Article
Neurosciences
Lili Chen, Junyan Sun, Linlin Gao, Junling Wang, Jinghong Ma, Erhe Xu, Dongling Zhang, Liang Li, Tao Wu
Summary: This study investigates the functional alterations of the parafascicular nucleus in Parkinson's disease patients and finds that damaged parafascicular nucleus-related projections are associated with clinical symptoms. These findings provide new insights into impaired neural circuits and support the parafascicular nucleus as a potential neuromodulating target for the disease.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Health Care Sciences & Services
Matteo Carpi, Mariangela Pierantozzi, Stefano Cofano, Mariana Fernandes, Rocco Cerroni, Francesca De Cillis, Nicola Biagio Mercuri, Alessandro Stefani, Claudio Liguori
Summary: This observational study investigates the presence of non-motor symptoms (NMS) and non-motor fluctuations (NMF) in Parkinson's disease (PD) patients using the Non-Motor Fluctuation Assessment questionnaire (NoMoFa). The study finds that NMF are frequently reported by mild-to-moderate PD patients and are associated with an increased number of NMS. The study emphasizes the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Melina Decourt, Haritz Jimenez-Urbieta, Marianne Benoit-Marand, Pierre-Olivier Fernagut
Summary: Parkinson's disease is associated with a variety of non-motor symptoms, including olfactory and autonomic dysfunction, neuropsychiatric issues, and cognitive impairments. These symptoms can worsen significantly over the course of the disease and may manifest before motor symptoms appear. Rodent models have shown that dopaminergic loss contributes to anxiety, apathy, depression-like behaviors, as well as learning and memory deficits in PD.
Article
Clinical Neurology
Elisa Montanaro, Alberto Romagnolo, Margherita Fabbri, Carlo Alberto Artusi, Gabriele Imbalzano, Mario Giorgio Rizzone, Leonardo Lopiano, Maurizio Zibetti
Summary: In advanced PD patients, sleep disturbances selectively correlate with specific neuropsychological functions and not with short-term memory and consolidation. It is suggested to consider treatment of sleep disturbances to minimize their potential impact on cognition.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Frederic Sampedro, Saul Martinez-Horta, Andrea Horta-Barba, Michel J. Grothe, Miguel A. Labrador-Espinosa, Silvia Jesus, Astrid Adarmes-Gomez, Fatima Carrillo, Arnau Puig-Davi, Florinda Roldan-Lora, Miquel Aguilar-Barbera, Pau Pastor, Sonia Escalante Arroyo, Berta Solano Vila, Anna Cots-Foraster, Javier Ruiz-Martinez, Francisco Carrillo-Padilla, Mercedes Pueyo-Morlans, Isabel Gonzalez-Aramburu, Jon Infante-Ceberio, Jorge Hernandez-Vara, Oriol de Fabregues-Boixar, Teresa de Deus Fonticoba, Asuncion Avila, Juan Carlos Martinez-Castrillo, Helena Bejr-Kasem, Antonia Campolongo, Berta Pascual-Sedano, Pablo Martinez-Martin, Diego Santos-Garcia, Pablo Mir, Pedro J. Garcia-Ruiz, Jaime Kulisevsky
Summary: This study explores the neural correlates of reduced facial expression and its relationship with other non-motor symptoms in Parkinson's disease. The severity of hypomimia was found to be closely associated with rigidity and bradykinesia, and significantly related to the severity of apathy. At the neural level, hypomimia was related to several brain regions involved in the recognition and production of facial expressions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Jingru Ren, Xiaoyan Zhan, Hao Zhou, Zhiying Guo, Yi Xing, Hangxing Yin, Chen Xue, Jun Wu, Weiguo Liu
Summary: Objective: GBA variants and onset age significantly affect clinical phenotype and progression in Parkinson's disease (PD). This study compared clinical characteristics and cognitive and motor progression among GBA-PD, early-iPD, and late-iPD patients. Results showed that GBA-PD patients had more severe symptoms and faster progression compared to early-iPD and late-iPD patients. However, onset age did not have a significant impact on clinical features and progression in GBA-PD patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Haoting Wu, Cheng Zhou, Xueqin Bai, Xiaocao Liu, Jingwen Chen, Jiaqi Wen, Tao Guo, Jingjing Wu, Xiaojun Guan, Ting Gao, Luyan Gu, Peiyu Huang, Xiaojun Xu, Baorong Zhang, Minming Zhang
Summary: Identifying a whole-brain connectome-based predictive model in drug-naive patients with Parkinson's disease and validating its predictions on drug-managed patients provides insights into the functional underpinnings of motor impairment and brain-behavior associations. The model was effective in predicting individual motor impairment severity in drug-naive patients and demonstrated generalizability in Parkinson's disease patients under long-term drug influence.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Damian M. Herz, David Meder, Julia A. Camilleri, Simon B. Eickhoff, Hartwig R. Siebner
Summary: Despite conflicting results in individual neuroimaging studies, this revised meta-analytic approach identified consistent patterns of abnormal motor-related activation in Parkinson's disease. The distinct patterns of decreased and increased activity might be determined by their connectivity with different subregions of the putamen.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Emahnuel Troisi Lopez, Roberta Minino, Marianna Liparoti, Arianna Polverino, Antonella Romano, Rosa De Micco, Fabio Lucidi, Alessandro Tessitore, Enrico Amico, Giuseppe Sorrentino, Viktor Jirsa, Pierpaolo Sorrentino
Summary: The clinical connectome fingerprint (CCF) is a method for assessing brain dynamics and can identify individuals based on brain networks. This study examines the performance of CCF in Parkinson's disease (PD) patients and healthy controls. It finds that PD patients have reduced identifiability compared to controls, and this reduction can be used to predict motor impairment. The findings suggest that CCF captures disrupted dynamics in neurodegenerative diseases and is particularly effective in predicting motor clinical impairment in PD.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Chang-hyun Park, Na-Young Shin, Sang-Won Yoo, Haeseok Seo, Uicheul Yoon, Ji-Yeon Yoo, Kookjin Ahn, Joong-Seok Kim
Summary: This study inferred the progression of Parkinson's disease through MRI observations and found that white matter disintegrity tends to occur earlier than cortical thinning. The staging of structural alterations indicates that these alterations mostly happen before major disease complications, and subsequent alterations are related to more severe clinical symptoms.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Christopher F. Madelung, David Meder, Soren A. Fuglsang, Marta M. Marques, Vincent O. Boer, Kristoffer H. Madsen, Esben T. Petersen, Anne-Mette Hejl, Annemette Lokkegaard, Hartwig R. Siebner
Summary: This study used neuromelanin sensitive magnetic resonance imaging (MRI) to examine the structural disintegration of the locus coeruleus (LC) and its association with nonmotor dysfunction in patients with Parkinson's disease (PD). The findings showed that PD patients had reduced structural integrity in the right LC, specifically in the mid-caudal region. The disintegration of the LC was linked to specific nonmotor symptoms, such as orthostatic dysregulation and apathy. Additionally, the severity of nonmotor symptoms was associated with the overall structural disintegration of the LC.
MOVEMENT DISORDERS
(2022)
Article
Computer Science, Information Systems
Luca Pietrosanti, Cristiano Maria Verrelli, Franco Giannini, Antonio Suppa, Francesco Fattapposta, Alessandro Zampogna, Martina Patera, Viviana Rosati, Giovanni Saggio
Summary: Parkinson's disease is a chronic neurodegenerative disorder that affects movement and is evaluated subjectively by clinicians. To provide more objective assessments, researchers have developed technology-based systems to measure motor symptoms, but there has been a lack of focus on the importance of upper limb swing during walking.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chun-Chao Huang, Pei-Hao Chen, Chih-Chien Tsai, Hsin-Fan Chiang, Cheng-Chih Hsieh, Ting-Lin Chen, Wei-Hsin Liao, Yao-Liang Chen, Jiun-Jie Wang
Summary: The study investigates the neuroimage change in Parkinson's disease patients with cognitive impairments by correlating plasma biomarkers with morphological brain changes in patients with normal cognition and mild cognitive impairment. The aim is to identify potential target deposition regions of plasma biomarkers and explore relevant early neuroimaging biomarkers for different cognitive domains.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Mattia Siciliano, Rosa De Micco, Andrea Gerardo Russo, Fabrizio Esposito, Valeria Sant'Elia, Lucia Ricciardi, Francesca Morgante, Antonio Russo, Jennifer G. Goldman, Carlo Chiorri, Gioacchino Tedeschi, Luigi Trojano, Alessandro Tessitore
Summary: This study identified three distinct memory-related phenotypes in patients with mild cognitive impairment related to Parkinson's disease (PD-MCI) through cluster analysis. These phenotypes were associated with motor and non-motor features as well as patients' quality of life. The findings contribute to understanding the pathophysiological mechanisms underlying PD-MCI and its subtypes and guiding appropriate treatments.
MOVEMENT DISORDERS
(2023)
Article
Mathematics, Interdisciplinary Applications
Gyeongcheol Cho, Heungsun Hwang
Summary: JCA is a standard method for structural equation modeling but often leads to improper solutions and lacks probabilistic inference for true factor scores. To address these issues, we propose SFA, a data matrix-based alternative that minimizes a cost function to estimate parameters and factor scores and enables probabilistic inference.
STRUCTURAL EQUATION MODELING-A MULTIDISCIPLINARY JOURNAL
(2023)
Article
Rehabilitation
Daphne J. Geerse, Melvyn Roerdink, Johan Marinus, Jacobus J. van Hilten
Summary: The study aimed to evaluate the potential of the Interactive Walkway as a new technology for assessing walking adaptability in stroke patients. Results demonstrated good known-groups validity for walking-adaptability outcomes, with only moderate correlations with clinical test scores and gait parameters. The Interactive Walkway walking-adaptability outcomes complement standard clinical tests and spatiotemporal gait parameters.
DISABILITY AND REHABILITATION
(2021)
Article
Public, Environmental & Occupational Health
Janneke D. M. Verberk, Stephanie M. van Rooden, Mayke B. G. Koek, David J. Hetem, Annelies E. Smilde, Wendy S. Bril, Roel H. R. A. Streefkerk, Titia E. M. Hopmans, Marc J. M. Bonten, Sabine C. de Greeff, Maaike S. M. van Mourik
Summary: The study evaluated the validity of a semiautomated surveillance algorithm for deep SSIs after THA or TKA in Dutch hospitals, showing that the algorithm can reliably detect patients with a high probability of developing deep SSIs and significantly reduce workload.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Rene Post, Menno R. Germans, Maud A. Tjerkstra, Mervyn D. I. Vergouwen, Korne Jellema, Radboud W. Koot, Nyika D. Kruyt, Peter W. A. Willems, Jasper F. C. Wolfs, Frits C. de Beer, Hans Kieft, Dharmin Nanda, Bram van der Pol, Gerwin Roks, Frank de Beer, Patricia H. A. Halkes, Loes J. A. Reichman, Paul J. A. M. Brouwers, Renske M. van den Berg-Vos, Vincent I. H. Kwa, C. van der Ree, Irene Bronner, Janneke van de Vlekkert, Henri P. Bienfait, Hieronymus D. Boogaarts, Catharina J. M. Klijn, Rene van den Berg, Bert A. Coert, Janneke Horn, Charles B. L. M. Majoie, Gabriel J. E. Rinkel, Yvo B. W. E. M. Roos, W. Peter Vandertop, Dagmar Verbaan
Summary: In patients with aneurysmal subarachnoid haemorrhage, ultra-early, short-term treatment with tranexamic acid did not improve clinical outcomes at 6 months, as measured by the modified Rankin Scale.
Article
Neurosciences
Arlin Keo, Oleh Dzyubachyk, Jeroen van der Grond, Anne Hafkemeijer, Wilma D. J. van de Berg, Jacobus J. van Hilten, Marcel J. T. Reinders, Ahmed Mahfouz
Summary: Structural covariance networks in healthy brains reveal upregulation of genes associated with serotonin, GPCR, GABA, glutamate, and RAS-signaling pathways. The involvement of the cholinergic circuit, as well as genes associated with neuropsychiatric disorders, may play a role in Parkinson's disease pathology. The disruption of healthy functions in cingulate networks could contribute to Parkinson's disease clinical events.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Ganqiang Liu, Jiajie Peng, Zhixiang Liao, Joseph J. Locascio, Jean-Christophe Corvol, Frank Zhu, Xianjun Dong, Jodi Maple-Grodem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Graziella Mangone, John H. Growdon, Albert Y. Hung, Michael A. Schwarzschild, Michael T. Hayes, Anne-Marie Wills, Todd M. Herrington, Bernard Ravina, Ira Shoulson, Pille Taba, Sulev Koks, Thomas G. Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjorn Tysnes, Joel S. Perlmutter, Peter Heutink, Sami S. Amr, Jacobus J. van Hilten, Meike Kasten, Brit Mollenhauer, Claudia Trenkwalder, Christine Klein, Roger A. Barker, Caroline H. Williams-Gray, Johan Marinus, Clemens R. Scherzer
Summary: A genome-wide survival study identified variants at RIMS2 associated with progression of Parkinson's disease to dementia and highlights divergence in the genetic architecture of disease onset and progression.
Article
Infectious Diseases
Maaike S. M. van Mourik, Stephanie M. van Rooden, Mohamed Abbas, Olov Aspevall, Pascal Astagneau, Marc J. M. Bonten, Elena Carrara, Aina Gomila-Grange, Sabine C. de Greeff, Sophie Gubbels, Wendy Harrison, Hilary Humphreys, Anders Johansson, Mayke B. G. Koek, Brian Kristensen, Alain Lepape, Jean-Christophe Lucet, Siddharth Mookerjee, Pontus Naucler, Zaira R. Palacios-Baena, Elisabeth Presterl, Miquel Pujol, Jacqui Reilly, Christopher Roberts, Evelina Tacconelli, Daniel Teixeira, Thomas Tangden, John Karlsson Valik, Michael Behnke, Petra Gastmeier
Summary: This paper discusses the transition of automated surveillance (AS) from research setting to large-scale implementation, providing guidance on surveillance target selection, organizational and methodological approaches, key performance requirements of AS systems, successful implementation, and future research directions.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Infectious Diseases
Michael Behnke, John Karlsson Valik, Sophie Gubbels, Daniel Teixeira, Brian Kristensen, Mohamed Abbas, Stephanie M. van Rooden, Petra Gastmeier, Maaike S. M. van Mourik
Summary: This document, published in 2021 by the European Society of Clinical Microbiology and Infectious Diseases on behalf of Elsevier Ltd, provides an overview of implementing an automated surveillance system for Healthcare-associated infections (HAI) in a clinical environment.
Written by a task force within the PRAISE network, it offers detailed guidance on key e-health aspects, data storage and structure, IT infrastructure organization, data standardization, interoperability, algorithms, and technical aspects of accessing, storing, and sharing healthcare data for HAI surveillance.
With the support of this document, along with the PRAISE roadmap and governance documents, readers will have comprehensive guidance on implementing large-scale automated surveillance in a healthcare network.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Janneke D. M. Verberk, Stephanie M. van Rooden, David J. Hetem, Herman F. Wunderink, Anne L. M. Vlek, Corianne Meijer, Eva A. H. van Ravensbergen, Elisabeth G. W. Huijskens, Saara J. Vainio, Marc J. M. Bonten, Maaike S. M. van Mourik
Summary: This study investigated the reliability and validity of surgical site infection (SSI) surveillance after colorectal surgery in the Netherlands. The study found that raters were consistent in their SSI-ascertainment (good reliability), but improvements can be made regarding the accuracy (moderate validity). Accuracy of surveillance may be improved by providing regular training, adapting definitions to reduce subjectivity, and by supporting surveillance through automation.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
J. D. M. Verberk, S. J. S. Aghdassi, M. Abbas, P. Naucler, S. Gubbels, N. Maldonado, Z. R. Palacios-Baena, A. F. Johansson, P. Gastmeier, M. Behnke, S. M. van Rooden, M. S. M. van Mourik
Summary: This study describes the design and implementation of AS systems in Europe, highlighting differences in methods, data sources, and targeted HAIs. AS systems can reduce workload for hospital staff, but implementation barriers include strict data security regulations and the establishment of information technology infrastructure.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Clinical Neurology
Hendrikus J. A. van Os, Dagmar Verbaan, Ynte M. Ruigrok, Paul Dennesen, Marcella C. A. Muller, Bert A. Coert, Mervyn D. Vergouwen, Marieke J. H. Wermer
Summary: This study investigated whether young patients with a history of migraine who had aneurysmal subarachnoid hemorrhage (aSAH) were at increased risk of delayed cerebral ischemia. The results showed that young aSAH patients under 50 years of age with a history of migraine were not at increased risk of delayed cerebral ischemia.
Article
Clinical Neurology
Annemijn M. Algra, Jacoba P. Greving, Jordi de Winkel, Arttu Kurtelius, Kamil Laban, Dagmar Verbaan, Rene van den Berg, William Vandertop, Antti Lindgren, Timo Krings, Peter Y. M. Woo, George K. C. Wong, Bob Roozenbeek, Adriaan C. G. M. van Es, Ruben Dammers, Nima Etminan, Hieronymus Boogaarts, Tristan van Doormaal, Albert van der Zwan, Irene C. van der Schaaf, Gabriel J. E. Rinkel, Mervyn D. I. Vergouwen
Summary: The study aimed to develop risk scores for complications of endovascular and microneurosurgical treatment to improve management decisions for patients with unruptured intracranial aneurysms. By studying the relationship between consistency and risk factors, corresponding predictive models were derived.
Article
Clinical Neurology
L. Kuiper, M. Sanchez van Kammen, B. A. Coert, D. Verbaan, B. J. Emmer, J. M. Coutinho, R. van den Berg
Summary: One-third of patients with dural AVFs in this study were diagnosed with cerebral venous thrombosis. In almost two-thirds of patients, cerebral venous thrombosis was diagnosed prior to or concurrent with the dural AVF. In 97% of patients, there was an anatomic association between the dural AVF and cerebral venous thrombosis.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Editorial Material
Clinical Neurology
Menno R. Germans, Wouter J. Dronkers, M. Irem Baharoglu, Rene Post, Dagmar Verbaan, Gabriel J. E. Rinkel, Yvo B. W. E. M. Roos
Article
Clinical Neurology
Liselore A. Mensing, Rick J. van Tuijl, Jacoba P. Greving, Birgitta K. Velthuis, Irene C. van der Schaaf, Marieke J. H. Wermer, Dagmar Verbaan, W. Peter Vandertop, Nicolaas P. A. Zuithoff, Gabriel J. E. Rinkel, Ynte M. Ruigrok
Summary: This study assessed the effectiveness of screening for UIAs in first-degree relatives (FDRs) of patients with UIA, finding a low rupture risk and no negative impact on quality of life.
Article
Clinical Neurology
Jonas M. den Heijer, Jacobus J. van Hilten, Anneke J. A. Kievit, Vincenzo Bonifati, Geert Jan Groeneveld
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)