Article
Radiology, Nuclear Medicine & Medical Imaging
Feifei Qu, Taotao Sun, Yongsheng Chen, Brijesh Kumar Yadav, Ling Jiang, Zhaoxia Qian, E. Mark Haacke
Summary: The study utilized STAGE imaging to estimate tissue properties in the fetal brain, finding that the ratios of T-1app and PDapp in different regions varied, indicating the potential utility of STAGE imaging for assessing fetal brain properties.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jacob Ellison, Kisoo Kim, Yi Li, Xin Mu, Orit Glenn, Eugene Ozhinsky, Shabnam Peyvandi, Duan Xu
Summary: This study evaluated the safety of T2-weighted Single Shot Fast Spin Echo (SSFSE) scans at 3 Tesla (3T) for fetal brains using magnetic resonance (MR) thermometry. The results showed that the relative temperature changes in fetal brains compared to the mother's gluteal tissue were minimal, indicating that fetal brain imaging at 3T is safe.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Neurosciences
Devanshi Jani, Alys Clark, Sophie Couper, John M. D. Thompson, Anna L. L. David, Andrew Melbourne, Ali Mirjalili, Anna-Maria Lydon, Peter R. R. Stone
Summary: Fetal growth restriction (FGR) and maternal supine going-to-sleep position are both risk factors for late stillbirth. This study used MRI to quantify the effect of maternal supine position on maternal-placental and fetoplacental blood flow, placental oxygen transfer, and fetal oxygenation in FGR and healthy pregnancies. It was found that FGR was associated with lower fetal oxygen saturation and reduced blood flow, while maternal supine positioning caused a further reduction in fetal oxygenation, particularly in FGR pregnancies.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cardiac & Cardiovascular Systems
Anjali Sadhwani, David Wypij, Valerie Rofeberg, Ali Gholipour, Maggie Mittleman, Julia Rohde, Clemente Velasco-Annis, Johanna Calderon, Kevin G. Friedman, Wayne Tworetzky, P. Ellen Grant, Janet S. Soul, Simon K. Warfield, Jane W. Newburger, Cynthia M. Ortinau, Caitlin K. Rollins
Summary: This study investigated whether fetal brain volume could predict neurodevelopmental outcomes in children with congenital heart disease (CHD). The results showed that fetal brain volume was correlated with cognitive, language, motor scores, and adaptive functioning scores. Fetal brain volume was found to be a strong independent predictor of neurodevelopmental outcomes, suggesting its potential as an important imaging biomarker for future risk assessment in CHD.
Review
Acoustics
D. Di Mascio, A. Khalil, G. Rizzo, G. Kasprian, M. Caulo, L. Manganaro, A. O. Odibo, M. E. Flacco, A. Giancotti, D. Buca, M. Liberati, I. E. Timor-Tritsch, F. D'Antonio
Summary: This study evaluated the methodology of 15 studies reporting reference ranges for fetal brain structures on MRI, finding that most of them had low-to-moderate quality and high risk of bias. Issues were identified in study design, statistical and reporting methods, and specific aspects relevant to MRI. The findings were similar to those reported for ultrasound studies.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
M. Stuempflen, A. Taymourtash, P. Kienast, V. U. Schmidbauer, E. Schwartz, C. Mitter, J. Binder, D. Prayer, G. Kasprian
Summary: This study used super-resolution processed MRI to evaluate the volume and growth dynamics of the ganglionic eminence (GE) in fetuses. The results showed that the volume of the GE reached its maximum at 21 weeks and then decreased linearly. The reduction in GE volume relative to cortical volume and total fetal brain volume (TBV) was more pronounced in the late second trimester, with a decline in this reduction observed in the third trimester. Three-dimensional reconstructions visualized the continuous changes in shape and size of the GE throughout the second and third trimesters.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Ameth Hawkins-Villarreal, Ana L. Moreno-Espinosa, Raigam J. Martinez-Portilla, Karen Castillo, Nadine Hahner, Ayako Nakaki, Lucas Trigo, Olivier Picone, Nathalie Siauve, Francesc Figueras, Alfons Nadal, Elisenda Eixarch, Anna Gonce
Summary: This study assessed the FLV of CMV-infected fetuses using MRI and compared it with a group of healthy fetuses. The results showed that the FLV of CMV-infected fetuses was higher when corrected for AC and FBV, indicating relative hepatomegaly.
FRONTIERS IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul D. Griffiths, Mariasavina Severino, Deborah Jarvis, Laura Mandefield, Cecilia Parazzini, Lorenzo Pinelli, Marco Di Maurizio, Fabio Triulzi, Elisa Scola, Giorgio Conte, Giovanni Palumbo, Maurilio Genovese, Andrea Rossi, Renzo Guerrini, Andrea Righini
Summary: The study included 64 foetuses with cortical formation abnormalities (CFA) who underwent two in utero magnetic resonance (iuMR) exams, with 62% showing consistent CFA description between the two studies. In 38% of cases, there was a category change, including cases without CFA initially detected, changes in laterality/symmetry, and re-classification within the same group. Brain abnormalities other than CFA were present in around half of the cases on both first and second studies. Prognosis was predicted to have changed in 8% of cases based on the second study, with all indicating a worse prognosis.
EUROPEAN RADIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Henriette Kuhle, Steven K. S. Cho, Nathaniel Barber, Datta Singh Goolaub, Jack R. T. Darby, Janna L. Morrison, Christoph Haller, Liqun Sun, Mike Seed
Summary: Over the past few decades, advanced imaging techniques have been used to assess cardiovascular physiology and cardiac function in the fetus. Technical development has been necessary to make these assessments feasible in the fetus, while an understanding of the unique physiology of fetal circulation is needed for proper interpretation of the results. This review discusses recent advances in fetal echocardiography and cardiovascular magnetic resonance, providing examples of their application in research and clinical settings, as well as future directions for these technologies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Junshen He, Chunlin Chen, Liqun Xu, Benheng Xiao, Zhao Chen, Ting Wen, Yi Xiang J. Wang, Ping Liu
Summary: The diagnostic value of placental diffusion-derived vessel density (DDVD) was explored in differentiating normal and early preeclampsia pregnancies. The results showed that DDVDmean allowed total separation of normal and early preeclampsia pregnancies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tom Halevy, Meirav Nezer, Jorden Halevy, Tomer Ziv-Baran, Eran Barzilay, Eldad Katorza
Summary: This study used MRI to compare brain volumes of discordant twins and found that twins with appropriate birth weight had smaller brain structure volumes compared to those with lower birth weight. However, there was no significant difference in neurodevelopmental outcomes between discordant twins.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Jiangjie Wu, Taotao Sun, Boliang Yu, Zhenghao Li, Qing Wu, Yutong Wang, Zhaoxia Qian, Yuyao Zhang, Ling Jiang, Hongjiang Wei
Summary: This study utilized an unbiased template construction algorithm to create a set of age-specific Chinese fetal atlases, revealing significant anatomical differences between the Chinese and Caucasian fetal populations. When guiding brain tissue segmentation, the Chinese fetal atlases resulted in significantly higher accuracy compared to the Caucasian fetal atlases.
Article
Obstetrics & Gynecology
Olivier Morel, Heleen J. van Beekhuizen, Thorsten Braun, Sally Collins, Petra Pateisky, Pavel Calda, Wolfgang Henrich, Ammar Al Naimi, Lone Nikoline Norgaardt, Kinga M. Chalubinski, Loic Sentilhes, Boris Tutschek, Alexander Schwickert, Vedran Stefanovic, Charline Bertholdt
Summary: The study evaluated the performance of ultrasound and magnetic resonance imaging in diagnosing the severity of placenta accreta spectrum disorders, finding that both imaging techniques had poor discriminatory abilities. The benefit of additional magnetic resonance imaging was not demonstrated in distinguishing mild from severe cases.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Flore-Anne Pain, Anthony Dohan, Gilles Grange, Louis Marcellin, Joelle Uzan-Augui, Francois Goffinet, Philippe Soyer, Vassilis Tsatsaris
Summary: The study aimed to assess the performance of ultrasound and MRI features in distinguishing different types of placenta accreta spectrum and developed a predictive score for predicting the risk of placenta percreta. The results showed that the predictive score had good accuracy in identifying placenta percreta.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Neurosciences
Pauline Mouches, Matthias Wilms, Deepthi Rajashekar, Sonke Langner, Nils D. Forkert
Summary: This study aimed to develop deep learning models to predict biological brain age using multimodal imaging data. The results showed that combining T1-weighted and angiography MRI data significantly improved prediction accuracy, while also identifying the most contributing brain regions and arteries.
HUMAN BRAIN MAPPING
(2022)
Meeting Abstract
Obstetrics & Gynecology
Alexis C. Gimovsky, Nickie Niforatos-Andescavage, Homa K. Ahmadzia, Subechya Pradhan, Jessica Quistorff, Mary Donofrio, Cathy Limeropoulos
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2019)
Review
Pediatrics
Katherine M. Ottolini, Nickie Andescavage, Susan Keller, Catherine Limperopoulos
PEDIATRIC RESEARCH
(2020)
Article
Pediatrics
Katherine M. Ottolini, Nickie Andescavage, Kushal Kapse, Marni Jacobs, Catherine Limperopoulos
Article
Developmental Biology
Nickie Andescavage, Wonsang You, Marni Jacobs, Kushal Kapse, Jessica Quistorff, Dorothy Bulas, Homa Ahmadzia, Alexis Gimovsky, Ahmet Baschat, Catherine Limperopoulos
Article
Radiology, Nuclear Medicine & Medical Imaging
Wonsang You, Nickie N. Andescavage, Kushal Kapse, Mary T. Donofrio, Marni Jacobs, Catherine Limperopoulos
Article
Pediatrics
Yao Wu, Kushal Kapse, Marni Jacobs, Nickie Niforatos-Andescavage, Mary T. Donofrio, Anita Krishnan, Gilbert Vezina, David Wessel, Adre du Plessis, Catherine Limperopoulos
Article
Nutrition & Dietetics
Katherine M. Ottolini, Nickie Andescavage, Kushal Kapse, Marni Jacobs, Jonathan Murnick, Rebecca VanderVeer, Sudeepta Basu, Mariam Said, Catherine Limperopoulos
Summary: Recent studies show that early cumulative lipid intake in the first weeks of life is associated with significantly greater cerebellar volume in very premature infants, highlighting the importance of early, aggressive nutrition interventions to optimize cerebellar development in VLBW infants.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Article
Obstetrics & Gynecology
Vedavalli Govindan, Rathinaswamy Govindan, An N. Massaro, Tareq Al-Shargabi, Nickie N. Andescavage, Gilbert Vezina, Jonathan Murnick, Yunfei Wang, Marina Metzler, Caitlin Cristante, Christopher Swisher, Daniel Reich, Adre du Plessis
JOURNAL OF PERINATOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zungho Zun, Kushal Kapse, Jessica Quistorff, Nickie Andescavage, Alexis C. Gimovsky, Homa Ahmadzia, Catherine Limperopoulos
Summary: This study demonstrates the feasibility of performing placental QSM in pregnant women, showing the potential for noninvasive assessment of placental oxygenation. The results of susceptibility and T2* maps were shown to reflect regional oxygenation differences and were responsive to maternal hyperoxia, with a linear relationship with gestational age.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Subechhya Pradhan, Kushal Kapse, Marni Jacobs, Nickie Niforatos-Andescavage, Jessica Lynn Quistorff, Catherine Lopez, Kathryn Lee Bannantine, Nicole Reinholdt Andersen, Gilbert Vezina, Catherine Limperopoulos
Review
Pediatrics
Ariunzaya Amgalan, Nickie Andescavage, Catherine Limperopoulos
Summary: Research shows that neuropsychiatric diseases have developmental origins related to intrauterine exposures, particularly affected by factors such as infection and inflammation. Identifying the timing and mechanisms of injury is crucial in studying fetal brain development, and clinical care should focus on maternal health during pregnancy and monitoring offspring for early recognition and treatment.
Article
Medicine, General & Internal
Josepheen De Asis-Cruz, Dhineshvikram Krishnamurthy, Li Zhao, Kushal Kapse, Gilbert Vezina, Nickie Andescavage, Jessica Quistorff, Catherine Lopez, Catherine Limperopoulos
Meeting Abstract
Cardiac & Cardiovascular Systems
Yuanchiao Lu, Kushal Kapse, Nicole Andersen, Nickie Andescavage, Andrea Fry, Catherine Lopez, Anita Krishnan, Dorothy Bulas, Mary Donofrio, Catherine Limperopoulos
Meeting Abstract
Obstetrics & Gynecology
Ariunzaya Amgalan, Catherine Limperopoulos, Kushal Kapse, Jessica Quistorff, Kathryn Bannantine, Nickie Andescavage
OBSTETRICS AND GYNECOLOGY
(2020)
Article
Medicine, General & Internal
Yao Wu, Yuan-Chiao Lu, Marni Jacobs, Subechhya Pradhan, Kushal Kapse, Li Zhao, Nickie Niforatos-Andescavage, Gilbert Vezina, Adre J. du Plessis, Catherine Limperopoulos
