Article
Immunology
Georgia Papapavlou Lingehed, Sandra Hellberg, Jesse Huang, Mohsen Khademi, Ingrid Kockum, Hanna Carlsson, Ivar Tjernberg, Maria Svenvik, Jonas Lind, Marie Blomberg, Magnus Vrethem, Johan Mellergard, Mika Gustafsson, Maria C. Jenmalm, Tomas Olsson, Jan Ernerudh
Summary: This study analyzed protein expression in multiple sclerosis (MS) patients and healthy controls during pregnancy using a sensitive technology. The results showed dynamic changes in plasma proteins during pregnancy, with increased expression during the third trimester and restoration post-partum. Certain proteins with immunoregulatory properties were upregulated during pregnancy, while inflammatory chemokines and members of the tumor necrosis factor family were downregulated.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Shahar Kahila, Omri Zveik, Netta Levin, Livnat Brill, Ariel Rechtman, Nitzan Haham, Tal Imbar, Adi Vaknin-Dembinsky
Summary: The study evaluated the correlation between MRI activity during the year before pregnancy and long-term clinically meaningful worsening in EDSS in MS patients. It found that an active MRI pre-conception is a strong predictor of lt-EDSS and a higher annual relapse rate during the follow-up period. Optimizing disease control and achieving imaging stability prior to conception may reduce the risk of long-term clinical deterioration.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Bitao Bu, Chao Quan, Wenyu Li, Qiuming Zeng, Ziyan Shi, Bo Chen, Lei Zhou, Luya Jin, Hongyu Zhou, Huan Yang
Summary: A retrospective study was conducted to compare the treatment outcomes of teriflunomide and no disease-modifying therapy in Chinese multiple sclerosis patients. The results showed that teriflunomide was associated with a lower relapse rate and less disability accumulation.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Review
Clinical Neurology
Siyuan Yang, Xiang Li, Jiahe Wang, Tianyi Wang, Zhongmou Xu, Heng Gao, Gang Chen
Summary: S1PR modulators have shown good efficacy and safety in the treatment of relapsing-remitting multiple sclerosis (RRMS), reducing relapse rate and lesion numbers significantly, and improving patients' quality of life.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Fred D. Lublin, Dieter A. Haering, Habib Ganjgahi, Alex Ocampo, Farhad Hatami, Jelena Cuklina, Piet Aarden, Frank Dahlke, Douglas L. Arnold, Heinz Wiendl, Tanuja Chitnis, Thomas E. Nichols, Bernd C. Kieseier, Robert A. Bermel
Summary: Patients with multiple sclerosis can acquire disability through either relapse-associated worsening or progression independent of relapses. This study found that early progression begins in all phenotypes of the disease, becoming the primary driver of disability accumulation in the progressive phase. Treatments with disease-modifying therapies significantly delay disability accumulation, with the greatest impact seen in patients in the earliest stages of multiple sclerosis.
Article
Cell Biology
Nicolas Fissolo, Laura Calvo-Barreiro, Herena Eixarch, Ursula Boschert, Carmen Espejo, Xavier Montalban, Manuel Comabella
Summary: Cladribine exerts regulatory effects on the proliferation and apoptosis of lymphocyte subsets while its impact on immune cell activation is mediated through both DCK-dependent and independent pathways. It shows cytotoxicity on monocytes and dendritic cells, affecting the activation of monocytes but not the maturation of dendritic cells.
Article
Multidisciplinary Sciences
Patrick Ostkamp, Anke Salmen, Beatrice Pignolet, Dennis Goerlich, Till F. M. Andlauer, Andreas Schulte-Mecklenbeck, Gabriel Gonzalez-Escamilla, Florence Bucciarelli, Isabelle Gennero, Johanna Breuer, Gisela Antony, Tilman Schneider-Hohendorf, Nadine Mykicki, Antonios Bayas, Florian Then Bergh, Stefan Bittner, Hans-Peter Hartung, Manuel A. Friese, Ralf A. Linker, Felix Luessi, Klaus Lehmann-Horn, Mark Muehlau, Friedemann Paul, Martin Stangel, Bjorn Tackenberg, Hayrettin Tumani, Clemens Warnke, Frank Weber, Brigitte Wildemann, Uwe K. Zettl, Ulf Ziemann, Bertram Muller-Myhsok, Tania Kuempfel, Luisa Klotz, Sven G. Meuth, Frauke Zipp, Bernhard Hemmer, Reinhard Hohlfeld, David Brassat, Ralf Gold, Catharina C. Gross, Carsten Lukas, Sergiu Groppa, Karin Loser, Heinz Wiendl, Nicholas Schwab
Summary: The study found that high serum vitamin D levels were associated with reduced MS severity, lower relapse risk, and slower disability accumulation, while low latitude was linked to higher vitamin D levels, lower MS severity, fewer lesions, and less disability accumulation. Sun exposure may have beneficial effects on established MS, but could potentially be harmful for photosensitive individuals. Additionally, UV-mediated immune-modulation in MS may involve direct induction of type I interferons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Martina Petruzzo, Antonio Reia, Giorgia T. Maniscalco, Fabrizio Luiso, Roberta Lanzillo, Cinzia Valeria Russo, Antonio Carotenuto, Lia Allegorico, Raffaele Palladino, Vincenzo Brescia Morra, Marcello Moccia
Summary: The study found an association between cardiovascular risk factors and the prognosis of multiple sclerosis (MS). An increase in the Framingham risk score was associated with higher risks of MS relapses, disability, and treatment escalation. Early identification and management of cardiovascular comorbidities should be considered in MS management.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Assunta Bianco, Matteo Lucchini, Rocco Totaro, Roberta Fantozzi, Giovanna De Luca, Sonia Di Lemme, Giorgia Presicce, Luana Evangelista, Valeria Di Tommaso, Roberta Pastorino, Chiara De Fino, Valeria De Arcangelis, Diego Centonze, Massimiliano Mirabella
Summary: This study aimed to evaluate the frequency and predictors of disease reactivation in patients who stopped FTY for pregnancy. Results showed a significant proportion of patients experienced relapses during pregnancy and postpartum, indicating that pregnancy increases the risk of disease reactivation in MS patients.
Article
Clinical Neurology
Ki Hoon Kim, Su-Hyun Kim, Na Young Park, Jae-Won Hyun, Ho Jin Kim
Summary: This study evaluated the efficacy and safety of natalizumab in Korean patients with active MS, showing high efficacy in reducing annual relapse rate and improving or stabilizing disability in the majority of patients. NEDA-3 was achieved in 92% and 82% of patients at 1 and 2 years after initiating natalizumab treatment, respectively. No serious adverse events leading to discontinuation of natalizumab were observed.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Steffen Pfeuffer, Leoni Rolfes, Timo Wirth, Falk Steffen, Marc Pawlitzki, Andreas Schulte-Mecklenbeck, Catharina C. Gross, Marcus Brand, Stefan Bittner, Tobias Ruck, Luisa Klotz, Heinz Wiendl, Sven G. Meuth
Summary: Immunoadsorption demonstrated better outcomes compared to double-dose methylprednisolone for treating steroid-refractory acute multiple sclerosis relapses, and modulation of B cell function may be a potential mechanism of action for immunoadsorption.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Tatiana Koudriavtseva, Svetlana Lorenzano, Maria Cellerino, Mauro Truglio, Marco Fiorelli, Caterina Lapucci, Giovanna D'Agosto, Laura Conti, Annunziata Stefanile, Silvana Zannino, Maria Maddalena Filippi, Antonio Cortese, Carlo Piantadosi, Marta Maschio, Andrea Maialetti, Edvina Galie, Marco Salvetti, Matilde Inglese
Summary: The objective of this observational study was to identify the most specific pro-coagulative/vascular factors for multiple sclerosis pathogenesis and to correlate them with brain hemodynamic abnormalities. The results showed that tissue-factor was one of the key variables in differentiating multiple sclerosis from controls and relapse from remission.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Emilio Portaccio, Angelo Bellinvia, Mattia Fonderico, Luisa Pasto, Lorenzo Razzolini, Rocco Totaro, Daniele Spitaleri, Alessandra Lugaresi, Eleonora Cocco, Marco Onofrj, Franco Di Palma, Francesco Patti, Davide Maimone, Paola Valentino, Paolo Confalonieri, Alessandra Protti, Patrizia Sola, Giacomo Lus, Giorgia Teresa Maniscalco, Vincenzo Brescia Morra, Giuseppe Salemi, Franco Granella, Ilaria Pesci, Roberto Bergamaschi, Umberto Aguglia, Marika Vianello, Marta Simone, Vito Lepore, Pietro Iaffaldano, Massimo Filippi, Maria Trojano, Maria Pia Amato
Summary: In early multiple sclerosis, progression independent of relapse activity is an important contributor to disability accumulation. The study suggests that inflammation and neurodegeneration may represent a single disease continuum, even in the earliest stages of the disease.
Article
Clinical Neurology
Dragana Obradovic, Tamara Andjelic, Milica Ninkovic, Bratislav Dejanovic, Jelena Kotur-Stevuljevic
Summary: The study found that increased baseline SOD activity, decreased AOPP levels, and ongoing disease-modifying therapy were associated with better clinical recovery after corticosteroid relapse treatment. There were no differences in oxidative stress markers between relapse and remission in MS patients, but they had higher oxidative damage markers and lower antioxidant markers compared to controls.
NEUROLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Mariell Ryssdal, Eszter Vanky, Live Marie T. Stokkeland, Anders Hagen Jarmund, Bjorg Steinkjer, Tone Shetelig Lovvik, Torfinn Stove Madssen, Ann-Charlotte Iversen, Guro F. Giskeodegard
Summary: A post-hoc analysis of two randomized controlled trials including 615 pregnant women with PCOS showed that metformin treatment can increase levels of various cytokines in the maternal serum, indicating its immunomodulating rather than anti-inflammatory properties.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Environmental Sciences
Francesco Armetta, Josue Cardenas, Eugenio Caponetti, Rosa Alduina, Alessandro Presentato, Luca Vecchioni, Pietro di Stefano, Alberto Spinella, Maria Luisa Saladino
Summary: This study conducted monitoring of environmental conditions in Santa Margherita's cave in Italy and found that degradation of ancient paintings in the cave was mainly influenced by exposure to sea aerosol, affecting salt composition and bacterial community diversity. Specific actions for conservation and restoration of the paintings and preservation of the site were suggested.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Giulia Festa, Claudia Scatigno, Francesco Armetta, Maria Luisa Saladino, Veronica Ciaramitaro, Viviana Mollica Nardo, Rosina Celeste Ponterio
Summary: This study presents a systematic classification method for natural powdered pigments using a multi-instruments spectroscopic study. The methodology allows for quick identification of unknown pigments and their recipes by accessing elementary and molecular unique benchmarks. The impact of different spectroscopic techniques and instrument setups is evaluated, opening new frontiers in dataset spectroscopic analyses.
Article
Chemistry, Multidisciplinary
Gabriella Chirco, Monica de Cesare, Giacomo Chiari, Sarah Maass, Maria Luisa Saladino, Delia Francesca Chillura Martino
Summary: This article introduces a white ground ceramic exhibited in the Pietro Griffo Archaeological Museum in Agrigento, Italy, dating back to 450-440 BC. The vase depicts two scenes from the Perseus myth. The study conducted non-destructive and non-invasive investigations, revealing the use of gypsum as the material for the white ground, which is an important finding for similar vases.
Article
Chemistry, Applied
Alessandro Gottuso, Francesco Armetta, Alessio Cataldo, Viviana Mollica Nardo, Francesco Parrino, Maria Luisa Saladino
Summary: In this study, three different functionalized mesoporous silica nanoparticles were synthesized through co-condensation in oil/water emulsion, using various organo-substituted silica precursors. The influence of different pendant groups and their concentrations on the mesostructured pore organization of the nanoparticles was evaluated using spectroscopy and microscopy techniques. Results showed that bulky aliphatic C16 chains, especially in higher concentrations, led to significant changes in mesoporous structure.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Substance Abuse
Anees Bahji, Laura Acion, Anne-Marie Laslett, Bryon Adinoff
Summary: This study examines the predominance of English in scientific addiction literature and proposes suggestions for making this literature more accessible to non-English speakers, including increasing the availability of translation services.
NORDIC STUDIES ON ALCOHOL AND DRUGS
(2023)
Article
Archaeology
Veronica Ciaramitaro, Francesco Armetta, Monica de Cesare, Maria Luisa Saladino
Summary: The analysis and identification of color traces found in architectural elements and artifacts from the Archeological Park of Segesta (Trapani, Italy) were conducted using various non-invasive techniques. The study identified several pigments, including hematite, umber, vegetable black, and bone black. Despite the limited amount of detectable pigment, the investigation provided insight into the ancient civilizations and allowed for a glimpse into the past.
JOURNAL OF CULTURAL HERITAGE
(2023)
Article
Materials Science, Multidisciplinary
Francesco Armetta, Vitalii Boiko, Dariusz Hreniak, Rosina C. Ponterio, Maria Luisa Saladino
Summary: A method was developed to prepare luminescent inks of YPO4:Eu dispersions with PVA. YPO4:Eu nanoparticles were prepared by precipitation and hydrothermal treatment. The process included systematic studies on preparing stable colloidal system, investigating the parameters affecting its stability and UV-excited YPO4:Eu emission intensity. The interaction responsible for the dispersion stability was also investigated.
Article
Chemistry, Multidisciplinary
Francesco Armetta, Maria Luisa Saladino, Maria Clara Martinelli, Rosario Vilardo, Gianfranco Anastasio, Sebastiano Trusso, Viviana Mollica Nardo, Dario Giuffrida, Rosina Celeste Ponterio
Summary: This study combines portable X-ray fluorescence spectroscopy with multivariate analysis to investigate glass supports in the archaeological park of the Aeolian Islands. The analysis of normalized peak areas provides a reliable grouping based on elemental compositions, offering a guideline for chemometrics in XRF data analysis.
Article
Materials Science, Multidisciplinary
Francesco Armetta, Dario Giuffrida, Maria Clara Martinelli, Viviana Mollica Nardo, Maria Luisa Saladino, Rosina Celeste Ponterio
Summary: The goal of this work is to contribute to the study of Neolithic painted pottery through the chemical characterization of samples from the Aeolian Islands. Analysis of 16 different sherds revealed the presence of pigments, including some no longer visible to the naked eye, and provided information about pottery differentiation using FT-IR.
Article
Biochemistry & Molecular Biology
Francesco Armetta, Rosina Celeste Ponterio, Ivana Pibiri, Maria Luisa Saladino
Summary: This paper reports on the investigation of metal finds from the wreck of a Punic ship, using techniques such as portable X-ray fluorescence and Raman spectroscopy to identify their composition. The degradation of these finds in the underwater environment was also explained through the analysis of micro-samples using X-ray diffractometry, polarised optical microscopy, and scanning electron microscopy.
Article
Materials Science, Multidisciplinary
Francesco Armetta, Mattia Gaboardi, Jasper Plaisier, Maria Luisa Saladino
Summary: Yttrium aluminium gallium garnet (YAGG) doped with rare-earth ions has been synthesized via the urea glass route followed by thermal treatment. The formation of the garnet was studied in situ using synchrotron powder diffraction. The results show that the onset of formation of the garnet is about 860 degrees C, with comparable cell parameters for both undoped and doped YAGG. A possible growth mechanism of YAGG is discussed based on observed microstructural parameters.
Article
Chemistry, Multidisciplinary
Francesco Armetta, Dario Giuffrida, Rosina C. Ponterio, Maria Fernanda Falcon Martinez, Francesca Briani, Elena Pecchioni, Alba Patrizia Santo, Veronica C. Ciaramitaro, Maria Luisa Saladino
Summary: This paper presents the findings of an investigation into six microsamples taken from the vault of San Panfilo Church in Tornimparte (AQ). The study aimed to identify the composition of the pigments and protective/varnishes, analyze the executive technique, evaluate the conservation state, and gather evidence of past restoration works. The samples were analyzed using optical microscopy, scanning electron microscopy with energy-dispersive spectroscopy (EDS), X-ray fluorescence (XRF), and infrared and Raman spectroscopy. This investigation was carried out as part of the Tornimparte project Archeometric investigation of the pictorial cycle of Saturnino Gatti in Tornimparte (AQ, Italy), sponsored by the Italian Association of Archeometry (AIAr) in 2021.
APPLIED SCIENCES-BASEL
(2023)
Article
Materials Science, Ceramics
Francesco Armetta, Vitalii Boiko, Dariusz Hreniak, Cecilia Mortalo, Cristina Leonelli, Ludovico Barbata, Maria Luisa Saladino
Summary: This study reports a method for controlling the desired shape and microstructure of YPO4:Eu3+ nanoparticles using the precipitation method followed by hydrothermal treatment. The method allows for highly controlled formation of YPO4:Eu3+ by selecting appropriate synthesis parameters. The shape and size of the nano-needle-shaped particles can be independently controlled in both directions through autoclave processing time, as confirmed by various analytical techniques.
CERAMICS INTERNATIONAL
(2023)
Article
Polymer Science
Maduka L. Weththimuni, Giacomo Fiocco, Chiara Milanese, Alberto Spinella, Maria Luisa Saladino, Marco Malagodi, Maurizio Licchelli
Summary: The aim of this research is to investigate the improvement of varnish resistance to different aging processes for classical violins. The traditional varnish was recreated in the laboratory and functionalized with a cross-linking agent. The functionalized varnish exhibited enhanced resistance to aging, particularly in terms of photostability and hardness.
Article
Materials Science, Multidisciplinary
Aleksandra Gerus, Vitalii Boiko, Veronica Concetta Ciaramitaro, Maria Luisa Saladino, Dariusz Hreniak
Summary: This paper reports on the control of high brightness persistent luminescence of the smallest ZGO:Cr nanoparticles by optimizing hydrothermal synthesis parameters. The influence of pH solution, synthesis temperature, and calcination on structure and optical properties was systematically investigated. The results show that different synthesis conditions modify the trap depths distribution, affecting the duration and intensity of persistent luminescence.
MATERIALS RESEARCH BULLETIN
(2023)