Article
Neurosciences
Lanfranco De Carolis, Silvia Galli, Edoardo Bianchini, Domiziana Rinaldi, Manikandan Raju, Bianca Calio, Marika Alborghetti, Francesco E. Pontieri
Summary: This study retrospectively investigated the clinical presentation and progression of Parkinson's disease (PD) during the first 5 years of illness in different age groups. The results showed significant differences in disease progression and non-motor symptoms among age groups in the early course of PD, with late-onset patients showing more pronounced gait disturbances and non-motor symptoms. These findings contribute to understanding the role of age at onset in PD progression and can be useful for managing the disease.
Article
Clinical Neurology
Efthalia Angelopoulou, Maria Bozi, Athina-Maria Simitsi, Christos Koros, Roubina Antonelou, Nikolaos Papagiannakis, Matina Maniati, Dafni Poula, Maria Stamelou, Demetrios K. Vassilatis, Ioannis Michalopoulos, Styliani Geronikolou, Nikolaos Scarmeas, Leonidas Stefanis
Summary: This study investigated the clinical differences between early-onset Parkinson's disease (EOPD) and mid-and-late-onset Parkinson's disease (MLOPD) in the Greek population. The results showed that EOPD and MLOPD have distinct clinical profiles regarding motor and non-motor symptoms, side of onset, and motor complications.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Health Care Sciences & Services
Emmie Cohen, Allison A. Bay, Liang Ni, Madeleine E. Hackney
Summary: Apathy is often overlooked in Parkinson's Disease (PD) but can have a negative impact on quality of life and increase with disease severity. Early identification of apathy can aid in treatment and improve prognosis.
Article
Neurosciences
Jingru Ren, Xiaoyan Zhan, Hao Zhou, Zhiying Guo, Yi Xing, Hangxing Yin, Chen Xue, Jun Wu, Weiguo Liu
Summary: Objective: GBA variants and onset age significantly affect clinical phenotype and progression in Parkinson's disease (PD). This study compared clinical characteristics and cognitive and motor progression among GBA-PD, early-iPD, and late-iPD patients. Results showed that GBA-PD patients had more severe symptoms and faster progression compared to early-iPD and late-iPD patients. However, onset age did not have a significant impact on clinical features and progression in GBA-PD patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Iago Garcia Diaz, Maria Cristina iniguez Alvarado, Jose Manuel Paz, Silvia Jesus, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Zebenzui Mendoza, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Seijo, Caridad Valero, Ruben Alonso Redondo, Maria Teresa Buongiorno, Carlos Ordas, Manuel Menendez-Gonzalez, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir, A. D. Adarmes, A. D. Adarmes, M. Almeria, M. G. Alonso Losada, A. Alonso Canovas, F. Alonso Frech, R. Alonso Redondo, I. alvarez, M. alvarez Sauco, A. Aneiros Diaz, S. Arnaiz, S. Arribas, A. Ascunce Vidondo, M. Aguilar, M. A. avila, N. Nernardo Lambrich, H. Bejr-Kasem, M. Blazquez Estrada, M. Boti, C. Borrue, M. T. Buongiorno, C. Cabello Gonzalez, I. Cabo Lopez, N. Caballol, A. Camara Lorenzo, H. Canfield Medina, E. Carabajal Pendon, F. Carrillo, F. J. Carrillo Padilla, E. Casas, M. J. Catalan, P. Clavero, A. Cortina Fernandez, M. Cosgaya, A. Cots Foraster, A. Crespo Cuevas, E. Cubo, T. de Deus Fonticoba, O. de Fabregues-Boixar, M. Diez-Fairen, J. Dotor Garcia-Soto, E. Erro, S. Escalante, EEstelrich Peyret, N. Fernandez Guillan, P. Gamez, M. Gallego, J. Garcia Caldentey, C. Garcia Campos, C. Garcia Diez, J. M. Garcia Moreno, I. Gaston, M. P. Gomez Garre, V. Gomez Mayordomo, J. Gonzalez Aloy, I. Gonzalez-Aramburu, J. Gonzalez Ardura, B. Gonzalez Garcia, M. J. Gonzalez Palmas, G. R. Gonzalez Toledo, A. Golpe Diaz, M. Grau Sola, G. Guardia, J. Hernandez Vara, A. Horta-Barba, DIdoate Calderon, J. Infante, S. Jesus, J. Kulisevsky, M. Kurtis, C. Labandeira, M. A. Labrador, F. Lacruz, M. Lage Castro, S. Lastres Gomez, I. Legarda, NLopez Ariztegui, L. M. Lopez Diaz, D. Lopez Dominguez, L. Lopez Manzanares, B. Lopez Seoane, S. Lucas del Pozo, Y. Macias, M. Mata, G. Marti Andres, M. J. Marti, J. C. Martinez Castrillo, P. Martinez-Martin, D. McAfee, M. T. Meitin, Z. Mendoza Plasencia, M. Menendez Gonzalez, C. Mendez del Barrio, P. Mir, J. Miranda Santiago, M. I. Morales Casado, A. Moreno Dieguez, I. Muro Garcia, V. Nogueira, A. Novo Amado, S. Novo Ponte, C. Ordas, J. Pagonabarraga, I. Parees, B. Pascual-Sedano, P. Pastor, A. Perez Fuertes, R. Perez Noguera, A. Planas-Ballve, L. Planellas, M. A. Prats, C. Prieto Jurczynska, V. Puente, M. Pueyo Morlans, A. Puig Davi, N. Redondo Rafales, L. Rodriguez Mendez, ABRodriguez Perez, F. Roldan, M. Ruiz De Arcos, J. Ruiz Martinez, P. Sanchez Alonso, M. Sanchez-Carpintero, G. Sanchez Diez, A. Sanchez Rodriguez, P. Santacruz, D. Santos Garcia, J. C. Segundo Rodriguez, M. Seijo, M. Sierra Pena, B. Solano Vila, E. Suarez Castro, J. P. Tartari, C. Valero, L. Vargas, L. Vela, C. Villanueva
Summary: This study aimed to analyze the change in cognitive function in patients with young-onset Parkinson's disease (YOPD) compared to those with a later onset and controls. The results showed that YOPD patients had better cognitive function compared to non-YOPD patients and controls, while non-YOPD patients experienced a significant decline in cognitive function during the study. At the end of the study, the incidence of dementia and mild cognitive impairment was significantly higher in non-YOPD patients than in YOPD patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Xuelin Tang, Paulina Gonzalez-Latapi, Connie Marras, Naomi P. Visanji, Wanli Yang, Christine Sato, Anthony E. Lang, Ekaterina Rogaeva, Ming Zhang
Summary: This study demonstrates for the first time that DNAm-age acceleration is associated with the age at onset of Parkinson's disease, and the faster-aging group has a higher risk.
MOVEMENT DISORDERS
(2022)
Article
Multidisciplinary Sciences
Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju
Summary: The study revealed that fall-related risk factors in patients with early Parkinson's disease (PD) were highly associated with gastrointestinal dysautonomia.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Kaixin Dou, Jiangnan Ma, Xue Zhang, Wanda Shi, Mingzhu Tao, Anmu Xie
Summary: This study aimed to develop clinical risk models using non-motor predictors to distinguish between early Parkinson's disease (PD) and healthy individuals. In addition, prognostic models were constructed to predict the progression of non-motor symptoms in de novo PD patients at a 5-year follow-up.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Xiangwei Kong, Shuying Li, Lan Wang, Xianran Xu, Xiaojing Gu, Junyu Lin, Zheng Jiang, Jiao Liu, Wei Song, Bei Cao, Huifang Shang
Summary: Patients with early-onset Parkinson's disease (EOPD) have a higher prevalence of suicidal ideation (SI) and depression, with risk factors including depression, non-smoking, and lower education level.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Carolin Gabbert, Inke R. Koenig, Theresa Lueth, Beke Kolms, Meike Kasten, Eva-Juliane Vollstedt, Alexander Balck, Anne Gruenewald, Christine Klein, Joanne Trinh
Summary: The study found that smoking, coffee drinking, and aspirin intake are associated with age at onset in Parkinson's disease patients, and this association was further supported by multivariate regression models.
JOURNAL OF NEUROLOGY
(2022)
Article
Gastroenterology & Hepatology
Michele D. Lewis, Jyothsna Talluri, C. Mel Wilcox, Judah N. Abberbock, Gong Tang, Darwin L. Conwell, Peter A. Banks, Gregory A. Cote, Stuart Sherman, Samer Alkaade, Timothy B. Gardner, Michelle A. Anderson, Bimaljit S. Sandhu, Thiruvengadam Muniraj, Chris E. Forsmark, Nalini Guda, Andres Gelrud, Joseph Romagnuolo, Randall Brand, Jessica LaRusch, Stephen T. Amann, Adam Slivka, David C. Whitcomb, Dhiraj Yadav
Summary: This study confirmed the characteristics of early-onset ICP and late-onset ICP, as well as their differences from ACP, in a large cohort of North American patients. Genetic factors have a significant impact on ICP patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Clinical Neurology
Irene Rosas, German Moris, Eliecer Coto, Marta Blazquez-Estrada, Esther Suarez, Ciara Garcia-Fernandez, Carmen Martinez, Israel Duarte Herrera, Sergio Perez-Oliveira, Victoria Alvarez, Manuel Menendez-Gonzalez
Summary: This study assessed the impact of genetic and non-genetic factors on the age at onset and survival in PD patients, finding associations between smoking, APOE variants, and increased survival rate in early-onset PD.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Pauli Ylikotila, Jussi Sipila, Tiina Alapirtti, Riitta Ahmasalo, Eriko Koshimizu, Satoko Miyatake, Anri Hurme-Niiranen, Ari Siitonen, Hiroshi Doi, Fumiaki Tanaka, Naomichi Matsumoto, Kari Majamaa, Laura Kytovuori
Summary: Recent study found that repeat expansion is a rare cause of early-onset Parkinson's disease. Among a nationwide cohort of Finnish patients, 1.10% had biallelic repeat expansion in the RFC1 gene.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jose A. Pineda-Pardo, Alvaro Sanchez-Ferro, Mariana H. G. Monje, Nicola Pavese, Jose A. Obeso
Summary: The striatal dopaminergic deficit in Parkinson's disease follows a somatotopically related pattern, with an upper-limb onset and progression to other regions of the striatum. The denervation of the putamen was confirmed in both hemispheres and corresponding hemibodies. The findings suggest a precise somatotopic onset of nigrostriatal denervation in Parkinson's disease.
Article
Clinical Neurology
Kangli Fan, Hongguang Zhao, Yinghua Li, Xiaoxiao Du, Yuyin Dai, Lulu Gao, Yi Li, Zhihui Sun, Ying Zhang
Summary: This study aims to explore the difference between C-11-CFT PET imaging in early-onset Parkinson's disease (EOPD) and late-onset Parkinson's disease (LOPD), and analyze its correlation with disease duration, H & Y stage, motor symptoms, and non-motor symptoms, in order to evaluate its value in assessing disease severity.
FRONTIERS IN NEUROLOGY
(2023)
Article
Primary Health Care
Sarah Tonkin-Crine, Monsey McLeod, Aleksandra J. Borek, Anne Campbell, Philip Anyanwu, Ceire Costelloe, Michael Moore, Benedict Hayhoe, Koen B. Pouwels, Laurence S. J. Roope, Liz Morrell, Susan Hopkins, Christopher C. Butler, Ann Sarah Walker
Summary: The use of an implementation intervention to improve antimicrobial stewardship strategies in high-prescribing practices did not have a significant effect on antibiotic prescribing. Clinicians need detailed information and monitoring of their engagement to ensure optimal use of these strategies.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Medicine, General & Internal
Christopher C. Butler, F. D. Richard Hobbs, Oghenekome A. Gbinigie, Najib M. Rahman, Gail Hayward, Duncan B. Richards, Jienchi Dorward, David M. Lowe, Joseph F. Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Benjamin R. Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P. B. Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D. Jani, Nigel D. Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C. Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little
Summary: This study aimed to determine the safety, effectiveness, and cost-effectiveness of molnupiravir in vaccinated high-risk patients in the community. The results showed that molnupiravir did not reduce hospital admissions or deaths associated with COVID-19 compared to usual care in this population.
Biographical-Item
Clinical Neurology
Huw R. Morris, Andrew J. Lees
MOVEMENT DISORDERS
(2023)
Biographical-Item
Clinical Neurology
Huw R. Morris, Andrew J. Lees
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Duncan Street, Edwin Jabbari, Alyssa Costantini, P. Simon Jones, Negin Holland, Timothy Rittman, Marte T. Jensen, Viorica Chelban, Yen Y. Goh, Tong Guo, Amanda J. Heslegrave, Federico Roncaroli, Johannes C. Klein, Olaf Ansorge, Kieren S. J. Allinson, Zane Jaunmuktane, Tamas Revesz, Thomas T. Warner, Andrew J. Lees, Henrik Zetterberg, Lucy L. Russell, Martina Bocchetta, Jonathan D. Rohrer, David J. Burn, Nicola Pavese, Alexander Gerhard, Christopher Kobylecki, P. Nigel Leigh, Alistair Church, Michele T. M. Hu, Henry Houlden, Huw Morris, James B. Rowe
Summary: The study compares candidate clinical trial end points in progressive supranuclear palsy, multiple system atrophy, corticobasal syndrome and related disorders. Neuroimaging metrics generally require smaller sample sizes than cognitive and functional measures, but the optimal outcome measures differ by disease type.
Article
Immunology
Jienchi Dorward, Yukteshwar Sookrajh, Richard Lessells, Elliot Bulo, Jessica Naidoo, Keshani Naidoo, Nicola Bodley, Mlungisi Khanyile, Claudia Jansen Van Vuuren, Pravikrishnen Moodley, Natasha Samsunder, Lara Lewis, Paul K. K. Drain, Gail Hayward, Christopher C. C. Butler, Nigel Garrett
Summary: This study aimed to assess the feasibility of conducting a randomized trial of point-of-care viral load testing and provide estimates of effect for potential future trial design. The results showed that point-of-care viral load testing led to quicker results and fewer clinical visits, but there was no significant difference in viral load suppression between the two arms at 24 weeks.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Primary Health Care
Melanie E. Hoste, Marta Wanat, Nina Gobat, Marilena Anastasaki, Femke Boehmer, Slawomir Chlabicz, Annelies Colliers, Karen Farrell, Maria-Nefeli Karkana, John Kinsman, Christos Lionis, Ludmila Marcinowicz, Katrin Reinhardt, Ingmarie Skoglund, Paer-Daniel Sundvall, Akke Vellinga, Herman Goossens, Christopher C. Butler, Alike van der Velden, Sarah Tonkin-Crine, Sibyl Anthierens
Summary: During the first wave of the COVID-19 pandemic, patients consulting in primary care in eight European countries expressed the need for testing to identify the cause of their illness and manage uncertainty. Some patients testing positive for COVID-19 believed they were immune from future infection, affecting their behavior.
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2023)
Article
Clinical Neurology
Patrick W. Cullinane, Riona Fumi, Marte Theilmann Jensen, Edwin Jabbari, Thomas T. Warner, Tamas Revesz, Huw R. Morris, Jonathan D. Rohrer, Zane Jaunmuktane
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Medicine, General & Internal
Su-Gwan Tham, Isabelle M. Hunt, Pauline Turnbull, Louis Appleby, Nav Kapur, Duleeka Knipe
Summary: This study examines the relationship between migration and suicide risk in the UK, finding that identifying the clinical profile and antecedents to suicide is crucial for tailoring mental health care to different migrant groups.
Article
Health Care Sciences & Services
Hein Heuvelman, Neil M. Davies, Yoav Ben-Shlomo, Alan Emond, Jonathan Evans, David Gunnell, Rachel Liebling, Richard Morris, Rupert Payne, Claire Storey, Maria Viner, Dheeraj Rai
Summary: This study examines the associations between the use of antidepressants during pregnancy and outcomes using multiple methods to strengthen causal inference. The results show that women who initiate or continue antidepressants during pregnancy are more likely to have contact with healthcare services and continue antidepressant use after pregnancy. However, there is little evidence for substantial associations between antidepressant use and autism, attention deficit hyperactivity disorder, or intellectual disability in children.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Infectious Diseases
Thomas R. Fanshawe, Rebecca K. Judge, Sam Mort, Christopher C. Butler, Gail N. Hayward
Summary: Given the lack of accurate rapid diagnostics for UTI in women, guidelines have been developed to support appropriate antibiotic prescribing, but some guidelines have not been validated. A study was conducted to validate the diagnostic accuracy of two guidelines: Public Health England (GW-1263) and Scottish Intercollegiate Guidelines Network (SIGN160). The results demonstrate the potential for diagnostic error when using these guidelines for managing uncomplicated UTI and making antimicrobial prescribing decisions.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Jane Vennik, Adam W. A. Geraghty, Kate Martinson, Lucy Yardley, Beth Stuart, Michael Moore, Nick Francis, Alastair Hay, Theo Verheij, Katherine Bradbury, Kate Greenwell, Laura Dennison, Sian Williamson, James Denison-Day, Ben Ainsworth, James Raftery, Shihua Zhu, Christopher Butler, Samantha Richards-Hall, Paul Little
Summary: Most adults in the UK experience viral respiratory tract infections (RTIs) annually, and certain individuals are at higher risk. Common nasal sprays and digital interventions promoting physical activity and stress management are being tested to reduce the incidence and severity of RTIs. This randomized controlled trial aims to compare the effectiveness and economic impact of these interventions. Recruitment started in December 2020 and is expected to be completed by April 2024.
Article
Medicine, General & Internal
Harriet A. Ball, Elizabeth Coulthard, Mark Fish, Antony Bayer, John Gallacher, Yoav Ben-Shlomo
Summary: This study examines the association between subjective cognitive decline (sSCD) and objective cognition, finding a weak correlation between the two. Older age, poor sleep quality, and higher anxiety are independent predictors of sSCD. The study suggests that sSCD, in the absence of objective decline, may be an example of poor meta-cognition and a potential driver for functional cognitive disorder (FCD).
Article
Psychiatry
Duleeka Knipe, Emma Vallis, Luke Kendall, Martha Snow, Kyla Kirkpatrick, Rosie Jarvis, Chris Metcalfe, Nathan Eisenstadt, Viv Bickham
Summary: The suicide rate in high-risk high-harm perpetrators of domestic abuse is significantly higher than many other high-risk groups. Improving their mental health and outcomes is essential to reduce the impact of suicides on the victims of abuse.
CRISIS-THE JOURNAL OF CRISIS INTERVENTION AND SUICIDE PREVENTION
(2023)
Article
Psychiatry
May C. van Schalkwyk, Jeff Collin, Michael Eddleston, Mark Petticrew, Melissa Pearson, Lisa Scholin, Nason Maani, Flemming Konradsen, David Gunnell, Duleeka Knipe
Summary: Suicide is preventable, but effective strategies are lacking in many settings. The influence of commercial actors on suicide prevention has been overlooked. Shifting focus to the underlying causes and understanding the impact of commercial determinants on suicide can bring transformative potential. A proposed framework aims to guide research and address the inequitable distribution of commercial determinants of suicide.