M. Strijbis, Jette L. Frederiksen, Stig P. Cramer, Enrico Fainardi, Maria Pia Amato, Claudio Gasperini, Serena Ruggieri, Vittorio Martinelli, Giancarlo Comi, Maria A. Rocca
Summary: This study compares the performance of the 2017 revisions to the McDonald criteria with the 2010 criteria in diagnosing and predicting prognosis of multiple sclerosis (MS) in patients with clinically isolated syndrome (CIS). The results show that the 2017 criteria have higher sensitivity, lower specificity, and shorter time to MS diagnosis compared to the 2010 criteria.
Review
Clinical Neurology
Virginia Meca-Lallana, Leticia Berenguer-Ruiz, Joan Carreres-Polo, Sara Eichau-Madueno, Jaime Ferrer-Lozano, Lucia Forero, Yolanda Higueras, Nieves Tellez Lara, Angela Vidal-Jordana, Francisco Carlos Perez-Miralles
Summary: Multiple sclerosis is an inflammatory and degenerative disease of the central nervous system triggered by unknown environmental factors in patients with genetic risk profiles. Prevention of neurological disability is essential, but mechanisms driving disease progression remain unknown. Lack of markers for early detection and varying definitions of disability progression complicate assessment in clinical practice.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Jiri Motyl, Lucie Friedova, Manuela Vaneckova, Jan Krasensky, Balazs Lorincz, Jana Blahova Dusankova, Michaela Andelova, Tom A. Fuchs, Eva Kubala Havrdova, Ralph H. B. Benedict, Dana Horakova, Tomas Uher
Summary: Only a small proportion of MS patients experience isolated cognitive decline (ICD) over short-term follow-up. Patients with severe MS are more prone to cognitive decline, but those with normal cognitive performance and mild MS may benefit the most from early detection of cognitive decline.
Review
Clinical Neurology
Sandra Vukusic, Clarisse Carra-Dalliere, Jonathan Ciron, Elisabeth Maillart, Laure Michel, Emmanuelle Leray, Anne-Marie Guennoc, Bertrand Bourre, David Laplaud, Geraldine Androdias, Caroline Bensa, Kevin Bigaut, Damien Biotti, Pierre Branger, Olivier Casez, Mikael Cohen, Elodie Daval, Romain Deschamps, Cecile Donze, Anne-Laure Dubessy, Cecile Dulau, Francoise Durand-Dubief, Maxime Guillaume, Benjamin Hebant, Laurent Kremer, Arnaud Kwiatkowski, Julien Lannoy, Adil Maarouf, Eric Manchon, Guillaume Mathey, Xavier Moisset, Alexis Montcuquet, Julie Pique, Thomas Roux, Romain Marignier, Christine Lebrun-Frenay
Summary: The objective of this study was to develop evidence-based recommendations on pregnancy management for persons with multiple sclerosis (MS). A total of 104 proposed recommendations were reached through a thorough review of literature and expert consensus. These recommendations cover various aspects including pregnancy planning, follow-up, delivery routes, anesthesia, prevention of relapses, breastfeeding, vaccinations, etc. These recommendations are expected to harmonize counseling and treatment practices, and provide better and individualized choices for individuals with MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Manon Rival, Eric Thouvenot, Lucile Du Trieu de Terdonck, Sabine Laurent-Chabalier, Christophe Demattei, Ugur Uygunoglu, Giovanni Castelnovo, Mikael Cohen, Darin T. Okuda, Orhun H. Kantarci, Daniel Pelletier, Christina Azevedo, Philippe Marin, Sylvain Lehmann, Aksel Siva, Thibault Mura, Christine Lebrun-Frenay
Summary: This study evaluates the predictive value of serum neurofilament light chain (sNfL) and CSF NfL (cNfL) in patients with radiologically isolated syndrome (RIS) for evidence of disease activity and clinical conversion. The results indicate that both sNfL and cNfL can independently predict disease activity and clinical conversion.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Darin T. Okuda, Orhun Kantarci, Christine Lebrun-Frenay, Maria Pia Sormani, Christina J. Azevedo, Francesca Bovis, Le H. Hua, Lilyana Amezcua, Ellen M. Mowry, Christophe Hotermans, Jason Mendoza, John S. Walsh, Christian von Hehn, Wendy S. Vargas, Stacy Donlon, Robert T. Naismith, Annette Okai, Gabriel Pardo, Pavle Repovic, Olaf Stuve, Aksel Siva, Daniel Pelletier
Summary: This study evaluated the impact of therapeutic intervention in preventing the first symptom manifestation in individuals with radiologically isolated syndrome (RIS), the pre-clinical phase of multiple sclerosis (MS). The results showed that drug treatment significantly reduced the risk of clinical symptoms.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Benjamin Cretin, Nathalie Philippi, Olivier Bousiges, Frederic Blanc
Summary: This study found that CSF sampling has good diagnostic value in TEA patients with characteristics suggestive of incipient degenerative diseases. It suggests that TEA may be the inaugurating feature in some cases of AD. The results also demonstrate the etiological heterogeneity in TEA.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Anna Inguanzo, Konstantinos Poulakis, Rosaleena Mohanty, Christopher G. Schwarz, Scott A. Przybelski, Patricia Diaz-Galvan, Val J. Lowe, Bradley F. Boeve, Afina W. Lemstra, Marleen van de Beek, Wiesje van der Flier, Frederik Barkhof, Frederic Blanc, Paulo Loureiro de Sousa, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Zuzana Nedelska, Jakub Hort, Barbara Segura, Carme Junque, Ketil Oppedal, Dag Aarsland, Eric Westman, Kejal Kantarci, Daniel Ferreira
Summary: Using MRI data, we identified three subtypes of Dementia with Lewy bodies (DLB): older subtype with reduced cortical GM volumes and worse cognition, subtype with low GM volumes in fronto-occipital regions, and a younger subtype with the highest cortical GM volumes, lower GM volumes in basal ganglia, and cognitive fluctuations. These subtypes have implications for clinical practice, research, and treatment decisions.
NPJ PARKINSONS DISEASE
(2023)
Letter
Clinical Neurology
Christine Lebrun-Frenay, Orhun H. Kantarci, Aksel Siva, Daniel Pelletier, Darin T. Okuda
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Susana Otero-Romero, Christine Lebrun-Frenay, Saul Reyes, Maria Pia Amato, Magda Campins, Mauricio Farez, Massimo Filippi, Yael Hacohen, Bernhard Hemmer, Rosa Juuti, Melinda Magyari, Celia Oreja-Guevara, Aksel Siva, Sandra Vukusic, Mar Tintore
Summary: This study developed a European consensus on vaccination strategies for people with multiple sclerosis (pwMS) who are candidates for disease-modifying therapies (DMTs). A multidisciplinary working group used formal consensus methodology to formulate recommendations based on the quality of evidence and risk-benefit balance. A total of 53 recommendations were agreed upon, aiming to homogenize immunization practices in pwMS.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Manon Querry, Frederic Blanc, Olivier Bousiges, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Candice Muller, Anne Botzung
Summary: The aim of this study was to describe the characteristics and evolution of the long-term memory profile of patients with prodromal and mild DLB and AD. The study found that DLB patients performed better than AD patients in terms of total recall, delayed total recall, recognition, and loss of information over time. The memory performance of DLB patients remained stable over 48 months, unlike that of AD patients. Four indicators were relevant to distinguish between DLB and AD patients in terms of memory performance.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Clinical Neurology
Susana Otero-Romero, Christine Lebrun-Frenay, Saul Reyes, Maria Pia Amato, Magda Campins, Mauricio Farez, Massimo Filippi, Yael Hacohen, Bernhard Hemmer, Rosa Juuti, Melinda Magyari, Celia Oreja-Guevara, Aksel Siva, Sandra Vukusic, Mar Tintore
Summary: This study aims to develop an evidence-based vaccination strategy for pwMS who are candidates for disease-modifying therapies. A multidisciplinary working group conducted a systematic literature search and formulated 53 recommendations based on the quality of evidence. The goal of this study is to homogenize immunization practices in pwMS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
J. -C. Lafontaine, J. Boucher, J. Giovannelli, J. Petit, O. Outteryck, S. Balagny, H. Zephir
Summary: The aim of this study is to describe and assess the safety of home infusion of natalizumab. The results indicate that the established home natalizumab procedure is safe using the university hospital home-care department.
REVUE NEUROLOGIQUE
(2023)
Article
Psychiatry
Candice Muller, Jeanne Merignac, Christophe Moog, Benoit Schorr, Herve Javelot, Frederic Blanc
Summary: This study describes three patients with DLB who presented with major visual hallucinations, delusion, and an orbitofrontal syndrome. They were intolerant of low-dose clozapine and were treated with a combination of pimavanserin and trazodone. After 4 to 6 weeks of treatment, a marked improvement in symptoms was observed.
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT
(2023)
Review
Biology
Alice Tisserand, Nathalie Philippi, Anne Botzung, Frederic Blanc
Summary: This review explores the relationship between the insula, a brain region, and the self. The insula is a multiconnected region that processes diverse information related to the self. Studies in healthy individuals and those with different conditions reveal the involvement of the insula in various aspects of the self. Damage to the insular cortex may lead to a collapse of the self across different pathologies.
Article
Clinical Neurology
Maria Camila Gonzalez, Diego Alejandro Tovar-Rios, Guido Alves, Ingvild Dalen, Caroline H. Williams-Gray, Marta Camacho, Lars Forsgren, David Backstrom, Rachael A. Lawson, Angus D. Macleod, Carl E. Counsell, Claire Paquet, Carlo DeLena, Fabrizia D'Antonio, Andrea Pilotto, Alessandro Padovani, Frederic Blanc, Cristian Falup-Pecurariu, Simon J. G. Lewis, Konrad Rejdak, Ewa Papuc, Jakub Hort, Zuzana Nedelska, John O'Brien, Laura Bonanni, Marta Marquie, Merce Boada, Vanesa Pytel, Carla Abdelnour, Daniel Alcolea, Katrin Beyer, Ole-Bjorn Tysnes, Dag Aarsland, Jodi Maple-Grodem
Summary: This study compares the rate of cognitive and motor decline in patients with DLB and PDD, finding that both disorders show similar rates of decline. This has implications for future clinical trial designs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Health Care Sciences & Services
Sarah Wilson, Floriane Calocer, Fabien Rollot, Mathieu Fauvernier, Laurent Remontet, Laure Tron, Sandra Vukusic, Emmanuelle Le Page, Marc Debouverie, Jonathan Ciron, Aurelie Ruet, Jerome De Seze, Helene Zephir, Thibault Moreau, Christine Lebrun-Frenay, David-Axel Laplaud, Pierre Clavelou, Pierre Labauge, Eric Berger, Jean Pelletier, Olivier Heinzlef, Eric Thouvenot, Jean Philippe Camdessanche, Emmanuelle Leray, Olivier Dejardin, Gilles Defer
Summary: This study examined the effects of socio-economic status on mortality in patients with multiple sclerosis. The findings showed that patients with lower socio-economic status had higher mortality rates. Therefore, improving overall care for multiple sclerosis patients with lower socio-economic status could help reduce socio-economic inequalities in disease-related mortality.
LANCET REGIONAL HEALTH-EUROPE
(2023)