期刊
MOVEMENT DISORDERS
卷 24, 期 11, 页码 1606-1612出版社
WILEY
DOI: 10.1002/mds.22570
关键词
essential tremor; pathology; degeneration; cerebellum; Purkinje cell; torpedo; rate of progression
资金
- National Institutes of Health (Bethesda, MD) [R01 NS42859, P50 AGO9702]
- Parkinson's Disease Foundation (New York, NY)
- Arlene Bronstein Essential Tren-tor Research Fund (Columbia University)
- Claire O'Neil Essential Tremor Research Fund (Columbia University)
There are few data on rate of progression in essential tremor (ET). TO quantify the rate of tremor progression in a cross-sectional sample of 348 ET cases in an epidemiological study; characterize the relationship between age of tremor onset and rate of tremor progression in that sample: and characterize the relationship between age of tremor onset, rate of tremor progression. and severity of underlying brain changes in 9 cases from a brain repository. Rate of tremor progression was defined as tremor severity divided by duration. The degeneration index = number of torpedoes per section divided by Purkinje cell linear density. In the epidemiological Study, older age of tremor onset was associated with faster rate of tremor progression (P < 0.001). In the brain repository, older age of tremor onset was associated with higher degeneration index (P = 0.037), and higher degeneration index was associated with faster rate of tremor progression (P = 0.018). In a large clinical sample. older age of onset was associated with more rapid tremor progression. In a brain bank, older age of onset was associated with more degenerative Pathology in the cerebellum. As in several neurodegenerative disorders, in older onset cases, it is possible that the disease advances more rapidly. (C) 2007 Movement Disorder Society
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