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Bilateral Cerebellorubrothalamic Fibers Stimulation for Essential Tremor?

MOVEMENT DISORDERS (2011)

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MOVEMENT DISORDERS

卷 26, 期 7, 页码 1366-1367

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WILEY-BLACKWELL

DOI: 10.1002/mds.23542

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Clinical Neurology

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Does Head Tremor Predict Postural Instability After Bilateral Thalamic Stimulation in Essential Tremor?

Jack Shen, Luca Marsili, Alok K. Dwivedi, Gregory Kuhlman, Andrew P. Duker, Alberto J. Espay, Abhimanyu Mahajan

Summary: This study found no correlation between head tremor and postural instability in patients with essential tremor who underwent bilateral ventral intermediate nucleus deep brain stimulation.

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Comparative connectivity correlates of dystonic and essential tremor deep brain stimulation

Takashi Tsuboi, Joshua K. Wong, Robert S. Eisinger, Lela Okromelidze, Mathew R. Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D. Foote, Michael S. Okun, Sanjeet S. Grewal, Erik H. Middlebrooks

Summary: The optimal targets for deep brain stimulation in essential tremor and dystonic tremor remain unknown. This study suggests that DBS targeting the ventral intermediate nucleus/ventralis oralis posterior nucleus border and ventral intermediate nucleus region may be a reasonable treatment option for medication-refractory dystonic tremor and essential tremor patients. Our findings highlight the involvement of cerebello-thalamo-cortical and basal ganglia-thalamo-cortical networks in the pathophysiology of dystonic tremor.

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Response to Thalamic Ventralis Intermedius Nucleus Deep Brain Stimulation in Essential Tremor vs. Essential Tremor-Plus

Gabriela S. Gilmour, Davide Martino, Karen Hunka, Pia Lawrence, Zelma H. T. Kiss, Veronica Bruno

Summary: In this study, it was found that patients with ET-plus had similar tremor outcomes after VIM DBS compared to those with ET, without the development of new neurological issues. This suggests that patients with ET-plus can still be considered good candidates for VIM DBS treatment of tremor.

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Bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of essential tremor: a case series study

Raul Martinez-Fernandez, Sujitha Mahendran, Jose Angel Pineda-Pardo, Lukas L. Imbach, Jorge U. Manez-Miro, Fabian Buechele, Marta del Alamo, Rafael Rodriguez-Rojas, Frida Hernandez-Fernandez, Beat Werner, Michele Matarazzo, Ignacio Obeso, Lain H. Gonzalez-Quarante, Gunther Deuschl, Lennart Stieglitz, Christian R. Baumann, Jose A. Obeso

Summary: Unilateral magnetic resonance-guided focused ultrasound (FUS) thalamotomy is effective for treating medically refractory essential tremor (ET). The feasibility, safety, and efficacy of bilateral staged FUS thalamotomy for ET were explored in this study, showing promising results in improving voice and head tremor.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

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Article Clinical Neurology

Bilateral Focused Ultrasound Thalamotomy for Essential Tremor (BEST-FUS Phase 2 Trial)

Christian Iorio-Morin, Kazuaki Yamamoto, Can Sarica, Ajmal Zemmar, Mathieu Levesque, Simon Brisebois, Jurgen Germann, Aaron Loh, Alexandre Boutet, Gavin J. B. Elias, Paula Azevedo, Elizabeth Adam, Urmi Patel, Martha Lenis, Suneil K. Kalia, Mojgan Hodaie, Alfonso Fasano, Andres M. Lozano

Summary: This study demonstrated that staged bilateral magnetic resonance-guided focused ultrasound thalamotomy can significantly improve quality of life and tremor symptoms in patients with medically refractory essential tremor, with a reasonable safety profile.

MOVEMENT DISORDERS (2021)

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Article Clinical Neurology

Wearable sensor-driven responsive deep brain stimulation for essential tremor

Stephanie Cernera, Jose D. Alcantara, Enrico Opri, Jackson N. Cagle, Robert S. Eisinger, Zachary Boogaart, Leena Pramanik, Madison Kelberman, Bhavana Patel, Kelly D. Foote, Michael S. Okun, Aysegul Gunduz

Summary: The study aimed to establish a physiology-driven responsive DBS system for personalized therapy in ET based on EMG signals. Results showed that EMG-driven rDBS provides clinically equivalent tremor suppression compared to traditional cDBS, while delivering less total electrical energy, leading to increased battery life of the INS.

BRAIN STIMULATION (2021)

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Deep brain stimulation for essential tremor versus essential tremor plus: should we target the same spot in the thalamus?

Cherry H. Yu, Daniel H. Lench, Christine Cooper, Nathan C. Rowland, Istvan Takacs, Gonzalo Revuelta

Summary: The study aimed to investigate the optimal stimulation sites and their overlap with white matter tracts in different subtypes of essential tremor (ET) and essential tremor plus syndrome (ET-plus). The results showed no significant differences in optimal stimulation site or white-matter tract overlap between ET, ET-plus, and ET-plus subgroups. This suggests that VIM DBS therapy is equally effective for ET and ET-plus patients.

FRONTIERS IN HUMAN NEUROSCIENCE (2023)

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Anodic and symmetric biphasic pulses enlarge the therapeutic window in deep brain stimulation for essential tremor

Alexandra Boogers, Jana Peeters, Tine Van Bogaert, Boateng Asamoah, Philippe De Vloo, Wim Vandenberghe, Bart Nuttin, Myles Mc Laughlin

Summary: This study aimed to investigate the effect of anodic and symmetric biphasic pulses on the therapeutic window in essential tremor patients. The results showed that anodic stimulation and symmetric biphasic stimulation could increase the therapeutic window in ET patients.

BRAIN STIMULATION (2022)

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Letter Clinical Neurology

Gender differences in referrals for deep brain stimulation for essential tremor

Paul Reker, Stefanie T. Jost, Petra Schiller, Alexandra Gronostay, Gereon R. Fink, Veerle Visser-Vandewalle, Keyoumars Ashkan, Alexandra Rizos, Pablo Martinez-Martin, Lena Strobel, Afsar Sattari, Lars Timmermann, Anna Sauerbier, K. Ray Chaudhuri, Elke Kalbe, Haidar S. Dafsari

Summary: Deep brain stimulation (DBS) is an effective treatment for essential tremor (ET). Gender differences have been observed in DBS for Parkinson's disease, and this systematic chart review also found gender differences in DBS treatment for ET. The main reason for this is the underrepresentation of women in referrals for surgical evaluation.

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Comparative neural correlates of DBS and MRgFUS lesioning for tremor control in essential tremor

Jurgen Germann, Brendan Santyr, Alexandre Boutet, Can Sarica, Clement T. Chow, Gavin J. B. Elias, Artur Vetkas, Andrew Yang, Mojgan Hodaie, Alfonso Fasano, Suneil K. Kalia, Michael L. Schwartz, Andres M. Lozano

Summary: Comparing the efficacy maps of DBS and MRgFUS suggests a potential alternative location for lesioning, more antero-superiorly. This may reduce complications, without sacrificing efficacy, and individualise targeting.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2023)

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Peripheral electrical stimulation to reduce pathological tremor: a review

Alejandro Pascual-Valdunciel, Grace W. Hoo, Simon Avrillon, Filipe Oliveira Barroso, Jennifer G. Goldman, Julio C. Hernandez-Pavon, Jose L. Pons

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Lateral cerebellothalamic tract activation underlies DBS therapy for Essential Tremor

AnneMarie Brinda, Julia P. Slopsema, Rebecca D. Butler, Salman Ikramuddin, Thomas Beall, William Guo, Cong Chu, Remi Patriat, Henry Braun, Mojgan Goftari, Tara Palnitkar, Joshua Aman, Lauren Schrock, Scott E. Cooper, Joseph Matsumoto, Jerrold L. Vitek, Noam Harel, Matthew D. Johnson

Summary: By using ultra-high field MRI, researchers developed subject-specific pathway activation models for directional DBS leads. The study found that the efficacy and side effects of DBS therapy for Essential Tremor were associated with the activation of different pathways in the brain, and the degree of activation was significantly correlated with the suppression of tremor and the severity of side effects. Therefore, a model-based programming approach can achieve more selective activation of specific regions in the brain.

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Yue Lv, Mengran Wang, Juan Yang, Jin Shi, Tingting Xuan, Junmei Zhang, Dandan Du, Jiang Cheng, Haining Li

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The effect of tremor on disability assessment in chronic inflammatory demyelinating polyradiculoneuropathy

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Protocol of a randomized controlled trial investigating Deep Brain Stimulation for MOtor symptoms in patients with Parkinson's disease DEmentia (DBS-MODE)

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Predicting Motor Outcome and Quality of Life After Subthalamic Deep Brain Stimulation for Parkinson's Disease: The Role of Standard Screening Measures and Wearable-Data

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JOURNAL OF PARKINSONS DISEASE (2023)

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Bilateral Cerebellorubrothalamic Fibers Stimulation for Essential Tremor?

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WILEY-BLACKWELL

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