Article
Neurosciences
An Vo, Katharina A. Schindlbeck, Nha Nguyen, Andrea Rommal, Phoebe G. Spetsieris, Chris C. Tang, Yoon Young Choi, Martin Niethammer, Vijay Dhawan, David Eidelberg
Summary: Functional imaging is widely used to identify disease-specific networks in neurodegenerative disorders. In Parkinson's disease, network assortativity increases over time, with high assortativity associated with clinically aggressive genetic variants and low assortativity associated with genes related to slow progression.
Article
Neurosciences
Cecilia Boccalini, Giulia Carli, Andrea Pilotto, Alessandro Padovani, Daniela Perani
Summary: This study investigated the impact of gender differences on clinical features, dopaminergic dysfunction, and connectivity in patients with Parkinson's disease across different clinical subtypes. Results showed that males and females with idiopathic PD exhibit distinct vulnerabilities and disease expressions, particularly in cognitive function, anxiety symptoms, and dopaminergic binding patterns in different brain regions.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Geriatrics & Gerontology
Eleonora Maggioni, Federica Arienti, Stella Minella, Francesca Mameli, Linda Borellini, Martina Nigro, Filippo Cogiamanian, Anna Maria Bianchi, Sergio Cerutti, Sergio Barbieri, Paolo Brambilla, Gianluca Ardolino
Summary: Music-based interventions have been shown to enhance motor, sensory, and cognitive functions in Parkinson's disease (PD). However, the underlying mechanisms are not fully understood. This study used EEG to investigate connectivity patterns in PD patients, finding enhanced activity but reduced information flow, partly normalized by music. Music appears to support inter-hemispheric communication in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
D. Santos-Garcia, T. de Deus Fonticoba, C. Cores Bartolome, E. Suarez Castro, S. Jesus, P. Mir, B. Pascual-Sedano, J. Pagonabarraga, J. Kulisevsky, J. Hernandez-Vara, L. L. Planellas, I. Cabo-Lopez, M. Seijo-Martinez, I. Legarda, F. Carrillo Padilla, N. Caballol, E. Cubo, V. Nogueira, M. G. Alonso Losada, N. Lopez Ariztegui, I. Gonzalez Aramburu, J. Garcia Caldentey, C. Borrue, C. Valero, P. Sanchez Alonso
Summary: The study found that Parkinson's disease patients with impulsive-compulsive behaviors are more likely to suffer from depression, particularly in relation to pathological gambling, compulsive eating behavior, and hobbyism-punding.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Yingtan Wang, Zhe Lu, Guanglei Xun
Summary: Piribedil, commonly used for Parkinson's disease, may lead to impulse control disorders like pathological gambling and depressive episodes as side effects. Close monitoring and timely adjustments during treatment are crucial in preventing adverse reactions.
Article
Engineering, Biomedical
Sandeep Avvaru, Keshab K. Parhi
Summary: This paper introduces a novel causality measure called frequency-domain convergent cross-mapping (FDCCM) that utilizes frequency-domain dynamics through nonlinear state-space reconstruction. The experiments on synthesized chaotic timeseries and Parkinson's disease datasets demonstrate that FDCCM is robust and can be used for causal inference and classification in complex systems.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Clinical Neurology
Jan Booij, Sem P. Tellier, John Seibyl, Chris Vriend
Summary: This study reveals the influence of season and sunlight on dopamine transporter availability in early Parkinson's disease patients and healthy controls. The researchers found that DAT availability in the left caudate nucleus of PD patients was higher in spring and summer, and positively correlated with higher sun exposure. In addition, the latitude of the PPMI site was negatively associated with DAT availability in both PD patients and healthy controls.
MOVEMENT DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Natasha S. R. Bidesi, Ida Vang Andersen, Albert D. Windhorst, Vladimir Shalgunov, Matthias M. Herth
Summary: Parkinson's disease is a widespread neurodegenerative disorder characterized by alpha-synuclein accumulation and dopaminergic neurons loss. Molecular imaging techniques such as MRI, SPECT, and PET have shown effectiveness in aiding clinical diagnosis and understanding the heterogeneity of PD. However, challenges remain in using molecular imaging for early diagnosis and differentiation from atypical parkinsonisms.ongoing research focuses on new imaging targets, particularly alpha-synuclein, for detecting pathological changes related to PD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Behavioral Sciences
Kirsi Murtomaki, Juho Joutsa, Tuomas Mertsalmi, Elina Jaakkola, Elina Makinen, Reeta Levo, Mikael Eklund, Simo Nuuttila, Eero Pekkonen, Tommi Noponen, Toni Ihalainen, Valtteri Kaasinen, Filip Scheperjans
Summary: In this study, it was found that Parkinson's disease patients with irritable bowel syndrome (IBS) had higher I-1(2)3-FP-CIT binding in the right posterior putamen and adjacent areas. No other significant associations were found between gastrointestinal symptoms and DAT or SERT binding.
BRAIN AND BEHAVIOR
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felipe Arriva Pitella, Ana Carolina Trevisan, Leonardo Alexandre-Santos, Mery Kato, Manuelina Mariana Capellari Macruz Brito, Vitor Tumas, Lauro Wichert-Ana
Summary: This study aimed to evaluate different quantitative indexes of striatum dopamine transporter density in healthy subjects and patients with Parkinson's disease (PD). The results showed that the binding potential index (BPI) had higher sensitivity and specificity in differentiating PD and healthy subjects, while the asymmetry index (AI) and putamen/caudate ratio (P/C) had lower performance and reliability. Caution should be exercised when using AI and P/C.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Clinical Neurology
Peng Liu, Dehao Yang, Fan Zhang, Shuqi Chen, Fei Xie, Yong Luo, Haotian Wang, Yueting Chen, Zhiru Lin, Lebo Wang, Xinhui Chen, Bo Wang, Sheng Wu, Zhiyuan Ouyang, Zhidong Cen, Wei Luo
Summary: In this study, the clinical, neuroimaging, and pathological characteristics of patients with Parkinson's disease carrying pathogenic GGC repeat expansion in NOTCH2NLC were investigated. Although these patients were clinically diagnosed with Parkinson's disease, their pathological findings indicated a phenotype of Parkinson's disease that mimics neuronal intranuclear inclusion disease. Systemic areflexia may be an important clinical clue for further genetic testing and confirmatory skin biopsy in patients presenting with a Parkinson's disease phenotype.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Sevilay Ayyildiz, Halil Aziz Velioglu, Behcet Ayyildiz, Bernis Sutcubasi, Lutfu Hanoglu, Zubeyir Bayraktaroglu, Suleyman Yildirim, Alper Atasever, Burak Yulug
Summary: The claustrum is a poorly understood structure of gray matter in the telencephalon. It is considered a multimodal computing network due to its connections with cortical and subcortical structures. Specific changes in the claustrum's connections in Alzheimer's disease and Parkinson's disease remain unclear.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Simo Nuuttila, Mikael Eklund, Juho Joutsa, Elina Jaakkola, Elina Makinen, Emma A. Honkanen, Kari Lindholm, Tommi Noponen, Toni Ihalainen, Kirsi Murtomaki, Tanja Nojonen, Reeta Levo, Tuomas Mertsalmi, Filip Scheperjans, Valtteri Kaasinen
Summary: The study on Parkinson's disease (PD), essential tremor (ET), and healthy controls found that the Glabellar tap reflex (GR) cannot effectively differentiate between PD and ET patients, and it exhibits significant inconsistency over time.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Clinical Neurology
Martin M. Reich, Joey Hsu, Michael Ferguson, Frederic L. W. V. J. Schaper, Juho Joutsa, Jonas Roothans, Robert C. Nickl, Anneke Frankemolle-Gilbert, Jay Alberts, Jens Volkmann, Michael D. Fox
Summary: The study demonstrates that the decline in cognitive function caused by deep brain stimulation (DBS) is related to the connectivity between the stimulation site and a specific brain network associated with memory impairment. Transforming this network into a heat map can help identify DBS patients at risk of delayed-onset side-effects and guide reprogramming efforts.
Article
Medical Laboratory Technology
Maia Norman, Tal Gilboa, David R. Walt
Summary: This study developed a panel of single molecule array assays for pathological isoforms and PTMs related to Parkinson's disease. Measurement of these analytes in the cerebrospinal fluid of Parkinson's disease patients showed potential utility in improving diagnostic accuracy and monitoring patients in clinical trials.
CLINICAL CHEMISTRY
(2022)
Article
Clinical Neurology
Emanuela Formaggio, Michele Tonellato, Angelo Antonini, Leonora Castiglia, Laura Gallo, Paolo Manganotti, Stefano Masiero, Alessandra Del Felice
Summary: This study aims to explore the pathophysiological mechanisms of Parkinson disease (PD) by examining changes in EEG rhythms after transcranial magnetic stimulation (TMS). The study found that TMS can temporarily normalize brain oscillations in PD patients, providing a theoretical basis for the development of practical, portable techniques to treat PD symptoms.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Psychology, Clinical
Franziska Maier, Andrea Greuel, Marius Hoock, Rajbir Kaur, Masoud Tahmasian, Frank Schwartz, Ilona Csoti, Frank Jessen, Alexander Drzezga, Thilo van Eimeren, Lars Timmermann, Carsten Eggers
Summary: This study investigated impaired self-awareness of cognitive deficits in Parkinson's disease (PD) and its associations with clinical-behavioral and neuroimaging markers. The results showed that PD patients with mild cognitive impairment (PD-MCI) had significantly higher impaired self-awareness than healthy controls and PD patients without MCI. Neuroimaging analysis revealed that glucose metabolism in the cingulate cortex was negatively correlated with impaired self-awareness. In PD-MCI patients, impaired self-awareness was associated with decreased metabolism in the right temporal lobe, insula, and midcingulate cortex. These findings suggest that impaired self-awareness of cognitive deficits in PD may be related to disruptions in the cognitive network and metabolic changes in specific brain regions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Jonathan Voeglein, Nicolai Franzmeier, John C. Morris, Marianne Dieterich, Eric McDade, Mikael Simons, Oliver Preische, Anna Hofmann, Jason Hassenstab, Tammie L. Benzinger, Anne Fagan, James M. Noble, Sarah B. Berman, Neill R. Graff-Radford, Bernardino Ghetti, Martin R. Farlow, Jasmeer P. Chhatwal, Stephen Salloway, Chengjie Xiong, Celeste M. Karch, Nigel Cairns, Richard J. Perrin, Gregory Day, Ralph Martins, Raquel Sanchez-Valle, Hiroshi Mori, Hiroyuki Shimada, Takeshi Ikeuchi, Kazushi Suzuki, Peter R. Schofield, Colin L. Masters, Alison Goate, Virginia Buckles, Nick C. Fox, Patricio Chrem, Ricardo Allegri, John M. Ringman, Igor Yakushev, Christoph Laske, Mathias Jucker, Gunter Hoglinger, Randall J. Bateman, Adrian Danek, Johannes Levin
Summary: Autosomal dominant Alzheimer's disease (ADAD) has distinct neurological examination findings that are useful for estimating prognosis and guiding clinical care and therapeutic trial designs.
ALZHEIMERS & DEMENTIA
(2023)
Review
Clinical Neurology
Andrew Lees, Eduardo Tolosa, Fabrizio Stocchi, Joaquim J. Ferreira, Olivier Rascol, Angelo Antonini, Werner Poewe
Summary: There is a resurgence of levodopa as the initial treatment for Parkinson's disease, while the addition of adjuvant treatments is an established strategy to reduce motor complications. Improving levodopa delivery to the brain and combining agents earlier in the disease course can leverage the full potential of this strategy.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Aron Emmi, Aleksandar Tushevski, Alessandro Sinigaglia, Silvia Barbon, Michele Sandre, Elena Stocco, Veronica Macchi, Angelo Antonini, Luisa Barzon, Andrea Porzionato, Raffaele De Caro
Summary: Angiotensin-converting enzyme 2 receptor (ACE2R) is a transmembrane protein that plays a key role in blood pressure regulation. It has gained attention for its involvement in the pathogenesis of COVID-19. This study investigated the expression of ACE2R and TMPRSS2 in the brainstem and found that they are expressed in neuronal and glial cells, particularly in specific nuclei. These findings help to understand the neurological manifestations of COVID-19.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Stefanie T. Jost, Agni Konitsioti, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Anna Sauerbier, Maria Gabriela dos Santos Ghilardi, Franz Rosenkranz, Lena Strobel, Alexandra Gronostay, Michael T. Barbe, Julian Evans, Veerle Visser-Vandewalle, Christopher Nimsky, Gereon R. Fink, Monty Silverdale, Rubens G. Cury, Erich T. Fonoff, Angelo Antonini, K. Ray Chaudhuri, Lars Timmermann, Pablo Martinez-Martin, Haidar S. Dafsari
Summary: This study suggests that patients with 'postural instability and gait difficulty' (PIGD) may experience more beneficial non-motor effects compared to patients with 'tremor-dominant' symptoms undergoing deep brain stimulation (DBS) for Parkinson's disease (PD). These differences in clinical efficacy on non-motor aspects should be taken into consideration when advising and monitoring PD patients undergoing DBS.
PARKINSONISM & RELATED DISORDERS
(2023)
Review
Clinical Neurology
Thilo van Eimeren, Kathrin Giehl, Kathrin Reetz, Cristina Sampaio, Tiago A. Mestre
Summary: Neuroimaging biomarkers play an important role in Huntington's disease clinical trials, but reliable biomarkers are still relatively scarce. The results of the study show that MRI-based volumetric analysis of the caudate and putamen is currently the most feasible biomarker for early disease stages.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Chemistry, Analytical
Mariana H. G. Monje, Sylvie Grosjean, Martin Srp, Laura Antunes, Raquel Bouca-Machado, Ricardo Cacho, Sergio Dominguez, John Inocentes, Timothy Lynch, Argyri Tsakanika, Dimitrios Fotiadis, George Rigas, Evzen Ruzicka, Joaquim Ferreira, Angelo Antonini, Norberto Malpica, Tiago Mestre, Alvaro Sanchez-Ferro
Summary: The healthcare model is shifting towards integrated care approaches that involve patients more closely. The iCARE-PD project aims to develop a technology-enabled, home-based, and community-centered integrated care paradigm to address this need. The project's central focus is the codesign process of the care model, with active patient participation in designing and iteratively evaluating sensor-based technological solutions. The results show the usefulness of this approach in testing usability and acceptability, as well as incorporating patients' feedback into the development.
Article
Biochemistry & Molecular Biology
Michael He, Tiffany A. Kolesar, Andrew L. Goertzen, Marcus C. Ng, Ji Hyun Ko
Summary: Although not traditionally associated, Alzheimer's disease (AD) and epilepsy share common features and can increase the risk of each other. This study utilized a machine learning algorithm (MAD) to analyze fluorodeoxyglucose positron emission tomography (FDG-PET) scans from epilepsy patients with and without cognitive symptoms. The results suggest that FDG-PET, combined with machine learning, may be useful in predicting dementia development in non-demented epilepsy patients. Further longitudinal studies are needed to evaluate the effectiveness of this approach.
Review
Pharmacology & Pharmacy
Marta Campagnolo, Aron Emmi, Roberta Biundo, Eleonora Fiorenzato, Lucia Batzu, K. Ray Chaudhuri, Angelo Antonini
Summary: Behavioural symptoms in Parkinson's disease, including depression, anxiety, impulse control disorders, hallucinations, psychosis, and cognitive dysfunction, are often overlooked and not adequately addressed in many patients. Current literature suggests refraining from using dopamine agonists without considering their potential benefits on motor complications.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Clinical Neurology
Andrea Guerra, Valentina D'Onofrio, Florinda Ferreri, Matteo Bologna, Angelo Antonini
Summary: Although clinician-based assessment is the gold standard for quantifying motor impairment in Parkinson's disease, there are limitations such as variability and approximation. Objective motion analyses can complement clinical assessment and provide more accurate evaluations of motor symptoms and complications in PD.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Alessandro Padovani, Angelo Antonini, Paolo Barone, Giuseppe Bellelli, Andrea Fagiolini, Luigi Ferini Strambi, Sandro Sorbi, Fabrizio Stocchi
Summary: This Delphi study aims to reach a shared point of view among Italian specialists on depression in Alzheimer's disease (AD). Consensus was achieved in most cases (86%), with 80% of statements receiving positive consensus and 6% receiving negative consensus. The study also highlights the strong link between depression and AD, as well as specific features of depression in AD compared to major depressive disorder (MDD).
NEUROLOGICAL SCIENCES
(2023)
Meeting Abstract
Clinical Neurology
K. Giehl, H. Theis, A. Ophey, J. Hammes, P. Reker, C. Eggers, E. Kalbe, T. Van Eimeren
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Meeting Abstract
Clinical Neurology
M. Hoenig, A. Weller, E. Doering, G. Bischof, A. Drzezga, T. Van Eimeren
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garri, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffaele De Caro, Gabor G. Kovacs, Angelo Antonini
Summary: This study investigated the alterations of alpha-synuclein and glial responses in duodenum biopsies of Parkinson's disease (PD) patients. The findings provide evidence of synuclein pathology and gliosis in the duodenum of PD patients, including early cases, suggesting the important role of the gut in PD pathogenesis.
MOVEMENT DISORDERS
(2023)