4.6 Article

Motor Patterns in Parkinson's Disease: A Data-Driven Approach

期刊

MOVEMENT DISORDERS
卷 24, 期 7, 页码 1042-1047

出版社

WILEY
DOI: 10.1002/mds.22512

关键词

Parkinson's disease; motor impairment; factor analysis; structural equation modeling

资金

  1. Prinses Beatrix Fonds [WAR05-0120]
  2. Michael J Fox Foundation
  3. Alkemade-Keuls Foundation
  4. Dutch Parkinson's Disease Society

向作者/读者索取更多资源

To identify patterns of motor disturbances in Parkinson's disease (PD) and evaluate their relation with other PD domains. A cohort of 399 PD patients was randomly divided into two samples. Factors within the motor section of the SPES/SCOPA were identified by exploratory factor analysis on data from the first sample and next tested by confirmatory factory analysis in the second sample. Relations with other Pd domains were evaluated by regression analyses. A four factor model was found to be valid. This included a tremor, a bradykinetic-rigid, and two axial factors. One axial factor (rise, gait, postural instability) was associated with age and cognition, while the other axial factor (freezing, speech, swallowing) was related to dopaminergic medshowed no relevant associations with demographic and clinical characteristics. The identification of motor factors and clinical characteristics. The identification of motor factors and their relation with other domains of the disease may help to elucidate the mechanisms responsible for these associations and provide an objective base for further research on subtypes in PD. (C) 2009 Movement Disorder Society

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