Article
Clinical Neurology
Demetris Pillas, Alexander Klein, Teresa Gasalla, Andreja Avbersek, Alexander Thompson, Jack Wright, Jennifer Mellor, Anna Scowcroft
Summary: Progressive supranuclear palsy (PSP) is a rare and fatal neurodegenerative disease that has a high burden on patients, caregivers, and healthcare systems across different PSP phenotypes. The study found that patients with different PSP phenotypes have varying degrees of functional impairment, needs for assistive devices and home modifications, and require different types of healthcare professionals and caregivers. However, once diagnosed with PSP, patients generally receive similar care.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Jong Hyeon Ahn, Junmo Kwon, Ji Hye Won, Kyoungseob Byeon, Jinyoung Youn, Hyunjin Park, Jin Whan Cho
Summary: This study investigated waiting impulsivity in progressive supranuclear palsy-Richardson's syndrome (PSP-RS) and introduced a novel evaluation method. The results showed that the JTG sign is a surrogate marker of waiting impulsivity in PSP-RS patients, enriching the current understanding of waiting impulsivity in PSP patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Natalia Madetko-Alster, Dagmara Otto-Slusarczyk, Alicja Wiercinska-Drapalo, Dariusz Koziorowski, Stanislaw Szlufik, Joanna Samborska-Cwik, Marta Struga, Andrzej Friedman, Piotr Alster
Summary: This study aimed to evaluate possible differences in neuroinflammatory patterns between the two most common progressive supranuclear palsy (PSP) phenotypes. The results indicate that levels of tau are significantly higher in PSP-P and PSP-RS patients, and the lowest concentrations of interleukins are observed in PSP-RS patients. This suggests that distinct neuroinflammatory patterns or increased inflammatory activity may play a role in the phenotypes and clinical course of PSP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Jan Necpal, Miroslav Borsek, Bibiana Jelenova
Summary: PSP has several clinical subtypes, with PSP-P showing distinct clinical features from PSP-RS but may eventually progress into PSP-RS over time. Despite similarities to Parkinson's disease, PSP-P still exhibits significant differences in presentation and course.
NEUROLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jannik Prasuhn, Martin Goettlich, Sinja S. Grosser, Katharina Reuther, Britt Ebeling, Christina Bodemann, Henrike Hanssen, Armin M. Nagel, Norbert Brueggemann
Summary: Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease with aggressive disease course, and total and intracellular-weighted sodium imaging (Na-23-MRI) is a promising method for investigating neurodegeneration.
Article
Clinical Neurology
Andrea Horta-Barba, Javier Pagonabarraga, Saul Martinez-Horta, Laura Busteed, Berta Pascual-Sedano, Ignacio Illan-Gala, Juan Marin-Lahoz, Ignacio Aracil-Bolanos, Jesus Perez-Perez, Frederic Sampedro, Helena Bejr-Kasem, Jaime Kulisevsky
Summary: The study found that motor deficits delineate the phenotypes included in currently accepted MDS-PSP criteria. Cognitive testing did not clearly differentiate between PSP phenotypes, but PSP-RS and PSP-SL appeared to have more cognitive impairment than PSP-PGF and PSP-P, mainly due to an increased impairment in frontal executive domains.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabio A. Simoes, Greig Joilin, Oliver Peters, Luisa-Sophie Schneider, Josef Priller, Eike Jakob Spruth, Ina Vogt, Okka Kimmich, Annika Spottke, Daniel C. Hoffmann, Bjoern Falkenburger, Moritz Brandt, Johannes Prudlo, Kathrin Brockmann, Franca Laura Fries, James B. Rowe, Alistair Church, Gesine Respondek, Sarah F. Newbury, P. Nigel Leigh, Huw R. Morris, Guenter U. Hoeglinger, Majid Hafezparast
Summary: This study identified dysregulated ncRNA in serum and CSF samples of patients with PSP, suggesting their potential as diagnostic biomarkers for PSP. Further research is needed to explore this possibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Fatma Ozlem Hokelekli, Farwa Ali, Arenn F. Carlos, Peter R. Martin, Heather M. Clark, Joseph R. Duffy, Rene L. Utianski, Hugo Botha, Erik K. St Louis, Jennifer L. Whitwell, Keith A. Josephs
Summary: The study found that sleep abnormalities are common in patients with Progressive Supranuclear Palsy (PSP) variants with speech and language problems (PSP-SL), but less frequent compared to other PSP-Richardson Syndrome (PSP-RS) patients.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Ryota Satoh, Stephen D. Weigand, Nha Trang Thu Pham, Farwa Ali, Arvin Arani, Matthew L. Senjem, Clifford R. Jack Jr, Jennifer L. Whitwell, Keith A. Josephs
Summary: This study identified different patterns of magnetic susceptibility in the subcortical regions among different PSP variants and CBS, contributing to our understanding of iron profiles and pathophysiology of PSP. These findings may also serve as a potential biomarker in differentiating PSP variants, PD, and CBS.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Mike Wattjes, Hans-Juergen Huppertz, Nima Mahmoudi, Sophia Stoecklein, Sophia Rogozinski, Florian Wegner, Martin Klietz, Ivayla Apostolova, Johannes Levin, Sabrina Katzdobler, Carsten Buhmann, Andrea Quattrone, Georg Berding, Matthias Brendel, Henryk Barthel, Osama Sabri, Guenter Hoeglinger, Ralph Buchert, Alzheimers Dis Neuroimaging Initiat
Summary: This study compared the value of different MRI reading strategies and automatic classification methods in the diagnosis of PSP. The results showed that the fully automatic classification method using support vector machine performed the best, especially in the diagnosis of vPSP. Therefore, it is recommended to use machine learning methods for fully automatic classification in settings with a broad phenotypic PSP spectrum.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Yasuo Miki, Eiki Tsushima, Sandrine C. Foti, Kate M. Strand, Yasmine T. Asi, Adam Kenji Yamamoto, Conceicao Bettencourt, Marcos C. B. Oliveira, Eduardo De Pablo-Fernandez, Zane Jaunmuktane, Andrew J. Lees, Koichi Wakabayashi, Thomas T. Warner, Niall Quinn, Janice L. Holton, Helen Ling
Summary: The study focused on patients with multiple system atrophy who presented symptoms closely resembling Parkinson's disease or progressive supranuclear palsy, pointing out the difficulties in diagnosing these mimicking cases accurately using current criteria. Differences in red flag features and autonomic dysfunction were observed in these atypical cases compared to typical ones.
Article
Clinical Neurology
Marina Picillo, Maria Francesca Tepedino, Filomena Abate, Sara Ponticorvo, Roberto Erro, Sofia Cuoco, Nevra Oksuz, Gianfranco Di Salle, Francesco Di Salle, Fabrizio Esposito, Maria Teresa Pellecchia, Renzo Manara, Paolo Barone
Summary: This study evaluated the asymmetry in motor and higher cortical features in PSP-RS patients and found that these features were commonly asymmetric in PSP-RS. There was also a greater degree of asymmetry in the hemispheres compared to healthy controls. These findings contribute to a better understanding of the characteristics of PSP-RS.
NEUROLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Piotr Alster, Natalia Madetko-Alster, Bartosz Migda, Michal Nieciecki, Dariusz Koziorowski, Leszek Krolicki
Summary: Progressive Supranuclear Palsy-Parkinsonism Predominant (PSP-P) is clinically difficult to diagnose and often misdiagnosed as Parkinson's Disease or Multiple System Atrophy-Parkinsonian type (MSA-P). This study used Single Photon Emission Computed Tomography to evaluate the differences between PSP-P and MSA-P patients and found that the right middle frontal gyrus was the most affected region in PSP-P.
Article
Clinical Neurology
Arvid Herwig, Almedin Agic, Hans-Jurgen Huppertz, Randolf Klingebiel, Frederic Zuhorn, Werner X. Schneider, Wolf-Ruediger Schaebitz, Andreas Rogalewski
Summary: Assessing eye movements in a head-mounted display (HMD) proved to be an effective tool in differentiating patients with progressive supranuclear palsy (PSP) from those with Parkinson's disease (PD). By multiplying the ratios of vertical to horizontal eye movements, a novel diagnostic index showed high sensitivity in distinguishing PSP from PD. Additionally, correlations were found between oculomotor abnormalities and midbrain volume in PSP patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Maja Klarendic, Manja Hribar, Nina Bozanic Urbancic, Nina Zupancic, Milica G. Kramberger, Maja Trost, Saba Battelino, Diego Kaski, Maja Kojovic
Summary: The study describes the prevalence and characteristics of nystagmus in patients with progressive supranuclear palsy (PSP), finding that over a third of patients have gaze-evoked nystagmus, possibly originating from neurodegeneration. The presence of nystagmus should not deter clinicians from diagnosing PSP.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Geriatrics & Gerontology
Celia Kun-Rodrigues, Tatiana Orme, Susana Carmona, Dena G. Hernandez, Owen A. Ross, John D. Eicher, Claire Shepherd, Laura Parkkinen, Lee Darwent, Michael G. Heckman, Sonja W. Scholz, Juan C. Troncoso, Olga Pletnikova, Ted Dawson, Liana Rosenthal, Olaf Ansorge, Jordi Clarimonm, Alberto Lleo, Estrella Morenas-Rodriguez, Lorraine Clark, Lawrence S. Honig, Karen Marder, Afina Lemstra, Ekaterina Rogaeva, Peter St George-Hyslop, Elisabet Londos, Henrik Zetterberg, Imelda Barber, Anne Braae, Kristelle Brown, Kevin Morgan, Claire Troakes, Safa Al-Sarraj, Tammaryn Lashley, Janice Holton, Yaroslau Compta, Vivianna Van Deerlin, Geidy E. Serrano, Thomas G. Beach, Suzanne Lesage, Douglas Galasko, Eliezer Masliah, Isabel Santana, Pau Pastor, Monica Diez-Fairen, Miquel Aguilar, Pentti J. Tienari, Liisa Myllykangas, Minna Oinas, Tamas Revesz, Andrew Lees, Brad F. Boeve, Ronald C. Petersen, Tanis J. Ferman, Valentina Escott-Price, Neill Graff-Radford, Nigel J. Cairns, John C. Morris, Stuart Pickering-Brown, David Mann, Glenda M. Halliday, John Hardy, John Q. Trojanowski, Dennis W. Dickson, Andrew Singleton, David J. Stone, Rita Guerreiro, Jose Bras
NEUROBIOLOGY OF AGING
(2019)
Article
Clinical Neurology
A. J. Lees
Summary: By observing birds and having a passion for natural history, Andrew Lees transformed into a proficient noticer and ultimately became a neurologist. Through this process, he developed strong diagnostic skills that helped him in his career.
Article
Clinical Neurology
George E. C. Thomas, Angeliki Zarkali, Mina Ryten, Karin Shmueli, Ana Luisa Gil-Martinez, Louise-Ann Leyland, Peter McColgan, Julio Acosta-Cabronero, Andrew J. Lees, Rimona S. Weil
Summary: This study investigated the mechanisms underlying the selective vulnerability of specific neuronal populations in Parkinson's disease, focusing on the role of iron accumulation. By analyzing the gene expression profiles associated with cortical iron deposition, the study revealed enrichment for biological processes related to heavy metal detoxification, synaptic function, and nervous system development, predominantly expressed in astrocytes and glutamatergic neurons. Additionally, the study found that genes differentially expressed in Parkinson's disease are associated with the cortical expression pattern identified in the study.
Article
Neurosciences
Jonathan P. Bestwick, Stephen D. Auger, Cristina Simonet, Richard N. Rees, Daniel Rack, Mark Jitlal, Gavin Giovannoni, Andrew J. Lees, Jack Cuzick, Anette E. Schrag, Alastair J. Noyce
Summary: The study developed an enhanced algorithm incorporating intermediate markers into the risk model, resulting in a much wider and more accurate range of risk estimates for PD. The enhanced algorithm also showed a closer correlation with subclinical dopamine depletion in the striatum.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Pedro Barbosa, Atbin Djamshidian, Andrew John Lees, Thomas Treharne Warner
Summary: This study investigated the brain samples of Parkinson's disease (PD) patients who received apomorphine treatment. It found that apomorphine can be used as an alternative treatment for patients with previous impulsive compulsive behaviors (ICBs) due to its low risk of recurrence.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2022)
Editorial Material
Neurosciences
Pedro Barbosa, Andrew John Lees
ARQUIVOS DE NEURO-PSIQUIATRIA
(2021)
Review
Ophthalmology
Evita Evangelia Christou, Ioannis Asproudis, Christoforos Asproudis, Alexandros Giannakis, Maria Stefaniotou, Spiridon Konitsiotis
Summary: A comprehensive review of the literature indicates that changes in the microvasculature of the macular capillary plexus as seen on OCT-A can serve as useful biomarkers for cerebral vasculature in PD. Further studies are needed to establish the OCT-A parameters as predicting factors in clinical practice.
SEMINARS IN OPHTHALMOLOGY
(2022)
Article
Neurosciences
Jonathan P. Bestwick, Stephen D. Auger, Anette E. Schrag, Donald G. Grosset, Sofia Kanavou, Gavin Giovannoni, Andrew J. Lees, Jack Cuzick, Alastair J. Noyce
Summary: By using likelihood ratios for specific test values such as smell, RBD, and anxiety/depression, classification between PD patients and controls can be enhanced.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
A. J. Lees
Summary: Through the works of Marquez, we can learn about the importance and pros and cons of memory and forgetting.
Review
Clinical Neurology
Sergio A. Castillo-Torres, Andrew J. Lees, Marcelo Merello
Summary: Intermittent subcutaneous injections of apomorphine have been proven to be an effective and safe treatment for off-period disability in Parkinson's disease, with almost four decades of clinical experience.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Biographical-Item
Clinical Neurology
Huw R. Morris, Andrew J. Lees
MOVEMENT DISORDERS
(2023)
Biographical-Item
Clinical Neurology
Huw R. Morris, Andrew J. Lees
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Angeliki Zarkali, Peter McColgan, Mina Ryten, Regina Reynolds, Louise-Ann Leyland, Andrew J. Lees, Geraint Rees, Rimona S. Weil
Meeting Abstract
Clinical Neurology
R. A. Hauser, M. Lew, A. J. Lees, W. Poewe, O. Rascol, K. Olson, K. Farahmand, S. Siegert, J. F. Rocha, P. Soares-da-Silva, G. S. Liang
MOVEMENT DISORDERS
(2019)
Letter
Clinical Neurology
Sergio A. Castillo-Torres, Carlos A. Soto-Rincon, Ingrid Estrada-Bellmann, Andrew J. Lees
MOVEMENT DISORDERS CLINICAL PRACTICE
(2019)