Article
Pediatrics
Lourdes M. DelRosso, Maria P. Mogavero, Raffaele Ferri
Summary: Sleep-related movement disorders, including restless legs syndrome, periodic limb movements of sleep, and restless sleep disorder, affect sleep quality. While advancements have been made in adults, research on the phenomenology and consequences of sleep-related movements in children is just beginning, necessitating new approaches and diagnostic standards.
PEDIATRIC PULMONOLOGY
(2022)
Article
Clinical Neurology
Davide Sparasci, Raffaele Ferri, Anna Castelnovo, Silvia Miano, Kosuke Tanioka, Naoko Tachibana, Chiara Carelli, Gianna Riccitelli, Giulio Disanto, Chiara Zecca, Claudio Gobbi, Mauro Manconi
Summary: Restless legs syndrome (RLS) is highly frequent in patients with multiple sclerosis (MS), with a comparable frequency of periodic limb movements during sleep (PLMS) to the general population. The low percentage of patients with RLS having a high PLMS index, together with the absence of correlation between RLS and clinical and polysomnography parameters, indicates the existence of a distinct symptomatic form of RLS in MS.
Article
Clinical Neurology
Jacob L. Edelson, Logan D. Schneider, David Amar, Andreas Brink-Kjaer, Katie L. Cederberg, Zoltan Kutalik, Erika W. Hagen, Paul E. Peppard, Priscila Farias Tempaku, Sergio Tufik, Daniel S. Evans, Katie Stone, Greg Tranah, Brian Cade, Susan Redline, Jose Haba-Rubio, Raphael Heinzer, Pedro Marques-Vidal, Peter Vollenweider, Juliane Winkelmann, James Zou, Emmanuel Mignot
Summary: A genome-wide association study discovered two genetic loci that were significantly associated with periodic limb movements in sleep. These movements were found to be genetically correlated with restless leg syndrome, insomnia, and risk of stroke, but not with iron deficiency. Causal effect of restless leg syndrome on periodic limb movements in sleep was identified through analysis.
Article
Behavioral Sciences
Raffaele Ferri, Maria P. Mogavero, Oliviero Bruni, Daniel L. Picchietti, Lourdes M. DelRosso
Summary: This study reviewed and selected studies on the evaluation of the effect of antidepressants on PLMS index during sleep. A meta-analysis using a random-effects model was conducted, and the level of evidence for each paper was assessed. Twelve studies were included in the analysis, seven interventional and five observational. The use of SSRIs showed a larger effect size compared to other antidepressants. However, more studies are needed to confirm the absent or smaller effect of other categories of antidepressants.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Donald L. Bliwise, Elias G. Karroum, Sophia A. Greer, Stewart A. Factor, Lynn Marie Trotti
Summary: The study found no association between restless legs symptoms and periodic leg movements in sleep in Parkinson's disease patients, suggesting that restless legs symptoms in PD patients may have a different pathophysiology compared to RLS in the non-PD population.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Raffaele Ferri, Davide Sparasci, Anna Castelnovo, Silvia Miano, Kosuke Tanioka, Naoko Tachibana, Chiara Carelli, Gianna Carla Riccitelli, Giulio Disanto, Chiara Zecca, Claudio Gobbi, Mauro Manconi
Summary: This study compared leg movement activity during sleep among patients with multiple sclerosis, idiopathic restless legs syndrome, and healthy controls. The results showed that patients with multiple sclerosis had poorer sleep quality and less leg movement activity compared to those with idiopathic restless legs syndrome. These findings may have important implications for the treatment of restless legs syndrome secondary to multiple sclerosis.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Clinical Neurology
Kevin J. Hochstrasser, Steven C. Rogers, Arshed Quyyumi, Dayna Johnson, Victoria Pak, Amit J. Shah, David B. Rye, Lynn Marie Trotti
Summary: This study aimed to evaluate the relationship between restless legs syndrome (RLS) and periodic limb movements of sleep (PLMS) with subclinical cardiovascular disease (CVD). The findings suggest that there is a certain association between RLS and subclinical CVD, and a significant correlation between PLMS and subclinical CVD. Further research is needed to determine the relationship between PLMS and CVD risk.
SLEEP AND BIOLOGICAL RHYTHMS
(2023)
Review
Clinical Neurology
Ioanna Kouri, Mithri R. Junna, Melissa C. Lipford
Summary: This article provides summaries of restless legs syndrome (RLS), periodic limb movements of sleep, and periodic limb movement disorder. RLS is a common sleep disorder that affects 5% to 15% of the general population. RLS can occur in childhood and its prevalence increases with age. It can be caused by various factors such as iron deficiency, chronic renal failure, peripheral neuropathy, and certain medications. Treatment options include pharmacologic agents and nonpharmacologic therapies. Periodic limb movements of sleep often accompany RLS but can also occur independently. The clinical significance of these movements is still debated. Periodic limb movement disorder is a distinct sleep disorder that occurs in individuals without RLS and is diagnosed by exclusion.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Raffaele Ferri, Alessandro Silvani, Maria P. Mogavero, Francesco Rundo, Oliviero Bruni, Daniel L. Picchietti, Lourdes M. DelRosso
Summary: The study found that important heart rate changes accompany leg movements during sleep in children and adolescents with restless legs syndrome, similar to adults. The heart rate changes during short-interval leg movements were characterized by tachycardia, while periodic leg movements and isolated leg movements were followed by relative bradycardia. Age-related differences were also observed in the relative bradycardia following heart rate increase during periodic leg movements and isolated leg movements.
JOURNAL OF SLEEP RESEARCH
(2021)
Review
Clinical Neurology
Lourdes M. DelRosso, Maria P. Mogavero, Raffaele Ferri, Oliviero Bruni
Summary: This review summarizes the latest evidence on the clinical presentation, pathophysiology, comorbidities, and treatment options of RSD, aiming to assist pediatricians in timely identifying children with RSD.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Clinical Neurology
Arunima Roy, Christopher J. Earley, Richard P. Allen, Zachary A. Kaminsky
Summary: This study developed an epigenetic biomarker for restless leg syndrome (RLS) and iron deficiency anemia, showing good replicability in lymphocytes and neural tissue samples. The blood-based biomarker model accurately predicted RLS status in the replication cohort, with further research needed for clinical translation and fine-tuning of the model.
Review
Clinical Neurology
Narat Srivali, Charat Thongprayoon, Supawit Tangpanithandee, Pajaree Krisanapan, Michael A. Mao, Andrey Zinchuk, Brain B. Koo, Wisit Cheungpasitporn
Summary: Through a systematic review and meta-analysis of observational studies, an association between periodic limb movements during sleep (PLMS) and hypertension was found. The pooled risk ratio of hypertension in patients with PLMS was 1.26 (95% CI, 1.12-1.41). Further prospective or interventional studies are needed to confirm this association.
Article
Clinical Neurology
Nicola Andrea Marchi, Arton Peci, Jose Haba-Rubio, Geoffroy Solelhac, Virginie Bayon, Mathieu Berger, Peter Vollenweider, Pedro Marques-Vidal, Armin von Gunten, Marie-Pierre Francoise Strippoli, Martin Preisig, Bogdan Draganski, Raphael Heinzer
Summary: This cross-sectional study found no significant association between periodic leg movements and cognitive functioning among community-dwelling older adults. However, further studies are needed to clarify the relationship between periodic leg movements and cognitive functioning, as there is a lack of data in this field.
Article
Clinical Neurology
Haipeng Zhang, Ye Zhang, Rong Ren, Linghui Yang, Yuan Shi, Michael V. Vitiello, Larry D. Sanford, Xiangdong Tang
Summary: This study explores the differences in sleep and leg movement between patients with idiopathic restless legs syndrome (RLS) and healthy controls using polysomnography. The results show significant differences in various sleep parameters and leg movement parameters between RLS patients and healthy controls. It is important to note that the distribution of periodic limb movement during sleep (PLMS) and the periodicity index may provide valuable information for understanding the specific characteristics of RLS.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Environmental Sciences
Hyeyun Kim, Kwang Ik Yang, Jun-Sang Sunwoo, Jongkyu Park, Nam Hun Heo, Jee Hyun Kim, Seung Bong Hong
Summary: Periodic limb movement during sleep (PLMS) and restless legs syndrome (RLS) are common in children and adolescents, but often overlooked. This study found that in Korean adolescents, PLMS without restless legs symptoms is associated with excessive daytime sleepiness (EDS) and insufficient sleep, while PLMS with restless legs symptoms is associated with male gender, witness apnea, consuming coffee, and being prone to Internet addiction.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ricardo Cardoso Cassilhas, Ricardo Augusto Leoni De Sousa, Luciana Caxa, Valter Viana, Romain Meeusen, Fabio Luiz Goncalves, Caique Olegario Magalhaes, Sergio Tufik, Marco Fabricio Dias Peixoto, Renato Sobral Monteiro Junior, Marco Tulio de Mello
Summary: Indoor aerobic exercise, compared to outdoor exercise, results in lower pollution exposure for elderly individuals, leading to improved cognitive function and increased BDNF levels. Additionally, indoor exercise shows significant benefits for glycemic control.
AIR QUALITY ATMOSPHERE AND HEALTH
(2022)
Article
Biology
Lucas Alves Facundo, Valdenio Martins Brant, Renato Carvalho Guerreiro, Henrique de Araujo Andrade, Fernando Mazzilli Louzada, Andressa Silva, Marco Tulio de Mello
Summary: This study aims to describe the sleep regularity of athletes using the Sleep Regularity Index (SRI) and investigate the effects of factors such as sex, competitive level, and sport type on their sleep/wake rhythm. The findings reveal that international level athletes, female athletes, and individual sport athletes have better sleep regularity.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Rehabilitation
Andressa Silva, Larissa Santos Pinto Pinheiro, Samuel Silva, Henrique Andrade, Andre Gustavo Pereira, Flavia Rodrigues da Silva, Renato Guerreiro, Bruna Barreto, Renan Resende, Marco Tulio de Mello
Summary: Paralympic athletes tend to have poor sleep quality, exhibit poor sleep behavior, and sleep less than recommended. Insomnia symptoms, frequency of awakenings at night, movements during sleep, and poor sleep quality are associated with the occurrence and/or severity of health problems.
PHYSICAL THERAPY IN SPORT
(2022)
Review
Rehabilitation
Samuel Silva, Mariana Castilho, Eduardo Stieler, Ingrid Ludimila Bastos Lobo, Marco Tulio de Mello, Andressa Silva
Summary: Cooling vests may not effectively attenuate the rise in core temperature in individuals with spinal cord injury, but they seem to be effective in controlling skin temperature and improving thermal comfort/sensation. Individuals with tetraplegia may benefit more, and the cooling vest may be more effective during strenuous exercises.
TECHNOLOGY AND DISABILITY
(2022)
Article
Nutrition & Dietetics
Sandra Maria Chemin Seabra da Silva, Aline de Piano Ganen, Deborah Cristina Landi Masquio, Marcus V. L. Dos Santos Quaresma, Debora Estadella, Lila Missae Oyama, Lian Tock, Marco Tulio de Mello, Ana Raimunda Damaso, Claudia Maria da Penha Oller do Nascimento, Danielle Arisa Caranti
Summary: This study aimed to verify the relationships between serum-free fatty acids (FA), inflammatory processes, and depressive symptoms in obese adolescents. The results showed positive correlations between depressive symptoms and saturated fatty acids (SFA) content, body fat, and inflammatory adipokines. On the other hand, n-3 polyunsaturated fatty acids (PUFA) content was negatively correlated with depressive symptoms. However, further longitudinal studies are needed to confirm the causality between dietary SFA and depression in obese individuals.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Physiology
Adriano A. L. Carmo, Karine N. O. Goulart, Christian E. T. Cabido, Ygor A. T. Martins, Gabriela C. F. Santos, Felipe L. T. Shang, Luciano S. Prado, Danusa D. Soares, Marco T. de Mello, Thiago T. Mendes, Emerson Silami-Garcia, Samuel P. Wanner
Summary: This study investigated the effects of an active warm-up and time-of-day variation on repeated-sprint performance and post-exercise recovery. The results showed that a warm-up improved sprint performance, and sprints performed in the late afternoon were better. Additionally, warm-up also led to faster post-exercise recovery.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Rehabilitation
Eduardo Stieler, Varley Teoldo da Costa, Aline Angela Silva Cruz, Joao Paulo Pereira Rosa, Ingrid LudImilla Bastos Lobo, Julia Romao, Andrea Maculano Esteves, Marco Tulio de Mello, Andressa Silva
Summary: This study evaluated the hormonal changes in athletes with cervical spinal cord injury during acute and chronic training. The results showed that testosterone concentrations decreased and cortisol concentrations increased during chronic training. On the other hand, cortisol decreased after acute training with reduced training load, indicating better recovery in athletes. It is suggested to assess hormones both acutely and long-term in athletes with cervical spinal cord injury to monitor anabolic/catabolic hormonal status during wheelchair rugby training.
JOURNAL OF SPORT REHABILITATION
(2022)
Article
Rehabilitation
Isadora Grade, Henrique Andrade, Renato Guerreiro, Eduardo Stieler, Flavia R. da Silva, Hesojy G. V. da Silva, Roberto Vital, Renan A. Resende, Dawit A. P. Goncalves, Andre G. Andrade, Marco T. de Mello, Andressa Silva
Summary: A systematic review found that Paralympic athletes have poor sleep quality and quantity, with high rates of daytime sleepiness. Subjective questionnaires are commonly used to assess their sleep.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Physiology
Marlene Salvina Fernandes da Costa, Vinicius de Oliveira Damasceno, Marco Tulio de Melo, Marcos Andre Moura dos Santos, Wlaldemir Roberto dos Santos, Fernanda Veruska Narciso, Walmir Romario dos Santos, Saulo Fernandes Melo de Oliveira, Pedro Pinheiro Paes
Summary: This study aims to investigate the direct influence of training load on sleep behavior during the tapering phase of training for young swimmers. The results show that there is no significant influence of training load on sleep variables. However, a strong association between total sleep time (TST) and external load (EL) was observed in the irregular sleep group.
REVISTA BRASILEIRA DE MEDICINA DO ESPORTE
(2023)
Review
Rehabilitation
Eduardo Stieler, Marco T. de Mello, Ingrid L. B. Lobo, Dawit A. Goncalves, Renan Resende, Andre G. Andrade, Thiago F. Lourenco, Anselmo A. C. Silva, Henrique A. Andrade, Renato Guerreiro, Andressa Silva
Summary: This review examines the methods used to assess external load in Paralympic sports, aiming to provide scientific evidence for multidisciplinary teams to prescribe and monitor athlete's development, enhance performance, and reduce injury/illness risks. The study identified 8 methods to quantify external load in 8 different Paralympic sports and highlights the need for further research to validate the effectiveness and reliability of these methods.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Nutrition & Dietetics
Ronaldo Angelo Dias da Silva, Leszek Antoni Szmuchrowski, Joao Paulo Pereira Rosa, Marcos Antonio Pereira dos Santos, Marco Tulio de Mello, Lucas Savoi, Yves Ferreira Porto, Francisco de Assis Dias Martins, Marcos Daniel Motta Drummond
Summary: Intermittent fasting (IF) is commonly used by combat sports athletes for weight loss but may decrease performance. This study examined the effects of IF on body weight and Taekwondo performance. The results showed that IF led to a decrease in body weight in the first two weeks but stabilized afterwards. Performance in vertical jumping had different patterns in fed and fasted states. Despite the decrease in body weight, IF did not significantly impact performance.
Article
Clinical Neurology
Fernanda Viegas, Juliana Melo Ocarino, Luisa de Sousa Freitas, Marina Costa Pinto, Lucas Alves Facundo, Adriana Souza Amaral, Samuel Silva, Marco Tulio de Mello, Andressa Silva
Summary: This study found that the quantity and quality of sleep are associated with musculoskeletal injuries in adolescent track and field athletes. Wake after sleep onset (WASO) is related to previous injuries, while time awake (TA) is related to injury occurrence. Furthermore, during the vacation period, athletes had lower TA and WASO, and higher total sleep time (TST) compared to school days.
Article
Sport Sciences
Daiane do Carmo Correa, Igor Moreira, Renan Resende, Andre Gustavo Andrade, Andressa Silva, Marco Tulio de Mello, Rafael Longhi, Dawit Albieiro Goncalves
Summary: The lack of studies on the effects of restrictive diets in paralympic athletes with Spinal Cord Injury justifies the need for this review. Spinal Cord Injury causes metabolic alterations, changes in digestive functions, and imbalance in body composition. Low carb diets and intermittent fasting can reduce body mass but may not be suitable for athletes during high-intensity training due to potential negative effects on performance and health.
RBNE-REVISTA BRASILEIRA DE NUTRICAO ESPORTIVA
(2022)
Article
Medicine, General & Internal
Rafael Mathias Pitta, Bruno Gion Cerazi, Luana Queiroga, Raphael Mendes Ritti Dias, Marco Tulio de Mello, Fernando Henpin Yue Cesena, Roberta Luksevicius Rica, Julien Steven Baker, Marcio Sommer, Gabriel Grizzo Cucato, Danilo Sales Bocalini, Oskar Kauffman
Summary: Sitting time and screen time are not directly associated with obstructive sleep apnea (OSA).
SAO PAULO MEDICAL JOURNAL
(2022)
Review
Sport Sciences
Aldo C. Silva, Adriana S. Amaral, Renato Guerreiro, Andressa Silva, Marco T. deMello, Sergio G. daSilva, Leandro Rechenchosky, Wilson Rinaldi
Summary: Sleep patterns and associated factors among elite soccer athletes were examined in this study. The findings indicate that elite soccer athletes often fail to meet the recommended sleep guidelines, which can be influenced by match outcomes and travel.
APUNTS SPORTS MEDICINE
(2022)