Article
Multidisciplinary Sciences
Martin S. Minns, Karl Liboro, Tatiane S. Lima, Serena Abbondante, Brandon A. Miller, Michaela E. Marshall, Jolynn Tran Chau, Alicia Roistacher, Arne Rietsch, George R. Dubyak, Eric Pearlman
Summary: This study reveals the differential requirements for IL-1β secretion in neutrophils and macrophages infected with Pseudomonas aeruginosa expressing T3SS effectors. It also highlights the unexpected role of NLRP3 in P. aeruginosa keratitis.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Miaomiao Yan, Ang Su, Suvarin Pavasutthipaisit, Rebecca Spriewald, Guntram A. Grassl, Andreas Beineke, Doris Hoeltig, Georg Herrler, Paul Becher
Summary: Researchers have developed different cell culture models that mimic the diversity, structure, and function of the intestine, providing valuable tools for studying the interaction between intestinal epithelial cells and enteric pathogens. These models demonstrate the susceptibility of different types of intestinal epithelial cells to viral infection and the subsequent inflammatory response. This study is significant for understanding enteric diseases and host immune reactions.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Immunology
Kehui Zhang, Jiacheng Li, Zhe Shi, Yingying Zhu, Jing Yang, Xiaolin Liu, Renye Que, Liubing Lin, Yirong Chen, Yong Li
Summary: This study found that ginsenosides (GSS) intervention can alleviate autoimmune hepatitis (AIH) by regulating the immune microenvironment and liver impairment. Specifically, GSS activated bone marrow-derived suppressor cells (MDSC) and promoted the differentiation of Treg cells, thereby enhancing immune tolerance. The results suggest that GSS may mitigate AIH by modulating the innate immunity and adaptive T cell immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takahisa Kouwaki, Tasuku Nishimura, Guanming Wang, Reiko Nakagawa, Hiroyuki Oshiumi
Summary: Post-translational modification of LGP2 fine-tunes antiviral innate immune responses by promoting late-phase expression of type I interferons, while attenuating other antiviral proteins.
Article
Fisheries
Xing Lv, Qiang Luo, Shiying Xin, Weiwei Zheng, Tianjun Xu, Yuena Sun
Summary: In recent years, there has been an increasing focus on the study of circular RNAs (circRNAs) in noncoding RNAs. While circRNAs are abundant in mammalian studies, research in lower vertebrates has been lacking. In this study, a circRNA called circPlce1 was found to be related to the innate immune response in Miichthys miiuy (miiuy croaker). Experimental results showed that circPlce1 could promote the production of antiviral genes and inflammatory response. It was also observed that circPlce1 can promote cell proliferation and improve cell viability. The study provides a foundation for understanding the biological function of circRNAs in the innate immune response in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Cell Biology
Vanessa Mancini, Alexandra C. Schrimpe-Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Helen M. Picton, Virginia Pensabene
Summary: This study utilized a microfluidic system to evaluate the metabolomics differences in murine embryos cultured with endometrial cells-conditioned media (CM). The results showed that CM significantly increased blastocyst rates and enhanced the abundance of metabolites involved in key metabolic pathways, suggesting a beneficial effect on embryo development. Further investigations are needed to identify specific pathways involved in embryo development and implantation.
Article
Physiology
Yueping Zheng, Yong Zhang, Zhe Xie, Paul K. S. Shin, Jianan Xu, Houyong Fan, Ping Zhuang, Menghong Hu, Youji Wang
Summary: Seasonal changes have a significant impact on the physiology of fish, as seen in this study on captive Chinese sturgeons. The results showed that seasonal variations affected the growth, innate immune parameters, and liver function of the sturgeons, with the male being more susceptible to these changes compared to the female.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sachin Shukla, Won Kyung Cho, Elsayed Elbasiony, Rohan B. Singh, Sharad K. Mittal, Sunil K. Chauhan
Summary: Regulation of innate inflammation is crucial for tissue homeostasis and barrier function, especially in the skin and cornea. IL36 gamma is the primary agonist expressed by corneal epithelium and is upregulated after corneal injury. Blocking IL36 gamma promotes rapid re-epithelialization and suppresses tissue inflammation.
Article
Immunology
Mary A. Brown, Sophie B. Morgan, Gillian E. Donachie, Katie L. Horton, Ian D. Pavord, Carolina V. Arancibia-Carcamo, Timothy S. C. Hinks
Summary: Type-2 low asthma or COPD is potentially caused by persistent bacterial colonization of the lower airways by bacteria such as non-encapsulated Haemophilus influenzae (NTHi), which is a commensal of the upper airways. The extent of NTHi invasion and activation of proinflammatory cytokines in airway epithelial cells is not fully understood. This study found that NTHi can be internalized transiently by airway epithelial cells and induce inflammation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Zhiwei Li, Guanwen Li, Yunfei Li, Yujie Luo, Yuhan Jiang, Ziyu Zhang, Ziyi Zhou, Shengde Liu, Chen Wu, Fuping You
Summary: OTUD6A is a deubiquitinase that plays crucial roles in various human diseases. This study found that OTUD6A significantly inhibits the production of type I interferon and enhances resistance to viral and bacterial infections. It also identified UBC13 as an interacting protein of OTUD6A, suggesting a potential therapeutic target for infectious diseases.
Article
Biochemistry & Molecular Biology
Hui Li, Annette Breedijk, Nadine Dietrich, Katja Nitschke, Jonas Jarczyk, Philipp Nuhn, Bernhard K. K. Kraemer, Benito A. A. Yard, Jan Leipe, Sibylle Hauske
Summary: Innate immune memory allows macrophages to respond to pathogens they have been pre-exposed to, and the factors influencing this memory require further exploration. This study investigated the effects of different pattern recognition receptors, cytokines, and resolution signals on LPS tolerance in monocytes and macrophages. The results showed that pre-stimulation with TLR 4 ligand inhibits the expression of IRG-1, TNF-α, and IL-6, while pre-stimulation with TLR 1/2 ligands only affects cytokine production. TNF-α stimulation increases LPS-mediated cytokine expression, and DMI inhibits IRG-1 expression in a dose-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Fujie Liu, Sheng Cai, Peng Wu, Lingjun Dai, Xinyi Li, Nijiang Ai, Guoli Feng, Ningshan Wang, Baoliang Zhou
Summary: In this study, the researchers identified a crucial gene, GRF7, in Gossypium australe that plays a significant role in the plant's defense against microbial pathogens.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Gastroenterology & Hepatology
Dulari Jayawardena, Shubha Priyamvada, Takahiro Kageyama, Zachary White, Anoop Kumar, Theodor F. Griggs, Apurba Majumder, Ramsha Akram, Arivarasu N. Anbazhagan, Teruyuki Sano, Pradeep K. Dudeja
Summary: The down-regulation of chloride transporter SLC26A3 in colonocytes is associated with the pathogenesis of ulcerative colitis (UC) by triggering a type 2 immune response through IL-33 release, which is a result of altered epithelial-immune cell crosstalk.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Virology
Yuejiao Liao, Shouqing Guo, Geng Liu, Zhenyu Qiu, Jiamin Wang, Di Yang, Xiaojing Tian, Ziling Qiao, Zhongren Ma, Zhenbin Liu
Summary: Host non-coding RNAs play an important regulatory role in the replication of influenza A virus (IAV). They directly target key proteins of IAV and indirectly participate in the regulation of multiple signal pathways. The findings provide a comprehensive understanding of the function and mechanism of host non-coding RNAs in the cellular anti-virus response, and offer clues to the mechanism of cell-virus interactions and the discovery of antiviral drug targets.
Article
Immunology
Tanjun Zhao, Liyuan Ren, Chengda Li, Li Liu, Yang Zou, Hanyu Yan, Yaoyao Zhan, Yaqing Chang
Summary: This study reveals the regulatory role of miR-7 in the pathogen-induced immune response in A. japonicus by targeting PAK1, highlighting its importance in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)