期刊
MOVEMENT DISORDERS
卷 26, 期 12, 页码 2283-2286出版社
WILEY-BLACKWELL
DOI: 10.1002/mds.23934
关键词
Parkinson's disease; alpha-synuclein; GATA transcription factors; biomarker; genome-wide association study
资金
- NIH [R01 NS064155, R21 NS060227, K24 NS060991]
- Harvard NeuroDiscovery Center
- Michael J. Fox Foundation
- M.E.M.O. Hoffman Foundation
- RJG Foundation
- Neurologix, Inc.
Background: Mutations in the alpha-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P = .0032). Conclusions: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to sporadic disease. (C) 2011 Movement Disorder Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据