期刊
MOVEMENT DISORDERS
卷 25, 期 16, 页码 2858-2862出版社
WILEY-LISS
DOI: 10.1002/mds.23300
关键词
huntington's disease; motor control; grip force; clinical physiology; biomarker
资金
- Innovative Medical Research of the University of Munster Medical School [RE 12 02 25]
Future clinical trials in subjects with premanifest Huntington's disease (preHD) may depend on the availability of biomarkers. It was previously shown in symptomatic HD that, the grip force variability coefficient-of-variation (GFV-C) in a grasping paradigm was correlated to the unified-Huntington's-Disease-Rating-Scale-TotaI-Motor-Score (UHDRS-TMS) and increased in a 3 year follow-up study. To further elucidate its potential as a biomarker, we investigated whether GFV-C is able to detect a motor phenotype in preHl) and is correlated to the genotype assessed by a disease-burdcn-scorc, The ability of preHD (n = 15) and symptomatic HD subjects (n = 20) to maintain stable grip forces, while holding an object (250 g and 500 g), was measured and compared with the controls (n - 19), GFV-C was increased in preHD at 500 g, in symptomatic subjects at both weights and as corrclated to the disease-burden-score and UHDRS-TMS. GFV-C may be a useful objective and quantitative marker of motor dysfunction across genetically diagnosed premanifest and symptomatic HD subjects. (c) 2010 Movement Disorder Society
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