Article
Clinical Neurology
Lucia K. Feldmann, Roxanne Lofredi, Bassam Al-Fatly, Johannes L. Busch, Varvara Mathiopoulou, Jan Roediger, Patricia Krause, Gerd-Helge Schneider, Katharina Faust, Andreas Horn, Andrea A. Kuehn, Wolf-Julian Neumann
Summary: This study investigated the influence of Christmas on beta activity in patients with Parkinson's disease. The results showed a significant reduction in beta activity on Christmas Eve. The study suggests that circadian and holiday-related changes should be considered when tailoring adaptive deep brain stimulation algorithms.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Zixiao Yin, Yin Jiang, Timon Merk, Wolf-Julian Neumann, Ruoyu Ma, Qi An, Yutong Bai, Baotian Zhao, Yichen Xu, Houyou Fan, Quan Zhang, Guofan Qin, Ning Zhang, Jun Ma, Hua Zhang, Huanguang Liu, Lin Shi, Anchao Yang, Fangang Meng, Guanyu Zhu, Jianguo Zhang
Summary: This study found that the oscillatory pattern of the pallidum in multiple movement disorders changes during sleep, and these changes can be used to differentiate sleep stages. Machine learning approaches can classify sleep stages in patients with different diseases based on the pallidal oscillatory features. These findings have broad translational prospects for the development of adaptive deep brain stimulation systems targeting sleep problems.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Neurosciences
Stefanie Perl, Anika Luettig, Rudiger Koehling, Angelika Richter
Summary: This review provides an overview of DBS research in animal models of dystonia, discussing the research aims, opportunities and limitations of different animal models, and technical challenges.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Deepak K. Ravi, Christian R. Baumann, Elena Bernasconi, Michelle Gwerder, Niklas K. Ignasiak, Mechtild Uhl, Lennart Stieglitz, William R. Taylor, Navrag B. Singh
Summary: This study systematically investigated changes in gait asymmetry and dyscoordination in PD patients 6 months postoperatively, revealing that STN-DBS increased step time asymmetry and phase coordination index, with higher effects in PIGD subgroup compared to tremor dominant subtype. The study suggests subtype-associated differences in treatment response.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Neurosciences
Jian Song, Shenquan Liu, Hui Lin
Summary: In this paper, a quantitative method based on the network model is proposed to determine the stimulation pattern, stimulation parameters, and target of deep brain stimulation (DBS) for Parkinson's disease (PD), and to predict the development of the disease, providing assistance for clinical practice.
Article
Biology
Timon Merk, Victoria Peterson, Witold J. Lipski, Benjamin Blankertz, Robert S. Turner, Ningfei Li, Andreas Horn, Robert Mark Richardson, Wolf-Julian Neumann
Summary: This study developed an invasive brain signal decoding approach using intraoperative sensorimotor electrocorticography (ECoG) and subthalamic LFP to predict grip-force in Parkinson's disease patients undergoing DBS. The results showed that ECoG outperformed subthalamic LFP for accurate grip-force decoding, and gradient boosted decision trees (XGBOOST) showed the best performance. ECoG based decoding performance negatively correlated with motor impairment, highlighting the impact of PD pathophysiology on movement encoding capacity.
Article
Biochemistry & Molecular Biology
Luca Parolari, Marc Schneeberger, Nathaniel Heintz, Jeffrey M. Friedman
Summary: The study anatomically characterized molecular markers for specific STN neurons, revealing Pitx2, Gabrr3, Ndnf, and Nos1 expression. Optogenetic studies showed that Gabrr3 neurons play a key role in mediating the beneficial effects of STN modulation, serving as potential cellular targets for PD and OCD drug discovery.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Vinith Johnson, Robert Wilt, Roee Gilron, Juan Anso, Randy Perrone, Martijn Beudel, Dan Pina-Fuentes, Jeremy Saal, Jill L. Ostrem, Ian Bledsoe, Philip Starr, Simon Little
Summary: The study utilized a novel, sensing-enabled deep brain stimulator device implanted in a patient with cervical dystonia to record neural data and conduct a proof-of-principle trial. It found that low-frequency oscillations are related to dystonia and demonstrated the potential for a novel adaptive stimulation strategy.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Lin Shi, Tianshuo Yuan, Shiying Fan, Jie Zheng, Yu Diao, Guofan Qin, Defeng Liu, Guanyu Zhu, Kai Qin, Huanguang Liu, Hua Zhang, Anchao Yang, Fangang Meng, Jianguo Zhang
Summary: This study assessed the memory function of patients with PD and DT during surgery and found no significant differences in cognitive performance between the two groups. The intraoperative memory test scores were highly correlated with MMSE and MoCA scores, suggesting that the test could be used as a quick assessment tool during surgery.
SCIENTIFIC REPORTS
(2021)
Article
Computer Science, Artificial Intelligence
Mahboubeh Ahmadipour, Mojtaba Barkhordari-Yazdi, Saeid R. Seydnejad
Summary: In this study, a predictive closed loop control strategy is employed to suppress Parkinson's disease in real-time. Simulation results demonstrate that the proposed MIMO subspace-based predictive controller can effectively suppress PD symptoms with less power consumption compared to conventional open-loop DBS and a recently proposed single-input single-output closed loop controller.
Article
Clinical Neurology
Luka Milosevic, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Milos R. Popovic, William D. Hutchison, Milad Lankarany
Summary: This study investigates the brain-region-specific and frequency-dependent effects of deep brain stimulation on neuronal activity. The results show that higher stimulation frequencies lead to neuronal suppression, while site-specific responses are influenced by local neuroanatomical properties and short-term synaptic plasticity.
Review
Cell Biology
Juan Wang, Xiaoting Wang, Hui Li, Limin Shi, Ning Song, Junxia Xie
Summary: In this review, the latest information related to movement disorders and modulations in Parkinson's disease (PD) is provided, with a focus on brain regions and neuronal circuits. Updates on deep brain stimulation (DBS) and other factors for motor improvement in PD are also discussed.
AGEING RESEARCH REVIEWS
(2023)
Article
Computer Science, Artificial Intelligence
Arooj Nawaz, Osman Hasan, Shaista Jabeen
Summary: Deep brain stimulation (DBS) is a widely accepted treatment for Parkinson's disease (PD). Traditional DBS is always ON and can cause side effects. Closed-loop DBS allows adjusting stimulation according to patient needs, addressing this problem.
NEURAL COMPUTATION
(2023)
Review
Neurosciences
Maja Klarendic, Diego Kaski
Summary: DBS treatment is widely used for movement disorders and other neurological and psychiatric conditions, with effects on eye movements dependent on stimulation location and underlying pathology. Understanding how DBS affects eye movements can provide insights into neural circuits involved in complex eye movement control. Further research is needed to explore the potential effects of DBS on eye movements with less common stimulation targets.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Oliver Bichsel, Lennart Stieglitz, Markus Oertel, Christian Baumann, Roger Gassert, Lukas Imbach
Summary: This study investigated the local field potential (LFP) in the subthalamic nucleus (STN) in Parkinson's disease (PD) patients using deep brain stimulation (DBS) electrodes. The results showed changes in beta-burst activity during movement and self-paced motor control, highlighting the importance of beta-burst modulation in movement generation. These findings support the use of adaptive DBS based on beta-bursts for more effective treatment.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Odeya Marmor, Pnina Rappel, Dan Valsky, Atira S. Bick, David Arkadir, Eduard Linetsky, Or Peled, Idit Tamir, Hagai Bergman, Zvi Israel, Renana Eitan
NEUROBIOLOGY OF DISEASE
(2020)
Article
Cell Biology
Oren Peles, Uri Werner-Reiss, Hagai Bergman, Zvi Israel, Eilon Vaadia
Article
Neurosciences
Muneer Abu Snineh, Amal Hajyahya, Eduard Linetsky, Renana Eitan, Hagai Bergman, Zvi Israel, David Arkadir
JOURNAL OF PARKINSONS DISEASE
(2020)
Article
Neurosciences
Marc Deffains, Tho Hai Nguyen, Hugues Orignac, Nathalie Biendon, Sandra Dovero, Erwan Bezard, Thomas Boraud
Summary: The study recorded and examined the inhibition of pallidal neurons using DREADD technology in the NHP model, demonstrating its effectiveness in this context.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Marc Deffains, Marie-Helene Canron, Margaux Teil, Qin Li, Benjamin Dehay, Erwan Bezard, Pierre-Olivier Fernagut
Summary: The study found that chronic dopamine-replacement therapy can significantly ameliorate alpha-synuclein pathology in the non-human primate model of Parkinson's disease. Therefore, patient's dopaminergic medication should be systematically considered when assessing the disease.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Biology
A. Nioche, N. P. Rougier, M. Deffains, S. Bourgeois-Gironde, S. Ballesta, T. Boraud
Summary: By studying the behavior of macaques in bets involving gains or losses and simulating the evolution of agents, it was found that monkeys' attitude toward risk is congruent with the simulation only when facing losses, supporting the view that risk-seeking behavior and probability distortion may be adaptive in the context of life-threatening challenges.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Joachim Mazere, Bixente Dilharreguy, Gwenaelle Catheline, Marie Vidailhet, Marc Deffains, Delphine Vimont, Bastien Ribot, Elodie Barse, Laura Cif, Bernard Mazoyer, Nicolas Langbour, Antonio Pisani, Michele Allard, Frederic Lamare, Dominique Guehl, Philippe Fernandez, Pierre Burbaud
Summary: Early-onset torsion dystonia (DYT1) patients show disrupted cholinergic system in the putamen and cerebellar vermis, with changes occurring with age. Functional connectivity within the motor network and interregional correlation of cholinergic expression are altered in patients, indicating plasticity or compensatory mechanisms over time.
Review
Clinical Neurology
Yanan Sui, Ye Tian, Wai Kin Daniel Ko, Zhiyan Wang, Fumin Jia, Andreas Horn, Dirk De Ridder, Ki Sueng Choi, Ausaf A. Bari, Shouyan Wang, Clement Hamani, Kenneth B. Baker, Andre G. Machado, Tipu Z. Aziz, Erich Talamoni Fonoff, Andrea A. Kuhn, Hagai Bergman, Terence Sanger, Hesheng Liu, Suzanne N. Haber, Luming Li
Summary: Deep brain stimulation (DBS) is a key clinical therapy for neurological disorders with potential for neuroscience research. A recent international workshop discussed cutting-edge technological achievements and clinical applications, focusing on new approaches and challenges in DBS treatment for various conditions. Key developments include advancements in neuroimaging, novel DBS recording capabilities, and online-based programming technology for global healthcare connections.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Jing Guang, Halen Baker, Orilia Ben-Yishay Nizri, Shimon Firman, Uri Werner-Reiss, Vadim Kapuller, Zvi Israel, Hagai Bergman
Summary: This study investigates the cortico-basal ganglia neuronal network in nonhuman primates under different sedation states, revealing that ketamine and propofol increase high and low-frequency power respectively, unlike regular healthy sleep. The results show that brain spectral states under ketamine and propofol mimic different sleep stages, providing a promising step towards asleep DBS with nondistorted physiological navigation.
NPJ PARKINSONS DISEASE
(2021)
Article
Multidisciplinary Sciences
L. Iskhakova, P. Rappel, M. Deffains, G. Fonar, O. Marmor, R. Paz, Z. Israel, R. Eitan, H. Bergman
Summary: This study reveals a strong coupling between beta oscillation frequency and dopamine tone in both monkeys and humans, indicating that beta frequency, rather than power, coherence, phase-locking, or PAC, is likely the key property of pathological oscillations in cortical and basal ganglia networks.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Osnat Oz, Lior Matityahu, Aviv Mizrahi-Kliger, Alexander Kaplan, Noa Berkowitz, Lior Tiroshi, Hagai Bergman, Joshua A. Goldberg
Summary: The tonic activity of striatal cholinergic interneurons (CINs) is modified differentially by their afferent inputs, and the localization of active dendritic conductances in CIN dendrites may promote their differential responses to thalamic vs. cortical inputs.
Article
Biology
Alexander Kaplan, Aviv D. Mizrahi-Kliger, Pnina Rappel, Liliya Iskhakova, Gennadiy Fonar, Zvi Israel, Hagai Bergman
Summary: Integrated analysis of non-human primate data reveals that pauses in GPe firing are associated with pupil dilation, suggesting that GPe pauses may influence basal ganglia downstream structures and play a role in exploratory behavior.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Shiran Katabi, Avital Adler, Marc Deffains, Hagai Bergman
Summary: To date, it is widely acknowledged that there are two neuronal populations, low-frequency discharge (LFD) and high-frequency discharge (HFD) neurons, in the non-human primate (NHP) external globus pallidus (GPe). However, the functional importance of LFD neurons has been overlooked in most NHP physiological studies. This study investigated the discharge characteristics of these two GPe neuronal subpopulations in NHPs engaged in a classical conditioning task and found that LFD neurons tend to burst, encode cue salience, and exhibit correlated spiking activity, while HFD neurons tend to pause, encode cue valence, and exhibit uncorrelated spiking activity. These findings suggest the dichotomic organization of the NHP GPe is critical for normal basal ganglia functions and computations.