Review
Clinical Neurology
Fatemeh Seifar, Ashok R. Dinasarapu, H. A. Jinnah
Summary: Numerous studies have found an association between low levels of uric acid (UA) and Parkinson's disease (PD), suggesting that low UA may contribute to oxidative stress and the degeneration of dopamine neurons, leading to the onset and progression of PD symptoms. However, recent research has raised questions about this explanation, proposing that low UA may be a biomarker rather than a causative factor for PD.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Michael Lawton, Manuela M. X. Tan, Yoav Ben-Shlomo, Fahd Baig, Thomas Barber, Johannes C. Klein, Samuel G. Evetts, Stephanie Millin, Naveed Malek, Katherine Grosset, Roger A. Barker, Nigel Williams, David J. Burn, Thomas Foltynie, Huw R. Morris, Nicholas Wood, Donald G. Grosset, Michele Tao-Ming Hu
Summary: This study explores the genetics of four previously described subtypes of Parkinson's disease and finds associations between different subtypes and GBA gene mutations and genetic risk. These findings provide insights into the underlying disease mechanisms and pathogenesis in different subtypes of Parkinson's disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
Summary: This study investigated the relationship between uric acid levels and improvement of motor symptoms in patients with Parkinson's disease after subthalamic nucleus deep brain stimulation. The results showed a non-linear correlation between uric acid levels and motor symptom improvement.
NEUROLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Renjie Shi, Jin Ye, Hua Fan, Chunxia Xiao, Danna Wang, Bing Xia, Zhenting Zhao, Beita Zhao, Xiaoshuang Dai, Xuebo Liu
Summary: Lactobacillus plantarum LLY-606 can affect the development of hyperuricemia by modulating gut microbiota, downregulating renal inflammation, and regulating uric acid metabolism.
Article
Medicine, General & Internal
Ji Hyoun Kim, In Ah Choi, Aryun Kim, Gilwon Kang
Summary: The study in Korea did not find an association between gout and Parkinson's disease. Independent risk factors for PD included age, female sex, stroke, and hypertension. Additionally, dyslipidemia exhibited a negative correlation with PD.
MEDICINA-LITHUANIA
(2021)
Review
Neurosciences
Hongtao Chang, Benqiao Wang, Yue Shi, Ruixia Zhu
Summary: This study aimed to evaluate the correlation between urate levels or gout and the risk for Parkinson's disease (PD). The analysis showed that high serum urate levels were associated with a decreased risk for PD, while gout was not closely correlated with the risk for PD. Subgroup analysis by sex revealed a neuroprotective effect of high urate levels against PD among both females and males.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Qian Li, Kaiwen Cen, Ying Cui, Xu Feng, Xiaowen Hou
Summary: A meta-analysis was conducted to investigate the association between uric acid (UA) levels and vascular dementia (VaD) and Parkinson's disease dementia (PDD). The results showed that UA levels were not associated with VaD, but were associated with PDD.
NEUROLOGICAL SCIENCES
(2023)
Review
Genetics & Heredity
Efthalia Angelopoulou, Anastasia Bougea, Sokratis G. Papageorgiou, Chiara Villa
Summary: Psychosis in Parkinson's disease (PDP) is a common and debilitating condition that significantly affects the quality of life for both patients and caregivers. It is associated with various risk factors such as age, sleep disturbances, disease duration, cognitive impairment, depression, and visual disorders. The pathophysiology of PDP is complex and not fully understood, and some medications used to treat PD can worsen or even precipitate PDP.
Article
Clinical Neurology
Jonggeol J. Kim, Mary B. Makarious, Sara Bandres-Ciga, Jesse Raphael Gibbs, Jinhui Ding, Dena G. Hernandez, Janet Brooks, Francis P. Grenn, Hirotaka Iwaki, Andrew B. Singleton, Mike A. Nalls, Cornelis Blauwendraat
Summary: This article presents the Parkinson's Disease Sequencing Browser, a Shiny-based web application that provides comprehensive summary-level frequency data from multiple large-scale genotyping and sequencing projects. Researchers can easily search for PD risk genes and variant candidates on this browser.
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Asra Fazlollahi, Mahdi Zahmatyar, Hossein Alizadeh, Maryam Noori, Nasrin Jafari, Seyed Aria Nejadghaderi, Mark J. M. Sullman, Koroush Gharagozli, Ali-Asghar Kolahi, Saeid Safiri
Summary: This study conducted a systematic review and meta-analysis to investigate the association between gout and the risk of developing Parkinson's disease (PD). The results showed no significant association between gout and PD among both sexes. However, a significant association was found for females. Subgroup analysis did not reveal any significant findings by age group, gout treatment, study design, quality assessment score, and gout ascertainment method. Studies that defined PD based on drug use showed significant results.
Article
Medicine, General & Internal
Svetlana Bivol, George D. Mellick, Jacob Gratten, Richard Parker, Aoibhe Mulcahy, Philip E. Mosley, Peter C. Poortvliet, Adrian Campos, Brittany L. Mitchell, Luis M. Garcia-Marin, Simone Cross, Mary Ferguson, Penelope A. Lind, Danuta Z. Loesch, Peter M. Visscher, Sarah E. Medland, Clemens R. Scherzer, Nicholas G. Martin, Miguel E. Renteria
Summary: The Australian Parkinson's Genetics Study aims to understand the sociodemographic, genetic, and environmental basis of Parkinson's disease (PD) susceptibility, symptoms, and progression by studying genetic and patient-reported data from a large cohort of PD patients in Australia. The study has recruited 1819 participants, mostly men of European descent, with a significant proportion reporting a previous traumatic brain injury. The most commonly reported comorbid conditions include constipation, depression, anxiety, melanoma, and diabetes. Future plans include recruiting unaffected controls, conducting genetic analysis, and collecting additional data on non-motor symptoms and cognitive function.
Article
Geriatrics & Gerontology
Bowen Chang, Chi Xiong, Chen Ni, Peng Chen, Manli Jiang, Jiaming Mei, Chaoshi Niu
Summary: This study investigated the relationship between uric acid-related brain function connectivity and the prognosis of subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease patients. The results showed that uric acid-related functional connectivity was closely related to treatment efficacy and could be used to predict prognosis. A machine learning model based on uric acid-related functional connectivity was successfully developed for predicting the prognosis of STN-DBS treatment in Parkinson's disease patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Elena Paccosi, Luca Proietti-De-Santis
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies. The current treatment options are limited, and there is a need for new drugs to improve therapeutic approaches. Epigenetic alterations, specifically dysregulation of miRNAs, have shown promise in PD research. Modified exosomes, loaded with therapeutic compounds and miRNAs, may be a potential treatment strategy for PD. This review aims to explore the therapeutic potential of the exosomes/miRNAs network in PD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Xiaoxue Shi, Jinhua Zheng, Jianjun Ma, Zhidong Wang, Wenhua Sun, Mingjian Li, Shen Huang, Shiyu Hu
Summary: Serum uric acid levels were found to be correlated with nonmotor symptoms and whole-brain gray matter volume in Parkinson's disease patients, with significant differences between early and middle-late stage patients. This study provides the first report on the relationships between serum uric acid and clinical manifestations and imaging features in PD.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Julie Lake, Xylena Reed, Rebekah G. Langston, Mike A. Nalls, Ziv Gan-Or, Mark R. Cookson, Andrew B. Singleton, Cornelis Blauwendraat, Hampton L. Leonard
Summary: This study conducted a large meta-analysis to investigate the association of LRRK2 rs76904798 with PD risk independently from LRRK2 coding variation, showing that rs76904798 remained significantly associated with PD after excluding carriers of relatively rare LRRK2 coding variants. The study also found that LRRK2 coding variants previously related to PD do not drive the 5' noncoding GWAS signal, suggesting an independent association of certain haplotypes with altered disease risk.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Diego Santos Garcia, Teresa de Deus Fonticoba, Carlos Cores, Ester Suarez Castro, Jorge Hernandez Vara, Silvia Jesus, Pablo Mir, Marina Cosgaya, Maria Jose Marti, Pau Pastor, Iria Cabo, Manuel Seijo, Ines Legarda, Barbara Vives, Nuria Caballol, Javier Ruiz Martinez, Ioana Croitoru, Esther Cubo, Javier Miranda, Maria Gema Alonso Losada, Carmen Labandeira, Nuria Lopez Ariztegui, Mabel Morales-Casado, Isabel Gonzalez Aramburu, Jon Infante, Sonia Escalante, Noemi Bernardo, Marta Blazquez Estrada, Manuel Menendez Gonzalez, Juan Garcia Caldentey, Carmen Borrue, Lydia Vela, Maria Jose Catalan, Victor Gomez Mayordomo, Monica Kurtis, Cristina Prieto, Carlos Ordas, Victor Nogueira, Lydia Lopez Manzanares, Maria Asuncion Avila Rivera, Victor Puente, Jose Manuel Garcia Moreno, Berta Solano Vila, Maria Alvarez Sauco, Francisco Carrillo Padilla, Juan Carlos Martinez Castrillo, Pilar Sanchez Alonso, Itziar Gaston, Jaime Kulisevsky, Caridad Valero, Oriol de Fabregues, Jessica Gonzalez Ardura, Luis Manuel Lopez Diaz, Pablo Martinez-Martin
Summary: This study analyzed the frequency, causes, and predictors of acute hospitalization in a cohort of Parkinson's disease patients in Spain. The results showed that falls were the most common cause of hospitalization and an independent predictor of acute hospitalization in Parkinson's disease patients.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Psychology, Multidisciplinary
Cristiano Termine, Linda Greta Dui, Laura Borzaga, Vera Galli, Rossella Lipari, Marta Vergani, Valentina Berlusconi, Massimo Agosti, Francesca Lunardini, Simona Ferrante
Summary: A cross-sectional study compared the effects of social distancing and lifestyle changes during the COVID-19 lockdown on children and adolescents with and without Neurodevelopmental Disorders (NDDs). Results showed that NDDs significantly impacted remote learning, sociality, scolding, and anxiety levels. There was agreement between parents and children regarding remote learning, lifestyle, and scolding. This study highlights the importance of supportive strategies for youth with NDDs during periods of lockdown.
CURRENT PSYCHOLOGY
(2023)
Review
Education, Special
Chiara Luoni, Maristella Scorza, Silvia Stefanelli, Barbara Fagiolini, Cristiano Termine
Summary: Developmental dyscalculia (DD) is closely related to other learning and developmental disabilities, such as reading and writing disorders, attention deficits, and problems in visual/spatial skills and memory. This study found that children with DD have different cognitive and neuropsychological profiles compared to typically developing children.
JOURNAL OF LEARNING DISABILITIES
(2023)
Article
Biochemistry & Molecular Biology
Pablo Garcia-Gonzalez, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Raquel Puerta, Emilio Alarcon-Martin, Ines Quintela, Adela Orellana, Victor Andrade, Pamela V. Martino Adami, Stefanie Heilmann-Heimbach, Pilar Gomez-Garre, Maria Teresa Perinan, Ignacio Alvarez, Monica Diez-Fairen, Raul Nunez Llaves, Claudia Olive Roig, Guillermo Garcia-Ribas, Manuel Menendez-Gonzalez, Carmen Martinez, Miquel Aguilar, Mariateresa Buongiorno, Emilio Franco-Macias, Maria Eugenia Saez, Amanda Cano, Maria J. Bullido, Luis Miguel Real, Eloy Rodriguez-Rodriguez, Jose Luis Royo, Victoria Alvarez, Pau Pastor, Gerard Pinol-Ripoll, Pablo Mir, Miguel Calero Lara, Miguel Medina Padilla, Pascual Sanchez-Juan, Angel Carracedo, Sergi Valero, Isabel Hernandez, Lluis Tarraga, Alfredo Ramirez, Merce Boada, Agustin Ruiz
Summary: Mosaic loss of chromosome Y (mLOY) is a common somatic event associated with Alzheimer's disease (AD) and can be age-confounded in genome-wide association studies. This study used Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) and found that higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment. The study suggests that mLOY is involved in AD pathogenesis and shows associations with cerebrospinal fluid biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Diego Santos-Garcia, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Jose M. Paz Gonzalez, Cristina Martinez Miro, Silvia Jesus, Miquel Aguilar, Pau Pastor, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Marta Blazquez Estrada, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Oriol de Fabregues, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. L. Lopez Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: Visual hallucinations and subjective cognitive complaints in Parkinson's disease are associated with cognitive impairment. This study aimed to determine the association between visual hallucinations and cognitive complaints and the risk of developing cognitive impairment in Parkinson's disease patients with normal cognition. The results showed that visual hallucinations were associated with the development of cognitive impairment, and the presence of both visual hallucinations and cognitive complaints increased the probability of developing cognitive impairment.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Laura Munoz-Delgado, Daniel Macias-Garcia, Maria Teresa Perinan, Silvia Jesus, Astrid D. Adarmes-Gomez, Marta Bonilla Toribio, Dolores Buiza Rueda, Maria Del Valle Jimenez-Jaraba, Belen Benitez Zamora, Rafael Diaz Belloso, Sergio Garcia-Diaz, Miguel Martin-Bornez, Rocio Pineda Sanchez, Fatima Carrillo, Pilar Gomez-Garre, Pablo Mir
Summary: Peripheral inflammatory immune response is involved in the pathophysiology of sporadic and GBA-associated Parkinson's disease (PD) but not in LRRK2-associated PD.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Esther Cubo, Sheng Luo, Pablo Martinez-Martin, Glenn T. Stebbins, Jeffrey Lin, Dongrak Choi, Alvaro Garcia-Bustillo, Pablo Mir, Diego Santos-Garcia, Marcos Serrano-Duenas, Mayela Rodriguez-Violante, Carlos Singer
Summary: This article summarizes the formal process of completing the MDS-NMS program and presents data on the first non-English version (Spanish). The results show that the Spanish version of MDS-NMS met the criteria to be designated as an official translation and is now available on the MDS website.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Diego Santos-Garcia, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Iago Garcia Diaz, Silvia Jesus, Maria Teresa Buongiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Sotos, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Menendez Gonzalez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez Diaz, Darrian McAfee, Matilde Calopa, Fatima Carrillo, Francisco Escamilla Sevilla, Eric Freire-Alvarez, Juan Carlos Gomez Esteban, Rocio Garcia Ramos, Maria Rosario Isabel Luquin, Irene Martinez-Torres, Angel Sesar Ignacio, Pablo Martinez-Martin, Pablo Mir
Summary: This study applied the MNCD classification to Parkinson's disease patients and analyzed its correlation with quality of life and disease severity. The results showed that a more advanced MNCD stage was associated with poorer quality of life and greater disease severity. Therefore, MNCD could be a useful tool for monitoring disease progression in Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Diego Santos-Garcia, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Silvia Jesus, Maria Teresa Buongiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Marta Blazquez Estrada, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Oriol de Fabregues, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. L. Lopez Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study aimed to examine the prevalence of drooling in Parkinson's disease (PD) patients and compare it with a control group. The results showed that drooling was frequent in PD patients, even at the early stages of the disease, and it was associated with greater motor severity and nonmotor symptom burden.
PARKINSONS DISEASE
(2023)
Article
Medicine, General & Internal
Konstantin G. Heimrich, Aline Schoenenberg, Diego Santos-Garcia, Pablo Mir, Tino Prell
Summary: Nonmotor symptoms have a negative impact on health-related quality of life in patients with Parkinson's disease. This study aimed to understand the network structure of nonmotor symptoms and their impact on quality of life, particularly focusing on the most influential symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Konstantin Heimrich, Sarah Mendorf, Aline Schoenenberg, Diego Santos-Garcia, Pablo Mir, Tino COPPADIS Study Group, Tino Prell
Summary: The clinical presentation of Parkinson's disease is often characterized by depressive symptoms, which significantly affect the patients' quality of life. Through network analysis, this study identified the depressive symptoms of loss of energy, past failure, and tiredness or fatigue as having the greatest impact on overall quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
