Article
Multidisciplinary Sciences
Shuolin Jiang, Cuijing Zhan, Peikun He, Shujun Feng, Yuyuan Gao, Jiehao Zhao, Limin Wang, Yuhu Zhang, Kun Nie, Yihui Qiu, Lijuan Wang
Summary: This study found that neuronavigated high-frequency rTMS at the left DLPFC is effective in improving depression, anxiety, and motor symptoms in Parkinson's disease patients.
Review
Medicine, General & Internal
Wenjie Zhang, Bin Deng, Fen Xie, Hang Zhou, Ji-Feng Guo, Hong Jiang, Amy Sim, Beisha Tang, Qing Wang
Summary: This article systematically reviewed randomized controlled trials (RCTs) on repetitive transcranial magnetic stimulation (rTMS) in patients with Parkinson's disease (PD), evaluating the efficacy of rTMS on motor and non-motor function in PD patients. The results showed that rTMS had a significant effect on improving motor symptoms and potentially alleviating depressive symptoms in PD.
Review
Medicine, General & Internal
Katherine Muksuris, David M. Scarisbrick, James J. Mahoney, Mariya V. Cherkasova
Summary: The main treatments for Parkinson's Disease (PD) have been limited to medication and deep brain stimulation, but new research is exploring noninvasive neuromodulation methods as potential treatments. Some promising methods include transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), and focused ultrasound (FUS). This rapid review assesses the available animal literature on these noninvasive techniques and discusses the possible mechanisms behind their therapeutic effects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Gong-Jun Ji, Tingting Liu, Ying Li, Pingping Liu, Jinmei Sun, Xingui Chen, Yanghua Tian, Xianwen Chen, Louisa Dahmani, Hesheng Liu, Kai Wang, Panpan Hu
Summary: Accelerated rTMS was found to significantly improve symptoms in patients with Parkinson's disease, with a swift and long-lasting treatment response. Imaging analyses revealed an increase in volume of the left globus pallidus (GP) after cTBS treatment, indicating a potential modulation of the motor circuitry involving the SMA-GP pathway for alleviating motor symptoms of PD.
HUMAN BRAIN MAPPING
(2021)
Article
Multidisciplinary Sciences
Shixie Jiang, Jingyu Huang, Hao Yang, Ryan Wagoner, F. Andrew Kozel, Glenn Currier, Huabei Jiang
Summary: This study utilized a novel diffuse optical tomography (DOT) device to investigate the neurophysiological effects of rTMS in depressed and healthy subjects. The results demonstrated that depressed subjects had a delayed and less robust response to rTMS with decreased volume of activation compared to healthy subjects.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Daniele Belvisi, Andrea Fabbrini, Maria Ilenia De Bartolo, Matteo Costanzo, Nicoletta Manzo, Giovanni Fabbrini, Giovanni Defazio, Antonella Conte, Alfredo Berardelli
Summary: The study aimed to identify the pathophysiological substrate of Parkinson's disease subtypes using neurophysiological techniques. Two clinical clusters were identified, with one having milder symptoms and the other having a combination of severe motor and nonmotor manifestations. Differences in motor system dysfunction were observed between the subtypes, while sensory function and sensorimotor integration mechanisms did not differ.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Emmanuelle Wilhelm, Caroline Quoilin, Gerard Derosiere, Susana Paco, Anne Jeanjean, Julie Duque
Summary: In Parkinson's disease, the lack of preparatory suppression in the primary motor cortex is associated with motor slowness and is related to disease duration and motor impairment. This finding suggests a potential marker for assessing motor preparation and impairment in Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Kaja Kolmancic, Nina K. Zupancic, Maja Trost, Dusan Flisar, Milica G. Kramberger, Zvezdan Pirtosek, Maja Kojovic
Summary: Switching from intermittent to continuous levodopa delivery can improve cortical maladaptive changes, reduce motor fluctuations and dyskinesias in patients with Parkinson's disease.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Nardin Samuel, Mandy Yi Rong Ding, Can Sarica, Ghazaleh Darmani, Irene E. Harmsen, Talyta Grippe, Xingyu Chen, Andrew Yang, Negar Nasrkhani, Ke Zeng, Robert Chen, Andres M. Lozano
Summary: Low-intensity transcranial focused ultrasound (TUS) can increase motor cortex excitability in patients with Parkinson's disease and is a feasible non-invasive neuromodulation strategy.
MOVEMENT DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Jiabin Liang, Jie Feng, Jinhua He, Yong Jiang, Haoyu Zhang, Hanwei Chen
Summary: The randomized controlled trial on the combination of noninvasive brain stimulation and antidepressants for poststroke depression suggests that low-frequency repeated transcranial magnetic stimulation combined with antidepressants may be more effective than antidepressants alone, without significant adverse effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
Yi Wu, Xue-bing Cao, Wei-qi Zeng, Heng Zhai, Xiao-qian Zhang, Xiao-man Yang, Chi Cheng, Jia-ling Wang, Xiao-mei Yang, Yan Xu
Summary: Transcranial magnetic stimulation is an effective non-invasive method for treating levodopa-induced dyskinesia, with beneficial effects and good patient tolerability. Changes in brain connectivity, neuroplasticity, and other factors play crucial roles in its efficacy, while new modes and targeting strategies may offer solutions for sustained efficacy in the future.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Xiaoying Zhang, Sheng Zhuang, Jiajing Wu, Lanxiang Wang, Chengjie Mao, Jing Chen, Chun-feng Liu
Summary: Low frequency rTMS over right DLPFC may improve symptoms of excessive daytime sleepiness in Parkinson's disease patients. This study provides new possibilities for the treatment of EDS.
Review
Clinical Neurology
Ruoyu Li, Yijing He, Wenting Qin, Zhuoyu Zhang, Junhui Su, Qiang Guan, Yuhui Chen, Lingjing Jin
Summary: This study systematically evaluated the efficacy of rTMS intervention for motor dysfunction in patients with Parkinson's disease (PD) and identified the optimal stimulation protocol. The results showed that rTMS can relieve motor symptoms in PD patients, with high-frequency stimulation on M1 being the most effective mode of intervention.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Clinical Neurology
Carl Johan Ekman, Katarzyna Popiolek, Robert Boden, Axel Nordenskjold, Johan Lundberg
Summary: This study investigated the effectiveness and tolerability of intermittent Theta-burst stimulation (iTBS) in a clinical setting. The results showed that iTBS was safe and well-tolerated, and the response rate was similar to that reported in clinical trials. Older age and milder illness predicted a better treatment response.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
David Mata-Marin, Jose angel Pineda-Pardo, Mario Michiels, Cristina Pagge, Claudia Ammann, Raul Martinez-Fernandez, Jose Antonio Molina, Lydia Vela-Desojo, Fernando Alonso-Frech, Ignacio Obeso
Summary: This study provides evidence for the balance between enhanced desire towards reward and cognitive control deficits in patients with impulse-control disorder, specifically hypersexuality, in Parkinson's disease under dopamine replacement therapy. The study also identifies the underlying fronto-striatal and mesolimbic circuitry involved in uncontrollable sexual responses and demonstrates that cortical neuromodulation can alleviate this symptom.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Jean-Christophe Corvol, Jean-Philippe Azulay, Bjorn Bosse, Yves Dauvilliers, Luc Defebvre, Fabian Klostermann, Norbert Kovacs, David Maltete, William G. Ondo, Rajesh Pahwa, Werner Rein, Stephane Thobois, Martin Valis, Aleksandar Videnovic, Olivier Rascol
Summary: The study of THN102 in PD patients with EDS showed that the 200/2 dose demonstrated efficacy and good tolerability, supporting further development. On the other hand, the 200/18 dose did not show significant improvement.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Reka A. Horvath, Zsofia Suto, Balazs Cseke, Daniel Schranz, Gergely Darnai, Norbert Kovacs, Imre Janszky, Jozsef Janszky
Summary: This study aimed to assess the prevalence of epilepsy among COVID-related deaths and found that epilepsy was more common among COVID-19 patients who died under the age of 50.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Neurosciences
Norbert Kovacs, Lars Bergmann, Marieta Anca-Herschkovitsch, Esther Cubo, Thomas L. Davis, Robert Iansek, Mustafa S. Siddiqui, Mihaela Simu, David G. Standaert, K. Ray Chaudhuri, Paul Bourgeois, Tianming Gao, Pavnit Kukreja, Francesco E. Pontieri, Jason Aldred
Summary: Motor and non-motor symptoms of Parkinson's disease have an impact on health-related quality of life (HRQoL), and improvements in HRQoL are correlated with improvements in non-motor symptoms and sleep. LCIG treatment can improve HRQoL.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Katina Aleksovska, Teia Kobulashvili, Joao Costa, Georg Zimmermann, Karen Ritchie, Carola Reinhard, Luca Vignatelli, Alessandra Fanciulli, Maxwel Damian, Lucia Pavlakova, Jean-Marc Burgunder, Svetlana Kopishinskaya, Martin Rakusa, Norbert Kovacs, Fusun Ferda Erdogan, Lori Renna Linton, Massimiliano Copetti, Costanza Lamperti, Serenella Servidei, Theresina Evangelista, Segolene Ayme, Davide Pareyson, Johann Sellner, Christian Krarup, Marianne de Visser, Peter van den Bergh, Antonio Toscano, Holm Graessner, Thomas Berger, Claudio Bassetti, Marie Vidailhet, Eugene Trinka, Guenther Deuschl, Antonio Federico, Maurizio A. Leone
Summary: This article introduces the impact of rare diseases on patients and the existing problems within the European Union. It also provides recommendations and methods for developing and reporting high-quality clinical practice guidelines (CPGs) for rare neurological diseases (RNDs). Through a consensus procedure, 63 final items were identified. These recommendations provide solutions to the specific issues of RNDs and are considered as a starting point for further harmonization and improving the quality of CPGs.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Daniel Pham, Beata Polgar, Tunde Toth, Adel Jungling, Norbert Kovacs, Istvan Balas, Endre Pal, Dora Szabo, Balazs Daniel Fulop, Dora Reglodi, Zalan Szanto, Robert Herczeg, Attila Gyenesei, Andrea Tamas
Summary: The study found that PACAP levels were significantly decreased in PD patients without DBS therapy and in the akinetic-rigid subtype. However, there were no significant correlations between PACAP levels and other clinical parameters. The results suggest that monitoring PACAP alterations in PD patients could improve therapeutic interventions and provide a clearer prognosis for the disease.
Article
Clinical Neurology
Norbert Kovacs, Jozsef Szasz, Lydia Vela-Desojo, Per Svenningsson, Samira Femia, Juan Carlos Parra, Olga Sanchez-Solino, Lars Bergmann, Tanya Gurevich, Alfonso Fasano
Summary: This study compared motor and nonmotor outcomes in APD patients receiving 24-hour versus 16-hour LCIG treatment. The results showed reductions in off time, dyskinesia, and prevalence of most symptoms in both treatment groups. Significant differences were found in freezing of gait, urinary symptoms, and cognitive impairment between the two groups.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Multidisciplinary Sciences
Dalma Tenyi, Tamas Tenyi, Gyorgyi Csabi, Sara Jeges, Beata Bone, Katalin Lorincz, Norbert Kovacs, Jozsef Janszky
Summary: This study aimed to investigate the occurrence and distribution of minor physical anomalies (MPAs) in adult epilepsy patients. The results showed that MPAs were more common in epilepsy patients and were positively associated with antiepileptic drug therapy resistance. This finding contributes to the understanding of the neurodevelopmental etiology of epilepsy and provides a basis for early non-pharmacological treatment.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Liesanne M. Centen, David Pinter, Martje E. van Egmond, Holm Graessner, Norbert Kovacs, Anne Koy, Belen Perez-Duenas, Carola Reinhard, Marina A. J. Tijssen, Sylvia Boesch
Summary: This study evaluated the current state of dystonia management in Europe and found that accessibility was only considered "satisfactory" in nearly half of the surveyed countries, with over half of the countries facing challenging access to genetic and neurophysiological testing. Main oral medications and botulinum toxin were available in all countries, but deep brain stimulation (DBS) was easily accessible in only one-third of the countries. For pediatric dystonia, over half of the countries had experts and specific training available.
JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
David Pinter, Evelyn Jardahazi, Jozsef Janszky, Norbert Kovacs
Summary: Teleprogramming for deep brain stimulation (DBS) can reduce travel and financial burdens for patients, especially during special situations like the COVID-19 pandemic. Research shows a significant decrease in the number of in-person visits during the pandemic.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
David Varga, Brigitta Perecz, Krisztina Fulop, Andrea Sipos, Jozsef Vlagyimir Janszky, Nandor Hajdu, Endre Pal
Summary: This study investigated the role of urinary titin as a biomarker for muscle injury in DM1. It found that the titin/creatinine ratio was significantly higher in DM1 patients compared to healthy controls, and it was related to the severity of muscle impairment. Urinary titin may be a potential biomarker for DM1 and further long-term follow-up is needed to explore its role in disease activity and progression.
Article
Clinical Neurology
Fran Borovecki, Romana Perkovic, Norbert Kovacs, Peter A. A. LeWitt, Monika Rudzinska Bar, Regina Katzenschlager
Summary: In advanced Parkinson's disease, motor and non-motor symptoms worsen and become harder to treat. When oral therapy is insufficient in controlling motor complications, device-aided treatments, such as infusion therapies and deep brain stimulation, should be considered. These treatments should be provided according to guidelines and treatment standards, and ensuring availability and education for patients and physicians is crucial.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Meeting Abstract
Clinical Neurology
G. Deuschl, R. Schuurman, G. Loret, N. Kovacs, M. Blazquez Estrada, F. Clement, J. Il Lee, L. Chen, R. Jain
MOVEMENT DISORDERS
(2022)
Meeting Abstract
Clinical Neurology
N. Kovacs, M. Simu, O. Sanchez Solino, J. Parra, J. Alcazar, S. Snedecor, V. Fung
MOVEMENT DISORDERS
(2022)
Meeting Abstract
Clinical Neurology
K. Chaudhuri, N. Kovacs, F. Pontieri, J. Aldred, P. Bourgeois, T. Davis, E. Cubo, M. Anca-Herschkovitsch, R. Iansek, M. Siddiqui, M. Simu, L. Bergmann, P. Kukreja, O. Ladhani, J. Jia, D. Standaert
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
E. Freire Alvarez, P. Vanni, E. Kurca, L. Lopez Manzanares, N. Kovacs, C. Spanaki, T. Gao, L. Bergmann, O. Sanchez-Solino, L. Barbato
EUROPEAN JOURNAL OF NEUROLOGY
(2022)