期刊
MOVEMENT DISORDERS
卷 30, 期 2, 页码 141-149出版社
WILEY
DOI: 10.1002/mds.26068
关键词
dopamine agonists; pramipexole; l-dopa; 6-OHDA; imaging; PET; fMRI; basal ganglia; prefrontal cortex
资金
- USPHSGs [NS074014, DA0331231, MH57440, DA036328, NS19608]
- Michael J. Fox Foundation
- National Center for Responsible Gaming
- program Investissements d'avenir [ANR-10-IAIHU-06]
- National Institutes of Health [DA027127]
- Brain Research Foundation
- Wellcome Trust [088324]
- Medical Research Council
- National Institute for Health Research
- James S McDonnell Foundation
- Newton Trust
- Evelyn Trust
- Parkinson's UK
- National Institute for Health Research Cambridge Biomedical Research Centre
- Medical Research Council [MC_US_A060_0016]
- Canadian Institute of Health Research
- Parkinson Society Canada
- Parkinson Disease Foundation
- Ontario Problem Gambling Research Centre
- MRC [MC_U105597119] Funding Source: UKRI
- Medical Research Council [G0001354, G1000183B, MC_U105597119, G0001354B] Funding Source: researchfish
- Wellcome Trust [103838/Z/14/Z] Funding Source: researchfish
Patients with Parkinson's disease (PD) may experience impulse control disorders (ICDs) when on dopamine agonist therapy for their motor symptoms. In the last few years, a rapid growth of interest for the recognition of these aberrant behaviors and their neurobiological correlates has occurred. Recent advances in neuroimaging are helping to identify the neuroanatomical networks responsible for these ICDs, and together with psychopharmacological assessments are providing new insights into the brain status of impulsive behavior. The genetic associations that may be unique to ICDs in PD are also being identified. Complementing human studies, electrophysiological and biochemical studies in animal models are providing insights into neuropathological mechanisms associated with these disorders. New animal models of ICDs in PD patients are being implemented that should provide critical means to identify efficacious therapies for PD-related motor deficits while avoiding ICD side effects. Here, we provide an overview of these recent advances, with a particular emphasis on the neurobiological correlates reported in animal models and patients along with their genetic underpinnings. (c) 2014 International Parkinson and Movement Disorder Society
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