Article
Biochemistry & Molecular Biology
Ranjithkumar Rajendran, Vinothkumar Rajendran, Liza Gupta, Kian Shirvanchi, Darja Schunin, Srikanth Karnati, Mario Giraldo-Velasquez, Martin Berghoff
Summary: This study found that short-term treatment with IFN beta-1a can alleviate symptoms during the peak of disease in multiple sclerosis, while the combined application of IFN beta-1a and specific deletion of FGFR1 can reduce symptoms in the chronic phase. These beneficial effects may be caused by the modulation of FGFR1 rather than interferon beta-1a.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Cristina-Florentina Plesa, Diana Maria Chitimus, Carmen Adella Sirbu, Monica Marilena Tantu, Minerva Claudia Ghinescu, Daniela Anghel, Florentina Ionita-Radu
Summary: This case study describes a particular association between the remission phase of multiple sclerosis and the violent onset of interferon-induced thrombotic thrombocytopenic purpura.
Article
Chemistry, Medicinal
Reinier Cardentey Sanchez, Amado Diaz de la Fe, Alejandro Pelaez Suarez, Dayme Grass, Teresa Morgado Vega, Armando Sanchez Canal, Dario Siniscalco, Maria de los Angeles Robinson Agramonte
Summary: Multiple sclerosis is an autoimmune neurodegenerative disease that lacks a curative treatment. The use of interferon beta 1a has shown safety and efficacy in treating relapsing remitting MS patients, with significant reductions in attacks, disability scale scores, and lesions observed.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Neuroimaging
Shannon Kolind, Shawna Abel, Carolyn Taylor, Roger Tam, Cornelia Laule, David K. B. Li, Hideki Garren, Laura Gaetano, Corrado Bernasconi, David Clayton, Irene Vavasour, Anthony Traboulsee
Summary: Ocrelizumab appears to protect against demyelination in multiple sclerosis patients and may provide a more favorable environment for remyelination.
NEUROIMAGE-CLINICAL
(2022)
Article
Pharmacology & Pharmacy
Francesco Piras, Lilian Arnaud, Eric Henninger, Matthew Keiser, Andrea Seitzinger, Dominic Jack, Quentin Le Masne
Summary: This study investigated adherence to, and duration of persistence with, the newest version of the RebiSmart (R) autoinjector among people with multiple sclerosis. The results showed that patients were highly adherent to using the device, and the longest persistence was observed in older individuals and males.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Clinical Neurology
Marco Battaglini, Hugo Vrenken, Riccardo Tappa Brocci, Giordano Gentile, Ludovico Luchetti, Adriaan Versteeg, Mark S. Freedman, Bernard M. J. Uitdehaag, Ludwig Kappos, Giancarlo Comi, Andrea Seitzinger, Dominic Jack, Maria Pia Sormani, Frederik Barkhof, Nicola De Stefano
Summary: This study found that patients with a first clinical demyelinating event who were treated with subcutaneous interferon beta-1a had significantly lower lesion occurrence in specific brain regions and the distribution of these lesions could predict conversion to multiple sclerosis.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Mark S. Freedman, Dominic Jack, Zuzana Murgasova, Milorad Todorovic, Andrea Seitzinger
Summary: The study found that patients treated with sc IFN beta-1a for relapsing MS had relatively low rates of COVID-19 infection, high recovery rates, and low rates of severe disease and death compared to the general population and other MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Immunology
Pablo Aliaga-Gaspar, Isaac Hurtado-Guerrero, Nicolas Lundahl Ciano-Petersen, Patricia Urbaneja, Isabel Brichette-Mieg, Virginia Reyes, Jose Luis Rodriguez-Bada, Roberto Alvarez-Lafuente, Rafael Arroyo, Ester Quintana, Lluis Ramio-Torrenta, Ana Alonso, Laura Leyva, Oscar Fernandez, Begona Oliver-Martos
Summary: IFN-beta treatment induces sIFNAR2 production in RRMS, with higher levels associated with a reduction in therapeutic response. In the short-term, some patients showed increased sIFNAR2 expression after IFN-beta stimulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Juliane Klehmet, Yvonne Begus-Nahrmann, Kirsi Taipale, Gabriele Niemczyk, Karin Rehberg-Weber
Summary: This study evaluated the pregnancy outcomes of women with multiple sclerosis (MS) treated with interferon therapy. The results showed that most mothers paused interferon therapy during pregnancy and breastfeeding, and the rates of spontaneous abortions and congenital anomalies were similar to the general population. Additionally, relapse activity during pregnancy and lactation was low.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Neurosciences
Maria Isabel Carrasco-Campos, Cristina Perez-Ramirez, Elena Macias-Cortes, Elena Puerta-Garcia, Antonio Sanchez-Pozo, Carmen Arnal-Garcia, Francisco Javier Barrero-Hernandez, Miguel Angel Calleja-Hernandez, Alberto Jimenez-Morales, Marisa Canadas-Garre
Summary: This study found that gene polymorphisms in TNFRSF10A-rs20576 and CTSS-rs1136774 have an impact on the response to IFN-beta after 24 months of treatment, while the variations in CBLB (rs12487066), OAS1 (rs10774671) or GRIA3 (rs12557782) genes do not affect individual response to IFN-beta.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Faezeh Abbasirad, Vahid Shaygannejad, Fahimeh Hosseininasab, Omid Mirmosayyeb, Behzad Mahaki, Behjat Moayedi, Nafiseh Esmaeil
Summary: The study demonstrates that simultaneous treatment of multiple sclerosis patients with Silymarin and IFN-beta can significantly reduce liver enzyme levels, decrease the percentage of Th17 cells, increase the frequency of Treg cells, lower IL-17 and IFN gamma levels, and raise IL-10 and TGF beta levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Robert W. Baumhefner, Mei Leng
Summary: The retrospective analysis confirmed that switching from once weekly to twice weekly administration of INF beta 1a may be an option for multiple sclerosis patients with breakthrough disease. Using IM INF beta 1a has advantages such as no skin reactions and a lower incidence of neutralizing antibodies.
NEUROLOGY AND THERAPY
(2022)
Article
Clinical Neurology
Arthur Allignol, Emmanuelle Boutmy, Meritxell Sabido Espin, Kurt Marhardt, Patrick Vermersch
Summary: In this real-world setting, the effectiveness of sc IFN beta-1a does not appear to be reduced based on age. Older patients showed lower discontinuation rates and reduced disease activity, as evidenced by lower relapse rates and fewer MRI scans compared to younger patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yuan Zhao, Kun Chen, Nancy Ramia, Sangeeta Sahu, Achint Kumar, Maria L. Naylor, Li Zhu, Himanshu Naik, Cherie L. Butts
Summary: The study showed bioequivalence between intramuscular and subcutaneous administration of peginterferon beta-1a, with similar pharmacokinetic and pharmacodynamic profiles. Intramuscular administration had lower frequency of injection site reactions, and safety profiles were generally balanced between the two administration routes.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Immunology
Mark S. Freedman, Jerome Wojcik, Kristina H. Holmberg, Markus Fluck, Mauro D'Antonio, Yann Hyvert, Sofia Stinchi, Vittorio D'Urso, Fernando Dangond
Summary: This study confirmed MX1, 2'5'OAS, and IL1RA as effective biomarkers for the efficacy of subcutaneous IFNβ-1a treatment, while also identifying Neopterin, TRAIL, and IP-10 as biomarkers associated with long-term treatment efficacy.
JOURNAL OF NEUROIMMUNOLOGY
(2021)
Article
Clinical Neurology
Marcus W. Koch, Jop Mostert, Pavle Repovic, James D. Bowen, Jerry S. Wolinsky, Fred D. Lublin, Eva Strijbis, Gary Cutter
Summary: This study investigated the risk factors associated with early treatment failure in RRMS and found that early treatment failure was related to NEDA-3 failure at 36 months, but not to subsequent disability worsening. The majority of NEDA-3 failures were due to MRI activity. Further research into defining treatment success and failure in RRMS is necessary.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Matteo Garibaldi, Tommaso Nicoletti, Elisabetta Bucci, Laura Fionda, Luca Leonardi, Stefania Morino, Laura Tufano, Girolamo Alfieri, Antonio Lauletta, Gioia Merlonghi, Alessia Perna, Salvatore Rossi, Enzo Ricci, Jorge Alonso Perez, Tommaso Tartaglione, Antonio Petrucci, Elena Maria Pennisi, Marco Salvetti, Gary Cutter, Jordi Diaz-Manera, Gabriella Silvestri, Giovanni Antonini
Summary: In a large cohort of DM1 patients, muscle involvement was characterized by fat replacement, muscle atrophy and STIR positivity, which correlated with disease severity and duration. The study also identified STIR hyperintensity as an early marker of muscle involvement, providing potential therapeutic targets for future clinical trials.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Maria Petracca, Gary Cutter, Sirio Cocozza, Leorah Freeman, John Kangarlu, Monica Margoni, Matteo Moro, Stephen Krieger, Mohamed Mounir El Mendili, Amgad Droby, Jerry S. Wolinsky, Fred Lublin, Matilde Inglese
Summary: In patients with relapsing-remitting multiple sclerosis, higher baseline Expanded Disability Status Scale (EDSS) score and higher volume of supratentorial and cerebellar T2 lesions are associated with manual dexterity worsening over time. Additionally, older age, lower baseline EDSS score, and higher volume of supratentorial T2 lesions are associated with confirmed disability progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Genetics & Heredity
Phillip H. Allman, Inmaculada Aban, Dustin M. Long, Amit Patki, Todd MacKenzie, Marguerite R. Irvin, Leslie A. Lange, Ethan Lange, Gary Cutter, Hemant K. Tiwari
Summary: The study proposed a general Mendelian randomization (MR) method applicable to any full-rank distribution from the exponential family. Through simulations and real data analyses, the method was found to have low bias and acceptable coverage across various scenarios.
GENETIC EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Preethi Patel, Abhishek Deshpande, Pei-Chun Yu, Peter B. Imrey, Peter K. Lindenauer, Marya D. Zilberberg, Sarah Haessler, Michael B. Rothberg
Summary: This study aimed to examine the association between different antibiotic regimens and hospital-onset Clostridioides difficile infection (CDI). The results showed that CDI was uncommon among patients with community-acquired pneumonia (CAP) in US hospitals, and there was no significant association between the choice of empiric antibiotic therapy and the development of CDI.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Editorial Material
Clinical Neurology
Gary Cutter
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Sammita Satyanarayan, Gary Cutter, Stephen Krieger, Stacey Cofield, Jerry S. Wolinsky, Fred Lublin
Summary: The stringency of relapse definition affects measurements of relapse rate and composite endpoints in RRMS. Even with the most inclusive relapse definition, 43% of patients did not have durable worsening in the clinical trial. Therefore, relapse definition and durability should be considered in RRMS research to avoid overestimating disease progression.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Robert W. Motl, Ariel Kidwell-Chandler, Brian M. Sandroff, Lara A. Pilutti, Gary R. Cutter, Roberto Aldunate, Rachel E. Bollaert
Summary: A randomized controlled trial was conducted to examine the effectiveness of an Internet-based behavioral intervention on increasing physical activity in persons with multiple sclerosis (MS). The study found that the intervention led to immediate and sustained increases in moderate-to-vigorous physical activity among participants. This study provides evidence for a scalable approach to promote physical activity in persons with MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Amber Salter, Alexander Keenan, Hoa H. Le, Kavita Gandhi, Maria Ait-Tihyaty, Samantha Lancia, Gary R. Cutter, Robert J. Fox, Ruth Ann Marrie
Summary: Fatigue is commonly experienced by multiple sclerosis patients, with a majority reporting worsening of fatigue over time. Factors associated with fatigue worsening include lower income, higher disability, lower initial fatigue level, use of injectable disease-modifying therapies, and increased levels of depression.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Clinical Neurology
Gary Cutter, Richard A. Rudick, Carl de Moor, Carol M. Singh, Elizabeth Fisher, Thijs Koster, Fred D. Lublin, Jerry S. Wolinsky, Henry McFarland, Steven Jacobson, Maria L. Naylor
Summary: This study investigated the changes in serum neurofilament light-chain (sNfL) levels in response to treatment and assessed baseline sNfL as a predictor of relapse in treatment-naive RRMS patients. The results showed that sNfL levels decreased significantly within 6 months and remained low at 36 months in all treatment arms. The combination of lesion activity and sNfL was found to be a stronger predictor of relapse.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2023)
Article
Urology & Nephrology
Michael Allon, Alian Al-Balas, Carlton J. Young, Gary R. Cutter, Timmy Lee
Summary: In CKD patients with an eGFR less than 15 ml/min per 1.73 m2, placement of an AV graft instead of an AV fistula reduces the likelihood of catheter use at the initiation of dialysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Michael Allon, Gary R. Cutter, Carlton J. Young
Summary: This study found that access-related distal ischemia requiring intervention was rare. It was more common in women and patients with peripheral vascular disease or coronary artery disease. In some cases, a subsequent vascular access could be placed with a low likelihood of recurrent distal ischemia.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Michael Allon, Alian Al-Balas, Carlton J. Young, Gary R. Cutter, Timmy Lee
Summary: This study compared two strategies for the choice of initial vascular access in hemodialysis patients. The results showed that a more selective approach to arteriovenous fistula (AVF) placement can reduce the frequency of vascular access procedures and the cost of access management.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Clinical Neurology
Ruth Ann Marrie, Maria Pia Sormani, Sean Apap Mangion, Francesca Bovis, Winson Y. Cheung, Gary R. Cutter, Peter Feys, Michael D. Hill, Marcus Werner Koch, Morgan McCreary, Ellen M. Mowry, Jay J. H. Park, Fredrik Piehl, Amber Salter, Jeremy Chataway
Summary: The current designs for clinical trials treating progressive multiple sclerosis (MS) have limitations and have not been successful. This paper discusses complex innovative trial designs and intermediate and composite outcomes to improve trial design efficiency in MS. Recommendations include increasing the use of complex innovative designs, developing biomarkers to enrich trial populations, prioritizing intermediate outcomes targeting therapeutic mechanisms, and investigating data linkage for long-term outcomes. Novel trial designs and further development of intermediate outcomes may improve clinical trial efficiency and address novel therapeutic questions in MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Health Care Sciences & Services
Marissa Betts, Kyle Fahrbach, Binod Neupane, Mahmoud Slim, Maria Pia Sormani, Gary Cutter, Thomas P. A. Debray, Marvin Rock
Summary: This study evaluates eight approaches for handling overlapping publications in network meta-analyses of real-world evidence (RWE) studies and recommends establishing an a priori hierarchy for selection.
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)