Article
Clinical Neurology
Hyunwoo Lee, Kunio Nakamura, Sridar Narayanan, Robert A. Brown, A. Nash, Linda M. Griffith, Kaitlyn C. Steinmiller, Steven M. Devine, George J. Hutton, Uday Popat, Michael K. Racke, George E. Georges, James Bowen, Douglas L. Arnold
Summary: In RRMS patients who received BEAM-based HDIT/HCT, short-term wholebrain, grey-matter, and white-matter volume loss was observed, with rates slowing down in the long term. Patients with gadolinium-enhancing lesions at baseline showed higher GM and WB volume loss rates at 1 year follow-up, while WM volume loss rates were not significantly different. Maintaining event-free survival did not impact the rates of BVL.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
N. Giedraitiene, G. Gasciauskaite, G. Kaubrys
Summary: This study aimed to evaluate the effects of AHSCT on quality of life, fatigue, anxiety, and depression in patients with multiple sclerosis. The results showed that AHSCT could improve the quality of life and reduce fatigue symptoms in these patients, with the improvement in quality of life occurring earlier than in fatigue.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Alessia Cafaro, Federica Pigliasco, Giammarco Baiardi, Sebastiano Barco, Manuela Stella, Roberto Bandettini, Francesca Mattioli, Maura Faraci, Giuliana Cangemi
Summary: Personalization of busulfan exposure through therapeutic drug monitoring (TDM) is recommended for high-dose conditioning regimens. However, current methods lack standardization. This study developed and validated a standardized LC-MS/MS method for the quantification of busulfan, enabling specific and rapid dose recommendations for pediatric patients undergoing hematopoietic stem cell transplantation (HSCT).
Article
Biochemistry & Molecular Biology
Aina Vaivade, Anna Wiberg, Payam Emami Khoonsari, Henrik Carlsson, Stephanie Herman, Asma Al-Grety, Eva Freyhult, Ulla Olsson-Stromberg, Joachim Burman, Kim Kultima
Summary: The study investigated the effect of autologous hematopoietic stem cell transplantation (AHSCT) on the metabolome and lipidome in peripheral blood of relapsing-remitting multiple sclerosis (RRMS) patients. The results showed that AHSCT had a larger impact on the lipidome compared to the metabolome. The variation in lipid concentration reflected the transient changes in the peripheral blood milieu during the treatment, rather than the changes in the immune system that are assumed to be the cause of clinical improvement.
LIPIDS IN HEALTH AND DISEASE
(2023)
Article
Immunology
Vinicius O. Boldrini, Ana M. Marques, Raphael P. S. Quintiliano, Adriel S. Moraes, Carla R. A. V. Stella, Ana Leda F. Longhini, Irene Santos, Marilia Andrade, Breno Ferrari, Alfredo Damasceno, Rafael P. D. Carneiro, Carlos Otavio Brandao, Alessandro S. Farias, Leonilda M. B. Santos
Summary: This study found that CD19(+) B cells in the peripheral blood of multiple sclerosis (MS) patients may express serine-protease granzyme-B (GzmB), resembling cytotoxic CD8(+) T lymphocytes. This finding may provide important clues for investigating the pathogenesis of MS and for the development of new therapeutic interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Hematology
Sridhar Rao, Larisa Broglie
Summary: In this article, Albert et al provide compelling evidence that allogeneic hematopoietic stem cell transplantation is a feasible and potentially curative approach for treating adults with inborn errors of immunity.
Review
Oncology
Teresa Lopez-Fernandez, Irene Sanchez Vadillo, Ana Lopez de la Guia, Karem Humala Barbier
Summary: Hematopoietic stem cell transplantation is considered a potentially curative option for many hemopathies since 1957, but survivors are at high cardiovascular risk. Advancements in techniques and strategies have reduced treatment-related mortality, leading to a growing number of HSCT survivors anticipated to exceed half a million by 2030.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Malin Boremalm, Peter Sundstrom, Jonatan Salzer
Summary: Rituximab is safe and effective in treating RRMS, with long-term effects on inflammatory disease activity. Disease reactivation is rare in MS patients who discontinued treatment, and low-dose rituximab (< 1000 mg yearly) is sufficient to maintain suppression of inflammatory disease activity in stable patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Cell & Tissue Engineering
Rashin Mohseni, Pouya Mahdavi Sharif, Maryam Behfar, Mohammad Reza Modaresi, Rohola Shirzadi, Mahta Mardani, Leila Jafari, Fahimeh Jafari, Zeynab Nikfetrat, Amir Ali Hamidieh
Summary: This study aimed to assess the safety and effectiveness of adipose tissue-derived mesenchymal stem cells (AT-MSCs) for pediatric patients with bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The results showed that a single injection of AT-MSCs partially improved the symptoms of patients and the treatment was safe and tolerable.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Zofia Szmit, Jowita Fraczkiewicz, Malgorzata Salamonowicz-Bodzioch, Anna Krol, Marek Ussowicz, Monika Mielcarek-Siedziuk, Karolina Liszka, Pawel Marschollek, Ewa Gorczynska, Krzysztof Kalwak
Summary: Hematopoietic stem cell transplantation is an effective treatment for nonmalignant diseases, but severe transplant-related complications and CMV infection pose significant risks to pediatric patients. A study of 94 children showed that high CMV viremia levels were associated with lower overall survival and increased risk of resistant and recurrent infections. Therefore, introducing effective anti-CMV prophylaxis in this patient population is crucial.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Kyung Taek Hong, Hyun Jin Park, Bo Kyung Kim, Hong Yul An, Jung Yoon Choi, Jung-Eun Cheon, Sung-Hye Park, Han-Soo Kim, Hyoung Jin Kang
Summary: In this study, we analyzed the treatment outcomes and prognostic factors of nonmetastatic osteosarcoma (OSA) and compared the outcomes of high-dose chemotherapy (HDC) and conventional chemotherapy (CC) in patients with poor response after neoadjuvant chemotherapy. The results showed that HDC had favorable outcomes in patients with non-metastatic OSA and less than 90% tumor necrosis after neoadjuvant chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Saskia R. Veldkamp, Marc H. A. Jansen, Joost F. Swart, Caroline A. Lindemans
Summary: This case presents a 9-year-old girl with relapsing polychondritis who underwent autoHSCT initially, experienced a relapse, and ultimately achieved long-term disease remission after successful alloHSCT. The case sheds light on the pathogenesis of relapsing polychondritis with a possible role for CD8(+) T cells, and highlights the potential use of alloHSCT as a treatment option for children with severe autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Rozanna Meijboom, Elizabeth York, Agniete J. Kampaite, Mathew Harris, Nicole White, Maria del C. Valdes Hernandez, Michael Thrippleton, N. J. J. D. MacDougall, Peter Connick, David P. J. Hunt, Siddharthan Chandran, Adam Waldman, FutureMS Consortium
Summary: This study investigates regional neurodegeneration of the brain in recently-diagnosed RRMS patients using volumetry and voxel-based morphometry (VBM). Widespread GM and NAWM atrophy was observed in this large recently-diagnosed RRMS cohort, particularly in the brainstem, cerebellar GM, and subcortical and occipital-temporal regions; indicative of neurodegeneration across tissue types, and consistent with limited previous studies in early disease. The results highlight the different features of longitudinal lobar and loco-regional change, and suggest that atrophy measures targeted to specific brain regions may provide improved markers of neurodegeneration.
Article
Oncology
Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata, Senji Kasahara, Takaaki Ono, Michio Sawada, Koichi Ohata, Hiroko Kato-Hayashi, Hideki Hayashi, Masahito Shimizu, Yoshinori Itoh, Hisashi Tsurumi, Akio Suzuki
Summary: This multi-center prospective study demonstrates that in patients undergoing HSCT, PZ lozenge is effective in reducing the incidence of grade >= 2 oral mucositis associated with chemotherapy without affecting the outcomes of HSCT or incidence rates of other adverse events.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Pediatrics
Manuela Spadea, Francesco Saglio, Valeria Ceolin, Marta Barone, Giulia Zucchetti, Paola Quarello, Franca Fagioli
Summary: Hematopoietic stem cell transplantation (HSCT) is a curative option for pediatric patients with various disorders, but immune-mediated complications, such as immune-mediated cytopenias (IMCs), can arise post-transplantation. The pathogenesis of IMCs is not well-understood, and treatment options beyond the first-line are not clear. This review aims to provide a deeper understanding of IMCs and improve their management.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Jan Fagius, Amalia Feresiadou, Elna-Marie Larsson, Joachim Burman
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2017)
Article
Clinical Neurology
J. Burman, R. Raininko, J. Fagius
ACTA NEUROLOGICA SCANDINAVICA
(2011)
Editorial Material
Clinical Neurology
J. Fagius, J. Burman
ACTA NEUROLOGICA SCANDINAVICA
(2014)
Article
Clinical Neurology
J. Burman, H. Zetterberg, M. Fransson, A. Sl Loskog, R. Raininko, J. Fagius
ACTA NEUROLOGICA SCANDINAVICA
(2014)
Article
Immunology
Moa Fransson, Joachim Burman, Camilla Lindqvist, Christina Atterby, Jan Fagius, Angelica Loskog
Article
Clinical Neurology
Jan Fagius, Ingela Nygren
CLINICAL AUTONOMIC RESEARCH
(2010)
Article
Immunology
Moa E. Fransson, Lina S. E. Liljenfeldt, Jan Fagius, Thomas H. Totterman, Angelica S. I. Loskog
Article
Immunology
Joachim Burman, Moa Fransson, Thomas H. Totterman, Jan Fagius, Sara M. Mangsbo, Angelica S. I. Loskog
Article
Immunology
Joachim Burman, Emma Svensson, Moa Fransson, Angelica S. I. Loskog, Henrik Zetterberg, Raili Raininko, Anders Svenningsson, Jan Fagius, Sara M. Mangsbo
JOURNAL OF NEUROIMMUNOLOGY
(2014)
Article
Clinical Neurology
Joachim Burman, Ellen Iacobaeus, Anders Svenningsson, Jan Lycke, Martin Gunnarsson, Petra Nilsson, Magnus Vrethem, Sten Fredrikson, Claes Martin, Anna Sandstedt, Bertil Uggla, Stig Lenhoff, Jan-Erik Johansson, Cecilia Isaksson, Hans Hagglund, Kristina Carlson, Jan Fagius
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2014)
Article
Clinical Neurology
H. Tedeholm, J. Lycke, B. Skoog, V. Lisovskaja, J. Hillert, C. Dahle, J. Fagius, S. Fredrikson, A-M Landtblom, C. Malmestrom, C. Martin, F. Piehl, B. Runmarker, L. Stawiarz, M. Vrethem, O. Nerman, O. Andersen
MULTIPLE SCLEROSIS JOURNAL
(2013)
Article
Clinical Neurology
Ingela Nygren, Jan Fagius
Article
Medicine, General & Internal
Richard K. Burt, Roumen Balabanov, Joachim Burman, Basil Sharrack, John A. Snowden, Maria Carolina Oliveira, Jan Fagius, John Rose, Flavia Nelson, Amilton Antunes Barreira, Kristina Carlson, Xiaoqiang Han, Daniela Moraes, Amy Morgan, Kathleen Quigley, Kimberly Yaung, Regan Buckley, Carri Alldredge, Allison Clendenan, Michelle A. Calvario, Jacquelyn Henry, Borko Jovanovic, Irene B. Helenowski
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2019)
Article
Physiology
J Fagius
ACTA PHYSIOLOGICA SCANDINAVICA
(2003)