Article
Clinical Neurology
Takashi Tsuboi, Joshua K. Wong, Robert S. Eisinger, Lela Okromelidze, Mathew R. Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D. Foote, Michael S. Okun, Sanjeet S. Grewal, Erik H. Middlebrooks
Summary: The optimal targets for deep brain stimulation in essential tremor and dystonic tremor remain unknown. This study suggests that DBS targeting the ventral intermediate nucleus/ventralis oralis posterior nucleus border and ventral intermediate nucleus region may be a reasonable treatment option for medication-refractory dystonic tremor and essential tremor patients. Our findings highlight the involvement of cerebello-thalamo-cortical and basal ganglia-thalamo-cortical networks in the pathophysiology of dystonic tremor.
Article
Behavioral Sciences
Jet M. J. Vonk, Rashid Ghaznawi, Maarten H. T. Zwartbol, Yaakov Stern, Mirjam I. Geerlings
Summary: This study investigated the associations of cognitive and brain reserve with memory decline in mid-life and late-life. The results showed that higher cognitive and brain reserve can protect against memory decline, particularly in late-life.
Review
Clinical Neurology
James Peters, Stephen Tisch
Summary: Deep brain stimulation is an effective treatment for essential, dystonic, and Parkinson's tremor, but long-term benefit can be reduced due to stimulation tolerance or habituation. The exact mechanisms and management of habituation in DBS for tremor syndromes remain unclear and challenging.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Gabriela S. Gilmour, Davide Martino, Karen Hunka, Pia Lawrence, Zelma H. T. Kiss, Veronica Bruno
Summary: In this study, it was found that patients with ET-plus had similar tremor outcomes after VIM DBS compared to those with ET, without the development of new neurological issues. This suggests that patients with ET-plus can still be considered good candidates for VIM DBS treatment of tremor.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Belen Gonzalez-Herrero, Ilaria Antonella Di Vico, Erlick Pereira, Mark Edwards, Francesca Morgante
Summary: Tremor is a symptom of dystonia and can be treated with oral medications, botulinum neurotoxin, or brain surgery. This study evaluated the outcome of different treatments for upper limb dystonic tremors and found that botulinum neurotoxin and surgery had better efficacy compared to oral medications, which had higher side effects and dropout rates. Further research is needed for better patient selection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Business, Finance
Xanthi Gkougkousi, Kose John, Suresh Radhakrishnan, Gil Sadka, Anthony Saunders
Summary: This study examines the relationship between cross-sectional earnings dispersion and banking sector performance. The findings confirm that cross-sectional earnings dispersion has a significant impact on bank performance, and it explains more of the overall bank performance than macroeconomic indicators. Banks tighten lending standards and increase interest rates to partially offset future loan losses. Additionally, there is a correlation between cross-sectional earnings dispersion and dispersion in bank performance, although this correlation is declining over time, indicating an increasing systematic risk in the banking sector.
JOURNAL OF BANKING & FINANCE
(2022)
Article
Geriatrics & Gerontology
Mariam Khayretdinova, Alexey Shovkun, Vladislav Degtyarev, Andrey Kiryasov, Polina Pshonkovskaya, Ilya Zakharov
Summary: This study utilized raw resting-state scalp EEG data to predict brain age using a deep learning model, achieving good prediction results with data augmentation techniques and convolutional neural networks in training.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Masato Murakami, Shiro Horisawa, Kilsoo Kim, Nobuhiko Takeda, Shinichi Goto, Kotaro Kohara, Takakazu Kawamata, Takaomi Taira
Summary: This study reported the long-term results of thalamotomy in 23 patients with task-specific tremor. Thalamotomy significantly improved the severity of tremor and related symptoms, with focal hand dystonia as a potential postoperative complication.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Cell Biology
Zu-Hong He, Ming Li, Qiao-Jun Fang, Fu-Ling Liao, Sheng-Yu Zou, Xia Wu, Hai-Ying Sun, Xue-Yan Zhao, Yu-Juan Hu, Xiao-Xiang Xu, Sen Chen, Yu Sun, Ren-Jie Chai, Wei-Jia Kong
Summary: Presbycusis, the result of aging on hearing, is closely related to common mitochondrial gene deletions. This study found that FOXG1 plays a crucial role in the degeneration process of the auditory system through regulation of autophagy. Aspirin was also found to increase FOXG1 expression and activate autophagy, suggesting a potential treatment for age-related hearing loss.
Article
Nutrition & Dietetics
Eri Nakazaki, Eunice Mah, Danielle Citrolo, Fumiko Watanabe
Summary: This study investigated the effects of Cognizin(R) on memory in healthy elderly populations with AAMI. Results showed that 12 weeks of citicoline dietary supplementation improved overall memory performance, especially episodic memory, in healthy older males and females with AAMI. Regular consumption of citicoline may be safe and potentially beneficial against memory loss due to aging.
JOURNAL OF NUTRITION
(2021)
Article
Geriatrics & Gerontology
Julien F. Bally, Ming Zhang, Emily Dwosh, Christine Sato, John Rutka, Anthony E. Lang, Ekaterina Rogaeva
Summary: This study conducted a genetic analysis of a rare Dutch-Canadian family and found that hearing loss and balance problems are associated with a mutation in the COCH gene, while action tremor is related to a rare mutation in the MCM9 gene. These novel findings suggest a potential association between the MCM9 gene and action tremor, warranting further investigation.
NEUROBIOLOGY OF AGING
(2022)
Article
Psychiatry
Cornelia Santoso, Manuel Serrano-Alarcon, David Stuckler, Stefan Serban, Martin McKee, Attila Nagy
Summary: Multiple studies have shown a positive association between missing teeth and cognitive impairment. However, this study, using a natural experiment approach, did not find a causal effect of missing teeth on early-onset cognitive impairment. The results suggest that the association between missing teeth and cognitive impairment may be due to unobserved confounding factors.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Review
Clinical Neurology
Roberto Erro, Stephen G. Reich
Summary: Although tremor is considered the most common movement disorder, it is often overdiagnosed as essential tremor or Parkinson's Disease, leading to the neglect of important rare syndromes. This review aims to highlight rare forms of tremor and tremor occurring in other neurological disorders to aid recognition and prompt intervention.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Microbiology
Ruo-Xin Zhang, Jia-Ting Xu, Hao-Jie Zhong, Ying-Li Cai, Yu-Pei Zhuang, Ya-Ting Xie, Xing-Xiang He
Summary: This study explored the effects of gut microbiota on essential tremor (ET) using a mouse model. Mice gavaged with fecal suspensions from ET patients showed worse performance in behavioral tests and exhibited longer tremor duration, higher tremor score, and worse motor performance after modeling. Additionally, there were significant differences in microbiota indices and a correlation between these indices and tremors in mice. This study provides evidence for gut microbiota dysbiosis in the pathogenesis of ET.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Begun Erbaba, Duygu Macaroglu, N. Ilgim Ardic-Avci, Ayca Arslan-Ergul, Michelle M. Adams
Summary: Overfeeding and obesity increase the risk for brain aging and neurodegenerative diseases, while caloric restriction has effects on extending lifespan and health-span. The study on zebrafish found that overfeeding led to downregulation of the stem cell marker Sox2, while caloric restriction may prolong lifespan by reinforcing the stem cell pool and downregulating inflammation.
Article
Clinical Neurology
Gabor G. Kovacs, Isidro Ferrer, Lea T. Grinberg, Irina Alafuzoff, Johannes Attems, Herbert Budka, Nigel J. Cairns, John F. Crary, Charles Duyckaerts, Bernardino Ghetti, Glenda M. Halliday, James W. Ironside, Seth Love, Ian R. Mackenzie, David G. Munoz, Melissa E. Murray, Peter T. Nelson, Hitoshi Takahashi, John Q. Trojanowski, Olaf Ansorge, Thomas Arzberger, Atik Baborie, Thomas G. Beach, Kevin F. Bieniek, Eileen H. Bigio, Istvan Bodi, Brittany N. Dugger, Mel Feany, Ellen Gelpi, Stephen M. Gentleman, Giorgio Giaccone, Kimmo J. Hatanpaa, Richard Heale, Patrick R. Hof, Monika Hofer, Tibor Hortobagyi, Kurt Jellinger, Gregory A. Jicha, Paul Ince, Julia Kofler, Enikoe Koevari, Jillian J. Kril, David M. Mann, Radoslav Matej, Ann C. McKee, Catriona McLean, Ivan Milenkovic, Thomas J. Montine, Shigeo Murayama, Edward B. Lee, Jasmin Rahimi, Roberta D. Rodriguez, Annemieke Rozemuller, Julie A. Schneider, Christian Schultz, William Seeley, Danielle Seilhean, Colin Smith, Fabrizio Tagliavini, Masaki Takao, Dietmar Rudolf Thal, Jon B. Toledo, Markus Tolnay, Juan C. Troncoso, Harry V. Vinters, Serge Weis, Stephen B. Wharton, Charles L. White, Thomas Wisniewski, John M. Woulfe, Masahito Yamada, Dennis W. Dickson
ACTA NEUROPATHOLOGICA
(2016)
Article
Clinical Neurology
J. N. Caviness, R. L. Utianski, J. G. Hentz, T. G. Beach, B. N. Dugger, H. A. Shill, E. D. Driver-Dunckley, M. N. Sabbagh, S. Mehta, C. H. Adler
EUROPEAN JOURNAL OF NEUROLOGY
(2016)
Article
Clinical Neurology
C. H. Adler, T. G. Beach, H. A. Shill, J. N. Caviness, E. Driver-Dunckley, M. N. Sabbagh, A. Patel, L. I. Sue, G. Serrano, S. A. Jacobson, K. Davis, C. M. Belden, B. N. Dugger, S. A. Paciga, A. R. Winslow, W. D. Hirst, J. G. Hentz
EUROPEAN JOURNAL OF NEUROLOGY
(2017)
Article
Clinical Neurology
Gabor G. Kovacs, Sharon X. Xie, Edward B. Lee, John L. Robinson, Carrie Caswell, David J. Irwin, Jon B. Toledo, Victoria E. Johnson, Douglas H. Smith, Irina Alafuzoff, Johannes Attems, Janos Bencze, Kevin F. Bieniek, Eileen H. Bigio, Istvan Bodi, Herbert Budka, Dennis W. Dickson, Brittany N. Dugger, Charles Duyckaerts, Isidro Ferrer, Shelley L. Forrest, Ellen Gelpi, Stephen M. Gentleman, Giorgio Giaccone, Lea T. Grinberg, Glenda M. Halliday, Kimmo J. Hatanpaa, Patrick R. Hof, Monika Hofer, Tibor Hortobagyi, James W. Ironside, Andrew King, Julia Kofler, Eniko Kovari, Jillian J. Kril, Seth Love, Ian R. Mackenzie, Qinwen Mao, Radoslav Matej, Catriona McLean, David G. Munoz, Melissa E. Murray, Janna Neltner, Peter T. Nelson, Diane Ritchie, Roberta D. Rodriguez, Zdenek Rohan, Annemieke Rozemuller, Kenji Sakai, Christian Schultz, Danielle Seilhean, Vanessa Smith, Pawel Tacik, Hitoshi Takahashi, Masaki Takao, Dietmar Rudolf Thal, Serge Weis, Stephen B. Wharton, Charles L. White, John M. Woulfe, Masahito Yamada, John Q. Trojanowski
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2017)
Editorial Material
Clinical Neurology
Charles H. Adler, Brittany N. Dugger, Joseph G. Hentz, Michael L. Hinni, David G. Lott, Erika Driver-Dunckley, Shyamal Mehta, Geidy Serrano, Lucia I. Sue, Amy Duffy, Anthony Intorcia, Jessica Filon, Joel Pullen, Douglas G. Walker, Thomas G. Beach
MOVEMENT DISORDERS
(2017)
Article
Cell Biology
Brittany N. Dugger, Daniel P. Perl, George A. Carlson
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2017)
Article
Geriatrics & Gerontology
Pengcheng Han, Megan Nielsen, Melissa Song, Junxiang Yin, Michele R. Permenter, Julie A. Vogt, James R. Engle, Brittany N. Dugger, Thomas G. Beach, Carol A. Barnes, Jiong Shi
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Clinical Neurology
Richard C. Gerkin, Charles H. Adler, Joseph G. Hentz, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Marwan N. Sabbagh, John N. Caviness, Brittany N. Dugger, Geidy Serrano, Christine Belden, Brian H. Smith, Lucia Sue, Kathryn J. Davis, Edward Zamrini, Thomas G. Beach
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2017)
Article
Neurosciences
T. Peter Lopez, Kurt Giles, Brittany N. Dugger, Abby Oehler, Carlo Condello, Zuzana Krejciova, Julian A. Castaneda, George A. Carlson, Stanley B. Prusiner
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2017)
Article
Clinical Neurology
David R. Shprecher, Charles H. Adler, Nan Zhang, Joseph G. Hentz, Geidy E. Serrano, Brittany N. Dugger, Holly A. Shill, Rodolfo Savica, John N. Caviness, Marwan N. Sabbagh, Christine M. Belden, Erika Driver-Dunckley, Shyamal H. Mehta, Lucia I. Sue, Kathryn J. Davis, Edward Zamrini, Thomas G. Beach
PARKINSONISM & RELATED DISORDERS
(2018)
Article
Neurosciences
Brittany N. Dugger, Brittany R. Hoffman, Alex Scroggins, Geidy E. Serrano, Charles H. Adler, Holly A. Shill, Christine M. Belden, Marwan N. Sabbagh, John N. Caviness, Erika Driver Dunckley, Thomas G. Beach
NEUROSCIENCE LETTERS
(2019)
Article
Multidisciplinary Sciences
Ziqi Tang, Kangway Chuang, Charles DeCarli, Lee-Way Jin, Laurel Beckett, Michael J. Keiser, Brittany N. Dugger
NATURE COMMUNICATIONS
(2019)
Review
Clinical Neurology
Mustafa N. Shakir, Brittany N. Dugger
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by the presence of neurofibrillary tangles and amyloid beta plaques in the brain. Advancements in technology have greatly enhanced our understanding of the disease, including diagnostic criteria and the identification of co-pathologies. Despite the lack of a cure, recent advancements in biomarkers and machine learning offer potential new therapies and precision medicine approaches.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Yamah Hamsafar, Qian Chen, Alexander D. Borowsky, Thomas G. Beach, Geidy E. Serrano, Lucia I. Sue, Charles H. Adler, Douglas G. Walker, Brittany N. Dugger
Summary: This study evaluated the protein levels of total tau and phosphorylated tau (p-tau) as well as other neuronal proteins in the submandibular gland and frontal cortex of AD patients at different clinicopathological stages. The findings showed differential protein levels based on the stage of AD, specific tau species, and differences in neuronal proteins. Additionally, a unique high molecular weight tau species called big tau was found in peripheral tissues.
NEUROSCIENCE LETTERS
(2023)
Article
Computer Science, Information Systems
Zhengfeng Lai, Luca Cerny Oliveira, Runlin Guo, Wenda Xu, Zin Hu, Kelsey Mifflin, Charles Decarli, Sen-Ching Cheung, Chen-Nee Chuah, Brittany N. Dugger
Summary: This paper proposes an automated segmentation pipeline (BrainSec) for segmenting grey matter/white matter, which combines a Convolutional Neural Network (CNN) module and a post-processing module. The robustness and reliability of BrainSec are demonstrated through testing on over 180 Whole Slide Images (WSIs). BrainSec is also integrated with an existing pathology classification model to identify and visualize the distribution of different pathologies in segmented grey matter/white matter regions.
