Article
Health Care Sciences & Services
Emmie Cohen, Allison A. Bay, Liang Ni, Madeleine E. Hackney
Summary: Apathy is often overlooked in Parkinson's Disease (PD) but can have a negative impact on quality of life and increase with disease severity. Early identification of apathy can aid in treatment and improve prognosis.
Article
Clinical Neurology
Edzard Schwedhelm, Catrin Englisch, Louisa Niemann, Susanne Lezius, Mirjam von Lucadou, Kristina Marmann, Rainer Boeger, Sven Peine, Guenter Daum, Christian Gerloff, Chi-un Choe
Summary: The study found that Parkinson's disease patients have lower serum S1P levels compared to controls, and lower S1P concentrations are associated with more severe motor symptoms and faster motor decline in PD patients, but not with cognitive decline.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Louisa Niemann, Susanne Lezius, Aleksandra Maceski, David Leppert, Catrin Englisch, Edzard Schwedhelm, Tanja Zeller, Christian Gerloff, Jens Kuhle, Chi-un Choe
Summary: In advanced PD patients, serum NfL concentrations are associated with motor function, cognitive decline, and subclinical cardiac damage.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Clinical Neurology
Carsten Buhmann, Tim Magnus, Chi-un Choe
Summary: Blood neurofilament light chain (NfL) is a viable biomarker for neuroaxonal damage in Parkinson's disease (PD) that shows high sensitivity and specificity in distinguishing idiopathic PD from atypical parkinsonian syndromes (APS). Studies have found significant correlations between blood NfL and motor and cognitive function, as well as consistent associations between baseline blood NfL and motor progression and cognitive worsening. Blood NfL has potential as a biomarker in predicting disease severity and progression in PD patients.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Multidisciplinary Sciences
Iris Lin, Briana Edison, Sneha Mantri, Steven Albert, Margaret Daeschler, Catherine Kopil, Connie Marras, Lana M. Chahine
Summary: This study investigated triggers and alleviating factors for fatigue reported by individuals with Parkinson's Disease, finding that poor sleep and physical exertion were common triggers, while many patients believed exercise could alleviate fatigue. These findings may inform future development of treatments or coping strategies for Parkinson's disease fatigue.
Article
Clinical Neurology
Roberta Bovenzi, Matteo Conti, Giulia Rebecca Degoli, Rocco Cerroni, Clara Simonetta, Claudio Liguori, Chiara Salimei, Antonio Pisani, Mariangela Pierantozzi, Alessandro Stefani, Nicola Biagio Mercuri, Tommaso Schirinzi
Summary: This article examines the clinical presentation and progression of early-onset Parkinson's disease (EOPD). The results show that EOPD primarily manifests as an asymmetric, rigid-akinetic motor syndrome. The study also found that the disease gradually progresses over a 10-year period and is influenced by gender.
NEUROLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Diego Santos-Garcia, Ariadna Laguna, Jorge Hernandez-Vara, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Iago Garcia Diaz, Silvia Jesus, Maria Teresa Boungiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso G. Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Menendez Gonzalez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez M. Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study analyzed sex difference manifestations in Spanish patients with Parkinson's disease (PD) and found important differences. Symptoms such as depression, fatigue, and pain were more frequent and/or severe in females, while symptoms such as hypomimia, speech problems, rigidity, and hypersexuality were more noted in males. Women received a lower levodopa equivalent daily dose and had worse perception of quality of life. After two years of follow-up, the NMS burden increased more significantly in males, while the functional capacity was more impaired in females.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Bruna Meira, Bertrand Degos, Elise Corsetti, Mohamed Doulazmi, Emeline Berthelot, Clara Virbel-Fleischman, Pauline Dodet, Aurelie Meneret, Louise-Laure Mariani, Cecile Delorme, Florence Cormier-Dequaire, David Bendetowicz, Nicolas Villain, Clement Tarrano, Lise Mantisi, Helene Letrillart, Celine Louapre, Eavan McGovern, Yulia Worbe, David Grabli, Marie Vidailhet, Elodie Hainque, Emmanuel Roze
Summary: The study found that continuous subcutaneous apomorphine infusion (CSAI) has an impact on health-related quality of life (HRQoL) and predictors of treatment outcomes in patients with advanced Parkinson's disease. Some patients may discontinue CSAI treatment, and identifying predictors can help in selecting the appropriate treatment approach for patients.
NPJ PARKINSONS DISEASE
(2021)
Article
Geriatrics & Gerontology
Yuling Wang, Hua Gao, Sen Jiang, Qin Luo, Xuejie Han, Yi Xiong, Zeheng Xu, Rui Qiao, Xinling Yang
Summary: This study found that peripheral blood disorders may be associated with the risk of Parkinson's disease (PD), but not with the severity of PD, after analyzing blood data from PD patients and controls. Principal component analysis helped reduce data dimensionality and identified potential associations between certain blood values/ratios and PD risk.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Clinical Neurology
Monika Poetter-Nerger, Janina Dutke, Susanne Lezius, Carsten Buhmann, Robert Schulz, Christian Gerloff, Jens Kuhle, Chi-un Choe
Summary: This study found that increased serum neurofilament light chain (NfL) levels were associated with PIGD subtype and PIGD scores in patients with advanced Parkinson's disease.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Neurosciences
Vasfiye Burcu Albay, Mesude Tutuncu
Summary: Fear of falling is a serious issue in Parkinson's Disease, impacting mortality and HRQoL. The study found that FOF in PD patients is associated with disability level and disease severity, with UPDRS and FOF identified as independent factors affecting HRQoL. Healthcare providers should be aware of the presence of FOF in PD patients, especially in those who are female, depressed or anxious, and have more severe disease symptoms.
Article
Geriatrics & Gerontology
Bei Xu, Xin Wang, Jifeng Guo, Huizhuo Xu, Beisha Tang, Bin Jiao, Lu Shen
Summary: The present study used OCTA to evaluate retinal microvascular variations in patients with PD at different clinical stages. The results showed that there were significant reductions in macular vessel density, peripapillary vessel density, and foveal avascular zone area in the PD groups compared to the healthy controls. These changes were also found to be correlated with clinical parameters. OCTA may serve as a valuable tool for monitoring the progression of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Frida Hjalte, Jenny M. Norlin, Klas Kellerborg, Per Odin
Summary: The study estimated resource use and costs in relation to severity levels in individuals with Parkinson's disease in a Swedish setting, showing that late stages of the disease were associated with significant societal costs. The findings suggest potential savings by optimizing symptomatic treatment for patients with advanced PD.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Neurosciences
Wei Lin, Chuan-Tao Zuo, Jian-Jun Wu, Li-Kun Yang, Jie Zhu, Yu-Hai Wang
Summary: The study revealed a significant difference in SAI of the posterior putamen among different stages of PD severity. However, there was no significant difference in SAI of the anterior putamen or caudate nucleus. The SAI of the posterior putamen in PD patients was significantly higher compared to patients with other degenerative diseases.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Zomer Sardar, Sumayyah Liaquat, Qudsum Yousaf, Safia Bano, Ahsan Numan
Summary: Non-motor symptoms in the early stages of Parkinson's disease have a significant burden but are often overlooked. Assessing the disease using non-motor symptom questionnaires and scales and providing appropriate care should be standard in clinical practice.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2023)
Article
Clinical Neurology
Rohan R. Mahale, Syam Krishnan, K. P. Divya, V. T. Jisha, Asha Kishore
Summary: The study reveals gender differences exist in terms of clinical characteristics and disease progression in PSP, with males displaying specific symptoms more frequently and females demonstrating a faster progression of the disease.
ACTA NEUROLOGICA BELGICA
(2022)
Editorial Material
Clinical Neurology
Ajith Cherian, K. P. Divya, Naveen Kumar Paramasivan, Syam Krishnan
Summary: Kufs disease, a type of adult neuronal ceroid lipofuscinosis, differs from childhood forms in its late onset and preserved vision. It is subclassified into type A, characterized by progressive myoclonus epilepsy, and type B, characterized by dementia with motor involvement.
Letter
Clinical Neurology
Mitesh Vinodray Chandarana, Ajith Cherian, K. P. Divya, Syam Krishnan, Mary Glenda, Udit Saraf
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2022)
Editorial Material
Clinical Neurology
Asish Vijayaraghavan, Ajith Cherian, Divya Kalikavil Puthenveedu, Syam Krishnan, Harini Pavuluri
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Asha Kishore, Praveen James, Traian Popa, Arun Thejaus, Parvathy Rajeswari, Gangadhara Sarma, Syam Krishnan, Sabine Meunier
Summary: The study showed that cerebellar stimulation can modulate the plastic response to PAS, and the M1 response of Non-Responders to PAS can be restored after cerebellar stimulation. This suggests that individual responses to plastic modulation may be influenced by the cerebellar neural system.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Ajith Cherian, K. P. Divya, Asish Vijayaraghavan, Syam Krishnan
Summary: Spinocerebellar ataxia 21 (SCA21) caused by TMEM240 disease-associated variation is characterized by a delayed acquisition of language, motor, and social skills, leading to severe cognitive impairment. This case report highlights the importance of genetic testing in patients with myoclonus dystonia (M-D) syndrome and suggests a trial of levodopa for dystonia caused by TMEM240 variation.
Letter
Clinical Neurology
Asish Vijayaraghavan, Madhusoodanan Urulangodi, Karthika Ajit Valaparambil, Soumya Sundaram, Syam Krishnan
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Syam Krishnan, Sneha Susan George, Vineeth Radhakrishnan, Sheelakumari Raghavan, Bejoy Thomas, Jissa Vinoda Thulaseedharan, Divya Kalikavil Puthenveedu
Summary: This study compared the mean magnetic susceptibility values in deep gray matter structures between patients with PSP, PD and healthy volunteers, and examined their correlation with PSP rating scale. Results showed that PSP patients had higher mean susceptibility values in all regions of interest compared to the other groups. The PSP rating scale scores correlated strongly with mean susceptibility values from the red nucleus, and moderately with those from the putamen and substantia nigra. Mean susceptibility values could serve as potential biomarkers for PSP.
ACTA NEUROLOGICA BELGICA
(2023)
Editorial Material
Clinical Neurology
Asish Vijayaraghavan, Patel Khushboo Subhash, Prabhu Selvaraj, Divya Kalikavil Puthanveedu, Syam Krishnan
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Khushboo Patel, Divya Kalikavil Puthanveedu, Asish Vijayaraghavan, Krishnakumar Kesavapisharady, Gangadhara Sarma, Sankara P. Sarma, Syam Krishnan
Summary: Less than one-fifth of patients with motor complications of PD finally underwent DBS in this study. Patients who opted for surgery tended to have higher socioeconomic status, be older, have longer duration of PD and motor complications, more freezing of gait, cognitive symptoms, and neuropsychiatric disturbances. Age, duration or severity of motor symptoms did not differ between patients who were finally selected for surgery and those who were not.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Kshiteeja Jain, Remya Ramesh, Syam Krishnan, Krishnakumar Kesavapisharady, K. P. Divya, Sankara P. Sarma, Asha Kishore
Summary: Bilateral STN DBS in Parkinson's disease patients may result in minor deficits in executive functions, especially in verbal fluency, but these effects may be inconsequential considering the significant improvement in motor functions and activities of daily living.
ACTA NEUROLOGICA BELGICA
(2022)
Article
Neurosciences
Syed M. Zafar, Roopa Rajan, Syam Krishnan, Krishnakumar Kesavapisharady, Asha Kishore
Summary: Interleaved stimulation (ILS) through two adjacent contacts of the subthalamic nucleus (STN) provided significant short-term beneficial effects on freezing of gait (FOG) in patients with advanced Parkinson's disease. This resulted in improved gait scores and reduced FOG episodes during testing.
Article
Clinical Neurology
Syam Krishnan, Kuldeep Shetty, Divya Kalikavil Puthanveedu, Krishnakumar Kesavapisharady, Jissa Vinoda Thulaseedharan, Gangadhara Sarma, Asha Kishore
Summary: New-onset apraxia of lid opening (ALO) is a rare phenomenon that occurs months after STN DBS in Parkinson's disease patients. Older age, non-tremor dominant PD subtype, and freezing of gait at baseline are predisposing factors for the development of ALO. Adjustments of dopaminergic medications and stimulation parameters have limited efficacy, while botulinum toxin therapy offers better relief of symptoms.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Rohan R. Mahale, Syam Krishnan, K. P. Divya, V. T. Jisha, Asha Kishore
Summary: The study categorized PSP patients based on clinical features and assessed the prognosis, finding that PSP-RS was the most common subtype while PSP-OM was the rarest. Among the subtypes, PSP-P showed a better prognosis compared to others.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2021)
Letter
Clinical Neurology
Ajith Cherian, Naveen Kumar Paramasivan, Divya Kalikavil Puthanveedu, Syam Krishnan, Amitha Radhakrishnan Nair
JOURNAL OF MOVEMENT DISORDERS
(2021)
