期刊
MOVEMENT DISORDERS
卷 27, 期 13, 页码 1694-1697出版社
WILEY
DOI: 10.1002/mds.25195
关键词
Parkinson's disease; depression; Tef; circadian genes
资金
- National Natural Science [81170309]
- Medical Science and Technology Foundation Project of Chinese Traditional Medicine from Jiangsu Province [LB09088]
- Key Project of Medical Science and Technology Development Foundation from the Nanjing Department of Health [200905016]
- American Academy of Neurology Research Fellowship
- Parkinson Disease Foundation
Background: Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. However, the relationship between these genes and depression symptoms in Parkinson's disease (PD) has not been established. Methods: Four hundred eight subjects with PD participated in this study. Demographics, UPDRS, MiniMental Status Examination (MMSE), and Hamilton Rating Scale for Depression (HAMD) were obtained in all subjects. Frequency of polymorphisms of Cry1 rs2287161, Cry2 rs10838524, and Tef rs738499 was determined, and the association between genetic polymorphisms of circadian genes and HAMD scores in patients with PD was examined. Results: Tef, but not Cry1 or Cry2, is associated with HAMD scores in patients with PD in a linear regression model after adjusting for clinical variables (P = 0.004). Conclusions: The polymorphism of Tef rs738499 is associated with depression symptoms in PD. (C) 2012 Movement Disorder Society
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