Article
Clinical Neurology
Josefine Waldthaler, Miriam Bopp, Nele Kuehn, Bugrahan Bacara, Merle Keuler, Marko Gjorgjevski, Barbara Carl, Lars Timmermann, Christopher Nimsky, David J. Pedrosa
Summary: This study compared changes in motor symptoms of Parkinson's Disease and the corresponding volume of the electrostatic field achieved by DBS programming using GUIDE XTTM versus standard-of-care clinical programming. The results showed that imaging-guided programming using GUIDE XTTM is as effective as clinical programming in controlling motor symptoms.
Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Neurosciences
Yingchuan Chen, Guanyu Zhu, Yuye Liu, Defeng Liu, Tianshuo Yuan, Xin Zhang, Yin Jiang, Tingting Du, Jianguo Zhang
Summary: The study found that changes in brain morphology are associated with the initial motor response to subthalamic nucleus deep brain stimulation in Parkinson's disease patients, and can be used to predict individual initial stimulation-related motor responses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Behavioral Sciences
Chun-Hwei Tai
Summary: Understanding the pathophysiological mechanism of Parkinson's disease in the subthalamic nucleus is crucial for effective treatment through deep brain stimulation. STN burst firing is considered an electrophysiological signature of the cortico-basal ganglia circuit in PD patients, and plays a significant role in the motor symptoms of PD as well. This review explores the origins of STN bursts, factors influencing their formation, and the potential for interventions to alleviate PD symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Neuroimaging
Bethany R. Isaacs, Margot Heijmans, Mark L. Kuijf, Pieter L. Kubben, Linda Ackermans, Yasin Temel, Max C. Keuken, Birte U. Forstmann
Summary: The study found that neurosurgeons are stable in selecting the DBS target site across MRI field strength, MRI contrast, and repetitions. However, the analysis of coordinates in MNI space revealed that the actual selected location of the electrode is seemingly more ventral when using the 3 T scan compared to the 7 T scans.
NEUROIMAGE-CLINICAL
(2021)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jiaming Mei, Bowen Chang, Chi Xiong, Manli Jiang, Chaoshi Niu
Summary: This study investigated the application of functional zonal image reconstruction in programming for deep brain stimulation (DBS) in Parkinson's disease (PD). The results showed that image reconstruction-guided programming led to reduced programming time and decreased patient discomfort episodes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Martina Bockova, Eva Vytvarova, Martin Lamos, Petr Klimes, Pavel Jurak, Josef Halamek, Sabina Goldemundova, Marek Balaz, Ivan Rektor
Summary: The response to subthalamic nucleus deep brain stimulation (STN-DBS) varies individually and is difficult to predict. While most patients did not show changes in global network organization, suboptimal responders exhibited decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas. The supplementary motor area was demonstrated to play an important role in the optimal response to DBS, with good responders showing increased node strength and eigenvector centrality in this brain region.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ahwon Kim, Jed Noel A. Ong, Hye Ran Park, Sun Ha Paek, Beomseok Jeon
Summary: This study aimed to investigate mortality and factors associated with mortality and causes of death after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. The results showed that 18.7% of patients died, with pneumonia being the most common cause of death. Older age, earlier disease onset, higher preoperative falling score while on medication, and higher preoperative total levodopa equivalent daily dose were associated with a higher risk of mortality.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jeanne Garcia, Cecile Hubsch, Ana Marques, Jean-Marc Gurruchaga, Cedric Lamirel, Emmanuel Roze, Antoine Moulignier
Summary: The study demonstrated that STN-DBS is a safe and effective treatment for PLHIV with Parkinson's disease, significantly improving symptoms without major adverse events; impulse control disorders were fully resolved after surgery.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Lulu Jiang, Wanru Chen, Qiyu Guo, Chao Yang, Jing Gu, Wenbiao Xian, Yanmei Liu, Yifan Zheng, Jing Ye, Shaohua Xu, Yu Hu, Lei Wu, Jie Chen, Hao Qian, Xiaoli Fu, Jinlong Liu, Ling Chen
Summary: The long-term therapeutic efficacy of STN-DBS can be achieved in southern China with relatively low stimulation intensity and medication dosage, maintaining motor improvement and medication reduction through an 8-year follow-up, while improvement in quality of life lasts for only 3 years. No definite changes in nonmotor symptoms were found after STN-DBS.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Clinical Neurology
Danilo Genovese, Francesco Bove, Leonardo Rigon, Tommaso Tufo, Alessandro Izzo, Paolo Calabresi, Anna Rita Bentivoglio, Carla Piano
Summary: This study assessed the clinical safety and efficacy of frameless bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients at 5 years after surgery. The results demonstrate that this technique is safe and well-tolerated, with sustained motor efficacy at 5 years post-surgery.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Samuel S. Bruce, Joshua Kahan, Tashfin Huq, Alejandro Santillan, Babak B. Navi, Alexander E. Merkler, Neal S. Parikh, Saad Mir, Andrew D. Schweitzer, Alan Z. Segal
Summary: This retrospective case series identified cerebrovascular complications in critically ill patients with COVID-19, primarily ischemic strokes, after prolonged sedation. Further studies are required to understand the risks of ischemic and hemorrhagic strokes, as well as the optimal management for this patient population.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Qiang Wang, Harith Akram, Muthuraman Muthuraman, Gabriel Gonzalez-Escamilla, Sameer A. Sheth, Simon Oxenford, Fang-Cheng Yeh, Sergiu Groppa, Nora Vanegas-Arroyave, Ludvic Zrinzo, Ningfei Li, Andrea Kuhn, Andreas Horn
Summary: This study compared the abilities of patient-specific, disease-matched, and normative structural connectivity data in predicting clinical improvement in DBS patients. The results indicated that patient-specific connectivity information and normative connectomes showed similar effectiveness in predicting clinical improvement.
Article
Neurosciences
Thomas Wirth, Viswas Dayal, Alexis de Roquemaurel, Francisca Ferreira, Nirosen Vijiaratnam, Harith Akram, Ludvic Zrinzo, Thomas Foltynie, Patricia Limousin
Summary: Short pulse width stimulation initially showed promise in improving tremor control and mitigating side effects, but these benefits seemed to dissipate during early follow-up. Our experience supports the need for longer-term outcome measurement when evaluating the usefulness of this stimulation mode in ET.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2021)
Article
Clinical Neurology
Joshua Kahan, Cameron J. Gibson, Sara B. Strauss, Matthew Bronstein, Robert J. Winchell, Philip S. Barie, Alan Z. Segal
Summary: COVID-19 can cause neurological manifestations, such as acute flaccid paralysis, in addition to respiratory symptoms. A case study reported a rare occurrence of spinal cord stroke associated with severe COVID-19 in a previously healthy young man. Early recognition and management of neurological complications in COVID-19 patients are crucial.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura Mancini, Stefano Casagranda, Guillaume Gautier, Philippe Peter, Bruno Lopez, Lewis Thorne, Andrew McEvoy, Anna Miserocchi, George Samandouras, Neil Kitchen, Sebastian Brandner, Enrico De Vita, Francisco Torrealdea, Marilena Rega, Benjamin Schmitt, Patrick Liebig, Eser Sanverdi, Xavier Golay, Sotirios Bisdas
Summary: This study investigated the clinical value of different CEST metrics for glioma classification and found that CEST-derived biomarkers for amides, amines, and their ratio are useful for histomolecular staging in gliomas. The study also revealed that AB/FS CEST mismatch can identify glioma subgroups that may have prognostic and clinical relevance.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Jordan Colman, Laura Mancini, Spyros Manolopoulos, Meetakshi Gupta, Michael Kosmin, Sotirios Bisdas
Summary: This review article examines the evidence for using diffusion tensor imaging (DTI) to guide intracranial radiotherapy and evaluates its applications in different diseases. The strongest evidence is found in arteriovenous malformations, while the evidence for other conditions is weaker.
APPLIED SCIENCES-BASEL
(2022)
Article
Clinical Neurology
Giorgio Lambru, Susie Lagrata, Andrew Levy, Sanjay Cheema, Indran Davagnanam, Khadija Rantell, Neil Kitchen, Ludvic Zrinzo, Manjit Matharu
Summary: Trigeminal microvascular decompression may be a safe and effective long-term treatment for patients with short-lasting unilateral neuralgiform headache attacks, especially those with MRI evidence showing neurovascular conflict with morphological changes. The study found that the majority of patients showed significant improvement in pain frequency after surgery, with no severe adverse events reported. MRI results indicated the presence of ipsilateral neurovascular conflict with morphological changes in most symptomatic nerves, supporting the efficacy of the surgical intervention.
Article
Cardiac & Cardiovascular Systems
Manuela De Michele, Joshua Kahan, Irene Berto, Oscar G. Schiavo, Marta Iacobucci, Danilo Toni, Alexander E. Merkler
Summary: The risk of stroke and cerebrovascular disease complicating SARS-CoV-2 infection has been extensively reported. The rapid development and mass vaccination of DNA and mRNA vaccines against SARS-CoV-2 have led to rare but catastrophic cases of thrombosis. This review provides an overview of stroke and cerebrovascular complications of SARS-CoV-2 infection, as well as vaccinations, with a focus on vaccine-induced immune thrombotic thrombocytopenia. A therapeutic protocol is proposed based on available data.
CIRCULATION RESEARCH
(2022)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Laura Mancini, Stefano Casagranda, Guillaume Gautier, Philippe Peter, Bruno Lopez, Lewis Thorne, Andrew McEvoy, Anna Miserocchi, George Samandouras, Neil Kitchen, Sebastian Brandner, Enrico De Vita, Francisco Torrealdea, Marilena Rega, Benjamin Schmitt, Patrick Liebig, Eser Sanverdi, Xavier Golay, Sotirios Bisdas
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Neurosciences
Adam Kenji Yamamoto, Ana Sanjuan, Rebecca Pope, Oiwi Parker Jones, Thomas M. H. Hope, Susan Prejawa, Marion Oberhuber, Laura Mancini, Justyna O. Ekert, Andrea Garjardo-Vidal, Megan Creasey, Tarek A. Yousry, David W. Green, Cathy J. Price
Summary: Using fMRI, researchers investigated the effects of right temporal lobe gliomas on neural processing during speech perception and production tasks. The study found that patients with right postero-superior temporal lobe tumors showed under-activation during auditory semantic matching, but over-activation during object naming. These findings highlight the importance of the right temporal lobe for language processing and suggest the need for further research on the effects of right temporal lobe tumors on language performance and neural reorganization.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Davide Cappon, James Gratwicke, Ludvic Zrinzo, Harith Akram, Jonathan Hyam, Marwan Hariz, Patricia Limousin, Thomas Foltynie, Marjan Jahanshahi
Summary: The study evaluated the three-year effects of NBM-DBS treatment in PDD patients and found that predictive factors for treatment efficacy include baseline attention level and sleep quality. Individual patients showed slower progression in cognitive decline, which may be related to responsiveness to NBM-DBS treatment.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Review
Neurosciences
Pauline Sarah Munchenberg, Eileen M. Joyce, Keith Matthews, David Christmas, Ludvic Zrinzo
Summary: Stereotactic radiofrequency ablation (SRA) may be beneficial for selected patients with refractory major depressive disorder (MDD), and the effect size is clearly defined.
Article
Clinical Neurology
Thomas Wirth, Francisca Ferreira, Nirosen Vijiaratnam, Christine Girges, Ashkan Pakzad, Alexis de Roquemaurel, Olga Sinani, Jonathan Hyam, Marwan Hariz, Ludvic Zrinzo, Harith Akram, Patricia Limousin, Thomas Foltynie
Summary: Severe postural tremor and less severe rest tremor are associated with poorer levodopa and STN-DBS response. Different brain locations are responsible for the correction of tremor and other parkinsonian features.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan Shapey, Sjoerd B. Vos, Laura Mancini, Brett Sanders, John S. Thornton, Jacques-Donald Tournier, Shakeel R. Saeed, Neil Kitchen, Sherif Khalil, Patrick Grover, Robert Bradford, Reuben Dorent, Rachel Sparks, Tom Vercauteren, Tarek Yousry, Sotirios Bisdas, Sebastien Ourselin
Summary: This study aimed to optimize a multi-shell rs-DWI protocol and develop a novel post-processing pipeline to accurately delineate the facial-vestibulocochlear complex within the skull base region, and evaluate its intraoperative accuracy using neuronavigation and tracked electrophysiological recordings.
EUROPEAN RADIOLOGY
(2023)
Review
Neurosciences
Alexis de Roquemaurel, Thomas Wirth, Nirosen Vijiaratnam, Francisca Ferreira, Ludvic Zrinzo, Harith Akram, Thomas Foltynie, Patricia Limousin
Summary: Through a systematic review of literature, this study supports the presence of a sweet spot located within the supero-lateral subthalamic nucleus and extending to the adjacent white matter.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2021)
