Article
Chemistry, Medicinal
G. Lakshma Reddy, Rupam Sarma, Shuhao Liu, Weifeng Huang, Jinping Lei, Jiasheng Fu, Wenhao Hu
Summary: This study describes the design and synthesis of novel benzo[4,5]imidazo[1,2-a]pyrazin-1-amine derivatives, which showed promising A(2A) adenosine receptor antagonist activity, with compound 27 demonstrating good activity and potential application in T-cell activation. Molecular docking studies were conducted to explain the observed binding affinity of compound 27.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Ghorbanali Rahimian, Milad Shahini Shams Abadi, Yousef Mirzaei, Ali Hussein Mer, Reza Ahmadi, Fatemeh Azadegan-Dehkordi
Summary: Helicobacter pylori infection increases gastric inflammation and the risk of gastritis and peptic ulcer disease (PUD). This study found that TNF-alpha expression in the gastric mucosa is significantly higher in infected patients, and it is related to Th1/Th17/Th22 lymphocytes. These findings suggest that the increase of TNF-alpha and Th1/Th17/Th22 responses play an important role in the increased risk of PUD caused by H. pylori infection.
Article
Immunology
Guojing Ruan, An Huang, Chupeng Hu, Ningyin Xu, Menghui Fan, Zhenxing Zhang, Yue Wang, Yingying Xing
Summary: DP T cells play an immunosuppressive role in Helicobacter felis-induced gastritis by inhibiting dendritic cell maturation and CD4(+) T lymphocyte proliferation. Elimination of these cells results in severe gastritis and a reduction in H. felis load. Vaccine efficacy can be enhanced by reducing the number of DP T cells using silk fibroin as a delivery system, indicating a potential impact of DP T cells on disease prognosis and vaccine effectiveness.
MICROBIAL PATHOGENESIS
(2021)
Article
Immunology
Ashley E. Ciecko, Yu Wang, Stephanie Harleston, Amber Drewek, David V. Serreze, Aron M. Geurts, Chien-Wei Lin, Yi-Guang Chen
Summary: IL-21 is crucial for the development of type 1 diabetes in the NOD mouse model. CD4 T cells that express IL-21 are found in the pancreatic islets and contribute to the progression of T1D. The phenotype and differentiation states of these cells are not well understood. Therefore, a novel IL-21 reporter NOD strain was generated to further investigate IL-21+ CD4 T cells in T1D.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Simon Melderis, Matthias T. Warkotsch, Julien Dang, Julia Hagenstein, Laura-Isabell Ehnold, Georg R. Herrnstadt, Christoph B. Niehus, Frederic C. Feindt, Dominik Kylies, Victor G. Puelles, Carmen Berasain, Matias A. Avila, Katrin Neumann, Gisa Tiegs, Tobias B. Huber, Pierre-Louis Tharaux, Oliver M. Steinmetz
Summary: Systemic lupus erythematosus (SLE) is a common autoimmune disorder, with lupus nephritis (LN) being a frequent and difficult to treat complication. This study identified the multifunctional cytokine AREG as an anti-inflammatory mediator in LN, suppressing pathogenic T cell immunity. These findings highlight the potential of the AREG/EGFR axis as a therapeutic target.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Medicine, Research & Experimental
Justin Harper, Susan P. Ribeiro, Chi Ngai Chan, Malika Aid, Claire Deleage, Luca Micci, Maria Pino, Barbara Cervasi, Gopalan Raghunathan, Eric Rimmer, Gulesi Ayanoglu, Guoxin Wu, Neeta Shenvi, Richard J. O. Barnard, Gregory Q. Del Prete, Kathleen Busman-Sahay, Guido Silvestri, Deanna A. Kulpa, Steven E. Bosinger, Kirk A. Easley, Bonnie J. Howell, Dan Gorman, Daria J. Hazuda, Jacob D. Estes, Rafick-Pierre Sekaly, Mirko Paiardini
Summary: IL-10 in SIV-infected macaques affects Tfh cell differentiation and germinal center formation. IL-10 correlates with LN CD4(+) memory subsets and predicts CD4(+) Tfh cell frequency during ART.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Li-Wei Dong, Zhi-Chao Ma, Jiao Fu, Bai-Li Huang, Fu-Jin Liu, Deming Sun, Cheng Lan
Summary: This study found that modulation of adenosine 2A receptor (A2AR) can promote the Th17 polarization of CD4+ T cells and increase the incidence of post-infectious irritable bowel syndrome (PI-IBS). Additionally, the A2AR antagonist improved the clinical symptoms of PI-IBS, such as abdominal withdrawal reflex and colon transportation.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Rheumatology
Talar Ahmad Merza Mohammad
Summary: PF-06651600 is a specific inhibitor of Janus-activated kinase 3 and the Tec family of kinases. This study evaluated the impact of PF-06651600 on the activity of T-helper cells in the pathogenesis of rheumatoid arthritis (RA). The results showed that PF-06651600 reduced the activity of immune cells in RA patients and decreased the generation of pathogenic Th1 and Th17 subsets.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Review
Surgery
Bilian Zheng, Junlong Song, Man Lu, Chuang Chen, Shengrong Sun
Summary: This article reviews the progress of research on the role of CD4+ T lymphocyte subsets in the development of granulomatous lobular mastitis (GLM). Current studies have confirmed the altered expression of immune molecules in the serum and tissue microenvironment of GLM patients, which may be associated with immune imbalance. The results suggest that immune molecules and immune-related pathways may serve as potential targets and breakthroughs for future GLM treatment.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Immunology
Mieko Tokano, Masaaki Kawano, Rie Takagi, Sho Matsushita
Summary: Extracellular adenosine plays a role in the regulation of neutrophilic inflammation, and istradefylline can suppress adenosine-induced cytokine production.
IMMUNOLOGICAL MEDICINE
(2022)
Meeting Abstract
Allergy
Lisa Workman, Jeffrey M. Wilson, Alexander J. Schuyler, Emily C. McGowan, Jonas Lidholm, Elizabeth A. Erwin, Thomas A. E. Platts-Mills
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Meeting Abstract
Allergy
Rung-chi Li, Alexander J. Schuyler, Lisa Workman, Elizabeth A. Erwin, Thomas A. E. Platts-Mills, Jeffrey M. Wilson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Letter
Allergy
Margaret Shin Kim, Matthew D. Straesser, Behnam Keshavarz, Lisa Workman, Emily C. McGowan, Thomas A. E. Platts-Mills, Jeffrey M. Wilson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Review
Allergy
Thomas A. E. Platts-Mills, Rung-chi Li, Behnam Keshavarz, Anna R. Smith, Jeffrey M. Wilson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Review
Allergy
Jeffrey M. Wilson, Thomas A. E. Platts-Mills
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2020)
Article
Allergy
Thomas A. E. Platts-Mills, Scott P. Commins, Tilo Biedermann, Marianne van Hage, Michael Levin, Lisa A. Beck, Maria Diuk-Wasser, Uta Jappe, Danijela Apostolovic, Michael Minnicozzi, Marshall Plaut, Jeffrey M. Wilson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Allergy
Jeffrey M. Wilson, Behnam Keshavarz, Maya Retterer, Lisa J. Workman, Alexander J. Schuyler, Emily C. McGowan, Charles Lane, Alaaddin Kandeel, Jane Purser, Eva Ronmark, Joseph LaRussa, Scott P. Commins, Tina Merritt, Thomas A. E. Platts-Mills
Summary: The alpha-Gal syndrome is widely recognized across the Southeast, Midwest, and Atlantic Coast of North America, commonly acquired in adulthood as a consequence of tick bites. The distribution of cases generally conforms to the reported range of the lone star tick, with an inverse relationship between alpha-Gal cases and cases of imported fire ant anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Jeffrey M. Wilson, Rung-chi Li, Emily C. McGowan
JOURNAL OF ASTHMA AND ALLERGY
(2020)
Letter
Virology
Jeffrey M. Wilson, Thomas A. E. Platts-Mills, Behnam Keshavarz
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Allergy
Emily C. McGowan, Jonathan Medernach, Behnam Keshavarz, Lisa J. Workman, Rung-Chi Li, Barrett H. Barnes, Bryan Sauer, Jeffrey M. Wilson, Thomas A. E. Platts-Mills
Summary: High levels of serum food-specific IgG4 (sIgG4) were found in patients with EoE. This study aimed to compare serum sIgG4 levels between EoE patients and allergic controls, and to investigate the association between sIgG4 and EoE clinical characteristics.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Meeting Abstract
Allergy
Thomas Platts-Mills, Behnam Keshavarz, Joseph La Russa, Jeffrey Wilson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Meeting Abstract
Allergy
Jeffrey Wilson, Behnam Keshavarz, Matthew Straesser, Margaret Kim, Lisa Workman, Emily McGowan, Thomas Platts-Mills
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Meeting Abstract
Allergy
Behnam Keshavarz, Jeffrey Wilson, Jonas Lidholm, Adnan Custovic, Philip Cooper, Peter Heymann, Thomas Platts-Mills
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Meeting Abstract
Allergy
Alice Knoedler, Monica Gupta, Will Eschenbacher, Behnam Keshavarz, Thomas Platts-Mills, Jeffrey Wilson
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Meeting Abstract
Allergy
Rung-chi Li, Jeffrey Wilson, Lisa Workman, Barrett Barnes, Bryan Sauer, Thomas Platts-Mills, Emily McGowan
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)