Article
Radiology, Nuclear Medicine & Medical Imaging
Yuliya Piatkova, Pierre Payoux, Caroline Boursier, Manon Bordonne, Veronique Roch, Pierre-Yves Marie, Gabriela Hossu, Laetitia Imbert, Antoine Verger
Summary: This study compared I-123-FP-CIT SPECT imaging obtained from a 360 degrees CZT camera with different focus configurations to that from a conventional Anger camera. The results showed that the 360 degrees CZT camera provided higher image quality, shorter acquisition times, and fewer discordant cases compared to the conventional camera, possibly due to its higher spatial resolution.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Biology
Maria Silvia De Feo, Viviana Frantellizzi, Nicoletta Locuratolo, Arianna Di Rocco, Alessio Farcomeni, Caterina Pauletti, Andrea Marongiu, Julia Lazri, Susanna Nuvoli, Francesco Fattapposta, Giuseppe De Vincentis, Angela Spanu
Summary: This multicenter retrospective study aimed to assess the diagnostic accuracy of 123I-FP-CIT (DAT-SPECT), 123I-MIBG (mIBG-scintigraphy), or a combination of both exams in de novo Parkinson's disease patients. The results showed that mIBG-scintigraphy has higher diagnostic accuracy in de novo Parkinson's disease patients compared to DAT-SPECT. Therefore, the combined use of both exams does not appear to be mandatory in the early phase of Parkinson's disease.
Review
Clinical Neurology
Balestrino Roberta, Barone Paolo, Filippi Massimo, Erro Roberto
Summary: Although the diagnosis of Parkinson's disease relies on clinical presentation, the use of imaging techniques, particularly DAT imaging, can aid in differential diagnosis. Structural lesions and certain medications may alter the results of DAT imaging, and unexpected findings such as SWEDD or SWIDD should be considered.
JOURNAL OF NEUROLOGY
(2022)
Article
Psychiatry
Ivan Milenkovic, Lucie Bartova, Konstantinos Papageorgiou, Siegfried Kasper, Tatjana Traub-Weidinger, Dietmar Winkler
Summary: Diagnosing parkinsonian syndromes in patients with severe depression can be challenging due to overlapping clinical phenomena. [I-123]FP-CIT-SPECT is a useful method for detecting degenerative parkinsonian disorders but drugs may influence the results. Consultation with a movement disorder specialist prior to dopamine transporter imaging is recommended.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Hiroo Terashi, Takeshi Taguchi, Yuki Ueta, Hiroshi Mitoma, Hitoshi Aizawa
Summary: The results of this study showed that I-123-FP-CIT-SPECT findings were significantly associated with motor severity and gait severity in drug-naive patients with Parkinson's disease (PD), particularly the mean specific binding ratios of the striatum and anterior putamen.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Yuan Chen, Marlies C. Goorden, Freek J. Beekman
Summary: The study investigated the feasibility of CNN methods for axially focused I-123-FP-CIT scans, showing that CNN-AC can significantly improve the quantitative accuracy of localized regions.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Geriatrics & Gerontology
Niels Hansen, Claudia Lange, Charles Timaeus, Jens Wiltfang, Caroline Bouter
Summary: The study found that 55% of patients with positive 123I-FP-CIT SPECT and probable DLB exhibited psychiatric features, and there was a significant increase in the number of probable DLB patients with psychiatric symptoms after undergoing 123I-FP-CIT SPECT over a 6-year period. Additionally, there were no phenotypical differences between DLB patients with positive and negative 123I-FP-CIT SPECT.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Youssef Chahid, Zulfiqar H. Sheikh, Max Mitropoulos, Jan Booij
Summary: This study aims to update the research on the effects of medications and drugs of abuse on dopamine transporter (DAT) binding in the brain. Through a systematic literature review, we found that certain medications may influence DAT binding, and therefore should be withdrawn before DAT imaging. These findings can help reduce the occurrence of false-positive results.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Minyoung Oh, Seung Jun Oh, Sang Ju Lee, Jungsu S. Oh, Sun Ju Chung, Jae Seung Kim
Summary: This study aims to evaluate the diagnostic accuracy of F-18-FP-CIT PET in patients with clinically uncertain Parkinsonism. The results show that compared to baseline clinical diagnosis, F-18-FP-CIT PET is more accurate in diagnosing CUPS, reducing the false-negative and inconclusive diagnosis rates at baseline.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Min Seung Kim, Don Gueu Park, Young-Sil An, Jung Han Yoon
Summary: This study compared the specific patterns of cortical hypoperfusion, dopamine transporter uptake, and cardiac MIBG uptake between glucocerebrosidase gene mutation Parkinson's disease (GBA-PD) and sporadic Parkinson's disease (sPD). The findings showed decreased regional perfusion in the bilateral posterior parietal and occipital cortex in GBA-PD patients and a higher prevalence of cardiac sympathetic denervation and non-motor symptoms in GBA-PD compared to sPD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Toji Miyagawa, Scott A. Przybelski, Daniela Maltais, Hoon-Ki Min, Lennon Jordan, Timothy G. Lesnick, Qin Chen, Jonathan Graff-Radford, David Jones, Rodolfo Savica, David Knopman, Ronald Petersen, Walter K. Kremers, Leah K. Forsberg, Julie A. Fields, Tanis J. Ferman, Laura Allen, Joseph Parisi, R. Ross Reichard, Melissa Murray, Dennis Dickson, Bradley F. Boeve, Kejal Kantarci, Val J. Lowe
Summary: Multimodal imaging with I-123-FP-CIT SPECT helps differentiate DLBs and ADem, providing additional diagnostic value and detecting complex pathology in patients with DLBs and ADem.
NEUROBIOLOGY OF AGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Makoto Ohba, Ryota Kobayashi, Chifumi Iseki, Kazukuni Kirii, Daichi Morioka, Koichi Otani, Yasuyuki Ohta, Yukihiko Sonoda, Koji Suzuki, Masafumi Kanoto
Summary: This study assessed the effect of CSF area mask correction on the specific binding ratio (SBR) in patients with idiopathic normal pressure hydrocephalus (iNPH). The results showed that CSF area mask correction effectively reduced the influence of CSF area dilatation on SBR, suggesting its potential benefit in iNPH patients.
BMC MEDICAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anthime Flaus, Remi Philippe, Stephane Thobois, Marc Janier, Christian Scheiber
Summary: This study aimed to demonstrate the equivalence between the specific binding ratios (SBR) of visually normal I-123-FP-CIT SPECT scans from patients and those from healthy volunteers or patients without dopaminergic degeneration, for use as a reference database. A statistical model was constructed, which showed significant correlations between SBR values and age and gender, as well as an interaction between SBR and age-gender. The proposed post-reconstruction harmonization method can facilitate the use of semi-quantitative analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoko Shigemoto, Hiroshi Matsuda, Yukio Kimura, Emiko Chiba, Masahiro Ohnishi, Moto Nakaya, Norihide Maikusa, Masayo Ogawa, Yohei Mukai, Yuji Takahashi, Kazuya Sako, Hiroshi Toyama, Yoshitaka Inui, Yasuyuki Taki, Hiroshi Nagayama, Kenjiro Ono, Atsushi Kono, Kenji Sekiguchi, Shigeki Hirano, Noriko Sato
Summary: In this study, the effects of age and gender on striatal dopamine transporter (DaT) binding were investigated in a group of 256 healthy Japanese adults using single photon emission computed tomography (SPECT) scans. The results showed a decrease in DaT binding with advancing age, and higher DaT binding in the bilateral caudate in females compared to males. In the young to middle-aged subjects, females also showed higher DaT binding throughout the striatum. These findings provide important information for the construction of a detailed DaT database in healthy Japanese subjects.
ANNALS OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shogo Watanabe, Tomohiro Ueno, Yuichi Kimura, Masahiro Mishina, Naozo Sugimoto
Summary: This study proposed a new image generative model based on Transformer decoder blocks, successfully generating and transforming SPECT images with characteristics of Parkinson's disease. Visual inspection and evaluation of generated images demonstrated the potential ability of the model.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Cristiano Termine, Linda Greta Dui, Laura Borzaga, Vera Galli, Rossella Lipari, Marta Vergani, Valentina Berlusconi, Massimo Agosti, Francesca Lunardini, Simona Ferrante
Summary: A cross-sectional study compared the effects of social distancing and lifestyle changes during the COVID-19 lockdown on children and adolescents with and without Neurodevelopmental Disorders (NDDs). Results showed that NDDs significantly impacted remote learning, sociality, scolding, and anxiety levels. There was agreement between parents and children regarding remote learning, lifestyle, and scolding. This study highlights the importance of supportive strategies for youth with NDDs during periods of lockdown.
CURRENT PSYCHOLOGY
(2023)
Letter
Clinical Neurology
Camila Abreu-Silveira, Egberto R. Barbosa, Laura Silveira-Moriyama
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Esther Cubo, Sheng Luo, Pablo Martinez-Martin, Glenn T. Stebbins, Jeffrey Lin, Dongrak Choi, Alvaro Garcia-Bustillo, Pablo Mir, Diego Santos-Garcia, Marcos Serrano-Duenas, Mayela Rodriguez-Violante, Carlos Singer
Summary: This article summarizes the formal process of completing the MDS-NMS program and presents data on the first non-English version (Spanish). The results show that the Spanish version of MDS-NMS met the criteria to be designated as an official translation and is now available on the MDS website.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Camila Abreu-Silveira, Fabiano Reis, Egberto R. Barbosa, Laura Silveira-Moriyama
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Letter
Clinical Neurology
Laura Silveira-Moriyama, Jonathan W. Mink
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Poornima Jayadev Menon, Christelle Nilles, Laura Silveira-Moriyama, Ruiyi Yuan, Claudio M. de Gusmao, Alexander Muenchau, Miryam Carecchio, Steve Grossman, Gay Grossman, Aurelie Meneret, Emmanuel Roze, Tamara Pringsheim
Summary: This scoping review summarizes the available clinical literature on ADCY5-RMD. Patients with ADCY5-RMD experience permanent and/or paroxysmal hyperkinetic movements, which can be worsened by environmental triggers. Treatment options are limited, but caffeine, benzodiazepines, and deep brain stimulation have shown some effectiveness.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Andrea Quattrone, Anna Latorre, Francesca Magrinelli, Eoin Mulroy, Roopa Rajan, Ray Jen Neo, Aldo Quattrone, John C. Rothwell, Kailash P. Bhatia
Summary: In this review, we discuss the clinical and pathophysiological aspects of various motor phenomena in patients with movement disorders. These phenomena, including mirror movements and dystonic overflow, share some similarities but also differ in terms of the body part involved, the type of movement, and the underlying neurological condition. We aim to improve the clinical recognition and standardize the terminology of these fascinating clinical signs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Tamara Pringsheim, Amit Batla, Ali Shalash, Jitendra Kumar Sahu, Carlos Cosentino, Darius Ebrahimi-Fakhari, Jennifer Friedman, Jean-Pierre Lin, Jonathan Mink, Alexander Munchau, Daniela Munoz, Nardo Nardocci, Belen Perez-Duenas, Zomer Sardar, Chahnez Triki, Hilla Ben-Pazi, Laura Silveira-Moriyama, Monica Troncoso-Schifferli, Kyoko Hoshino, Russell C. Dale, Victor S. C. Fung, Manju A. Kurian, Emmanuel Roze
Summary: The International Parkinson and Movement Disorders Society (MDS) established a working group to provide recommendations for the transition process from pediatric to adult healthcare systems for patients with childhood-onset movement disorders. Through a multi-round, web-based Delphi survey, the group developed recommendations related to team composition and structure, planning and readiness, goals of care, and administration and research.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Duncan Austin, John Rothwell
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Clinical Neurology
Anna Latorre, Daniele Belvisi, John C. Rothwell, Kailash P. Bhatia, Lorenzo Rocchi
Summary: Cortical myoclonus is a result of abnormal electrical discharges in the sensorimotor cortex. Electrophysiological criteria for diagnosing cortical myoclonus have been proposed, but their application can be challenging. Combining observations from multiple tests is necessary to increase the diagnostic accuracy of cortical myoclonus. Further research is needed to standardize methods, resolve methodological issues, establish diagnostic criteria sensitivity and specificity, and develop additional methods to clarify the pathophysiology of myoclonus.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Geruza P. Bella, Laura Silveira-Moriyama, Alberto Cliquet Jr
Summary: A study investigated the relationship between adapted competitive sports, pain, and quality of life in individuals with spinal cord injuries. The results indicated that athletes had better quality of life and less pain interference compared to non-athletes.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Neurosciences
Po-Yu Fong, Danny Spampinato, Kevin Michell, Marco Mancuso, Katlyn Brown, Jaime Ibanez, Alessandro Di Santo, Anna Latorre, Kailash Bhatia, John C. Rothwell, Lorenzo Rocchi
Summary: The study found that magnetically-induced activity in the cerebral cortex can provide valuable insights into the connectivity between the cortex and the cerebellum, as well as the function of the cerebellum. By using this method, researchers were able to detect brain activity evoked by cerebellar stimulation and demonstrated its involvement in learning and executing complex behaviors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sofia K. Michopoulou, John C. Dickson, Glen G. Gardner, Thomas R. Gee, Andrew J. Fenwick, Timothy Melhuish, Clare A. Monaghan, Neil O'Brien, Angus M. J. Prosser, Catherine J. Scott, Roger T. Staff, Jonathan Taylor
Summary: This study evaluated the use of Brain SPECT and PET scans in the UK and explored drivers and barriers to using quantitative analysis through an online survey. The results showed variations across the UK, with high availability of DaTscan imaging and quantification and lower availability of other SPECT and PET scans.
NUCLEAR MEDICINE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Konstantin Heimrich, Sarah Mendorf, Aline Schoenenberg, Diego Santos-Garcia, Pablo Mir, Tino COPPADIS Study Group, Tino Prell
Summary: The clinical presentation of Parkinson's disease is often characterized by depressive symptoms, which significantly affect the patients' quality of life. Through network analysis, this study identified the depressive symptoms of loss of energy, past failure, and tiredness or fatigue as having the greatest impact on overall quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)