Article
Immunology
Weiwei Zhu, Huifang Zhang, Qiming Dong, Hongyong Song, Lin Zhao
Summary: This study reveals the dual wave of neutrophil recruitment during C. albicans infection, emphasizing the importance of early fungal clearance for favorable disease outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Haleigh E. Conley, M. Katie Sheats
Summary: Neutrophils use beta(2)-integrin cell surface receptors to move out of blood vessels and respond to inflammation and infection. However, dysregulated neutrophil responses can contribute to disease pathophysiology. Investigating the function and signaling of beta(2)-integrins can help in designing future therapeutics.
Article
Cell Biology
Pei Xiong Liew
Summary: Inflammation-induced kidney damage is a major cause of proliferative glomerulonephritis, and the immune response plays a crucial role in patient outcomes and effective treatment. Neutrophils are significant in responding to infection or injury, and their recruitment to the kidney environment requires careful regulation to avoid nonspecific damage. The unique microvasculature of the kidney influences neutrophil recruitment, and advancements in live-animal imaging have revealed novel pathways of recruitment in the kidney, particularly in the glomeruli.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Immunology
Eliza Gil, Cristina Venturini, David Stirling, Carolin Turner, Liku B. Tezera, Giuseppe Ercoli, Tina Baker, Katharine Best, Jeremy S. Brown, Mahdad Noursadeghi
Summary: Excessive neutrophil extravasation can lead to immunopathology, but the mechanisms that amplify this process are not well understood. This study shows that human brain vascular pericytes (HBVP) contribute to neutrophil extravasation by enhancing endothelial barrier formation and promoting neutrophil transmigration. This process is mediated by paracrine signaling from monocyte derived macrophages, which upregulates the production of neutrophil chemokines by pericytes. Understanding the role of pericytes in amplifying neutrophil extravasation may provide new therapeutic targets for reducing neutrophil mediated pathology in pyogenic meningitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jingxia Gao, Guanzhong Song, Haibo Shen, Yiming Wu, Chongqi Zhao, Zhuo Zhang, Qian Jiang, Xilong Li, Xiaokang Ma, Bie Tan, Yulong Yin
Summary: This study found that allicin improves intestinal barrier function and prevents damage caused by bacteria. It increases cell viability and enhances the integrity of cell monolayers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Andong Zha, Bie Tan, Jing Wang, Ming Qi, Yuankun Deng, Rui Li, Peng Liao
Summary: The study aimed to investigate the beneficial effect of modified attapulgites on piglet diarrhea. The results showed that dietary supplementation with 1.5 mg/kg modified attapulgites significantly reduced the severity and frequency of diarrhea, and improved survival rate. This effect was achieved through regulating the intestinal microbial community composition and alleviating intestinal epithelial barrier.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Hua Yao, Xin Fu, Qian Xu, Tingting Li, Yao Li, Yan Kang, Qin Wu
Summary: This study aimed to investigate the mechanisms that activate immune and neuronal cells, and the contribution of macrophages to the recovery of intestinal motility dysfunction after sepsis. The results showed that muscular neutrophil infiltration led to neuronal loss and intestinal motility dysfunction after pneumonia sepsis, and reducing neutrophil infiltration did not improve the dysfunction. Additionally, macrophage depletion aggravated gut motility dysfunction, while the addition of macrophages to smooth muscle helped in the recovery of intestinal motility.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Qijiang Mao, Haoqi Pan, Yiyin Zhang, Yi Zhang, Qiuwen Zhu, Yi Hong, Zhengze Huang, Yang Li, Xu Feng, Yifeng Fang, WenChao Chen, Pengfei Chen, Bo Shen, Hongwei Ouyang, Yuelong Liang
Summary: This study demonstrates a novel and effective treatment strategy for inflammatory bowel disease (IBD) using a tissue-adhesive molecular coating. The coating effectively protects the damaged intestinal epithelium from irritation and promotes intestinal repair and regeneration, ultimately reducing intestinal inflammation.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Veedamali S. Subramanian, Trevor Teafatiller, Hamid Moradi, Jonathan S. Marchant
Summary: Intestinal absorption of vitamin C in humans is mediated by specific transporters, with decreased expression in patients with inflammatory bowel disease. In this study, histone deacetylase inhibitors were found to significantly decrease the expression and function of hSVCT1 in intestinal epithelial cells, partly mediated through transcription factor regulation and chromatin modification. Epigenetic regulation of SVCT1 expression in intestinal epithelia was demonstrated through HDAC isoforms two and three, with potential implications for vitamin C homeostasis.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Xuemeng Si, Zhuan Song, Ning Liu, Hai Jia, Haozhen Liu, Zhenlong Wu
Summary: This study found that alpha-ketoglutarate (alpha-KG) has preventive effects on Citrobacter rodentium-induced colitis by regulating endoplasmic reticulum stress and activating Wnt signaling to restore barrier function.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Chang Liu, Yue-Xian He, Jia-Ning Zhang, Fang Yang, Shu-Yuan Wang, Ji-Liang Hu, Yang Yu
Summary: This study found that Angelica oil has a protective effect on the intestinal mucosal barrier in mice with ulcerative colitis, and it improves barrier damage by inhibiting the expression and activation of S100A8/A9 and the TLR4/NF-kappa B signaling pathway in the inflammatory environment.
Article
Biochemistry & Molecular Biology
Snezhanna Saydakova, Ksenia Morozova, Olga Snytnikova, Maryana Morozova, Lidiya Boldyreva, Elena Kiseleva, Yuri Tsentalovich, Elena Kozhevnikova
Summary: Dietary composition has a significant impact on human health and can influence the development of complex diseases such as obesity, inflammation, and cancer. This study investigated the effects of major dietary phospholipids (PLs) on the morphology of intestinal epithelial cells in mice subjected to high-dose feeding. The results showed that high levels of PLs caused mitochondrial damage and lipid droplet accumulation, making the mitochondria more vulnerable to respiratory uncoupling. However, these mitochondrial changes did not induce intestinal permeability. It is suggested that caution should be exercised when using PL supplementation in individuals with mitochondrial disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Yajuan Bai, Yue Zhou, Xiang Li, Ruifen Zhang, Fei Huang, Bei Fan, Litao Tong, Fengzhong Wang, Mingwei Zhang
Summary: Longan pulp polysaccharide, known as LPIIa, is a bioactive compound that acts as a prebiotic and protects the intestinal barrier. This study found that LPIIa's molecular weight remained stable after gastrointestinal digestion and that 56.02% of it was consumed by gut microbiota during fecal fermentation. The intake of LPIIa increased the production of short-chain fatty acids and expression of G-protein-coupled receptor 41 in the colon, as well as improved the richness of beneficial bacteria in the colon content. Fecal fermented LPIIa showed better protection of the intestinal epithelial barrier compared to LPIIa alone.
Article
Chemistry, Multidisciplinary
Yi Fu, Ang Li, Jie Wu, Robert F. Kunz, Ren Sun, Zurong Ding, Jianhua Wu, Cheng Dong
Summary: This study investigated the interactions between cells involved in the two-step theory, revealing that soluble fibrinogen and fibrin play a role in promoting the adhesion and retention of tumor cells on an endothelial monolayer.
APPLIED SCIENCES-BASEL
(2021)
Article
Agriculture, Dairy & Animal Science
Weilei Yao, Tongxin Wang, Lu Huang, Zhengxi Bao, Shu Wen, Feiruo Huang
Summary: The study demonstrated that embelin exerts protective effects against intestinal inflammation in weaned pigs by suppressing the PCAF/NF-kappa B signaling pathway, as evidenced by decreased serum D-lactate and diamine oxidase levels, increased expression of ZO-1, occludin and claudin-1 proteins in the jejunum and ileum, and downregulation of critical inflammatory molecules in the jejunal and ileal mucosa. Additionally, embelin also downregulated PCAF activity and attenuated the acetylation and activities of NF-kappa B in IPEC-1 cells with overexpression of PCAF.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)