Article
Clinical Neurology
Georgia Sousouri, Christian R. Baumann, Lukas L. Imbach, Reto Huber, Esther Werth
Summary: This study found a relationship between motor laterality in Parkinson's disease patients and sleep neural asymmetry. Left-dominant patients showed significant changes pre- and post-Deep Brain Stimulation, while right-dominant patients did not exhibit neural asymmetry or motor laterality.
CLINICAL NEUROPHYSIOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Konstanze Krueger, Sophie Schwarz, Isabell Marr, Kate Farmer
Summary: For centuries, straightening a horse has been a traditional goal in training to achieve responsiveness and suppleness. However, it is natural for horses to have body asymmetry, motor laterality, and sensory laterality. Enforcing straightness may cause psychological and physical imbalance. Body asymmetry has little impact on performance, but increases in motor and sensory laterality may indicate insufficiencies in housing, handling, and training. It is suggested to focus on psychological and physical balance, coordination, and equal strength on both sides instead of enforcing straightness.
Article
Neurosciences
Yuichi Nishikawa, Kohei Watanabe, Ales Holobar, Noriaki Maeda, Hirofumi, Maruyama, Shinobu Tanaka
Summary: Patients with Parkinson's disease (PD) exhibit greater laterality of muscle contraction properties compared to other parkinsonism diseases, with abnormalities in single motor unit behavior even in early stages of the disease. This highlights the importance of detecting abnormal muscle properties in PD patients early on.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Sha Zhu, Min Zhong, Yu Bai, Zhuang Wu, Ruxin Gu, Xu Jiang, Bo Shen, Jun Zhu, Yang Pan, Jingde Dong, Pingyi Xu, Jun Yan, Li Zhang
Summary: The study found that patients with left-dominant motor symptoms in Parkinson's Disease (PD) experienced more severe impairment in sleep quality compared to those with right-dominant symptoms. There was no significant difference in gait performance between left-dominant and right-dominant PD patients. However, PD patients with severe asymmetry in left-dominant symptoms showed shorter stride length and decreased range of motion of hip joints compared to those with severe asymmetry in right-dominant symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Jingwen Chen, Xianchen Jiang, Jingjing Wu, Haoting Wu, Cheng Zhou, Tao Guo, Xueqin Bai, Xiaocao Liu, Jiaqi Wen, Zhengye Cao, Luyan Gu, Wenyi Yang, Jiali Pu, Xiaojun Guan, Xiaojun Xu, Baorong Zhang, Minming Zhang
Summary: This study aimed to explore the clinical characteristics and underlying brain structure alterations in Parkinson's disease (PD) patients with different predominant sides and motor types. The study found that patients with left akinetic/rigid-dominant subtype experienced the worst motor impairment and showed worse cognitive performance compared to healthy controls. Additionally, this subtype showed significant reduction in cortical thickness and fractional anisotropy in specific brain regions.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Anatomy & Morphology
Sebastian Ocklenburg, Dorothea Metzen, Caroline Schlueter, Christoph Fraenz, Larissa Arning, Fabian Streit, Onur Guentuerkuen, Robert Kumsta, Erhan Genc
Summary: The study found significant associations between polygenic scores from large-scale handedness GWAS and individual handedness in smaller validation samples with more detailed phenotypic assessment, suggesting potential benefits for validation samples.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Karlo J. Lizarraga, Bhairavei Gnanamanogaran, Tameem M. Al-Ozzi, Melanie Cohn, George Tomlinson, Alexandre Boutet, Gavin J. B. Elias, Jurgen Germann, Derrick Soh, Suneil K. Kalia, Mojgan Hodaie, Renato P. Munhoz, Connie Marras, William D. Hutchison, Andres M. Lozano, Anthony E. Lang, Alfonso Fasano
Summary: Unilateral subthalamic stimulation does not significantly improve gait velocity in patients with Parkinson's disease, but left overstimulation may contribute to axial deterioration.
MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Francesco Bove, Francesco Cavallieri, Anna Castrioto, Sara Meoni, Emmanuelle Schmitt, Amelie Bichon, Eugenie Lhommee, Pierre Pelissier, Andrea Kistner, Eric Chevrier, Eric Seigneuret, Stephan Chabardes, Franco Valzania, Valerie Fraix, Elena Moro
Summary: Research on patients with Parkinson's disease (PD) shows that the side of motor symptom onset does not significantly affect the outcome of bilateral subthalamic nucleus deep brain stimulation (STN-DBS).
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Seok Jong Chung, Phil Hyu Lee, Young H. Sohn, Yun Joong Kim
Summary: This study investigated the potential role of glucocerebrosidase (GBA) variants as determinants of motor reserve in Parkinson's disease. The results demonstrated a detrimental effect of GBA variants on individual capacity to cope with PD-related pathologies, with different impacts depending on the motor laterality.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Surgery
David K. Chong, Mithila Somasundaram, Emily Ho, Nicolas S. Dhooghe, David M. Fisher
Summary: Left and right complete cleft lips have anthropometric differences, with right cleft lips showing greater deficiencies in lateral lip element development.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Multidisciplinary Sciences
Agneta Egenvall, Hilary M. Clayton, Anna Bystrom
Summary: Horses show asymmetry in their walking patterns, with differences between left and right directions. Objective data showed that horses had more symmetric hip and stifle motion when walking on the right circle, which correlated with subjective perceptions of laterality by horse owners.
Article
Biochemistry & Molecular Biology
Masuelli Sofia, Real Sebastian, Campoy Emanuel, Maria Teresita Branham, Diego Matias Marzese, Salomon Matthew, Gerardo De Blas, Arias Rodolfo, Levin Michael, Roque Maria
Summary: This study discovered differential DNA methylation and bioelectric differences between left-sided and right-sided breast tumors, which were associated with tumor proliferation. These findings provide new targets for future breast cancer therapeutic approaches.
MOLECULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Eric Chevrier, Elena Moro, Pierre Pelissier, Anna Castrioto, Paul Krack, Valerie Fraix, Bettina Debu
Summary: Balance disorders are common in Parkinson's disease (PD), and one-leg stance performance can predict fall risk. This study investigated one-leg stance strategies in PD patients and found that they tend to choose and perform better on the leg with less impairment. However, the most stable leg is not always chosen, and the side of the chosen leg may switch after seven years of disease duration. It is important to identify PD patients who choose the least stable leg as they may be at a higher risk of falls and may benefit from specific rehabilitation strategies.
Article
Behavioral Sciences
Julian Packheiser, Marietta Papadatou-Pastou, Angeliki Koufaki, Silvia Paracchini, Clara C. Stein, Judith Schmitz, Sebastian Ocklenburg
Summary: This study conducted a meta-analysis to investigate the link between hand preference and dyslexia and found that there is an increase in atypical hand preference in dyslexia, especially in mixed-handers.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Agriculture, Dairy & Animal Science
Sophie Schwarz, Isabell Marr, Kate Farmer, Katja Graf, Volker Stefanski, Konstanze Krueger
Summary: This study investigated the laterality in horses when carrying a rider. The results showed that carrying a rider increased the motor laterality, but did not affect the sensory laterality. This suggests that carrying a passive rider does not have a negative impact on the stress levels and mental state of horses.
Review
Clinical Neurology
P. D. Delgado-Lopez, S. Ortega-Cubero, J. J. Gonzalez Bernal, E. Cubo-Delgado
Summary: There is currently no formal indication for seizure prophylaxis in neurosurgical oncology patients. This study aimed to explore the effectiveness of antiepileptic prophylaxis in patients with meningioma and no history of seizures through a systematic review and meta-analysis.
Review
Clinical Neurology
R. Lopez-Blanco, A. Sorrentino Rodriguez, E. Cubo, I. Gabilondo, D. Ezpeleta, M. A. Labrador-Espinosa, A. Sanchez-Ferro, C. Tejero, M. Matarazzo
Summary: This study evaluated the impact of new technologies on Spanish neurology and found that advanced neuroimaging, biosensors, electrophysiology and neurostimulation, and telemedicine are widely used in the field. Madrid has the highest number of communications related to new technologies.
Article
Public, Environmental & Occupational Health
Inaki Galan, Cristina Ortiz, Monica Perez-Rios, Ana Ayuso-alvarez, Carmen Rodriguez-Blazquez, Javier Damian, Carlos Fernandez-Escobar, Esther Garcia-Esquinas, Teresa Lopez-Cuadrado
Summary: This study aims to assess the impact of light smoking on mortality. The results show that smokers have an increased risk of mortality compared to non-smokers. Therefore, it is necessary to conduct awareness-raising campaigns to increase people's awareness of the health hazards of light smoking.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Josep Gamez, Matilde Calopa, Esteban Munoz, Aileen Ferre, Oscar Huertas, Kevin McAllister, Nuria Reig, Catherine Scart-Gres, Raul Insa, Jaime Kulisevsky
Summary: The aim of this study was to investigate the efficacy and safety of SOM3355 as a repositioned treatment for reducing chorea in Huntington's disease. The results showed that SOM3355 reduced chorea in HD patients and was well-tolerated. Larger studies are needed to confirm its therapeutic utility as an antichoreic drug.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Clinical Neurology
Frederic Sampedro, Arnau Puig-Davi, Saul Martinez-Horta, Javier Pagonabarraga, Andrea Horta-Barba, Ignacio Aracil-Bolan, Jaime Kulisevsky
Summary: Cognitive and neuropsychiatric symptoms in Parkinson's disease reflect cortical degeneration, and intracortical diffusivity can detect symptom-specific cortical microstructural damage.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Family Studies
Cristina Alfaro-Diaz, Nuria Esandi, Maria Pueyo-Garrigues, Navidad Canga-Armayor, Maria Joao Forjaz, Carmen Rodriguez-Blazquez, Ana Canga-Armayor
Summary: Nurses' attitudes toward families are crucial in improving relationships with patients' families. This study analyzed the psychometric properties of the refined Spanish version of the FINC-NA, finding it to be a reliable and valid measure with good fit to the Rasch model. The scale showed multidimensionality and a simpler response scheme compared to the original version, and was unbiased regarding age and experience time.
JOURNAL OF FAMILY NURSING
(2023)
Article
Clinical Neurology
David Mata-Marin, Jose angel Pineda-Pardo, Mario Michiels, Cristina Pagge, Claudia Ammann, Raul Martinez-Fernandez, Jose Antonio Molina, Lydia Vela-Desojo, Fernando Alonso-Frech, Ignacio Obeso
Summary: This study provides evidence for the balance between enhanced desire towards reward and cognitive control deficits in patients with impulse-control disorder, specifically hypersexuality, in Parkinson's disease under dopamine replacement therapy. The study also identifies the underlying fronto-striatal and mesolimbic circuitry involved in uncontrollable sexual responses and demonstrates that cortical neuromodulation can alleviate this symptom.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Valentina Leta, Daniel J. van Wamelen, Federico Aureli, Vinod Metta, Dhaval Trivedi, Pietro Cortelli, Carmen Rodriguez-Blazquez, Alexandra Rizos, K. Ray Chaudhuri
Summary: This study aimed to evaluate the long-term effects of opicapone and entacapone on non-motor symptoms (NMS) in levodopa-treated people with Parkinson's disease. The results showed that opicapone can stabilize NMS burden and sleep dysfunction, while entacapone leads to worsening of NMS burden and sleep scores over a 1-year follow-up.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Neurosciences
Andrea Horta-Barba, Saul Martinez-Horta, Frederic Sampedro, Jesus Perez-Perez, Javier Pagonabarraga, Jaime Kulisevsky
Summary: This study aimed to explore the performance and neural correlates of arithmetic deficits in individuals with pre-manifest and early symptomatic Huntington's disease (HD). The results revealed that lower arithmetic performance in HD participants was associated with reduced gray-matter volume and metabolic dysfunction, while in preHD individuals, it was associated with prefrontal alterations. These findings suggest that cognitive deficits in HD involve not only frontal-striatal dysfunctions but also fronto-temporal and parieto-occipital damage.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Clinical Neurology
Jaime Kulisevsky, Saul Martinez-Horta, Antonia Campolongo, Berta Pascual-Sedano, Juan Marin-Lahoz, Helena Bejr-kasem, Jose L. Labandeira-Garcia, Jose L. Lanciego, Arnau Puig-Davi, Andrea Horta-Barba, Javier Pagonabarraga, Jon Rodriguez-Antiguedad
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Neurosciences
Diego Santos-Garcia, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Iago Garcia Diaz, Silvia Jesus, Maria Teresa Buongiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Sotos, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Menendez Gonzalez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez Diaz, Darrian McAfee, Matilde Calopa, Fatima Carrillo, Francisco Escamilla Sevilla, Eric Freire-Alvarez, Juan Carlos Gomez Esteban, Rocio Garcia Ramos, Maria Rosario Isabel Luquin, Irene Martinez-Torres, Angel Sesar Ignacio, Pablo Martinez-Martin, Pablo Mir
Summary: This study applied the MNCD classification to Parkinson's disease patients and analyzed its correlation with quality of life and disease severity. The results showed that a more advanced MNCD stage was associated with poorer quality of life and greater disease severity. Therefore, MNCD could be a useful tool for monitoring disease progression in Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Imane Jroundi, Nerea Fernandez de Larrea-Baz, Carmen Rodriguez-Blazquez, Roberto Pastor-Barriuso, Marina Pollan-Santamaria, Maria Joao Forjaz, Beatriz Perez-Gomez
Summary: In 2020, we evaluated whether compliance with preventive measures against SARS-CoV-2 infection among adults living with children was different from that of those not living with them. The results showed that adults living with children more frequently avoided going to bars, crowded places, and using public transportation, and they were more worried about work and family conciliation and closure of education centers.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Sociology
Maria Falcon-Romero, Carmen Rodriguez-Blazquez, Maria Romay-Barja, Maria Joao Forjaz
Summary: The study explores the concerns and attitudes of the population towards the COVID-19 pandemic, and analyzes their acceptance and adherence to preventive measures, as well as their perception of risk and trust in information sources and institutions. The results show that attitudes are dynamic and influenced by both individual and contextual factors.
REVISTA ESPANOLA DE SOCIOLOGIA
(2023)
Article
Behavioral Sciences
Daniel Collerton, James Barnes, Nico J. Diederich, Rob Dudley, Dominic Ffytche, Karl Friston, Christopher G. Goetz, Jennifer G. Goldman, Renaud Jardri, Jaime Kulisevsky, Simon J. G. Lewis, Shigetoshi Naral, Claire O'Callaghan, Marco Onofrj, Javier Pagonabarraga, Thomas Parr, James M. Shine, Glenn Stebbins, John-Paul Taylor, Ichiro Tsuda, Rimona S. Weil
Summary: Despite years of research, it remains uncertain why people sometimes perceive things that aren't there. Eight models of complex visual hallucinations have been proposed since 2000, each based on different understandings of brain organization. To address this variability, researchers established an integrated Visual Hallucination Framework that aligns with current theories of veridical and hallucinatory vision, enabling a systematic investigation of the relationship between hallucination phenomenology and cognitive structures. The episodic nature of hallucinations suggests a complex relationship between state and trait markers, highlighting new avenues for research and potential approaches to treating distressing hallucinations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Letter
Clinical Neurology
Celia Delgado, Alejandro Lopez-Jimenez, Eva Lopez-Valdes, Victor Gomez-Mayordomo, Ana Baltasar-Corral, Juan Carlos Martinez-Castrillo, Araceli Alonso-Canovas, Guillermo Tabar, Pedro J. Garcia-Ruiz, Soraya de la Fuente, Lydia Vela-Desojo, Isabel Parees, Monica M. Kurtis
PARKINSONISM & RELATED DISORDERS
(2023)