Article
Clinical Neurology
Patricia Krause, Johanna Reimer, Jonathan Kaplan, Friederike Borngraeber, Gerd-Helge Schneider, Katharina Faust, Andrea A. Kuehn
Summary: Subthalamic Deep Brain Stimulation (STN-DBS) is a safe and effective therapy for managing motor symptoms in patients with Parkinson's disease. It can also improve non-motor symptoms and reduce additional neuropsychiatric features, which is important for the management of Early-onset PD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Weibing Liu, Tatsuya Yamamoto, Yoshitaka Yamanaka, Masato Asahina, Tomoyuki Uchiyama, Shigeki Hirano, Keisuke Shimizu, Yoshinori Higuchi, Satoshi Kuwabara
Summary: Frontal lobe functions, depression, and verbal fluency significantly worsened 3 years after STN-DBS. The UPDRS part I score and higher impulsivity might be associated with QOL after STN-DBS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Inken Toedt, Bassam Al-Fatly, Oliver Granert, Andrea A. Kuehn, Paul Krack, Joern Rau, Lars Timmermann, Alfons Schnitzler, Steffen Paschen, Ann-Kristin Helmers, Andreas Hartmann, Eric Bardinet, Michael Schuepbach, Michael T. Barbe, Till A. Dembek, Valerie Fraix, Dorothee Kuebler, Christine Brefel-Courbon, Alireza Gharabaghi, Lars Wojtecki, Marcus O. Pinsker, Stephane Thobois, Philippe Damier, Tatiana Witjas, Jean-Luc Houeto, Carmen Schade-Brittinger, Marie Vidailhet, Andreas Horn, Guenther Deuschl
Summary: This study assessed the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on clinical outcomes and quality of life in patients with Parkinson's disease, finding a correlation between the stimulated part of the STN and improvements in symptom control and quality of life.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Takashi Tsuboi, Janine Lemos Melo Lobo Jofili Lopes, Kathryn Moore, Bhavana Patel, Joseph Legacy, Adrianna M. Ratajska, Dawn Bowers, Robert S. Eisinger, Leonardo Almeida, Kelly D. Foote, Michael S. Okun, Adolfo Ramirez-Zamora
Summary: Globus pallidus internus deep brain stimulation in Parkinson's disease patients showed sustained long-term benefits in tremor scores, motor complications, but gradual worsening in HRQoL and cardinal motor symptoms other than tremor in the long term. Benefits in tremor and dyskinesia are expected to be most persistent following bilateral GPi DBS implantation.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Deepa Dash, Diane Cote, Jennifer Conway, David Grimes, Tiago A. Mestre
Summary: The Integrated Parkinson Care Network (IPCN) is a care delivery model designed to meet the specific care needs of people with Parkinson's disease and chronic DBS. The study results show that after the IPCN program, there was a positive change in patients' perception of chronic care support and self-management, along with an improvement in quality of life.
JOURNAL OF PARKINSONS DISEASE
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Clinical Neurology
Lais M. Oliveira, Marta Ruiz-Lopez, Alexandre Boutet, Gavin J. B. Elias, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano
Summary: The study found that using the advanced functions of the patient programmer delays programming optimization and is associated with a higher number of side effects. Therefore, there is a need for other faster and safer stimulation programming methods.
Article
Clinical Neurology
Martin M. Reich, Joey Hsu, Michael Ferguson, Frederic L. W. V. J. Schaper, Juho Joutsa, Jonas Roothans, Robert C. Nickl, Anneke Frankemolle-Gilbert, Jay Alberts, Jens Volkmann, Michael D. Fox
Summary: The study demonstrates that the decline in cognitive function caused by deep brain stimulation (DBS) is related to the connectivity between the stimulation site and a specific brain network associated with memory impairment. Transforming this network into a heat map can help identify DBS patients at risk of delayed-onset side-effects and guide reprogramming efforts.
Article
Neurosciences
Marle M. Van Hienen, Roy Kuiper, Huub A. M. Middelkoop, Jacobus J. Van Hilten, Maria Fiorella Contarino, Victor J. Geraedts
Summary: The study found that deep brain stimulation (DBS) does not appear to impact caregiver burden, but there are different symptom values in caregiver burden between preoperative and postoperative assessments. Early recognition of at-risk caregivers may improve guidance for patient-caregiver dyads throughout the DBS process.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Gian D. Pal, Daniel M. Corcos, Leo Verhagen Metman, Zvi Israel, Hagai Bergman, David Arkadir
Summary: Genetic subtyping of patients with Parkinson's disease may help predict the cognitive and motor outcomes of subthalamic deep brain stimulation. However, there are still controversies and gaps in understanding the effects of STN-DBS on PD patients with pathogenic variants in the GBA1 gene. Further research is needed to determine the clinical significance, risk-to-benefit ratio, and strategies to minimize the negative effects of STN-DBS. Genetic testing for GBA1 may be considered in PD patients considering DBS to properly assess the potential risks and benefits.
MOVEMENT DISORDERS
(2023)
Review
Psychology, Multidisciplinary
Joshua A. Wilt, Amanda R. Merner, Jaclyn Zeigler, Michelle Montpetite, Cynthia S. Kubu
Summary: Deep Brain Stimulation (DBS) is a safe and effective treatment for Parkinson's Disease (PD) in improving motor symptoms, but concerns about its effects on patients' personality remain. Research shows that while there is little evidence of changes in dispositional traits following DBS, there is some positive progress in characteristic adaptations. Further research is needed in exploring the impact on narrative identity after DBS treatment for PD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Faisal Alosaimi, Jackson Tyler Boonstra, Sonny Tan, Yasin Temel, Ali Jahanshahi
Summary: DBS is a successful paradigm for treating movement disorders, but its specific mechanisms and effects on neurotransmitter dynamics are still not fully understood. This review discusses the role of neurotransmitter dynamics in mediating DBS effects in Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jonathan Voeglein, Nicolai Franzmeier, John C. Morris, Marianne Dieterich, Eric McDade, Mikael Simons, Oliver Preische, Anna Hofmann, Jason Hassenstab, Tammie L. Benzinger, Anne Fagan, James M. Noble, Sarah B. Berman, Neill R. Graff-Radford, Bernardino Ghetti, Martin R. Farlow, Jasmeer P. Chhatwal, Stephen Salloway, Chengjie Xiong, Celeste M. Karch, Nigel Cairns, Richard J. Perrin, Gregory Day, Ralph Martins, Raquel Sanchez-Valle, Hiroshi Mori, Hiroyuki Shimada, Takeshi Ikeuchi, Kazushi Suzuki, Peter R. Schofield, Colin L. Masters, Alison Goate, Virginia Buckles, Nick C. Fox, Patricio Chrem, Ricardo Allegri, John M. Ringman, Igor Yakushev, Christoph Laske, Mathias Jucker, Gunter Hoglinger, Randall J. Bateman, Adrian Danek, Johannes Levin
Summary: Autosomal dominant Alzheimer's disease (ADAD) has distinct neurological examination findings that are useful for estimating prognosis and guiding clinical care and therapeutic trial designs.
ALZHEIMERS & DEMENTIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sabrina Katzdobler, Alexander Nitschmann, Henryk Barthel, Gerard Bischof, Leonie Beyer, Ken Marek, Mengmeng Song, Olivia Wagemann, Carla Palleis, Endy Weidinger, Anne Nack, Urban Fietzek, Carolin Kurz, Jan Haeckert, Theresa Stapf, Christian Ferschmann, Maximilian Scheifele, Florian Eckenweber, Gloria Biechele, Nicolai Franzmeier, Anna Dewenter, Sonja Schoenecker, Dorothee Saur, Matthias L. Schroeter, Jost-Julian Rumpf, Michael Rullmann, Andreas Schildan, Marianne Patt, Andrew W. Stephens, Thilo van Eimeren, Bernd Neumaier, Alexander Drzezga, Adrian Danek, Joseph Classen, Katharina Buerger, Daniel Janowitz, Boris-Stephan Rauchmann, Sophia Stoecklein, Robert Perneczky, Florian Schoeberl, Andreas Zwergal, Gunter U. Hoeglinger, Peter Bartenstein, Victor Villemagne, John Seibyl, Osama Sabri, Johannes Levin, Matthias Brendel
Summary: Early-phase [F-18]PI-2620 PET can be used for regional assessment of neuronal injury in neurodegenerative diseases, while standard late-phase [F-18]PI-2620 tau-PET is able to discriminate 4RTs from controls. This study investigated the additive value of early-phase [F-18]PI-2620 PET for biomarker-based evaluation of 4RTs.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Clinical Neurology
Henrieke L. Frequin, Jason Schouten, Constant V. M. Verschuur, Sven R. Suwijn, Judith A. Boel, Bart Post, Bastiaan R. Bloem, Johannes J. van Hilten, Teus van Laar, Gerrit Tissingh, Alexander G. Munts, Joke M. Dijk, Gunther Deuschl, Anthony Lang, Marcel G. W. Dijkgraaf, Rob J. de Haan, Rob M. A. de Bie
Summary: The study found that levodopa had similar effects on bradykinesia, rigidity, and tremor in patients with early Parkinson's disease. The improvements in symptoms were larger at 22 weeks compared to 4 weeks. At 80 weeks, fewer patients in the early-start group experienced motor response fluctuations.
Article
Clinical Neurology
David J. Whiteside, Maura Malpetti, P. Simon Jones, Boyd C. P. Ghosh, Ian Coyle-Gilchrist, John C. van Swieten, Harro Seelaar, Lize Jiskoot, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Chris R. Butler, Isabel Santana, Isabelle Le Ber, Alexander Gerhard, Simon Ducharme, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Florence Pasquier, Arabella Bouzigues, Lucy L. Russell, Jonathan D. Rohrer, James B. Rowe, Timothy Rittman
Summary: This study investigated the role of changes in functional networks in predicting cognitive decline and conversion to symptomatic disease in familial frontotemporal dementia (FTD). The study found a characteristic pattern of dynamic network changes in FTD, which were correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was more prominent in those who later converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Multidisciplinary Sciences
Carlos Trenado, Matthias Boschheidgen, Karim N'Diaye, Alfons Schnitzler, Luc Mallet, Lars Wojtecki
Summary: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is effective in treating motor symptoms in Parkinson's disease (PD), but its impact on high cognitive processes such as metacognition remains unclear. This study found no significant effect of STN-DBS on reversal learning (RL) or metacognition.
SCIENTIFIC REPORTS
(2023)
Article
Neuroimaging
Matthias Sure, Sean Mertiens, Jan Vesper, Alfons Schnitzler, Esther Florin
Summary: The stun effect from deep brain stimulation (DBS) electrodes in Parkinson's disease (PD) patients can temporarily improve motor symptoms. However, the network changes induced by the stun effect have not been well characterized. This study investigated whether the DBS-related stun effect also modulated resting-state networks (RSNs) and found that it alters different functional RSNs throughout the brain.
NEUROIMAGE-CLINICAL
(2023)
Letter
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Johannes Meyne, Mirjam Domschikowski, Johannes Hensler, Ann-Kristin Helmers, Daniela Berg, Guenther Deuschl, Steffen Paschen
Summary: The study found that patients with previous deep brain stimulation (DBS) surgery can undergo intravenous thrombolysis (IVT) and endovascular mechanical thrombectomy therapy (MT) for acute ischemic stroke, without bleeding complications, at least 6 months after the surgery.
JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Editorial Material
Clinical Neurology
Guenther Deuschl
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Rachel K. Spooner, Bahne H. Bahners, Alfons Schnitzler, Esther Florin
Summary: Research shows that optimal contact orientations in subthalamic deep brain stimulation can lead to larger cortical responses and smoother hand movements in patients with Parkinson's disease. These findings have clinical implications for optimizing DBS parameter settings to alleviate motor symptoms.
NPJ PARKINSONS DISEASE
(2023)
Article
Psychology, Experimental
Julia Henkel, Christian Hartmann, Valentina Niccolai, Ruben van de Vijver, Alfons Schnitzler, Katja Biermann-Ruben
Summary: Parkinson's disease not only affects the motor system, but also language abilities, particularly syntactic subordination. This study found that patients with Parkinson's disease showed a significant reduction in subordinating structures compared to a healthy control group, while the number of non-embedding sentences remained unaffected. Additionally, the medication status of levodopa did not have a significant effect on language abilities. These results suggest a contribution of the basal ganglia to language processing, which is not dopamine dependent.
Article
Clinical Neurology
Tobias Binder, Florian Lange, Nicolo Pozzi, Thomas Musacchio, Christine Daniels, Thorsten Odorfer, Patrick Fricke, Cordula Matthies, Jens Volkmann, Philipp Capetian
Summary: This study investigated the potential advantages of beta-guided programming in STN-DBS for Parkinson's disease. The results showed that beta-guided programming had similar clinical efficacy compared to clinically and image-guided programming, but required significantly less time. This new method has the potential to improve current clinical practice in DBS programming.
Article
Clinical Neurology
Dana Brinker, Oliver Granert, Felix Goevert, Inken Toedt, Alexander Baumann, Kirsten E. Zeuner, Robin Wolke, Guenther Deuschl, Jos S. Becktepe
Summary: This study aims to explore alterations of brain grey matter in patients with essential tremor (ET) combined with dystonic soft signs (ET + ds). The results showed a significant increase of grey matter in the right lentiform nucleus in ET + ds and tremor associated with manifest dystonia (TAWD) compared to healthy controls and ET patients without dystonic soft signs (ET-ds). Additionally, an increase of cortical grey matter in the middle frontal gyrus was observed in ET + ds. The hypertrophy of the lentiform nucleus in ET + ds was correlated with disease severity and duration.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Marius Kroesche, Silja Kannenberg, Markus Butz, Christian J. Hartmann, Esther Florin, Alfons Schnitzler, Jan Hirschmann
Summary: This study identified spectral slowing, particularly affecting the frontal beta oscillations, in patients with atypical parkinsonian syndromes. This finding may serve as an electrophysiological marker for the differential diagnosis of Parkinson's disease in the future.
MOVEMENT DISORDERS
(2023)
