期刊
MOVEMENT DISORDERS
卷 25, 期 9, 页码 1284-1288出版社
WILEY
DOI: 10.1002/mds.22895
关键词
cerebrospinal fluid; biomarker; progressive supranuclear palsy; Richardson's syndrome; PSP-P; multiple system atrophy
资金
- European Union [OLG1-CT-2000-01262]
- Sanofi-Aventis
- CHDI Foundation
- Neurosearch
- Siena Biotech
- German Research Foundation (DFG)
- German Ministry of Research and Education (BMBF)
- Thyssen Foundation
- Santhera
- Takeda
- Merz
- Pfizer
- Lundbeck
- GlaxoSmithKline
- European commission (Anteprion, cNeurpro, NeuroTAS)
- foundation of the state Baden-Wurttemberg
- German Research Foundation (Deutsche Forschungsgemeinschaft)
- Boehringer Ingelheim
- F.Hoffmann La Roche
- Knopp Neurosciences
- ONO Pharma
- Teva
- Thierry Latran Foundation
- Bayer Vital GmbH
- Teva-Aventis
To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (A beta 1-42), A beta 1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P <= 0.001). Ratios of P-tau/T-tau were significantly different in Parkinsonian syndromes. CSF A beta 1-42 was decreased only in patients with Richardson's syndrome. In a subset of Parkinsonian syndromes, we found elevated GFAP concentrations and increased CSF/serum albumin ratios. There were no correlations between biomarker concentrations and clinical scores in any of the diseases. In conclusion, this preliminary data show that changes in CSF tau and A beta 1-42 may indicate different protein processing in PSP patients and might, therefore, be relevant in the differentiation of PSP subtypes. (C) 2010 Movement Disorder Society
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据