期刊
MOVEMENT DISORDERS
卷 26, 期 7, 页码 1282-1289出版社
WILEY-BLACKWELL
DOI: 10.1002/mds.23681
关键词
botulinum toxin; primary dystonia; cervical dystonia; cortical plasticity; paired associative stimulation; transcranial magnetic stimulation; TMS
资金
- EFNS Scientific Fellowship
- Movement Disorders Society
- Dystonia Medical Research Foundation, Tourette Syndrome Association
- GSK
- Boehringer-Ingelheim
- Ipsen
- Merz
- Wellcome Trust
- MRC [WT089698]
- Dystonia Society UK
- Teva Pharmaceuticals and Orio
- NIHR
- [222918]
- [223524]
- MRC [MC_G1000735] Funding Source: UKRI
- Medical Research Council [MC_G1000735] Funding Source: researchfish
Botulinum toxin injections ameliorate dystonic symptoms by blocking the neuromuscular junction and weakening dystonic contractions. We asked if botulinum toxin injections in dystonia patients might also affect the integrity of sensorimotor cortical plasticity, one of the key pathophysiological features of dystonia. We applied a paired associative stimulation protocol, known to induce long-term potentiation-like changes in the primary motor cortex hand area to 12 patients with cervical dystonia before and 1 and 3 months after botulinum toxin injections to the neck muscles. Primary motor cortex excitability was probed by measuring transcranial magnetic stimulation-evoked motor evoked potentials before and after paired associative stimulation. We also measured the input-output curve, short-interval intracortical inhibition, intracortical facilitation, short afferent inhibition, and long afferent inhibition in hand muscles and the clinical severity of dystonia. Before botulinum toxin injections, paired associative stimulation significantly facilitated motor evoked potentials in hand muscles. One month after injections, this effect was abolished, with partial recovery after 3 months. There were significant positive correlations between the facilitation produced by paired associative stimulation and (1) the time elapsed since botulinum toxin injections and (2) the clinical dystonia score. One effect of botulinum toxin injection treatment is to modulate afferent input from the neck. We propose that subsequent reorganization of the motor cortex representation of hand muscles may explain the effect of botulinum toxin on motor cortical plasticity. (C) 2011 Movement Disorder Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据