Letter
Clinical Neurology
T. J. C. Zoon, V. Mathiopoulou, G. van Rooijen, P. van den Munckhof, D. A. J. P. Denys, P. R. Schuurman, R. M. A. de Bie, M. Bot
Summary: This study used subthalamic nucleus deep brain stimulation (STN DBS) and network analysis to investigate the relationship between the location of active DBS contact points and apathy in Parkinson's disease (PD) patients. The results showed that active contacts in apathy patients were more often positioned in the area with a high density of surrounding projections to associative cortex areas. The study provides insight into the anatomical connectivity substrate for apathy in DBS.
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Neurosciences
Yingchuan Chen, Guanyu Zhu, Yuye Liu, Defeng Liu, Tianshuo Yuan, Xin Zhang, Yin Jiang, Tingting Du, Jianguo Zhang
Summary: The study found that changes in brain morphology are associated with the initial motor response to subthalamic nucleus deep brain stimulation in Parkinson's disease patients, and can be used to predict individual initial stimulation-related motor responses.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Behavioral Sciences
Chun-Hwei Tai
Summary: Understanding the pathophysiological mechanism of Parkinson's disease in the subthalamic nucleus is crucial for effective treatment through deep brain stimulation. STN burst firing is considered an electrophysiological signature of the cortico-basal ganglia circuit in PD patients, and plays a significant role in the motor symptoms of PD as well. This review explores the origins of STN bursts, factors influencing their formation, and the potential for interventions to alleviate PD symptoms.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Clinical Neurology
Thomas J. C. Zoon, Geeske van Rooijen, Georgina M. F. C. Balm, Isidoor O. Bergfeld, Joost G. Daams, Paul Krack, Damiaan A. J. P. Denys, Rob M. A. de Bie
Summary: This meta-analysis found that apathy is increased after STN DBS compared to the pre-operative state and medication only. The difference in severity of apathy remained significant after multiple analyses.
MOVEMENT DISORDERS
(2021)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Miranda J. Munoz, Rishabh Arora, Yessenia M. Rivera, Quentin H. Drane, Gian D. Pal, Leo Verhagen Metman, Sepehr B. Sani, Joshua M. Rosenow, Lisa C. Goelz, Daniel M. Corcos, Fabian J. David
Summary: This study found that medication worsens saccade performance and benefits reaching performance, while STN-DBS benefits both saccade and reaching performance. These findings suggest potential physiological changes due to treatment.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Fabian J. David, Yessenia M. Rivera, Tara K. Entezar, Rishabh Arora, Quentin H. Drane, Miranda J. Munoz, Joshua M. Rosenow, Sepehr B. Sani, Gian D. Pal, Leonard Verhagen-Metman, Daniel M. Corcos
Summary: This study investigated the effects of encoding type, medication, and subthalamic nucleus deep brain stimulation (STN-DBS) on memory-guided movements in Parkinson's disease (PD). The findings revealed that encoding type influenced reaching performance and deficits in PD, medication had differential effects depending on the encoding type, and STN-DBS was superior to medication in increasing amplitude and velocity. The study provides valuable insights into the understanding of memory-guided movements in PD and the effects of different treatments.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Alberto Averna, Sara Marceglia, Mattia Arlotti, Marco Locatelli, Paolo Rampini, Alberto Priori, Tommaso Bocci
Summary: This study evaluated the spectrum of local field potentials (LFP) obtained from different contacts within the subthalamic nucleus in Parkinson's disease patients, and their correlations with clinical symptoms. The results showed differences in spectral patterns and correlations with motor symptoms between LFP12 and LFP03 before and after levodopa administration, suggesting potential for optimizing adaptive deep brain stimulation protocols for Parkinson's disease.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Stefanie T. Jost, Lena Strobel, Alexandra Rizos, Philipp A. Loehrer, Keyoumars Ashkan, Julian Evans, Franz Rosenkranz, Michael T. Barbe, Gereon R. Fink, Jeremy Franklin, Anna Sauerbier, Christopher Nimsky, Afsar Sattari, K. Ray Chaudhuri, Angelo Antonini, Lars Timmermann, Pablo Martinez-Martin, Monty Silverdale, Elke Kalbe, Veerle Visser-Vandewalle, Haidar S. Dafsari
Summary: Previous studies have shown that women with Parkinson's disease (PD) have less access to deep brain stimulation (DBS) compared to men. This study observed and compared a total of 505 patients and found that women with PD were less likely to be referred for DBS, but more likely to be approved for the treatment. The study also found that women and men with PD had different preoperative symptoms and characteristics. However, both genders had similar improvements in clinical outcomes after the surgery.
NPJ PARKINSONS DISEASE
(2022)
Article
Neurosciences
Martina Bockova, Eva Vytvarova, Martin Lamos, Petr Klimes, Pavel Jurak, Josef Halamek, Sabina Goldemundova, Marek Balaz, Ivan Rektor
Summary: The response to subthalamic nucleus deep brain stimulation (STN-DBS) varies individually and is difficult to predict. While most patients did not show changes in global network organization, suboptimal responders exhibited decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas. The supplementary motor area was demonstrated to play an important role in the optimal response to DBS, with good responders showing increased node strength and eigenvector centrality in this brain region.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Takao Nozaki, Kenji Sugiyama, Tetsuya Asakawa, Hiroki Namba, Masamichi Yokokura, Tatsuhiro Terada, Tomoyasu Bunai, Yasuomi Ouchi
Summary: This study investigated the impact of STN-DBS on neuronal terminal survival and found that STN-DBS can increase dopamine transporter levels in the anteroventral striatum, which is correlated with motor recovery and may suggest a regulatory effect of STN-DBS on dopaminergic terminals in Parkinson's disease patients.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ahwon Kim, Jed Noel A. Ong, Hye Ran Park, Sun Ha Paek, Beomseok Jeon
Summary: This study aimed to investigate mortality and factors associated with mortality and causes of death after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. The results showed that 18.7% of patients died, with pneumonia being the most common cause of death. Older age, earlier disease onset, higher preoperative falling score while on medication, and higher preoperative total levodopa equivalent daily dose were associated with a higher risk of mortality.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Jeanne Garcia, Cecile Hubsch, Ana Marques, Jean-Marc Gurruchaga, Cedric Lamirel, Emmanuel Roze, Antoine Moulignier
Summary: The study demonstrated that STN-DBS is a safe and effective treatment for PLHIV with Parkinson's disease, significantly improving symptoms without major adverse events; impulse control disorders were fully resolved after surgery.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Letter
Clinical Neurology
Benedetta Demartini, Federico Wiedenmann, Adelaide Baccara, Veronica Nistico, Orsola Gambini, Antonio Emanuele Elia, Marina Grisoli, Luigi Michele Romito
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Lisette H. Koens, Marrit R. Klamer, Deborah A. Sival, Bettina Balint, Kailash P. Bhatia, Maria Fiorella Contarino, Martje E. van Egmond, Roberto Erro, Jennifer Friedman, Victor S. C. Fung, Christos Ganos, Manju A. Kurian, Anthony E. Lang, Eavan M. McGovern, Emmanuel Roze, Tom J. de Koning, Marina A. J. Tijssen
Summary: This article describes an easy-to-use clinical screening tool to help nonmovement disorder specialists recognize movement disorders in patients with inborn errors of metabolism (IEMs). Through scoring videos of 55 patients with different IEMs, informative tasks including walking, observations of the arms, and drawing a spiral were identified and incorporated into the screening tool. The study suggests that this tool can assist in selecting patients who should be referred to a movement disorder specialist for further evaluation and treatment.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Alessia Nasca, Niccolo E. Mencacci, Federica Invernizzi, Michael Zech, Ignacio J. Keller Sarmiento, Andrea Legati, Chiara Frascarelli, Bernabe Bustos, Luigi M. Romito, Dimitri Krainc, Juliane Winkelmann, Miryam Carecchio, Nardo Nardocci, Giovanna Zorzi, Holger Prokisch, Steven J. Lubbe, Barbara Garavaglia, Daniele Ghezzi
Summary: Nasca et al. have discovered a new candidate gene for dystonia, ATP5F1B, which encodes a subunit of the mitochondrial ATP synthase. This gene is associated with early-onset isolated dystonia in two families with autosomal dominant inheritance and incomplete penetrance. Functional studies showed a dominant-negative effect of the identified ATP5F1B variants, leading to reduced activity of complex V and impaired mitochondrial function.
Article
Neurosciences
Victor J. Geraedts, Jeroen P. P. Van Vugt, Johan Marinus, Roy Kuiper, Huub A. M. Middelkoop, Rodi Zutt, Niels A. Van der Gaag, Carel F. E. Hoffmann, Lucille D. A. Dorresteijn, Jacobus J. Van Hilten, Maria Fiorella Contarino
Summary: Standardized screening for STN DBS in Parkinson's disease patients is crucial to determine eligibility, but its utility to predict postoperative outcomes is inconclusive. This study aimed to evaluate the utility of universal components incorporated in the DBS screening, complemented by a wearable sensor, to predict motor outcomes and QoL one year after surgery. The results showed that preoperative tests, including wearable data, do not predict postoperative motor outcome, but post-DBS QoL is primarily driven by non-motor symptoms.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Tiziana De Santis, Valentina Serpieri, Tommaso Mazza, Michele Lanotte, Carlotta Criffo, Tommaso Mazza, Enza Maria Valente, Alberto Albanese
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Micol Avenali, Roberta Zangaglia, Giada Cuconato, Ilaria Palmieri, Alberto Albanese, Carlo Alberto Artusi, Marco Bozzali, Giovanna Calandra-Buonaura, Francesco Cavallieri, Roberto Cilia, Antoniangela Cocco, Filippo Cogiamanian, Fabiana Colucci, Pietro Cortelli, Alessio Di Fonzo, Roberto Eleopra, Giulia Giannini, Alberto Imarisio, Gabriele Imbalzano, Claudia Ledda, Leonardo Lopiano, Maria Chiara Malaguti, Francesca Mameli, Raffaella Minardi, Pierfrancesco Mitrotti, Edoardo Monfrini, Francesca Spagnolo, Cristina Tassorelli, Francesca Valentino, Franco Valzania, Claudio Pacchetti, Enza Maria Valente, PARKNET Study Gp
Summary: This study evaluated the long-term impact of GBA variants in a large Italian DBS-PD cohort and supported the role of DBS surgery as a valid therapeutic strategy in GBA-PD, with long-term benefit on motor performance and ICD. Despite the selective worsening of cognitive scores since 3 years post-DBS, the majority of GBA-PD had not developed dementia at 5-year follow-up.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Letter
Clinical Neurology
Luigi Michele Romito, Sara Prioni, Arianna Braccia, Marcella Catania, Antonio Emanuele Elia, Francesco Dondi, Silvia Lucchini, Francesco Bertagna, Sylvie H. M. J. Piacentini, Roberto Eleopra, Giuseppe Di Fede
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Alessio Di Fonzo, Marco Percetti, Edoardo Monfrini, Ilaria Palmieri, Alberto Albanese, Micol Avenali, Anna Bartoletti-Stella, Fabio Blandini, Gloria Brescia, Giovanna Calandra-Buonaura, Rosa Campopiano, Sabina Capellari, Isabel Colangelo, Giacomo Pietro Comi, Giada Cuconato, Rosangela Ferese, Caterina Galandra, Stefano Gambardella, Barbara Garavaglia, Andrea Gaudio, Emiliano Giardina, Federica Invernizzi, Paola Mandich, Rossana Mineri, Celeste Panteghini, Chiara Reale, Lucia Trevisan, Stefania Zampatti, Pietro Cortelli, Enza Maria Valente
Summary: This study attempts to harmonize the reporting of PD genetic testing across multiple diagnostic labs and highlights the current challenges in interpreting genetic variants from NGS-multigene panels, which has significant implications for counseling.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Luigi Michele Romito, Fabio Paio, Nico Golfre Andreasi Parkinson, Celeste Panteghini, Sara Rinaldo, Ahmet Kaymak, Alberto Mazzoni, Fabiana Colucci, Vincenzo Levi, Giuseppe Messina, Barbara Garavaglia, Roberto Eleopra
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Christian Geroin, Martina Petracca, Sonia Di Tella, Enrico Marcuzzo, Roberto Erro, Sofia Cuoco, Roberto Ceravolo, Sonia Mazzucchi, Andrea Pilotto, Alessandro Padovani, Luigi Michele Romito, Roberto Eleopra, Mario Zappia, Alessandra Nicoletti, Carlo Dallocchio, Carla Arbasino, Francesco Bono, Vincenzo Laterza, Benedetta Demartini, Orsola Gambini, Nicola Modugno, Enrica Olivola, Laura Bonanni, Alberto Albanese, Gina Ferrazzano, Alessandro Tessitore, Leonardo Lopiano, Giovanna Calandra-Buonaura, Francesca Morgante, Marcello Esposito, Antonio Pisani, Paolo Manganotti, Lucia Tesolin, Francesco Teatini, Serena Camozzi, Tommaso Ercoli, Fabrizio Stocchi, Mario Coletti Moja, Giovanni Defazio, Michele Tinazzi
Summary: This study assessed the prevalence and clinical manifestations of functional motor disorders (FMD) with elderly and younger onset, and their relationship with demographic and clinical variables.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Edoardo Monfrini, Laura Avanzino, Giovanni Palermo, Giulia Bonato, Gloria Brescia, Roberto Ceravolo, Giovanna Cantarella, Paola Mandich, Holger Prokisch, Karin Storm Vans Gravesande, Giulia Straccia, Antonio Elia, Chiara Reale, Celeste Panteghini, Giovanna Zorzi, Roberto Eleopra, Roberto Erro, Miryam Carecchio, Barbara Garavaglia, Michael Zech, Luigi Romito, Alessio Di Fonzo
Summary: This case collection expands the genetic and clinical spectrum of VPS16-related disease, prompting movement disorder specialists to suspect mutations of this gene not only in patients with isolated dystonia.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Luigi M. Romito, Valentina Leta, Barbara Garavaglia, Celeste Panteghini, Giovanna Zorzi, Antonio E. Elia, Fabiana Colucci, Miryam Carecchio, Roberto Eleopra
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Nicola Rifino, Anna Bersano, Alessandro Padovani, Giancarlo Maria Conti, Anna Cavallini, Luca Colombo, Alberto Priori, Raffaella Pianese, Maria Rosaria Gammone, Alessandra Erbetta, Elisa Francesca Ciceri, Davide Sattin, Riccardo Varvello, Eugenio Agostino Parati, Emma Scelzo
Summary: The development of virtual care options, including virtual hospital platforms, is rapidly changing healthcare, especially during the pandemic. A pilot study on neurological Virtual Hospital (NOVHO) was conducted in 2020 to explore a multidisciplinary second opinion evaluation system for neurological diseases. The diagnosis and treatment of rare cerebrovascular diseases (rCVD) face challenges due to the lack of data on patient phenotype and clinical course. Virtual consultation strategies are increasingly used for patient management in peripheral areas. The use of Artificial Intelligence and the Internet of Things will bring healthcare closer to personalized medicine.
NEUROLOGICAL SCIENCES
(2023)
Meeting Abstract
Clinical Neurology
R. Telese, L. Romito, N. Golfre Andreasi, G. Zorzi, A. Elia, S. Rinaldo, G. Devigili, R. Cilia, G. Messina, V. Levi, A. Franzini, R. Eleopra
MOVEMENT DISORDERS
(2023)
Meeting Abstract
Clinical Neurology
G. Devigili, S. Prioni, M. Corradi, R. Telese, P. Amami, R. Cilia, A. Elia, L. Romito, N. Golfre' Andreasi, S. Piacentini, R. Eleopra
EUROPEAN JOURNAL OF NEUROLOGY
(2023)