Article
Medicine, General & Internal
Jingyi Wang, Kangping Xiong, Jingyuan Chao, Sheng Zhuang, Jie Li, Chunfeng Liu
Summary: Seasonal change is associated with the severity of nonmotor symptoms (NMS) in Chinese Parkinson's disease (PD) patients. PD patients assessed in summer showed less severe autonomic dysfunction and REM sleep behavior disorder (RBD) symptoms, while those assessed in spring and winter experienced more sleep disturbance. These findings suggest a relationship between seasonal change and NMS fluctuation, particularly in early stage PD patients.
CHINESE MEDICAL JOURNAL
(2023)
Article
Neurosciences
Ana Gomez-Lopez, Arantxa Sanchez-Sanchez, Elena Natera-Villalba, Victoria Ros-Castello, Alvaro Beltran-Corbellini, Samira Fanjul-Arbos, Isabel Parees Moreno, Jose Luis Lopez-Sendon Moreno, Juan Carlos Martinez Castrillo, Araceli Alonso-Canovas
Summary: A retrospective study found that the use of Safinamide significantly improves urinary symptoms in patients with Parkinson's disease, particularly urgency, incontinence, frequency, and nocturia, providing a treatment option for patients.
Article
Neurosciences
Lili Chen, Junling Wang, Mingrui Xia, Lianglong Sun, Junyan Sun, Linlin Gao, Dongling Zhang, Tao Wu
Summary: This study aimed to identify the functional connectivity changes of nucleus accumbens subregions in Parkinson's disease and characterize the association of network changes and non-motor symptoms. The results showed reduced connectivity between the subregions of nucleus accumbens and extensive brain regions in Parkinson's disease patients compared to healthy controls. These subregions were associated with depression, anxiety, apathy, cognitive impairment, excessive daytime sleepiness, olfactory impairment, and rapid eye movement sleep behavior disorder.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Ryul Kim, Han-Joon Kim, Jung Hwan Shin, Chan Young Lee, Seung Ho Jeon, Beomseok Jeon
Summary: This study found that peripheral inflammation in early-stage Parkinson's disease (PD) may be related to the progression of nonmotor symptoms (NMSs), particularly mood symptoms. By measuring six inflammatory markers, the researchers found that elevated levels of IL-2 and IL-6 were associated with the progression of NMSs.
MOVEMENT DISORDERS
(2022)
Article
Behavioral Sciences
Panteleimon Oikonomou, Daniel J. van Wamelen, Daniel Weintraub, Dag Aarsland, Dominic Ffytche, Pablo Martinez-Martin, Carmen Rodriguez-Blazquez, Valentina Leta, Corinne Borley, Carolina Sportelli, Dhaval Trivedi, Aleksandra M. Podlewska, Katarina Rukavina, Alexandra Rizos, Claudia Lazcano-Ocampo, Kallol Ray Chaudhuri
Summary: Identifying predictors of incident cognitive impairment in Parkinson's disease through comprehensive baseline measures of nonmotor symptoms, particularly hallucinations and perceptual problems, can be used to predict future cognitive impairment in this population. This approach offers a simple holistic strategy for prognostic counseling and personalized medicine.
BRAIN AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Angel Carvajal-Oliveros, Carmen Dominguez-Baleon, Ivan Sanchez-Diaz, Diego Zambrano-Tipan, Rene Hernandez-Vargas, Jorge M. M. Campusano, Veronica Narvaez-Padilla, Enrique Reynaud
Summary: Synphilin-1, encoded by the SNCAIP gene, is associated with familial Parkinson's disease and is a major component of Lewy bodies in PD patients. Expression of Synphilin-1 in fruit flies induces neurodegeneration and PD-like symptoms. This study investigated the contribution of serotonergic and dopaminergic circuits in the development of PD-like phenotypes and found that olfactory and visual symptoms are primarily due to the serotonergic system, while motor symptoms and reduced survival are mainly contributed by the dopaminergic system. Chronic nicotine treatment was able to alleviate some of these symptoms, suggesting beneficial effects of nicotine on specific PD symptoms.
Article
Cell Biology
Viviana Lo Buono, Rosanna Palmeri, Simona De Salvo, Matteo Berenati, Agata Greco, Rosella Ciurleo, Chiara Sorbera, Vincenzo Cimino, Francesco Corallo, Placido Bramanti, Silvia Marino, Giuseppe Di Lorenzo, Lilla Bonanno
Summary: Anxiety and depression in Parkinson's disease can reduce patients' well-being, but multidisciplinary rehabilitative training has positive effects on mood, motor abilities, cognitive and speech skills, and quality of life. Non-motor symptoms are often overlooked, but can be managed effectively through comprehensive rehabilitation programs.
NEURAL REGENERATION RESEARCH
(2021)
Article
Geriatrics & Gerontology
Juan Huang, Lin Chen, Binbin Hu, Hui Wang, Xinyue Zhang, Xingfu Tian, Shu Wang, Wei Huang
Summary: The prevalence and related factors of subjective cognitive complaints (SCCs) differ between early-stage and advanced-stage Parkinson's disease (PD) patients. Higher nonmotor symptoms questionnaire (NMSQ) scores are associated with SCCs in early-stage PD, while lower attention and visuospatial/executive abilities scores are related to SCCs in advanced-stage PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Sule Tinaz, Serageldin Kamel, Sai S. Aravala, Mine Sezgin, Mohamed Elfil, Rajita Sinha
Summary: This study found that subclinical neuropsychiatric symptoms in Parkinson's disease patients are associated with abnormal functional connectivity of distinct neural circuits, even at an early stage of the disease. Understanding these neural correlates may help in early interventions to prevent the onset of clinical symptoms.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Shengfang Song, Zhehui Luo, Chenxi Li, Xuemei Huang, Eric J. Shiroma, Eleanor M. Simonsick, Honglei Chen
Summary: This study longitudinally assessed depressive symptoms in older adults with Parkinson's disease (PD) and found that depressive symptoms start to increase a few years prior to PD diagnosis and become significantly different from expected levels one year before diagnosis.
Article
Neurosciences
Monica R. Langley, Shivani Ghaisas, Bharathi N. Palanisamy, Muhammet Ay, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
Summary: Mitochondrial dysfunction is implicated in the pathogenesis of Parkinson's disease. MitoPark mice exhibit progressive deficits in olfactory discrimination, cognitive learning and memory, anxiety, and depression-like behaviors. Antidepressant treatment can reverse depressive behavior observed in the forced swim test.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Detao Meng, Zhaohui Jin, Yixuan Wang, Boyan Fang
Summary: The study aimed to investigate the effect of neuropsychiatric symptoms on cognitive decline in patients with Parkinson's disease. Longitudinal data from the Parkinson's Progression Markers Initiative cohort were analyzed using linear mixed-effects models and generalized estimating equations. The results showed that depression, anxiety, apathy, and psychosis were associated with global cognitive decline, and patients with these symptoms were more likely to meet the criteria for mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Zimple Kurlawala, Paul H. Shadowen, Joseph D. McMillan, Levi J. Beverly, Robert P. Friedland
Summary: Nonmotor symptoms in Parkinson's disease can start up to a decade before motor manifestations and strongly correlate with quality of life. This study systematically characterized the progression of NMS in PD, with males experiencing a greater burden compared to females. The laterality of motor symptoms did not significantly influence NMS progression, except for anxious mood.
PARKINSONS DISEASE
(2021)
Article
Medicine, General & Internal
Fanny Urbain, Isabelle Hardy-Leger, Ghaidaa Adebs-Nasser, Mathilde de Menthon, Cecile Pivert, Aude Mausoleo, Ariane Laparra, Nathalie Lerolle, Paul-Albert Domnariu, Olivier Lambotte, Christian Denier, Cecile Goujard, Alicia Castro-Gordon, Nicolas Noel
Summary: This study investigated the psychological symptoms and cognitive impairment in patients with Behcet's disease. The findings suggest that some patients experience psychological problems and cognitive dysfunction, with anxiety, somatization, and phobia being the most common symptoms. Cognitive impairment is associated with disease activity score but not with brain MRI abnormalities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Svetlana Tomic, Igor Kuric, Tihana Gilman Kuric, Zvonimir Popovic, Jagoda Kragujevic, Tea Mirosevic Zubonja, Ines Rajkovaca, Sara Matosa
Summary: This study found that SD in PD patients is related to age, motor symptoms severity, and an increased risk in patients with moderate-to-severe motor symptoms. There was no correlation between SD and autonomic dysfunction, sleep disturbances, or other nonmotor symptoms, and no sex difference.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
Article
Clinical Neurology
Thomas Guttuso, Daniel Sirica, Duygu Tosun, Robert Zivadinov, Ofer Pasternak, Daniel Weintraub, Francesca Baglio, Niels Bergsland
Summary: This study assessed the free water content changes in cognitive-relevant brain regions in early Parkinson's disease patients and their correlation with cognitive decline over time and baseline cognitive status. Results showed that free water was the most robust assessment modality for these outcomes and may assist in identifying cognition protective therapies in clinical trials.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Hannah Staunton, Kim Kelly, Louise Newton, Mathias Leddin, Raul Rodriguez-Esteban, K. Ray Chaudhuri, Daniel Weintraub, Ronald B. Postuma, Pablo Martinez-Martin
Summary: This study aims to create a conceptual model of symptoms and impacts for individuals with early-stage Parkinson's disease (PD) by collecting qualitative data. The results show that the most frequently reported symptoms in early-stage PD include tremors, stiffness and rigidity, and fatigue, while the most commonly reported impacts include anxiety, eating and drinking, and exercise/sport and relationship with family/family life. The conceptual model can be used to guide researchers in developing and selecting patient-centered outcomes for clinical trials and inform future qualitative research and outcome development specifically for early-stage PD patients.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Maiko Takahashi, Jinsoo Koh, Shoko Yorozu, Yoshinori Kajimoto, Yoshiaki Nakayama, Mayumi Sakata, Masaaki Yasui, Yasuhiro Hiwatani, Daniel Weintraub, Hidefumi Ito
Summary: The present study validated the Japanese version of QUIP-RS and determined the characteristics of ICBs in Japan. The use of QUIP-RS-J enables standardized assessment of ICBs and can be used in clinical research.
PARKINSONS DISEASE
(2022)
Article
Neurosciences
Lara Bloemeke, Marlene Pils, Victoria Kraemer-Schulien, Alexandra Dybala, Anja Schaffrath, Andreas Kulawik, Fabian Rehn, Anneliese Cousin, Volker Nischwitz, Johannes Willbold, Rebecca Zack, Thomas F. Tropea, Tuyen Bujnicki, Gultekin Tamgueney, Daniel Weintraub, David Irwin, Murray Grossman, David A. Wolk, John Q. Trojanowski, Oliver Bannach, Alice Chen-Plotkin, Dieter Willbold
Summary: The formation of toxic oligomers by proteins such as aSyn and Tau is a characteristic feature of neurodegenerative diseases. This study measured the concentrations of aSyn and Tau aggregates in cerebrospinal fluid samples from different diagnostic groups and found that sFIDA-based measurements can differentiate between these groups. The findings suggest that sFIDA has the potential to improve pre-clinical and clinical studies and identify individuals who are likely to respond to compounds designed to target specific oligomers.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Thomas F. Tropea, Teresa Waligorska, Sharon X. Xie, Ilya M. Nasrallah, Katheryn A. Q. Cousins, John Q. Trojanowski, Murray Grossman, David J. Irwin, Daniel Weintraub, Edward B. Lee, David A. Wolk, Alice S. Chen-Plotkin, Leslie M. Shaw
Summary: The objective of this study was to determine if plasma tau phosphorylated at threonine 181 (p-tau181) can distinguish Alzheimer's disease (AD) from normal cognition (NC) in adults, predict cognitive and functional decline, and validate findings in an external cohort. The results showed that plasma p-tau181 can accurately differentiate AD pathology from NC, and higher levels of p-tau181 are associated with faster cognitive and functional decline.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
John L. Robinson, Sharon X. Xie, Daniel R. Baer, EunRan Suh, Vivianna M. Van Deerlin, Nicholas J. Loh, David J. Irwin, Corey T. McMillan, David A. Wolk, Alice Chen-Plotkin, Daniel Weintraub, Theresa Schuck, Virginia M. Y. Lee, John Q. Trojanowski, Edward B. Lee
Summary: In this retrospective study, the incidence of 10 pathologies in neurodegenerative disease (ND) and normal aging was examined, with up to seven pathologies observed concurrently resulting in 161 different combinations. The presence of multiple additive pathologies was associated with factors such as longer disease duration, clinical dementia, older age, and APOE e4 status.
Article
Clinical Neurology
Danielle S. Abraham, Thanh Phuong Pham Nguyen, Leah J. Blank, Dylan Thibault, Shelly L. Gray, Sean Hennessy, Charles E. Leonard, Daniel Weintraub, Allison W. Willis
Summary: This study examined the differential prescribing patterns between new and established treatments for common neurological conditions. Using data from a national sample of US commercially insured adults from 2005-2019, the study compared new users of recently approved medications for three conditions: diabetic peripheral neuropathy, Parkinson disease psychosis, and epilepsy. The results showed that newer medications were more frequently prescribed to individuals with prior treatment, suggesting potential bias in comparative effectiveness and safety studies. The study emphasizes the importance of reporting propensity score non-overlap in comparative studies involving newer medications and suggests methodological approaches to address channeling bias.
Article
Clinical Neurology
Katheryn A. Q. Cousins, David J. Irwin, Alice Chen-Plotkin, Leslie M. Shaw, Sanaz Arezoumandan, Edward B. Lee, David A. Wolk, Daniel Weintraub, Meredith Spindler, Andres Deik, Murray Grossman, Thomas F. Tropea
Summary: This study found that plasma GFAP may be sensitive to concomitant AD pathology in LBSD, especially accumulation of beta-amyloid plaques.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Kalpana M. Merchant, Tanya Simuni, Janel Fedler, Chelsea Caspell-Garcia, Michael Brumm, Kelly N. H. Nudelman, Elizabeth Tengstrandt, Frank Hsieh, Roy N. Alcalay, Christopher Coffey, Lana Chahine, Tatiana Foroud, Andrew Singleton, Daniel Weintraub, Samantha Hutten, Todd Sherer, Brit Mollenhauer, Andrew Siderowf, Caroline Tanner, Ken Marek
Summary: We quantified concentrations of three isoforms of BMP in different cohorts of Parkinson's disease patients and found that LRRK2 and GBA1 gene mutations were associated with elevated BMP levels. However, BMP is not a prognostic or disease progression biomarker.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Daniel Weintraub, Marina Picillo, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Cornelis Blauwendraat, Ethan G. Brown, Lana M. Chahine, Christopher S. Coffey, Roseanne D. Dobkin, Tatiana Foroud, Doug Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Tanya Simuni, Andrew Siderowf, Andrew Singleton, John Seibyl, Caroline M. Tanner
Summary: This study used data from a multi-site, international, prospective cohort study to investigate the impact of dopamine system-related biomarkers on cognitive impairment in Parkinson's disease. The results showed that alterations in the dopamine system were associated with the development of cognitive impairment in Parkinson's disease. If confirmed causative, these findings suggest that the dopamine system is instrumental to cognitive health status throughout the disease course.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Daniel Weintraub
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hubert H. Fernandez, Daniel Weintraub, Eric Macklin, Irene Litvan, Michael A. Schwarzschild, Jamie Eberling, Aleksandar Videnovic, Christopher J. Kenney
Summary: In patients with Parkinson disease dementia (PDD), SYN120 did not improve cognition significantly but showed potential benefits in cognitive activities of daily living and apathy.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Thanh Phuong Pham Nguyen, Shelly L. Gray, Craig W. Newcomb, Qing Liu, Ali G. Hamedani, Daniel Weintraub, Sean Hennessy, Allison W. Willis
Summary: This study found that there were no significant differences in medication prescriptions between Parkinson disease (PD) patients hospitalized for serious injury and those hospitalized for other reasons, indicating a missed opportunity to deprescribe high-risk medications during care transitions.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Vindhya Koneru, Alberto J. Espay, Allan J. Cole, Daniel Weintraub, Kathleen Crist, Maria B. Pascual, William G. Ondo
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Daniel Weintraub
MOVEMENT DISORDERS
(2023)