期刊
MULTIPLE SCLEROSIS JOURNAL
卷 14, 期 7, 页码 981-984出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458508091368
关键词
anti-inflammatory; atorvastatin; C-reactive protein; multiple sclerosis
资金
- Swiss Multiple Sclerosis Society (SMSG)
The anti-inflammatory potential of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, as reflected by modulation of C-reactive protein (CRP), might be beneficial in the treatment of patients with multiple sclerosis (MS). We evaluated serum levels of high-sensitivity (hs)-CRP in relapsing-remitting MS patients receiving interferon-beta 1b and atorvastatin as add-on therapy. This study shows that interferon-beta treatment is associated with increased serum levels of hs-CRP in MS patients (P < 0.01). In contrast, when atorvastatin is added to interferon-beta, hs-CRP serum levels decrease to the normal range (P < 0.05), indicating an anti-inflammatory action of atorvastatin in MS. However, whether add-on treatment with atorvastatin modifies the course of MS remains to be investigated.
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