期刊
MOVEMENT DISORDERS
卷 26, 期 5, 页码 837-843出版社
WILEY-BLACKWELL
DOI: 10.1002/mds.23576
关键词
Parkinson's disease; illusory misidentification; visual cortices; positron emission tomography; overlapping figure identification test
资金
- Grants-in-Aid for Scientific Research [23700617, 22800056, 22611002, 22300345, 23135502] Funding Source: KAKEN
Idiopathic Parkinson's disease (PD) is associated with documented impairments in various visual functions. However, there have been only a limited number of studies that have reported on the brain regions responsible for impairment of visual recognition in PD. In our study, we evaluated the performance of PD patients and 24 healthy controls on the Poppelreuter-type overlapping figure identification test to investigate the impairment of visual recognition. We also measured the PD patients' resting cerebral glucose metabolism using (18)F-fluorodeoxyglucose positron emission tomography and investigated the relationship between the impairment of visual recognition and cortical hypometabolism. The PD patients had substantial and frequent illusory responses in the overlapping figure identification test, and their illusory misidentifications were correlated with hypometabolism in the visual cortices, including the right inferior temporal gyrus and the bilateral temporo-parieto-occipital junction. These findings suggest that PD patients have impaired visual recognition characterized by illusory misidentifications of visual stimuli, which could be attributed to dysfunction of the visual cortices. (C) 2011 Movement Disorder Society
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