Article
Neurosciences
Michaela Kaiserova, Katerina Mensikova, Lucie Tuckova, Petr Hlustik, Petr Kanovsky
Summary: Corticobasal syndrome (CBS) presents with progressive asymmetric rigidity and apraxia, often associated with a wide range of neurodegenerative diseases. This case study highlights a 71-year-old woman with CBS showing concomitant pathology corresponding to Lewy-related and Alzheimer's-type pathology, expanding the spectrum of neurodegenerative pathological processes that may manifest with the typical CBS phenotype. Identifying specific biomarkers is crucial for accurate in vivo differential diagnosis and determining the underlying pathological processes of these diseases.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jacy Bezerra Parmera, Isabel Junqueira de Almeida, Marcos Castello Barbosa de Oliveira, Marcela Lima Silagi, Camila de Godoi Carneiro, Adalberto Studart-Neto, Carla Rachel Ono, Egberto Reis Barbosa, Ricardo Nitrini, Carlos Alberto Buchpiguel, Sonia Maria Dozzi Brucki, Artur Martins Coutinho
Summary: In investigating CBS speech and language impairment patterns with a multimodal imaging approach, a wide linguistic profile was identified, with aphasia being a prominent cognitive impairment. Dysarthria may help distinguish CBS patients not related to AD, with distinct metabolic and structural signatures providing further insights into the motor speech production network and aiding the differentiation of CBS variants.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Adolfo M. Garcia, Ariane E. Welch, Maria Luisa Mandelli, Maya L. Henry, Sladjana Lukic, Maria Jose Torres Prioris, Jessica Deleon, Buddhika M. Ratnasiri, Diego L. Lorca-Puls, Bruce L. Miller, William Seeley, Adam P. Vogel, Maria Luisa Gorno-Tempini
Summary: This study utilized automated speech timing analyses in a cohort of autopsy-proven cases to investigate motor speech function in individuals with nfvPPA. The results indicated that automated analysis can capture specific markers of nfvPPA and potentially discriminate between patients with different tauopathies. The objectivity and scalability of this approach could support standard speech assessments.
Article
Clinical Neurology
Adolfo M. Garcia, Ariane E. Welch, Maria Luisa Mandelli, Maya L. Henry, Sladjana Lukic, Maria Jose Torres Prioris, Jessica Deleon, Buddhika M. Ratnasiri, Diego L. Lorca-Puls, Bruce L. Miller, William Seeley, Adam P. Vogel, Maria Luisa Gorno-Tempini
Summary: Automated speech timing analyses can identify specific markers of nfvPPA and potentially differentiate between patients with different tauopathies. This approach, thanks to its objectivity and scalability, could be a valuable support for standard speech assessments.
Review
Clinical Neurology
Shunsuke Koga, Keith A. Josephs, Ikuko Aiba, Mari Yoshida, Dennis W. Dickson
Summary: Corticobasal syndrome (CBS) is a clinical syndrome characterized by progressive asymmetric limb rigidity and apraxia. It is associated with various underlying pathologies such as Corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), Alzheimer's disease (AD), and frontotemporal lobar degeneration with TDP-43 inclusions. Regardless of the underlying pathology, CBS is associated with frontoparietal, motor and premotor pathology.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Vasilios C. Constantinides, George P. Paraskevas, Fotini Boufidou, Mara Bourbouli, Leonidas Stefanis, Elisabeth Kapaki
Summary: This study applied three different sets of criteria for interpreting CSF AD biomarkers in probable CBD patients, revealing diverse results in AD pathology detection. About 50% of probable CBD patients were categorized as having AD, indicating suboptimal positive predictive value of CBD diagnostic criteria. A consensus on interpretation criteria of CSF AD biomarkers is essential.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Anna E. Goodheart, Joseph J. Locascio, Wesley R. Samore, Jessica A. Collins, Michael Brickhouse, Aaron Schultz, Alexandra Touroutoglou, Keith A. Johnson, Matthew P. Frosch, John H. Growdon, Bradford C. Dickerson, Stephen N. Gomperts
Summary: The study found that corticobasal syndrome patients without amyloid deposition showed higher F-18-AV-1451 retention and regional atrophy, particularly in areas associated with corticobasal degeneration pathology, while cases associated with Alzheimer's disease exhibited greater and more diffuse brain involvement on tau-PET imaging. The differences between the two groups were significant.
Review
Geriatrics & Gerontology
Anna Dunalska, Julia Pikul, Katarzyna Schok, Katarzyna Anna Wiejak, Piotr Alster
Summary: Corticobasal syndrome (CBS) is classified as atypical Parkinsonism characterized by motor and higher cortical dysfunctions. Vascular CBS cases are associated with vascular lesions, particularly internal carotid artery stenosis and ischemic strokes, and often occur in elderly patients with cardiovascular risk factors.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Cell Biology
Federica Arienti, Giulia Lazzeri, Maria Vizziello, Edoardo Monfrini, Nereo Bresolin, Maria Cristina Saetti, Marina Picillo, Giulia Franco, Alessio Di Fonzo
Summary: CBS is a atypical parkinsonian syndrome with heterogeneous clinical features and different underlying neuropathology. The most common gene involved in CBS is GRN, followed by MAPT, C9ORF72, and PRNP. GRN-CBS patients commonly exhibit symptoms such as visuospatial impairment, behavioral changes, aphasia, and language alterations. Specific demographic, clinical, biochemical, and radiological features may suggest mutations in other genes.
Article
Audiology & Speech-Language Pathology
Anja Staiger, Matthias L. Schroeter, Wolfram Ziegler, Daniele Pino, Frank Regenbrecht, Theresa Schoelderle, Theresa Rieger, Lina Riedl, Felix Mueller-Sarnowski, Janine Diehl-Schmid
Summary: This study aims to examine the characteristics of motor speech disorders (MSDs) in primary progressive aphasia (PPA) patients. The results show that common MSDs in PPA include apraxia of speech, dysarthria, and mixed forms. These findings emphasize the need for future studies to consider all clinical variants of PPA and the qualitative characteristics of motor speech dysfunction across speech dimensions.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2023)
Article
Clinical Neurology
Makoto Sainouchi, Mari Tada, Yusran Ady Fitrah, Norikazu Hara, Kou Tanaka, Jiro Idezuka, Izumi Aida, Takashi Nakajima, Akinori Miyashita, Kohei Akazawa, Takeshi Ikeuchi, Osamu Onodera, Akiyoshi Kakita
Summary: The presence of TDP-43 inclusions in the brains of CBD patients has been correlated with clinical phenotypes. This study investigated the relationship between TDP-43 inclusions and neuronal loss in CBD. The results suggest that TDP-43 alterations in neurons, independent of tau pathology, may contribute to neuronal degeneration in CBD.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Kosei Nakamura, Yasuko Kuroha, Masahiro Hatakeyama, Atsushi Michael Kimura, Yukimi Nakamura, Yoshihiro Murakami, Masaki Watanabe, Hironaka Igarashi, Tetsuya Takahashi, Hitoshi Shimada
Summary: We present here an atypical case of CBS that initially presented with clinical features resembling FCMS. TDP-43 proteinopathy was suspected based on early clinical symptoms, but the clinical course and imaging findings, including tau PET, suggested that the pathological background of the patient was 4-repeat tauopathy.
Article
Clinical Neurology
Carla Palleis, Matthias Brendel, Anika Finze, Endy Weidinger, Kai Boetzel, Adrian Danek, Leonie Beyer, Alexander Nitschmann, Maike Kern, Gloria Biechele, Boris-Stephan Rauchmann, Jan Haeckert, Matthias Hoellerhage, Andrew W. Stephens, Alexander Drzezga, Thilo van Eimeren, Victor L. Villemagne, Andreas Schildan, Henryk Barthel, Marianne Patt, Osama Sabri, Peter Bartenstein, Robert Perneczky, Christian Haass, Johannes Levin, Guenter U. Hoeglinger
Summary: The study showed that the tau PET ligand [F-18]PI-2620 has diagnostic value in patients with corticobasal syndrome, providing quantitatively and regionally distinct signals. Regardless of beta-amyloid status, the hemispheric lateralization of [F-18]PI-2620 signal reflects the severity of the disease clinically.
MOVEMENT DISORDERS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Keith A. Josephs, Nirubol Tosakulwong, Stephen D. Weigand, Marina Buciuc, Val J. Lowe, Dennis W. Dickson, Jennifer L. Whitwell
Summary: F-18-flortaucipir PET uptake is not associated with 4R tau lesion types, but may have marginal correlation with thread-like lesions in specific brain regions and astrocytic lesions in the red nucleus.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Katie A. Peterson, P. Simon Jones, Nikil Patel, Kamen A. Tsvetanov, Ruth Ingram, Stefano F. Cappa, Matthew A. Lambon Ralph, Karalyn Patterson, Peter Garrard, James B. Rowe
Summary: Speech and language impairments in patients with PSP, CBS, and nfvPPA show similarities in cortical thickness reduction in bilateral frontal regions and striatal volume reduction. Multivariate analysis reveals associations between different speech and language domains and atrophy of specific brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
C. Koriath, J. Kenny, G. Adamson, R. Druyeh, W. Taylor, J. Beck, L. Quinn, T. H. Mok, A. Dimitriadis, P. Norsworthy, N. Bass, J. Carter, Z. Walker, C. Kipps, E. Coulthard, J. M. Polke, M. Bernal-Quiros, N. Denning, R. Thomas, R. Raybould, J. Williams, C. J. Mummery, E. J. Wild, H. Houlden, S. J. Tabrizi, M. N. Rossor, H. Hummerich, J. D. Warren, J. B. Rowe, J. D. Rohrer, J. M. Schott, N. C. Fox, J. Collinge, S. Mead
MOLECULAR PSYCHIATRY
(2020)
Article
Green & Sustainable Science & Technology
Savitha Basri, Iqbal Thonse Hawaldar, Raveendranath Nayak, Habeeb Ur Rahiman
Summary: Distress and problematic internet use in online classrooms during the COVID-19 pandemic have led to student burnout and affected perceived learning. A study in India found that psychological stress, academic burnout, and resilience have direct and indirect effects on perceived learning. Burnout acts as a complete mediator in the relationship between stress and perceived learning. Changing educational policies and implementing prevention strategies can address this societal problem.
Article
Education & Educational Research
I. S. Rekha, Jyothi Shetty, Savitha Basri
Summary: This study investigates the learner's continued intention to use MOOC by combining the expectation-confirmation model with MOOC features. The results show that confirmation and perceived usefulness have a significant influence on satisfaction, and perceived computer self-efficacy, satisfaction, and perceived usefulness directly affect continuance intention.
EDUCATION AND INFORMATION TECHNOLOGIES
(2023)
Article
Economics
Basri Savitha, Iqbal Thonse Hawaldar
Summary: This study aims to elucidate the factors affecting customers' intention to use budgeting apps after the outbreak of COVID-19. A cross-sectional survey of 285 FinTech users in South India was conducted, and the results showed that app engagement and self-efficacy have a positive effect on usage intentions. Users who use FinTech services less frequently and those who use it for various expenses were found to have a greater impact on customer engagement, perceived trust, and perceived ease of use.
COGENT ECONOMICS & FINANCE
(2022)
Article
Multidisciplinary Sciences
Basri Savitha, Iqbal Thonse Hawaldar, Naveen K. Kumar
Summary: This study aims to identify the determinants of continuance intentions to use FinTech P2P payment apps in India. The findings show that confirmation of prior expectations and post-adoption perceived usefulness play a decisive role in the continuance intention to use FinTech payment services. Cognitive acceptance and normative acceptance not only determine behavioral acceptance but also influence continuance intentions. Satisfaction and post-purchase perceived usefulness are determined by the confirmation of initial expectations. Fulfilling users' post-purchase expected benefits, fostering trust, and social influence are key practical implications for ensuring the continuous use of FinTech P2P services.
Article
Economics
Archana Nayak Kini, Savitha Basri
Summary: The article investigates the influence of consumer empowerment on customer engagement behaviors (CEBs) and their impact on customer value in India's FinTech industry. A cross-sectional analytical study collected data from 380 Indian FinTech app users through a survey questionnaire. The Partial Least Square Structural Equation Modeling (PLS-SEM) method was used to test the conceptual model. This study, one of the first conducted during the COVID-19 pandemic, reveals that customer-empowered behaviors predict positive CEBs, such as reviews and testimonials, which in turn contribute to customer value. The indirect effects suggest that CEB mediates the relationship between customer empowerment and value. This research also validates customer engagement behavior as a formative higher-order construct comprised of four dimensions: customers' social media influence, form/modality, scope, and channel of engagement. To create customer value, practitioners and e-marketers in the FinTech industry should foster online communities, identify and manage customers' need for control and empowerment, and design customized marketing strategies accordingly. The study provides guidance for academicians and researchers in developing engagement models that encourage positive CEBs, including e-word of mouth, customer reviews, and testimonials.
ORGANIZATIONS AND MARKETS IN EMERGING ECONOMIES
(2023)
Article
Health Care Sciences & Services
Basri Savitha, Subrato Banerjee
Summary: This study examines the various factors influencing enrollment in micro health insurance (MHI) in India and finds that education is not as significant as experience in determining new insurance purchases. Individuals who have experienced illness or seen the risks of usurious borrowing are more likely to understand the importance of new insurance.
INTERNATIONAL JOURNAL OF HEALTH POLICY AND MANAGEMENT
(2021)
Correction
Business, Finance
Subrato Banerjee, Basri Savitha
GENEVA PAPERS ON RISK AND INSURANCE-ISSUES AND PRACTICE
(2021)
Article
Business, Finance
Subrato Banerjee, Basri Savitha
Summary: This research investigates the impact of market and firm-level concentration on return on equity in the Indian life microinsurance industry. The findings suggest that companies in the Indian LMI market perform better financially when competitive pressures are lower. Concentration has a positive effect on performance in this industry, while market share has a negative impact, indicating that LMI-specialized insurers in India outperform diversified insurers.
GENEVA PAPERS ON RISK AND INSURANCE-ISSUES AND PRACTICE
(2021)
Article
Business
Ankitha Shetty, Savitha Basri
GLOBAL BUSINESS REVIEW
(2020)
Article
Business
Shetty Ankitha, Savitha Basri
INTERNATIONAL JOURNAL OF BANK MARKETING
(2019)
Article
Business, Finance
Basri Savitha, Subrato Banerjee, Ankitha Shetty
GENEVA PAPERS ON RISK AND INSURANCE-ISSUES AND PRACTICE
(2019)
Article
Gerontology
John H. Spreadbury, Christopher Kipps
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2019)
Article
Gerontology
J. H. Spreadbury, C. M. Kipps
DEMENTIA-INTERNATIONAL JOURNAL OF SOCIAL RESEARCH AND PRACTICE
(2019)
Article
Clinical Neurology
Bhaskara P. Shelley, Prasanth Prasad, Malla M. Manjunath, Shrijeet Chakraborti
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2019)