Article
Health Care Sciences & Services
Stephanie L. Silveira, Katie L. J. Cederberg, Brenda Jeng, E. Morghen Sikes, Brian M. Sandroff, Catherine D. Jones, Robert W. Motl
Summary: This study found that symptom clusters among patients with multiple sclerosis were correlated with quality of life, with three distinct clusters identified based on the severity of symptoms. Patterns of symptom clusters varied among different age groups, particularly with the presence of severe sleep problem clusters in older adults. The severity of symptom clusters was significantly associated with worse quality of life, highlighting the importance of addressing co-occurring symptoms in MS patients.
QUALITY OF LIFE RESEARCH
(2021)
Review
Rehabilitation
Areum Han
Summary: This study examined the effects of mindfulness-and acceptance-based interventions (MABIs) on reducing symptoms in individuals with multiple sclerosis (MS). The results showed significant effects of MABIs in reducing symptoms of depression, anxiety, stress, and pain, but a moderate effect on fatigue symptoms. Future high-quality studies with follow-up evaluations are needed to further support these findings and explore intervention features that enhance and sustain effects.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Clinical Neurology
Nasim Rezaeimanesh, Pegah Rafiee, Roghayyeh Saeedi, Sharareh Eskandarieh, Mohammad Ali Sahraian, Pegah Khosravian, Maryam Abolhasani, Soodeh Razeghi Jahromi, Abdorreza Naser Moghadasi
Summary: This study investigated the role of physical activity level and body mass index in the comorbidities of depression, fatigue, and anxiety in multiple sclerosis (MS) patients. The results suggest that maintaining a physically active lifestyle and a normal weight category may lead to reduced symptoms of depression, fatigue, and anxiety in MS patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Katie L. J. Cederberg, Brenda Jeng, Jeffer E. Sasaki, E. Morghen Sikes, Stephanie L. Silveira, Gary Cutter, Robert W. Motl
Summary: This study found that anxiety, fatigue, depression, and unemployment were associated with worse sleep quality in adults with multiple sclerosis. Specific subgroups within the MS population were identified as experiencing more sleep problems and in greatest need for interventions targeting sleep impairment.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Neurosciences
Luana Gilio, Diego Fresegna, Antonietta Gentile, Livia Guadalupi, Krizia Sanna, Francesca De Vito, Sara Balletta, Silvia Caioli, Francesca Romana Rizzo, Alessandra Musella, Ennio Iezzi, Alessandro Moscatelli, Giovanni Galifi, Roberta Fantozzi, Paolo Bellantonio, Roberto Furlan, Annamaria Finardi, Valentina Vanni, Ettore Dolcetti, Antonio Bruno, Fabio Buttari, Georgia Mandolesi, Diego Centonze, Mario Stampanoni Bassi
Summary: Exercise has an immunomodulatory effect in MS patients, reducing levels of proinflammatory cytokines and improving mood disorders. IL-2 plays a causal role in mood disorders and synaptic dysfunction in MS. Further studies are needed to investigate the long-term effects of exercise as a disease-modifying therapy in MS.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Clinical Neurology
Joanna Tarasiuk, Katarzyna Kapica-Topczewska, Agata Czarnowska, Monika Chorazy, Jan Kochanowicz, Alina Kulakowska
Summary: Fatigue and depression are common symptoms in patients with multiple sclerosis (MS). Primary fatigue and depression in MS are caused by inflammatory, oxidative/nitrosative, and neurodegenerative processes. Secondary fatigue and depression may be caused by emotional factors, sleep disorders, pain, coexisting diseases, and medication use.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Safanah AlSaeed, Tamadher Aljouee, Nuha M. Alkhawajah, Rola Alarieh, Hanan AlGarni, Salman Aljarallah, Mohsen Ayyash, Amani Abu-Shaheen
Summary: This study aims to assess the prevalence of depression, anxiety, and fatigue among pwMS who have no physical disability in Saudi Arabia and demonstrate any correlation between these factors and physical activity as well as the QoL. The results revealed that depression, anxiety, and fatigue tend to be correlated and clustered together among pwMS in our cohort.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychology, Multidisciplinary
Ana Jerkovic, Ana Prorokovic, Meri Matijaca, Jelena Vuko, Ana Poljicanin, Angela Mastelic, Ana Curkovic Katic, Vana Kosta, Lea Kustura, Kresimir Dolic, Zoran Dogas, Maja Rogic Vidakovic
Summary: The study examined the factor structure and correlates of the Hospital Anxiety and Depression Scale (HADS) in multiple sclerosis patients, finding it to be a reliable and valid self-assessment scale for monitoring the psychiatric and psychological status of patients with MS. The HADS subscales showed good internal consistencies and convergent validity, suggesting its use in clinical monitoring.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Jara Francalancia, Paraskevi Mavrogiorgou, Georg Juckel, Tina Mitrovic, Jens Kuhle, Yvonne Naegelin, Ludwig Kappos, Pasquale Calabrese
Summary: The study found that patients with multiple sclerosis had low levels of death anxiety, which was moderately correlated with disability. Depression was significantly correlated with fatigue and disability in MS patients, but not with death anxiety.
Article
Rehabilitation
Tugba Ozsoy-Unubol, Emre Ata, Muyesser Cavlak, Serkan Demir, Zeynep Candan, Figen Yilmaz
Summary: This study compared the effects of conventional gait training and robot-assisted gait training on fatigue, mood, and quality of life in patients with multiple sclerosis. The results showed that both training methods had improvements in the measured outcomes, but robot-assisted gait training had superior effects on fatigue, depression, and anxiety.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Clinical Neurology
Thomas R. Valentine, Kevin N. Alschuler, Dawn M. Ehde, Anna L. Kratz
Summary: The study found that pain, fatigue, depression, and anxiety are common in patients with multiple sclerosis, often co-occurring. Most patients experienced at least one clinically significant symptom within the year after diagnosis, indicating a significant impact on patients. Symptom severity showed fluctuations at the individual level, highlighting the need for timely screening and treatment.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Karl M. Fleming, Susan B. Coote, Matthew P. Herring
Summary: The study quantified the effects of 8 weeks of home-based Pilates on symptoms of anxiety, depression and fatigue among PwMS. Results showed significant improvements in depressive and fatigue symptoms, as well as anxiety, cognitive, physical, psychosocial and total fatigue symptoms. The home-based Pilates significantly improved these symptoms among PwMS with minimal-to-mild mobility disability.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Neurosciences
Samar S. Ayache, Benjamin Bardel, Jean-Pascal Lefaucheur, Moussa A. Chalah
Summary: Fatigue, affective manifestations, cognitive deficits, and pain are common and debilitating symptoms in patients with multiple sclerosis (MS), which may have a complex pathophysiology and challenging management. Neurofeedback (NFB) could potentially improve outcomes by modulating brain activity in specific electroencephalographic bands, but further research is needed to explore its utility. Different NFB protocols and comprehensive evaluation may help optimize interventions for specific symptoms and potentially combine with other approaches to enhance management of MS symptoms.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Safanah AlSaeed, Nuha M. Alkhawajah, Mohsen Ayyash, Salman Aljarallah, Rola Alarieh, Amani Abu-Shaheen
Summary: This study investigated the factors of depression and anxiety in pwMS in Saudi Arabia and found that depression and anxiety are not uncommon in pwMS. Factors such as being male, low education, unemployment, physical inactivity, and fatigue significantly affect depression, while region, unemployment, short duration since last MS relapse, physical inactivity, and fatigue significantly affect anxiety.
Article
Clinical Neurology
Justin Abe, Saba Jafarpour, My H. Vu, Devon O'Brien, Natalie K. Boyd, Benjamin N. Vogel, Lina Nguyen, Kelli C. Paulsen, Laura E. Saucier, Nusrat Ahsan, Wendy G. Mitchell, Jonathan D. Santoro
Summary: The endocrine status of children with pediatric onset multiple sclerosis (POMS) is not associated with the severity of the disease or non-motor symptoms, but levels of free testosterone, cortisol, ACTH, and progesterone are abnormal in these patients.
FRONTIERS IN NEUROLOGY
(2023)