Review
Clinical Neurology
Roberta Bonomo, Antonio E. Elia, Giulio Bonomo, Luigi M. Romito, Caterina Mariotti, Grazia Devigili, Roberto Cilia, Riccardo Giossi, Roberto Eleopra
Summary: In patients with Huntington's disease, deep brain stimulation in the globus pallidus internus can lead to significant improvements in disease rating and motor symptoms, while effectively reducing chorea scores. Further studies are needed to identify reliable criteria to guide patient selection for DBS therapy.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Summary: The study investigated the behavioral responses of Parkinson's disease patients under globus pallidus internus DBS settings, revealing a negative correlation between the volume of tissue activation connected to the right prefrontal cortex and impulsivity, while greater overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.
Article
Geriatrics & Gerontology
Jinlu Xie, Zheng Chen, Tingting He, Hengya Zhu, Tingyu Chen, Chongbin Liu, Xuyan Fu, Hong Shen, Tao Li
Summary: This study found that GP-DBS can improve motor symptoms and reverse the electrical activity of the PF nucleus in PD model rats, providing a potential mechanism for GP-DBS treatment of PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Vanessa M. Holanda, Robert Stephen Eisinger, Leonardo Almeida, Takashi Tsuboi, Huimin Wang, Michael S. Okun, Wissam Deeb, Addie Patterson, Aparna Wagle Shukla, Janine Lobo Lopes, Kelly Douglas Foote
Summary: This study aimed to evaluate the evolution of GPi DBS targeting in patients with dystonia or PD. During 15 years of follow-up, lead locations in the PD group migrated laterally, posteriorly, and dorsally, whereas leads in the dystonia group showed a trend in the dorsal direction. The evolving target may result from improvements in targeting techniques and clinical feedback intraoperatively and post-operatively.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Takashi Tsuboi, Marc Charbel, David T. Peterside, Mohit Rana, Ahmad Elkouzi, Wissam Deeb, Adolfo Ramirez-Zamora, Janine Lemos Melo Lobo Jofili Lopes, Leonardo Almeida, Pamela R. Zeilman, Robert S. Eisinger, Kelly D. Foote, Lela Okromelidze, Sanjeet S. Grewal, Michael S. Okun, Erik H. Middlebrooks
Summary: This study aimed to identify anatomical regions related to stimulation-induced dyskinesia (SID) in PD patients after pallidal DBS and analyze the connectivity associated with SID. The results showed that SID VTAs were primarily located in the dorsal GPi/GPe and had higher structural connectivity to certain cortical regions compared to non-SID VTAs. Differences in connectivity between motor-related cortices and subcortical regions may explain the presence or absence of SID.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Florian Lange, Carolina Soares, Jonas Roothans, Rita Raimundo, Hazem Eldebakey, Benedikt Weigl, Robert Peach, Christine Daniels, Thomas Musacchio, Jens Volkmann, Maria Jose Rosas, Martin M. Reich
Summary: Deep brain stimulation is effective for alleviating dystonia motor symptoms, but delayed symptom control and lack of therapeutic biomarkers and optimal programming settings complicate postoperative management. This study prospectively tested machine-predicted programming settings and found that they significantly reduced dystonia symptoms compared to clinical programming.
Article
Clinical Neurology
Leon Sobesky, Lukas Goede, Vincent J. J. Odekerken, Qiang Wang, Ningfei Li, Clemens Neudorfer, Nanditha Rajamani, Bassam Al-Fatly, Martin Reich, Jens Volkmann, Rob M. A. de Bie, Andrea A. Kuehn, Andreas Horn
Summary: This study investigated the connectivity profiles of deep brain stimulation electrodes in patients with Parkinson's disease and found a common functional network between subthalamic and pallidal stimulation that is associated with optimal clinical improvements. Furthermore, the study showed that connectivity maps based on different motor symptom subscores can predict treatment outcomes.
Article
Clinical Neurology
Daniel G. Di Luca, Carolina Ramirez-Gomez, Jurgen Germann, Brendan Santyr, Alexandre Boutet, Luka Milosevic, Anthony E. Lang, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: This study aimed to evaluate the safety and efficacy of deep brain stimulation on the globus pallidus pars interna and externa in MSA-P patients. The surgery did not result in major complications, but did not provide significant clinical benefit as measured by MDS-UPDRS III.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Suzhen Lin, Yimei Shu, Chencheng Zhang, Lingbing Wang, Peng Huang, Yixin Pan, Jianqing Ding, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: This study compared the effectiveness of targeting the globus pallidus internus (GPi) and the subthalamic nucleus (STN) in patients with isolated dystonia. The results showed that STN-DBS had superior effects at 1 month, 1 year, and 3 years, while GPi-DBS was better for axis symptoms, particularly for trunk involvement. STN-DBS was also more effective for symptoms involving the eyes and generalized dystonia, and required less electrical energy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biology
Gaetan Poulen, Emilie Chan-Seng, Emily Sanrey, Philippe Coubes
Summary: Cerebral palsy is a heterogeneous group of non-progressive syndromes with various clinical variations due to brain damage and etiologies. The treatment of acquired dystonia in CP is challenging, with pharmacological and surgical treatments showing limitations.
Article
Clinical Neurology
Yijie Lai, Naying He, Hongjiang Wei, Lifu Deng, Haiyan Zhou, Jun Li, Marcus Kaiser, Chencheng Zhang, Dianyou Li, Bomin Sun
Summary: This study investigated patient-specific functional connectivity related to globus pallidus internus (GPi) deep brain stimulation (DBS) outcome in Parkinson disease (PD) and established connectivity models for outcome prediction. The results showed that patient-specific functional connectivity seeding from the VTA-GPi intersection could help in GPi DBS outcome prediction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Behavioral Sciences
Aijun Liu, Yongcheng Jiao, Shaohui Zhang, Haibo Kong
Summary: Bilateral posteroventral GPi DBS can significantly alleviate motor tics and depressive symptoms in GTS patients, but vocal tics and other psychiatric symptoms may worsen without statistical difference during the follow-up period.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Zhitong Zeng, Linbin Wang, Weikun Shi, Lu Xu, Zhengyu Lin, Xinmeng Xu, Peng Huang, Yixin Pan, Zhonglue Chen, Yun Ling, Kang Ren, Chencheng Zhang, Bomin Sun, Dianyou Li
Summary: This study found that subthalamic nucleus (STN) deep brain stimulation (DBS) is more effective than unilateral globus pallidus interna (GPi) DBS in treating motor symptoms. STN DBS improves symptoms on both sides of the body, while GPi DBS mainly affects the contralateral side.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Tariq Parker, Ashley L. B. Raghu, James J. FitzGerald, Alexander L. Green, Tipu Z. Aziz
Summary: Dual thalamo-pallidal stimulation demonstrates great flexibility and efficacy in managing complex movement disorders, but also has limitations.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Brent Bluett, Elissa Ash, Amtul Farheen, Alfonso Fasano, Joachim K. Krauss, Alessio Maranzano, Massimiliano Passaretti, David F. Tang-Wai, Jay Van Gerpen, Araceli Alonso-Canovas, Jinyoung Youn, Jan Malm, Davide Martino
Summary: This review evaluated the phenomenology of idiopathic normal pressure hydrocephalus (iNPH). Wide-based gait was found to be the most common gait dysfunction, while cognitive testing showed significant variations and no specific cognitive profile was identified. Urodynamic testing revealed detrusor overactivity and overactive bladder as the most common symptoms of urinary dysfunction.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Conor Fearon, Arun E. Sundaram, Renato P. Munhoz, Alfonso Fasano, Felix Tyndel
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Alfonso Fasano, Rocio Garcia-Ramos, Tanya Gurevich, Robert Jech, Lars Bergmann, Olga Sanchez-Solino, Juan Carlos Parra, Mihaela Simu
Summary: A multinational retrospective study found that long-term use of levodopa-carbidopa intestinal gel (LCIG) can improve motor and nonmotor symptoms in patients with Parkinson's disease, while potentially reducing the need for additional medications.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Stefanie Jost, Marie-Ann Kaldenbach, Angelo Antonini, Pablo Martinez-Martin, Lars Timmermann, Per Odin, Regina Katzenschlager, Rupam Borgohain, Alfonso Fasano, Fabrizio Stocchi, Nobutaka Hattori, Prashanth Lingappa Kukkle, Mayela Rodriguez-Violante, Cristian Falup-Pecurariu, Sebastian Schade, Jan Niklas Petry-Schmelzer, Vinod Metta, Daniel Weintraub, Guenther J. Deuschl, Alberto J. Espay, Eng-King Tan, Roongroj Bhidayasiri, Victor S. C. Fung, Francisco Cardoso, Claudia Trenkwalder, Peter Jenner, K. S. Ray Chaudhuri, Haidar Dafsari
Summary: This study reviewed the investigations on drug therapy for Parkinson's disease since 2010 and proposed a new drug conversion formula. These conversion formulas can help us compare drug regimens across different clinical trials. The results are important for studying the pharmacological efficacy of Parkinson's disease treatments as well as other non-pharmacological interventions.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Matteo Bologna, Alberto J. Espay, Alfonso Fasano, Giulia Paparella, Mark Hallett, Alfredo Berardelli
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Jinyoung Youn, Carolina Gorodetsky, Andres M. Lozano, Anthony E. Lang, Alfonso Fasano
Summary: Despite no previous reports on parkinsonism in Poland syndrome (PS) and the lack of studies on treatment response, we present a case of ipsilateral parkinsonism in PS, resembling hemiatrophy-hemiparkinsonism, with a positive response to levodopa and subthalamic deep brain stimulation.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Multidisciplinary Sciences
Sabrina Schlienger, Patricia T. Yam, Nursen Balekoglu, Hugo Ducuing, Jean-Francois Michaud, Shirin Makihara, Daniel K. Kramer, Baoyu Chen, Alfonso Fasano, Alfredo Berardelli, Fadi F. Hamdan, Guy A. Rouleau, Myriam Srour, Frederic Charron
Summary: Mirror movements (MM) disorder is characterized by involuntary movements on one side of the body that mirror intentional movements on the opposite side. In this study, we identified ARHGEF7 as a candidate MM gene and demonstrated its role in Netrin-1-mediated axon guidance. We further showed that Arhgef7/Git1 acts as a multifunctional effector complex, activating Rac1 and Cdc42 and inhibiting Arf1 downstream of Netrin-1.
Review
Clinical Neurology
Massimiliano Passaretti, Alessio Maranzano, Brent Bluett, Rajasumi Rajalingam, Alfonso Fasano
Summary: Gait analysis is a reliable tool to assess gait impairment in iNPH patients. Gait parameters improve after tap-test and CSF shunt surgery, but do not completely normalize. Tap-test's effect on gait velocity reaches its peak after 24-48 hours and returns to baseline after 90-100 hours.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
John A. Thompson, Lisa Hirt, Pamela David-Gerecht, Alfonso Fasano, Daniel R. Kramer, Steven G. Ojemann, Drew S. Kern
Summary: This study compared two methods of deep brain stimulation (DBS) programming: monopolar review (MR) and fixed parameter vertical and horizontal fractionalization (FPF). The results showed that FPF is a viable and efficient methodology that can be used for initial programming in clinical practice.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Rajasumi Rajalingam, Alfonso Fasano
Summary: This study systematically reviewed the literature of the past decade on punding in Parkinson's disease (PD), focusing on its clinical features, underlying pathophysiological mechanisms, and treatment. The review confirmed that predictors of punding in PD are higher doses of dopamine replacement therapy, younger age, male sex, and increasing disease severity. Neuroimaging studies have shown a disconnection between midbrain, limbic and white matter tracts projecting to the frontal cortices and a breakdown of the connectivity among the crucial nodes of the reward circuit in PD patients with punding. Low-frequency repetitive transcranial magnetic stimulation on the dorsolateral prefrontal cortex has been shown to produce a transient beneficial effect.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Daniel G. Di Luca, Carolina Ramirez-Gomez, Jurgen Germann, Brendan Santyr, Alexandre Boutet, Luka Milosevic, Anthony E. Lang, Suneil K. Kalia, Andres M. Lozano, Alfonso Fasano
Summary: This study aimed to evaluate the safety and efficacy of deep brain stimulation on the globus pallidus pars interna and externa in MSA-P patients. The surgery did not result in major complications, but did not provide significant clinical benefit as measured by MDS-UPDRS III.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Robin Wolke, Jos Steffen Becktepe, Steffen Paschen, Ann-Kristin Helmers, Dorothee Kuebler-Weller, Jinyoung Youn, Dana Brinker, Hagai Bergman, Andrea A. Kuehn, Alfonso Fasano, Guenther Deuschl
Summary: The efficacy of deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease varies among patients. The levodopa challenge can be used to predict individual responses, but its accuracy is limited.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Alexandra Boogers, Alfonso Fasano
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Elahe Amini, Mohammad Rohani, Alfonso Fasano, Zahra Azad, Shahnaz Miri, Seyed Amir Hassan Habibi, Maziar Emamikhah, Reza Mirshahi, Mohammad Taghi Joghataei, Zeinab Gholibeigian, Khalil Ghasemi Falavarjani
Summary: Observing pathological structural and functional neurovascular changes in NBIA patients may provide an opportunity to elucidate the underlying mechanisms and differential retinal biomarkers in NBIA subtypes.
MOVEMENT DISORDERS
(2023)
Letter
Neurosciences
Sergio Rodriguez-Quiroga, Mayra Aldecoa, Nicolas Morera, Carolina Gatti, Cesar Gil, Nelida Garretto, Alfonso Fasano
