Article
Clinical Neurology
V Lepore, C. Bosetti, C. Santucci, P. Iaffaldano, M. Trojano, P. Mosconi
Summary: This study compared the use of fixed baseline and roving EDSS reference scores in detecting disability-worsening events in RRMS patients, and found that roving EDSS reference scores were more sensitive in detecting worsening events unrelated to relapse.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Yi Chao Foong, Daniel Merlo, Melissa Gresle, Chao Zhu, Katherine Buzzard, Jeannette Lechner-Scott, Michael Barnett, Bruce Taylor, Tomas Kalincik, Trevor Kilpatrick, David Darby, Pamela Dobay, Johan van Beek, Robert Hyde, Helmut Butzkueven, Anneke van Der Walt
Summary: This study investigated the psychometric properties and longitudinal performance of the PDDS scale in patients with multiple sclerosis (MS). The findings showed that PDDS had greater correlation with patient-reported outcomes (PROs) and less correlation with other MS-related outcome measures compared to the EDSS. Furthermore, PDDS had little correlation with EDSS longitudinally.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Ana Jerkovic, Sanda Pavelin, Josko Soda, Igor Vujovic, Maja Rogic Vidakovic
Summary: The present study investigated disability severity in people with multiple sclerosis (pwMS) in Croatia in 2021 using an electronic, unsupervised patient-reported Expanded Disability Status Scale (ePR-EDSS). The results showed significant differences in disability severity among patients of different ages, genders, and immunomodulatory drug use. There were also significant differences in disability symptoms among different types of multiple sclerosis. The study also found that the application of ePR-EDSS was a reliable tool for assessing disability status in pwMS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Andrew R. Romeo, William M. Rowles, Erica S. Schleimer, Patrick Barba, Wan-Yu Hsu, Refujia Gomez, Adam Santaniello, Chao Zhao, Jennifer R. Pearce, J. B. Jones, Bruce C. Cree, Stephen L. Hauser, Jeffrey M. Gelfand, Walter F. Stewart, Douglas S. Goodin, Riley M. Bove
Summary: The study found that the developed ePR-EDSS can effectively capture MS-related disability and has a high degree of agreement with traditional EDSS evaluations. It can also facilitate broader patient participation in research.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Biology
S. Mungan, I. Guzel, B. C. Demirdogen
Summary: This study aimed to assess the relationship between dietary antioxidant capacity and the Expanded Disability Status Scale (EDSS) scores in multiple sclerosis (MS) patients. The results showed significant correlations between levels of vitamins A, D, E, C, and retinol and the EDSS scores. The study findings suggest that evaluating antioxidant levels may be helpful in determining the severity of MS and the success of treatment.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Tobia Zanotto, Jacob J. Sosnoff, Edward Ofori, Daniel Golan, Myassar Zarif, Barbara Bumstead, Marijean Buhse, Olivia Kaczmarek, Jeffrey Wilken, Lisa Muratori, Thomas J. Covey, Mark Gudesblatt
Summary: This study aimed to quantify the variability of spatiotemporal gait measures within homologous EDSS categories. The results showed that there was a correlation between gait measures and EDSS scores, and the variability of gait measures increased with the increase in EDSS categories. Therefore, more comprehensive objective metrics are needed to accurately evaluate disability in pwMS, in addition to the EDSS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Ian-Christopher Tanoh, Elisabeth Maillart, Pierre Labauge, Mikael Cohen, Adil Maarouf, Sandra Vukusic, Cecile Donze, Philippe Gallien, Jerome De Seze, Bertrand Bourre, Thibault Moreau, Celine Louapre, Morgane Vallee, Severine Bieuvelet, Lissandra Klaeyle, Anne-Laure Argoud, Saad Zinai, Ayman Tourbah
Summary: The software medical device MSCopilot has shown high specificity, sensitivity, and reliability in self-assessment of Multiple Sclerosis patients, with significant correlations to the Expanded Disability Status Scale (EDSS) and the ability to distinguish patients with different EDSS levels. The device was found to be able to capture nuances in different stages of MS that traditional tests like MSFC could not.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Antonio Barreiro-Gonzalez, Maria T. Sanz, Sara Carratala-Bosca, Francisco Perez-Miralles, Carmen Alcala, Joan Carreres-Polo, Enrique Espana-Gregori, Bonaventura Casanova
Summary: The study developed and validated an EDSS model using clinical, OCT, and MRI measures in MS patients. Results showed correlations between EDSS and patient's age, SC volume, and GCL, leading to a regression model predicting diverse EDSS scores. This study suggests that MS disability measured through EDSS is age-dependent and influenced by SC and GCL, warranting further research on paraclinical disability predictors.
EUROPEAN NEUROLOGY
(2022)
Article
Clinical Neurology
Sharon Lynch, Sara Baker, Muhammad Nashatizadeh, Amanda Thuringer, Joan Thelen, Jared Bruce
Summary: The study on older individuals found that EDSS scores may be influenced by factors such as age, comorbidities, and polypharmacy, rather than just disability caused by multiple sclerosis. Pyramidal and cerebellar functional systems accounted for a significant portion of unique variance between groups.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Health Care Sciences & Services
Abdulrahman M. Alsubiheen, Nawaf A. Alzain, Alaa M. Albishi, Afaf A. M. Shaheen, Mishal M. Aldaihan, Muneera M. Almurdi, Abdulfattah S. Alqahtani, Asma A. Alderaa, Ali H. Alnahdi
Summary: The purpose of this study was to examine the reliability and validity of the Arabic version of the patient-specific functional scale (PSFS-Ar) in patients with multiple sclerosis. A longitudinal cohort study design was used to assess reliability and validity in 100 participants with MS. The PSFS-Ar demonstrated excellent test-retest reliability and acceptable measurement error, and was positively correlated with predefined hypotheses.
Article
Medicine, Research & Experimental
Peter Kosa, Ruturaj Masvekar, Mika Komori, Jonathan Phillips, Vighnesh Ramesh, Mihael Varosanec, Mary Sandford, Bibiana Bielekova
Summary: This study aimed to enhance the clinical value of serum neurofilament light chain (sNFL) through mathematical adjustment. The results showed that adjustment including age, blood urea nitrogen, alkaline phosphatase, creatinine, and weight significantly improved the correlations between sNFL and cerebrospinal fluid NFL (cNFL), as well as the correlations with the number of lesions in multiple sclerosis patients. In addition, there was a weak but significant correlation between sNFL and cross-sectional severity outcomes in multiple sclerosis.
Article
Clinical Neurology
Franziska Di Pauli, Anne Zinganell, Bettina Boettcher, Janette Walde, Michael Auer, Robert Barket, Klaus Berek, Alexander Egger, Andrea Griesmacher, Natasa Sukalo, Florian Deisenhammer, Harald Hegen
Summary: The prevalence of sexual dysfunction (SD) in people with multiple sclerosis (pwMS) is 47%. Risk factors for SD in pwMS include smoking, disability, depression, and bladder and bowel dysfunction, while the use of disease-modifying treatment lowers the risk. SD is associated with worse quality of life and lower physical activity. Screening for SD is recommended, especially in patients with disability, depression, or bladder and bowel dysfunction.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Federica Felicetti, Silvia Tommasin, Maria Petracca, Laura De Giglio, Flavia Gurreri, Antonio Ianniello, Riccardo Nistri, Carlo Pozzilli, Serena Ruggieri
Summary: The study found that individuals with multiple sclerosis (MS) generally have healthier dietary patterns compared to healthy controls, with the intake of vegetables and fish being associated with disability outcomes.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Saeed Sadigh-Eteghad, Negin Abbasi Garravnd, Mahsa Feizollahi, Mahnaz Talebi
Summary: This study found that information processing speed and working memory were the most affected cognitive domains in multiple sclerosis patients. The severity of cognitive impairment was positively correlated with current age, EDSS score, and disease duration, and negatively correlated with education level, while age at disease onset and relapse rate were not correlated with cognitive impairment severity.
JOURNAL OF CLINICAL NEUROLOGY
(2021)
Article
Clinical Neurology
Barbora Srpova, Lukas Sobisek, Klara Novotna, Tomas Uher, Lucie Friedova, Manuela Vaneckova, Jan Krasensky, Eva Kubala Havrdova, Dana Horakova
Summary: The study identified that employment status of multiple sclerosis patients is independently associated with EDSS score, walking ability, cognitive performance, and MRI volumetric parameters.
NEUROLOGICAL SCIENCES
(2022)
Article
Transplantation
Anirudh Rao, Stephanie J. MacNeill, Moniek W. M. van de Luijtgaarden, Nicholas C. Chesnaye, Christiane Drechsler, Chistoph Wanner, Claudia Torino, Maurizio Postorino, Maciej Szymczak, Marie Evans, Friedo W. Dekker, Kitty J. Jager, Yoav Ben-Shlomo, Fergus J. Caskey
Summary: This study evaluates the external validity of the European EQUAL cohort study on older adults with Stage 4/5 chronic kidney disease. Findings suggest that factors such as gender, age, and comorbidities can influence participation rates and outcomes in cohort studies.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Clinical Neurology
Marija Cauchi, Harriet Ball, Yoav Ben-Shlomo, Neil Robertson
Summary: Recent significant scientific investment has led to an expanding range of COVID-19 vaccines and increasing global uptake. However, concerns around potential risks and adverse events, such as vaccine-induced thrombosis and thrombocytopenia, pose challenges in interpreting data, communicating risks, and establishing causality. The 'infodemic' facilitated by the Internet and media further complicates understanding and communicating these risks to clinicians and the general population.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ilaria Poggiolini, Vandana Gupta, Michael Lawton, Seoyun Lee, Aadil El-Turabi, Agustin Querejeta-Coma, Claudia Trenkwalder, Friederike Sixel-Doering, Alexandra Foubert-Samier, Anne Pavy-Le Traon, Giuseppe Plazzi, Francesco Biscarini, Jacques Montplaisir, Jean-Francois Gagnon, Ronald B. Postuma, Elena Antelmi, Wassilios G. Meissner, Brit Mollenhauer, Yoav Ben-Shlomo, Michele T. Hu, Laura Parkkinen
Summary: The study aimed to assess the diagnostic value of CSF alpha-synuclein RT-QuIC quantitative parameters in regard to disease progression, stratification, and conversion in synucleinopathies. The results showed that alpha-synuclein RT-QuIC adds value in diagnosing Parkinson's disease and may provide a way to distinguish variations within Parkinson's disease phenotype. The assay also showed potential as an early biomarker detecting synucleinopathy in idiopathic REM sleep behaviour disorder patients prior to conversion.
Article
Endocrinology & Metabolism
Francesca Spiga, Michael A. Lawton, Stafford L. Lightman, George Davey Smith, Yoav Ben-Shlomo
Summary: The study found differences in the association between social class and cortisol in an aging male population, with lower social class being linked to slower recovery of cortisol levels after exposure to stress.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Karolis Zienius, Mio Ozawa, Willie Hamilton, Will Hollingworth, David Weller, Lorna Porteous, Yoav Ben-Shlomo, Robin Grant, Paul M. Brennan
Summary: A rapid triage test, verbal fluency task (VFT), has the potential to support the identification of patients with brain tumours and facilitate urgent brain imaging triage. By incorporating VFT scores into clinical decision making, the timeliness and efficiency of diagnosis can be improved.
Article
Clinical Neurology
Christine Lo, Siddharth Arora, Michael Lawton, Thomas Barber, Timothy Quinnell, Gary J. Dennis, Yoav Ben-Shlomo, Michele Tao-Ming Hu
Summary: The composite clinical motor score may offer greater consistency and sensitivity in detecting motor changes in early disease than the MDS-UPDRS III alone. It is also more accurate in predicting clinical outcomes, requiring fewer participants in sample size estimations.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Medicine, Research & Experimental
Matthew D. Smith, Emma Tenison, Hashim Hashim, Yoav Ben-Shlomo, Emily J. Henderson
Summary: This study systematically reviewed the use of neuromodulation techniques for treating bladder symptoms in Parkinson disease (PD). The findings suggest that neuromodulation techniques, such as tibial nerve stimulation (TNS) and sacral neuromodulation (SNM), can be beneficial in improving bladder symptoms in PD. However, more well-designed and sham-controlled studies are needed to provide definitive evidence.
Article
Multidisciplinary Sciences
Katie Wong, Fergus J. Caskey, Anna Casula, Yoav Ben-Shlomo, Pippa Bailey
Summary: Little is known about the clinical demographics and access to transplantation for Chinese diaspora populations with kidney disease. UK Chinese patients are younger at start of KRT, with higher rates of diabetic kidney disease and glomerulonephritis compared to White patients. UK Chinese men have lower odds of pre-emptive transplant and transplant within 3 years of KRT start, while both UK Chinese men and women have markedly lower odds of LDKT compared to Whites. Understanding these disparities will help ensure equitable access to transplantation.
Article
Clinical Neurology
Michael Lawton, Manuela M. X. Tan, Yoav Ben-Shlomo, Fahd Baig, Thomas Barber, Johannes C. Klein, Samuel G. Evetts, Stephanie Millin, Naveed Malek, Katherine Grosset, Roger A. Barker, Nigel Williams, David J. Burn, Thomas Foltynie, Huw R. Morris, Nicholas Wood, Donald G. Grosset, Michele Tao-Ming Hu
Summary: This study explores the genetics of four previously described subtypes of Parkinson's disease and finds associations between different subtypes and GBA gene mutations and genetic risk. These findings provide insights into the underlying disease mechanisms and pathogenesis in different subtypes of Parkinson's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Panayiotis Louca, Ana Nogal, Aurelie Moskal, Neil J. Goulding, Martin J. Shipley, Taryn Alkis, Joni Lindbohm, Jie Hu, Domagoj Kifer, Ni Wang, Bo Chawes, Kathryn M. Rexrode, Yoav Ben-Shlomo, Mika Kivimaki, Rachel A. Murphy, Bing Yu, Marc J. Gunter, Karsten Suhre, Deborah A. Lawlor, Massimo Mangino, Cristina Menni
Summary: This study identified multiple metabolites associated with hypertension, with lipid and organic acids being predominant, and discovered 5 novel metabolites. Pathway analysis suggested important roles of amino acids, serine/glycine, and bile acids in hypertension regulation.
Article
Medicine, Research & Experimental
Matthew D. Smith, Emma Tenison, Marcus J. Drake, Yoav Ben-Shlomo, Emily J. Henderson
Summary: This study is a randomized controlled trial of tibial nerve stimulation in Parkinson's disease patients conducted in the patients' own home. The aim is to explore a novel and easy to use method of delivering tibial nerve stimulation as a potential new treatment modality.
Article
Health Care Sciences & Services
Hein Heuvelman, Neil M. Davies, Yoav Ben-Shlomo, Alan Emond, Jonathan Evans, David Gunnell, Rachel Liebling, Richard Morris, Rupert Payne, Claire Storey, Maria Viner, Dheeraj Rai
Summary: This study examines the associations between the use of antidepressants during pregnancy and outcomes using multiple methods to strengthen causal inference. The results show that women who initiate or continue antidepressants during pregnancy are more likely to have contact with healthcare services and continue antidepressant use after pregnancy. However, there is little evidence for substantial associations between antidepressant use and autism, attention deficit hyperactivity disorder, or intellectual disability in children.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Medicine, General & Internal
Harriet A. Ball, Elizabeth Coulthard, Mark Fish, Antony Bayer, John Gallacher, Yoav Ben-Shlomo
Summary: This study examines the association between subjective cognitive decline (sSCD) and objective cognition, finding a weak correlation between the two. Older age, poor sleep quality, and higher anxiety are independent predictors of sSCD. The study suggests that sSCD, in the absence of objective decline, may be an example of poor meta-cognition and a potential driver for functional cognitive disorder (FCD).
Article
Clinical Neurology
Laura Winchester, Imelda Barber, Michael Lawton, Jessica Ash, Benjamine Liu, Samuel Evetts, Lucinda Hopkins-Jones, Suppalak Lewis, Catherine Bresner, Ana Belen Malpartida, Nigel Williams, Steve Gentlemen, Richard Wade-Martins, Brent Ryan, Alejo Holgado-Nevado, Michele Hu, Yoav Ben-Shlomo, Donald Grosset, Simon Lovestone
Summary: In this study, a multi-protein panel representative of Parkinson's disease was discovered using multiple cohorts and different measures. The researchers aimed to understand the disease mechanisms through protein expression profiles and find novel biomarkers. The results provide mechanistic insights into the disease and propose a protein signature classifier for further biomarker evaluation.
BRAIN COMMUNICATIONS
(2022)
Review
Medicine, General & Internal
Samuel T. Creavin, Anna H. Noel-Storr, Ryan J. Langdon, Edo Richard, Alexandra L. Creavin, Sarah Cullum, Sarah Purdy, Yoav Ben-Shlomo
Summary: This study examines the diagnostic accuracy of general practitioners' (GPs) clinical judgement for cognitive impairment and dementia in primary care. The results show that GPs' clinical judgement has higher specificity but lower sensitivity for the diagnosis of dementia, and higher sensitivity but lower specificity for the diagnosis of cognitive impairment. Additional tests are needed to confirm the diagnosis in both cases, but clinical judgement can inform the choice of further testing. The analysis of heterogeneity yields uncertain results. The study highlights the importance of formal tests in ruling out conditions and providing appropriate treatment.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)