Article
Neurosciences
Linbo Wang, Cheng Zhou, Wei Cheng, Edmund T. Rolls, Peiyu Huang, Ningning Ma, Yuchen Liu, Yajuan Zhang, Xiaojun Guan, Tao Guo, Jingjing Wu, Ting Gao, Min Xuan, Quanquan Gu, Xiaojun Xu, Baorong Zhang, Weikang Gong, Jingnan Du, Wei Zhang, Jianfeng Feng, Minming Zhang
Summary: Parkinson's disease is characterized by the loss of dopaminergic cells and atrophy in subcortical regions, which in turn affects cortical synchronization and metastability. The study shows that dopamine depletion leads to decreased cortical synchronization and metastability in PD patients, impacting cognitive performance. Thalamic volume and thalamocortical fiber connectivity play roles in mediating the relationship between subcortical dysfunction, dopamine levels, and cognitive performance in PD.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Gabriella Hernadi, David Pinter, Szilvia Anett Nagy, Gergely Orsi, Samuel Komoly, Jozsef Janszky, Norbert Kovacs, Gabor Perlaki
Summary: The study compared different MRI sequences for nigral hyperintensity imaging and found that EPISEG performed the best in reducing motion artifacts, increasing radiologist confidence, and lowering the rate of non-diagnostic scans.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Michela Leocadi, Elisa Canu, Giulia Donzuso, Tanja Stojkovic, Silvia Basaia, Nikola Kresojevic, Iva Stankovic, Elisabetta Sarasso, Noemi Piramide, Aleksandra Tomic, Vladana Markovic, Igor Petrovic, Elka Stefanova, Vladimir S. Kostic, Massimo Filippi, Federica Agosta
Summary: This study found that PD patients with GBA mutation experienced a more rapid decline in motor and cognitive functions over 5 years, showing greater, earlier and faster cortical thinning. Measures of cortical thickness may be a useful tool for monitoring and predicting PD progression based on genetic background.
JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Xia Deng, Zheng Liu, Qin Kang, Lin Lu, Yu Zhu, Renshi Xu
Summary: This study explored the potential damaged pathogenesis of other brain regions associated with the multiple and complex clinical symptoms of mid-stage sporadic Parkinson's disease (sPD) through magnetic resonance imaging (MRI). Results showed significant alteration of cortical structural connectivity in multiple brain regions at the mid-stage of sPD, suggesting that extensive alteration of cortical structural connectivity may be one of possible pathogenesis resulting in the multiple and complex clinical symptoms in sPD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Se Jin Cho, Yun Jung Bae, Jong-Min Kim, Hyun Jin Kim, Sung Hyun Baik, Leonard Sunwoo, Byung Se Choi, Cheolkyu Jung, Jae Hyoung Kim
Summary: Iron-sensitive nigral magnetic resonance imaging showed favorable diagnostic performance in distinguishing patients with Parkinson's disease from control participants. Factors influencing diagnostic performance included disease duration, analysis method, pixel size, flip angle, slice thickness, and specific targeting of the substantia nigra pars compacta. Further improvements in spatial resolution and contrast-to-noise ratio are needed for objective analytic methods targeting the nigrosome-1.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Calogero Edoardo Cicero, Giulia Donzuso, Antonina Luca, Marco Davi, Roberta Baschi, Giovanni Mostile, Loretta Giuliano, Stefano Palmucci, Andrea Salerno, Roberto Monastero, Alessandra Nicoletti, Mario Zappia
Summary: This study found that Parkinson's disease patients with mild cognitive impairment showed midbrain atrophy and thinning of the frontal cortical regions on MRI scans. These findings may serve as structural MRI features of Parkinson's disease patients with cognitive impairment.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Hui Wang, Jianxia Xu, Miao Yu, Gaiyan Zhou, Jingru Ren, Yajie Wang, Huifen Zheng, Yu Sun, Jun Wu, Weiguo Liu
Summary: This study aimed to explore the potential clinical utility of functional and structural magnetic resonance imaging (MRI) in the diagnosis of depression in Parkinson's disease (DPD). The results showed that both the ReHo value of the left dorsolateral superior frontal gyrus and the DC value of the left inferior temporal gyrus were equally well suited for the diagnosis and differential diagnosis of DPD, with a combination of them being slightly preferable. The multimodal MRI technique represents a promising approach for the classification of subjects with PD.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Se Jin Cho, Yun Jung Bae, Jong-Min Kim, Donghyun Kim, Sung Hyun Baik, Leonard Sunwoo, Byung Se Choi, Jae Hyoung Kim
Summary: Neuromelanin-sensitive magnetic resonance imaging showed good diagnostic performance in discriminating patients with Parkinson's disease from healthy controls. Factors such as disease duration, imaging parameters, and segmentation methods were found to influence the diagnostic performance. Further investigations comparing these factors and optimizing parameters are necessary to improve diagnostic accuracy.
EUROPEAN RADIOLOGY
(2021)
Article
Geriatrics & Gerontology
Qin Shen, Haiyan Liao, Sainan Cai, Qinru Liu, Min Wang, Chendie Song, Fan Zhou, Yujing Liu, Jiaying Yuan, Yuqing Tang, Xu Li, Jun Liu, Changlian Tan
Summary: This study found that PD patients with depression showed decreased cortical gyrification in specific brain regions compared to those without depression, and these changes were associated with the severity of depression. Reduced gyrification was particularly observed in mo-dPD and se-dPD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Isabel Kerrebijn, Michael Wainberg, Peter Zhukovsky, Yuxiao Chen, Melanie Davie, Daniel Felsky, Shreejoy J. Tripathy
Summary: Many neuropsychiatric disorders are characterized by altered cortical thickness, but the underlying cell types are largely unknown. A new method called case-control virtual histology (CCVH) was developed and applied to Alzheimer's disease and dementia cohorts. CCVH identified cell types associated with cortical thickness differences, revealing a lack of excitatory and inhibitory neurons and an increase in astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells, and endothelial cells in AD cases compared to controls.
Article
Radiology, Nuclear Medicine & Medical Imaging
Paul D. Griffiths, Mariasavina Severino, Deborah Jarvis, Laura Mandefield, Cecilia Parazzini, Lorenzo Pinelli, Marco Di Maurizio, Fabio Triulzi, Elisa Scola, Giorgio Conte, Giovanni Palumbo, Maurilio Genovese, Andrea Rossi, Renzo Guerrini, Andrea Righini
Summary: The study included 64 foetuses with cortical formation abnormalities (CFA) who underwent two in utero magnetic resonance (iuMR) exams, with 62% showing consistent CFA description between the two studies. In 38% of cases, there was a category change, including cases without CFA initially detected, changes in laterality/symmetry, and re-classification within the same group. Brain abnormalities other than CFA were present in around half of the cases on both first and second studies. Prognosis was predicted to have changed in 8% of cases based on the second study, with all indicating a worse prognosis.
EUROPEAN RADIOLOGY
(2021)
Review
Geriatrics & Gerontology
Yanbing Hou, Huifang Shang
Summary: Cognitive impairment is a common and disturbing complication in patients with Parkinson's disease. Magnetic resonance imaging has shown promise in identifying biomarkers associated with cognitive impairment. Various MRI techniques, including structural MRI and other specific MRI methods, can provide imaging features that predict cognitive impairment.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiahui Zhang, Yuyuan Gao, Xuetao He, Shujun Feng, Jinlong Hu, Qingxi Zhang, Jiehao Zhao, Zhiheng Huang, Limin Wang, Guixian Ma, Yuhu Zhang, Kun Nie, Lijuan Wang
Summary: PD-MCI is characterized by widespread structural and EEG abnormalities. Composite markers could be valuable for the individualized diagnosis of PD-MCI through machine learning. The SVM model based on qEEG and structural MR features showed high accuracy in identifying PD-MCI.
EUROPEAN RADIOLOGY
(2021)
Article
Neurosciences
Gozde Filiz, Daphnee Poupon, Sarah Banks, Pauline Fernandez, Johannes Frasnelli
Summary: Brain plasticity is crucial for experts to acquire necessary abilities. In this study, a longitudinal design was used to investigate the brain plasticity of sommelier students. It was found that the volume of the olfactory bulb increased in sommelier students, while there were no significant changes in cortical thickness and olfactory performance. This is the first longitudinal study to report the effects of training-related brain plasticity on the olfactory bulb volume in olfaction experts.
HUMAN BRAIN MAPPING
(2022)
Article
Neuroimaging
Erlei Wang, Yujing Jia, Yang Ya, Jin Xu, Chengjie Mao, Weifeng Luo, Guohua Fan, Zhen Jiang
Summary: Studies on patients with Parkinson's disease revealed widespread lower sulcal depth and relatively localized lower cortical thickness, suggesting that sulcal depth may be more sensitive to brain changes than cortical thickness, and may be mainly affected by white matter damage. The significant positive correlation between sulcal depth and cognitive scores also indicates that sulcal depth could be a potential prognostic indicator for cognitive decline in Parkinson's disease patients.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Young Hee Sung, Joong-Seok Kim, Sang-Won Yoo, Na-Young Shin, Yoonho Nam, Tae-Beom Ahn, Dallah Yoo, Kyung Mi Lee, Hyug-Gi Kim, Seong-Beom Koh, Jinhee Kim, Ilsoo Kim, Do-Young Kwon, Younghen Lee, Chulhan Kim, Sun Ju Chung, Sungyang Jo, Seung Hyun Lee, Sang Joon Kim, Minjae Kim, Chul Hyoung Lyoo, Min Seok Baek, Suk Yun Kang, Suk Ki Chang, Sang-Won Jo, Seun Ah Lee, Hyeo-il Ma, Young Eun Kim, Eun Soo Kim, Yun Joong Kim, Hyun Sook Kim, Min-Hee Woo, Hye Jeong Choi, Eung Yeop Kim
Summary: This study compared the diagnostic performance of susceptibility map-weighted imaging (SMwI) using different MRI machines with N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl)nortropane (F-18-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism. The results showed that SMwI had a high diagnostic sensitivity, specificity, and accuracy, and there was no significant difference between the results of SMwI and F-18-FP-CIT PET. The study demonstrated the generalisability of SMwI for determining nigrostriatal degeneration in patients with parkinsonism in a multi-centre setting.
EUROPEAN RADIOLOGY
(2022)
Article
Neurosciences
Wha Jin Lee, Jesse A. Brown, Hye Ryun Kim, Renaud La Joie, Hanna Cho, Chul Hyoung Lyoo, Gil D. Rabinovici, Joon-Kyung Seong, William W. Seeley
Summary: This study identified two interactions between amyloid-beta and tau associated with the onset and propagation of tau spreading in living humans, addressing long-standing questions regarding the topographical dissimilarity between early amyloid-beta and tau deposition.
Article
Multidisciplinary Sciences
Yoon-Sang Oh, Sang-Won Yoo, Chul Hyoung Lyoo, Joong-Seok Kim
Summary: Drug-induced parkinsonism (DIP) is a major cause of misdiagnosis of Parkinson's disease (PD) and is characterized by a dopamine receptor blockade. This study found that monoamine availability in the thalamus was lower in DIP patients compared to healthy controls and similar to that of early PD patients, suggesting that this could be an imaging biomarker of DIP.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yoon-Sang Oh, Sang-Won Yoo, Chul Hyoung Lyoo, Kwang-Soo Lee, Joong-Seok Kim
Summary: Previous cancer history may have a protective effect on motor reserve in patients with Parkinson's disease.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Min Seok Baek, Han-Kyeol Kim, Kyungdo Han, Hyuk-Sung Kwon, Han Kyu Na, Chul Hyoung Lyoo, Hanna Cho
Summary: This study investigated the incidence and prevalence of Alzheimer's disease (AD) in Korea, utilizing data from the National Health Insurance System. It found a gradual increase in AD among the Korean population aged 40 years and older, with the highest increase observed in older age groups. Interestingly, individuals with hypertension or dyslipidemia were found to have lower prevalence of AD in recent years. Efforts toward early diagnosis and modification of underlying risks may be key in reducing the socioeconomic burden of AD.
FRONTIERS IN NEUROLOGY
(2022)
Correction
Neurosciences
Myung Jun Lee, Kyoungjune Pak, Han-Kyeol Kim, Kelly N. Nudelman, Jong Hun Kim, Yun Hak Kim, Junho Kang, Min Seok Baek, Chul Hyoung Lyoo
NPJ PARKINSONS DISEASE
(2022)
Letter
Clinical Neurology
Han-Kyeol Kim, Min Seok Baek, Sung Jun Ahn, Chul Hyoung Lyoo
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Han Kyu Na, Han-Kyeol Kim, Hye Sun Lee, Mina Park, Jae Hoon Lee, Young Hoon Ryu, Hanna Cho, Chul Hyoung Lyoo
Summary: By studying 272 participants with MRI and PET scans, we found that a high degree of temporal lobe perivascular space (EPVS) is associated with a higher likelihood of amyloid positivity in patients with Alzheimer's disease. This finding suggests that impaired perivascular drainage may be related to cerebral amyloidosis.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Han-Kyeol Kim, Tae Won Kim, Min Seok Baek, Eung Yeop Kim, Young Hee Sung, Jae Hoon Lee, Young Hoon Ryu, Sung Jun Ahn, Han Soo Yoo, Chul Hyoung Lyoo
Summary: In this study, the visibility of NG1 in SMwI was found to be associated with the degree of nigrostriatal degeneration in PD patients. It was concluded that SMwI can be used for diagnosing PD only after the onset of motor symptoms.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Yoon-Sang Oh, Joong-Seok Kim, Chul Hyoung Lyoo, Hosung Kim
Summary: This study found that Parkinson's disease patients with obstructive sleep apnea had significantly lower dopamine availability in the caudate nucleus compared to those without obstructive sleep apnea. This association was more pronounced in female patients. However, there was no difference in dopamine availability in other structures (putamen, globus pallidus, thalamus) between the two groups.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Sang-Won Yoo, Yoon-Sang Oh, Dong-Woo Ryu, Seunggyun Ha, Chul Hyoung Lyoo, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Kim
Summary: This study aimed to explore subtypes of early Parkinson's disease (PD) patients with cardiac sympathetic denervation and their characteristics. The results showed an association between cardiac denervation subtypes and presynaptic dopamine transporter densities in PD patients. The study also observed an association between cardiac catecholamine capacity and cognition in PD patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Sang-Won Yoo, Seunggyun Ha, Chul Hyoung Lyoo, Yuna Kim, Ji-Yeon Yoo, Joong-Seok Kim
Summary: This study explores the interaction between essential tremor (ET) and Parkinson's disease (PD), finding that patients with PD preceded by ET may exhibit different characteristics from those with pure ET or PD. Patients with PD preceded by ET show typical striatal pathology, but with a delay in noradrenergic impairment. ET patients have similar patterns of presynaptic dopamine transporter deficits as PD patients.
NPJ PARKINSONS DISEASE
(2023)
Article
Medicine, General & Internal
Soyoung Kim, Jae-Hoon Lee, Eun Jung Park, Hye Sun Lee, Seung Hyuk Baik, Tae Joo Jeon, Kang Young Lee, Young Hoon Ryu, Jeonghyun Kang
Summary: This study investigated the feasibility of using preoperative 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/ computed tomography (CT) radiomics with machine learning to predict microsatellite instability (MSI) status in colorectal cancer (CRC) patients. A predictive model incorporating PET radiomic features, called rad_score, was established and evaluated for its ability to predict MSI status. The rad_score showed similar predictive performance in both the training and test sets, and it was found to be an independent predictor of MSI status in CRC. Furthermore, the rad_score outperformed conventional PET parameters in predicting MSI status.
YONSEI MEDICAL JOURNAL
(2023)
