Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2016) Teruyuki Sano et al.   CELL

mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile

(2016) Shurong Hu et al.   PLoS One

The activation of mTOR is required for monocyte pro-inflammatory response in patients with coronary artery disease

(2015) Shanshan Gao et al.   CLINICAL SCIENCE

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway

(2015) Bin Huang et al.   PLoS Genetics

Sphingosine-1-Phosphate Mediates COX-2 Expression and PGE2/IL-6 Secretion via c-Src-Dependent AP-1 Activation

(2014) Chih-Kai Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

In Vitro Differentiation of Dendritic Cells in the Presence of Prostaglandin E2 Alters the IL-12/IL-23 Balance and Promotes Differentiation of Th17 Cells

(2014) T. Khayrullina et al.   JOURNAL OF IMMUNOLOGY

Opposing Roles of Prostaglandin D2Receptors in Ulcerative Colitis

(2014) Eva M. Sturm et al.   JOURNAL OF IMMUNOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Inactivation of the Enzyme GSK3α by the Kinase IKKi Promotes AKT-mTOR Signaling Pathway that Mediates Interleukin-1-Induced Th17 Cell Maintenance

(2012) Muhammet F. Gulen et al.   IMMUNITY

Combined therapeutic application of mTOR inhibitor and vitamin D3 for inflammatory bone destruction of rheumatoid arthritis

(2012) Tae-Hwan Kim et al.   MEDICAL HYPOTHESES

Generation of a Transgenic Mouse for Colorectal Cancer Research with Intestinal Cre Expression Limited to the Large Intestine

(2010) Y. Xue et al.   MOLECULAR CANCER RESEARCH

Cyclooxygenase-2 Is a Novel Transcriptional Target of the Nuclear EGFR-STAT3 and EGFRvIII-STAT3 Signaling Axes

(2010) H.-W. Lo et al.   MOLECULAR CANCER RESEARCH

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

(2009) Rajan P Nair et al.   NATURE GENETICS

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel mTOR inhibitor is efficacious in a murine model of colitis

(2008) Mandar R. Bhonde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE